LOCUS       NM_001810               2890 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens centromere protein B (CENPB), mRNA.
ACCESSION   NM_001810
VERSION     NM_001810.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2890)
  AUTHORS   Tian,W., Zhang,Y., Liu,H., Jin,H. and Sun,T.
  TITLE     LINC01123 potentially correlates with radioresistance in glioma
            through the miR-151a/CENPB axis
  JOURNAL   Neuropathology 42 (1), 3-15 (2022)
   PUBMED   34519373
  REMARK    GeneRIF: LINC01123 potentially correlates with radioresistance in
            glioma through the miR-151a/CENPB axis.
REFERENCE   2  (bases 1 to 2890)
  AUTHORS   Ishikura,S., Yoshida,K., Hashimoto,S., Nakabayashi,K., Tsunoda,T.
            and Shirasawa,S.
  TITLE     CENP-B promotes the centromeric localization of ZFAT to control
            transcription of noncoding RNA
  JOURNAL   J Biol Chem 297 (4), 101213 (2021)
   PUBMED   34547289
  REMARK    GeneRIF: CENP-B promotes the centromeric localization of ZFAT to
            control transcription of noncoding RNA.
REFERENCE   3  (bases 1 to 2890)
  AUTHORS   Chen,Y., Zhang,Q., Teng,Z. and Liu,H.
  TITLE     Centromeric transcription maintains centromeric cohesion in human
            cells
  JOURNAL   J Cell Biol 220 (7) (2021)
   PUBMED   33881484
  REMARK    GeneRIF: Centromeric transcription maintains centromeric cohesion
            in human cells.
REFERENCE   4  (bases 1 to 2890)
  AUTHORS   Nagpal,H. and Fierz,B.
  TITLE     The Elusive Structure of Centro-Chromatin: Molecular Order or
            Dynamic Heterogenetity?
  JOURNAL   J Mol Biol 433 (6), 166676 (2021)
   PUBMED   33065112
  REMARK    GeneRIF: The Elusive Structure of Centro-Chromatin: Molecular Order
            or Dynamic Heterogenetity?
            Review article
REFERENCE   5  (bases 1 to 2890)
  AUTHORS   Hoffmann,S., Izquierdo,H.M., Gamba,R., Chardon,F., Dumont,M.,
            Keizer,V., Herve,S., McNulty,S.M., Sullivan,B.A., Manel,N. and
            Fachinetti,D.
  TITLE     A genetic memory initiates the epigenetic loop necessary to
            preserve centromere position
  JOURNAL   EMBO J 39 (20), e105505 (2020)
   PUBMED   32945564
  REMARK    GeneRIF: A genetic memory initiates the epigenetic loop necessary
            to preserve centromere position.
REFERENCE   6  (bases 1 to 2890)
  AUTHORS   Yoda,K., Kitagawa,K., Masumoto,H., Muro,Y. and Okazaki,T.
  TITLE     A human centromere protein, CENP-B, has a DNA binding domain
            containing four potential alpha helices at the NH2 terminus, which
            is separable from dimerizing activity
  JOURNAL   J Cell Biol 119 (6), 1413-1427 (1992)
   PUBMED   1469042
REFERENCE   7  (bases 1 to 2890)
  AUTHORS   Pluta,A.F., Saitoh,N., Goldberg,I. and Earnshaw,W.C.
  TITLE     Identification of a subdomain of CENP-B that is necessary and
            sufficient for localization to the human centromere
  JOURNAL   J Cell Biol 116 (5), 1081-1093 (1992)
   PUBMED   1740467
REFERENCE   8  (bases 1 to 2890)
  AUTHORS   Sullivan,K.F. and Glass,C.A.
  TITLE     CENP-B is a highly conserved mammalian centromere protein with
            homology to the helix-loop-helix family of proteins
  JOURNAL   Chromosoma 100 (6), 360-370 (1991)
   PUBMED   1893793
REFERENCE   9  (bases 1 to 2890)
  AUTHORS   Yen,T.J., Compton,D.A., Wise,D., Zinkowski,R.P., Brinkley,B.R.,
            Earnshaw,W.C. and Cleveland,D.W.
  TITLE     CENP-E, a novel human centromere-associated protein required for
            progression from metaphase to anaphase
  JOURNAL   EMBO J 10 (5), 1245-1254 (1991)
   PUBMED   2022189
REFERENCE   10 (bases 1 to 2890)
  AUTHORS   Cooke,C.A., Bernat,R.L. and Earnshaw,W.C.
  TITLE     CENP-B: a major human centromere protein located beneath the
            kinetochore
  JOURNAL   J Cell Biol 110 (5), 1475-1488 (1990)
   PUBMED   2335558
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AL109804.41, BC053847.1 and BC003649.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001810.5.
            
            Summary: This gene product is a highly conserved protein that
            facilitates centromere formation. It is a DNA-binding protein that
            is derived from transposases of the pogo DNA transposon family. It
            contains a helix-loop-helix DNA binding motif at the N-terminus,
            and a dimerization domain at the C-terminus. The DNA binding domain
            recognizes and binds a 17-bp sequence (CENP-B box) in the
            centromeric alpha satellite DNA. This protein is proposed to play
            an important role in the assembly of specific centromere structures
            in interphase nuclei and on mitotic chromosomes. It is also
            considered a major centromere autoantigen recognized by sera from
            patients with anti-centromere antibodies. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC053847.1, X05299.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379751.5/ ENSP00000369075.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AL109804.41        111277-111326       c
            51-2887             BC053847.1         1-2837
            2888-2890           BC003649.2         1267-1269
FEATURES             Location/Qualifiers
     source          1..2890
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..2890
                     /gene="CENPB"
                     /note="centromere protein B"
                     /db_xref="GeneID:1059"
                     /db_xref="HGNC:HGNC:1852"
                     /db_xref="MIM:117140"
     exon            1..2890
                     /gene="CENPB"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..2057
                     /gene="CENPB"
                     /note="centromere autoantigen B; CENP-B; centromere
                     protein B, 80kDa"
                     /codon_start=1
                     /product="major centromere autoantigen B"
                     /protein_id="NP_001801.1"
                     /db_xref="CCDS:CCDS13064.1"
                     /db_xref="GeneID:1059"
                     /db_xref="HGNC:HGNC:1852"
                     /db_xref="MIM:117140"
                     /translation="MGPKRRQLTFREKSRIIQEVEENPDLRKGEIARRFNIPPSTLST
                     ILKNKRAILASERKYGVASTCRKTNKLSPYDKLEGLLIAWFQQIRAAGLPVKGIILKE
                     KALRIAEELGMDDFTASNGWLDRFRRRHGVVSCSGVARARARNAAPRTPAAPASPAAV
                     PSEGSGGSTTGWRAREEQPPSVAEGYASQDVFSATETSLWYDFLPDQAAGLCGGDGRP
                     RQATQRLSVLLCANADGSEKLPPLVAGKSAKPRAGQAGLPCDYTANSKGGVTTQALAK
                     YLKALDTRMAAESRRVLLLAGRLAAQSLDTSGLRHVQLAFFPPGTVHPLERGVVQQVK
                     GHYRQAMLLKAMAALEGQDPSGLQLGLTEALHFVAAAWQAVEPSDIAACFREAGFGGG
                     PNATITTSLKSEGEEEEEEEEEEEEEEGEGEEEEEEGEEEEEEGGEGEELGEEEEVEE
                     EGDVDSDEEEEEDEESSSEGLEAEDWAQGVVEAGGSFGAYGAQEEAQCPTLHFLEGGE
                     DSDSDSEEEDDEEEDDEDEDDDDDEEDGDEVPVPSFGEAMAYFAMVKRYLTSFPIDDR
                     VQSHILHLEHDLVHVTRKNHARQAGVRGLGHQS"
     polyA_site      2890
                     /gene="CENPB"
                     /note="major polyA site"
ORIGIN      
        1 ctgccttccg cgcccgcgcc gcccgccctc gtctgcgccc gtcgcctgcc gcccgccgcc
       61 cggcgacgcg cccgccggcg tccccggagg tgcccccggc ccggccgggt cgtcgccccg
      121 ccgccgcgcc cgcgagccgc tttgtctcgg gcggggcgcg cgggagaggc cgccaggtgc
      181 cccccgccac gggcccgggc cccccgcccc ggggcggcgg cggcggcgcc gggccccggg
      241 gcggggggcg cgccgggatg ggccccaaga ggcgacagct gacgttccgg gagaagtcac
      301 ggatcatcca ggaggtggag gagaatccgg acctgcgcaa gggcgagatc gcgcggcgct
      361 tcaacatccc gccgtccacg ctgagcacga tcctgaagaa caagcgcgcc atcctggcgt
      421 cggagcgcaa gtacggggtg gcctccacct gccgcaagac caacaagctg tctccctacg
      481 acaagctcga gggcttgctc atcgcctggt tccagcagat ccgcgccgcc ggcctgccgg
      541 tcaagggcat catcctcaag gagaaggcgc tgcgcatagc cgaggagctg ggcatggacg
      601 acttcaccgc ctccaacggc tggctggacc gcttccgccg gcgccacggc gtggtgtcct
      661 gcagcggcgt ggcccgcgcc cgcgcgcgaa acgctgcccc ccgcaccccg gcggcgcctg
      721 ccagtccggc cgcggtgccc tcggagggca gtggcgggag cactactggt tggcgcgctc
      781 gggaggagca gccgccgtcg gtggccgagg gctacgcctc gcaggacgtg ttcagcgcca
      841 ccgagaccag tctatggtac gacttcctgc ccgaccaggc cgcggggctg tgcggaggcg
      901 acggacggcc gcgtcaagcc acccagcgcc tgagcgtcct gctatgcgcc aatgccgacg
      961 gcagcgagaa gctgcccccg ctggtggccg gcaagtcggc caagccccgc gcaggccaag
     1021 ccggcctgcc ctgcgactac accgccaact ccaagggtgg tgtcaccacc caggccctgg
     1081 ccaagtactt gaaggccttg gacacccgaa tggctgcaga gtctcgccgg gtcctgctgt
     1141 tggccggccg cttggctgcc cagtccttgg acacctcggg cctgcggcat gtgcagctgg
     1201 ccttcttccc tcccggcacc gtgcatccgc tggagagggg agtggtccag caggtgaagg
     1261 gccactaccg ccaggccatg ctgctcaagg ccatggccgc gctagagggc caggatccct
     1321 caggcctgca gctgggtctc acggaggccc tgcactttgt ggctgccgcc tggcaggcag
     1381 tggagccttc ggacatagcc gcctgctttc gtgaggctgg ctttgggggt ggccctaatg
     1441 ccaccatcac cacttccctc aagagtgagg gagaggaaga ggaggaggag gaggaagaag
     1501 aggaggagga agagggtgaa ggagaggaag aggaggagga aggggaggag gaggaggagg
     1561 aaggggggga aggagaggaa ttgggggagg aagaggaggt ggaggaggag ggtgatgttg
     1621 atagtgatga agaagaggag gaagatgagg agagctcctc ggagggcttg gaggctgagg
     1681 actgggccca gggagtagtg gaggccggtg gcagcttcgg ggcttatggt gcccaggagg
     1741 aagcccagtg ccctactctg catttcctgg aaggtgggga ggactctgat tcagacagtg
     1801 aggaagagga cgatgaggaa gaggatgatg aagatgaaga cgacgatgat gatgaggagg
     1861 atggtgatga ggtgcctgta cccagctttg gggaggccat ggcttacttt gccatggtca
     1921 agaggtacct gacctccttc cccattgatg accgcgtgca gagccacatc ctccacttgg
     1981 aacacgatct ggttcatgtg accaggaaga accacgccag gcaggcggga gttcgaggtc
     2041 ttggacatca aagctgagtc actggaccta gctgtgcccc caacctagat tggcagcacc
     2101 accccagggc agaggactct ctgggcaccc gctgtgcatg gagccagagt gcagagcccc
     2161 agatccttta gtaatgcttc ccctggtcct gcaacaggcc cggtcacctc ggccgggccc
     2221 ggggctgagg tcagcctcac tgcctgctta ttgcctcttt ctcagaatcc tctttcctcc
     2281 ccatttggcc ctgggctcag gggaccaggt ggggcgggtg gggagctgtc cggtgctacc
     2341 acaccgtgcc ctcagtggac taaccacagc agcagccagg gatgggccct ggaggttccc
     2401 ggccggagag tgcctctccc ctctgccatc cacgtcaggt ctttggtggg gggaccccaa
     2461 agccattctg ggaagggctc cagaagaagg tccagcctag gccccctgca aggctggcag
     2521 cccccacccc caccccccag gccgccttga gaagcacagt ttaactcact gcgggctcct
     2581 gagcctgctt ctgcctgctt tccacctccc cagtcccttt ctctggccct gtccatgtga
     2641 ctttggccct tggttttctt tccagattgg aggtttccaa gaggcccccc accgtggaag
     2701 taaccaaggg cgcttccttg tgggcagctg caggccccat gcctctcctc cctctctggc
     2761 agggccccat cctgggcaga ggggcctggg gctgggccca gagtccagcc gtccagctgc
     2821 tcctttccca gtttgatttc aataaatctg tccactcccc ttttgtgggg gtgaacgttt
     2881 taacagccaa
//
