LOCUS       NM_001809               1389 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens centromere protein A (CENPA), transcript variant 1,
            mRNA.
ACCESSION   NM_001809
VERSION     NM_001809.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1389)
  AUTHORS   Kang,Z., Li,R., Liu,C., Dong,X., Hu,Y., Xu,L., Liu,X., Xiang,Y.,
            Gao,L., Si,W., Wang,L., Li,Q., Zhang,L., Wang,H., Yang,X. and
            Liu,J.
  TITLE     m6A-modified cenRNA stabilizes CENPA to ensure centromere integrity
            in cancer cells
  JOURNAL   Cell 187 (21), 6035-6054 (2024)
   PUBMED   39305902
  REMARK    GeneRIF: m[6]A-modified cenRNA stabilizes CENPA to ensure
            centromere integrity in cancer cells.
REFERENCE   2  (bases 1 to 1389)
  AUTHORS   Peng,Y., Zhang,Y., Fang,R., Jiang,H., Lan,G., Xu,Z., Liu,Y.,
            Nie,Z., Ren,L., Wang,F., Zhang,S.D., Ma,Y., Yang,P., Ge,H.H.,
            Zhang,W.D., Luo,C., Li,A. and He,W.
  TITLE     Target Identification and Mechanistic Characterization of Indole
            Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential
            for Cdh1-Mediated Proteolysis of CENP-A
  JOURNAL   Adv Sci (Weinh) 11 (29), e2305593 (2024)
   PUBMED   38873820
  REMARK    GeneRIF: Target Identification and Mechanistic Characterization of
            Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is
            Essential for Cdh1-Mediated Proteolysis of CENP-A.
REFERENCE   3  (bases 1 to 1389)
  AUTHORS   Shen,X., Zhong,J., Yu,P., Liu,F., Peng,H. and Chen,N.
  TITLE     YTHDC1-dependent m6A modification modulated FOXM1 promotes
            glycolysis and tumor progression through CENPA in triple-negative
            breast cancer
  JOURNAL   Cancer Sci 115 (6), 1881-1895 (2024)
   PUBMED   38566554
  REMARK    GeneRIF: YTHDC1-dependent m6A modification modulated FOXM1 promotes
            glycolysis and tumor progression through CENPA in triple-negative
            breast cancer.
REFERENCE   4  (bases 1 to 1389)
  AUTHORS   Li,S., Zhang,Z., Li,Z., Yang,L., Liu,J., Liu,Y., Liu,Y., Hou,Y.,
            Mei,M. and Huang,Y.
  TITLE     CENPA promotes glutamine metabolism and tumor progression by
            up-regulating SLC38A1 in endometrial cancer
  JOURNAL   Cell Signal 117, 111110 (2024)
   PUBMED   38382691
  REMARK    GeneRIF: CENPA promotes glutamine metabolism and tumor progression
            by up-regulating SLC38A1 in endometrial cancer.
REFERENCE   5  (bases 1 to 1389)
  AUTHORS   Sethi,S.C., Shrestha,R.L., Balachandra,V., Durairaj,G., Au,W.C.,
            Nirula,M., Karpova,T.S., Kaiser,P. and Basrai,M.A.
  TITLE     beta-TrCP-Mediated Proteolysis of Mis18beta Prevents
            Mislocalization of CENP-A and Chromosomal Instability
  JOURNAL   Mol Cell Biol 44 (10), 429-442 (2024)
   PUBMED   39135477
  REMARK    GeneRIF: beta-TrCP-Mediated Proteolysis of Mis18beta Prevents
            Mislocalization of CENP-A and Chromosomal Instability.
REFERENCE   6  (bases 1 to 1389)
  AUTHORS   Biterge,B. and Schneider,R.
  TITLE     Histone variants: key players of chromatin
  JOURNAL   Cell Tissue Res 356 (3), 457-466 (2014)
   PUBMED   24781148
  REMARK    Review article
REFERENCE   7  (bases 1 to 1389)
  AUTHORS   Shelby,R.D., Vafa,O. and Sullivan,K.F.
  TITLE     Assembly of CENP-A into centromeric chromatin requires a
            cooperative array of nucleosomal DNA contact sites
  JOURNAL   J Cell Biol 136 (3), 501-513 (1997)
   PUBMED   9024683
REFERENCE   8  (bases 1 to 1389)
  AUTHORS   Sullivan,K.F., Hechenberger,M. and Masri,K.
  TITLE     Human CENP-A contains a histone H3 related histone fold domain that
            is required for targeting to the centromere
  JOURNAL   J Cell Biol 127 (3), 581-592 (1994)
   PUBMED   7962047
REFERENCE   9  (bases 1 to 1389)
  AUTHORS   Palmer,D.K., O'Day,K., Trong,H.L., Charbonneau,H. and Margolis,R.L.
  TITLE     Purification of the centromere-specific protein CENP-A and
            demonstration that it is a distinctive histone
  JOURNAL   Proc Natl Acad Sci U S A 88 (9), 3734-3738 (1991)
   PUBMED   2023923
REFERENCE   10 (bases 1 to 1389)
  AUTHORS   Palmer,D.K., O'Day,K., Wener,M.H., Andrews,B.S. and Margolis,R.L.
  TITLE     A 17-kD centromere protein (CENP-A) copurifies with nucleosome core
            particles and with histones
  JOURNAL   J Cell Biol 104 (4), 805-815 (1987)
   PUBMED   3558482
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011740.7.
            
            On Nov 22, 2018 this sequence version replaced NM_001809.3.
            
            Summary: Centromeres are the differentiated chromosomal domains
            that specify the mitotic behavior of chromosomes. This gene encodes
            a centromere protein which contains a histone H3 related histone
            fold domain that is required for targeting to the centromere.
            Centromere protein A is proposed to be a component of a modified
            nucleosome or nucleosome-like structure in which it replaces 1 or
            both copies of conventional histone H3 in the (H3-H4)2 tetrameric
            core of the nucleosome particle. The protein is a
            replication-independent histone that is a member of the histone H3
            family. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Nov
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL560695.3, U14518.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match              :: ENST00000335756.9/
                                               ENSP00000336868.4
            RefSeq Select criteria          :: based on manual assertion,
                                               conservation, expression,
                                               longest protein
            replication-independent histone :: PMID: 24781148
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-241               AC011740.7         41228-41468
            242-351             AC011740.7         47303-47412
            352-429             AC011740.7         47928-48005
            430-611             AC011740.7         48317-48498
            612-1389            AC011740.7         48984-49761
FEATURES             Location/Qualifiers
     source          1..1389
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..1389
                     /gene="CENPA"
                     /gene_synonym="CenH3; CENP-A"
                     /note="centromere protein A"
                     /db_xref="GeneID:1058"
                     /db_xref="HGNC:HGNC:1851"
                     /db_xref="MIM:117139"
     exon            1..241
                     /gene="CENPA"
                     /gene_synonym="CenH3; CENP-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..564
                     /gene="CENPA"
                     /gene_synonym="CenH3; CENP-A"
                     /note="isoform a is encoded by transcript variant 1;
                     centromere protein A, 17kDa; histone H3-like centromeric
                     protein A; centromere autoantigen A; centromere-specific
                     histone"
                     /codon_start=1
                     /product="histone H3-like centromeric protein A isoform a"
                     /protein_id="NP_001800.1"
                     /db_xref="CCDS:CCDS1729.1"
                     /db_xref="GeneID:1058"
                     /db_xref="HGNC:HGNC:1851"
                     /db_xref="MIM:117139"
                     /translation="MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRR
                     QGWLKEIRKLQKSTHLLIRKLPFSRLAREICVKFTRGVDFNWQAQALLALQEAAEAFL
                     VHLFEDAYLLTLHAGRVTLFPKDVQLARRIRGLEEGLG"
     exon            242..351
                     /gene="CENPA"
                     /gene_synonym="CenH3; CENP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            352..429
                     /gene="CENPA"
                     /gene_synonym="CenH3; CENP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            430..611
                     /gene="CENPA"
                     /gene_synonym="CenH3; CENP-A"
                     /inference="alignment:Splign:2.1.0"
     exon            612..1389
                     /gene="CENPA"
                     /gene_synonym="CenH3; CENP-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1363..1368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENPA"
                     /gene_synonym="CenH3; CENP-A"
                     /note="hexamer: AATAAA"
     polyA_site      1389
                     /gene="CENPA"
                     /gene_synonym="CenH3; CENP-A"
                     /note="major polyA site"
ORIGIN      
        1 ggacttctgc caagcaccgg ctcatgtgag gctcgcggca cagcgttctc tgggctcccc
       61 agaagccagc ctttcgctcc cggacccggc agcccgagca ggagccgtgg gaccgggcgc
      121 cagcaccctc tgcggcgtgt catgggcccg cgccgccgga gccgaaagcc cgaggccccg
      181 aggaggcgca gcccgagccc gaccccgacc cccggcccct cccggcgggg cccctcctta
      241 ggcgcttcct cccatcaaca cagtcggcgg agacaaggtt ggctaaagga gatccgaaag
      301 cttcagaaga gcacacacct cttgataagg aagctgccct tcagccgcct ggcaagagaa
      361 atatgtgtta aattcactcg tggtgtggac ttcaattggc aagcccaggc cctattggcc
      421 ctacaagagg cagcagaagc atttctagtt catctctttg aggacgccta tctcctcacc
      481 ttacatgcag gccgagttac tctcttccca aaggatgtgc aactggcccg gaggatccgg
      541 ggccttgagg agggactcgg ctgagctcct gcacccagtg tttctgtcag tctttcctgc
      601 tcagccaggg gggatgatac cggggactct ccagagccat gactagatcc aatggattct
      661 gcgatgctgt ctggactttg ctgtctctga acagtatgtg tgtgttgctt taaatatttt
      721 tctttttttt gagaaggaga agactgcatg actttcctct gtaacagagg taatatatga
      781 gacaatcaac accgttccaa aggcctgaaa ataattttca gataaagaga ctccaaggtt
      841 gactttagtt tgtgagttac tcatgtgact atttgaggat tttgaaaaca tcagatttgc
      901 tgtggtatgg gagaaaaggc tatgtactta ttattttagc tctttctgta atatttacat
      961 tttttaccat atgtacattt gtacttttat tttacacata agggaaaaaa taagaccact
     1021 ttgagcagtt gcctggaagg ctgggcattt ccatcatata gacctctgcc cttcagagta
     1081 gcctcaccat tagtggcagc atcatgtaac tgagtggact gtgcttgtca acggatgtgt
     1141 agcttttcag aaacttaatt ggggatgaat agaaaacctg taagctttga tgttctggtt
     1201 acttctagta aattcctgtc aaaatcaatt cagaaattct aacttggaga atttaacatt
     1261 ttactcttgt aaatcataga agatgtatca taacagttca gaattttaaa gtacattttc
     1321 gatgctttta tgggtatttt tgtagtttct ttgtagagag ataataaaaa tcaaaatatt
     1381 taatgaaaa
//
