LOCUS       NM_016564               1605 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens cell cycle exit and neuronal differentiation 1
            (CEND1), mRNA.
ACCESSION   NM_016564
VERSION     NM_016564.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Park,J., Lee,Y. and Won,C.W.
  TITLE     CEND1 and miR885 methylation changes associated with successful
            cognitive aging in community-dwelling older adults
  JOURNAL   Exp Gerontol 160, 111704 (2022)
   PUBMED   35045349
  REMARK    GeneRIF: CEND1 and miR885 methylation changes associated with
            successful cognitive aging in community-dwelling older adults.
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Aravantinou-Fatorou,K., Vejdani,S. and Thomaidou,D.
  TITLE     Cend1 and Neurog2 efficiently reprogram human cortical astrocytes
            to neural precursor cells and induced-neurons
  JOURNAL   Int J Dev Biol 66 (1-2-3), 199-209 (2022)
   PUBMED   34549796
  REMARK    GeneRIF: Cend1 and Neurog2 efficiently reprogram human cortical
            astrocytes to neural precursor cells and induced-neurons.
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Hou,B., Ji,L., Chen,Z., An,L., Zhang,N., Ren,D., Yuan,F., Liu,L.,
            Bi,Y., Guo,Z., Ma,G., Xu,F., Yang,F., Yu,S., Yi,Z., Xu,Y., He,L.,
            Liu,C., Bai,B., Yu,T., Wu,S., Zhao,L., Cai,C., Wu,X., Li,X. and
            He,G.
  TITLE     Interaction of CEND1 gene and life events in susceptibility to
            depressive symptoms in Chinese Han college students
  JOURNAL   J Affect Disord 278, 570-575 (2021)
   PUBMED   33027701
  REMARK    GeneRIF: Interaction of CEND1 gene and life events in
            susceptibility to depressive symptoms in Chinese Han college
            students.
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   Scaturro,P., Stukalov,A., Haas,D.A., Cortese,M., Draganova,K.,
            Plaszczyca,A., Bartenschlager,R., Gotz,M. and Pichlmair,A.
  TITLE     An orthogonal proteomic survey uncovers novel Zika virus host
            factors
  JOURNAL   Nature 561 (7722), 253-257 (2018)
   PUBMED   30177828
REFERENCE   6  (bases 1 to 1605)
  AUTHORS   Katsimpardi,L., Gaitanou,M., Malnou,C.E., Lledo,P.M., Charneau,P.,
            Matsas,R. and Thomaidou,D.
  TITLE     BM88/Cend1 expression levels are critical for proliferation and
            differentiation of subventricular zone-derived neural precursor
            cells
  JOURNAL   Stem Cells 26 (7), 1796-1807 (2008)
   PUBMED   18499894
  REMARK    GeneRIF: BM88/Cend1 participates in cell cycle control and neuronal
            differentiation mechanisms during neonatal SVZ neurogenesis and
            becomes crucial for the transition from neuroblasts to mature
            neurons when reaching high levels
REFERENCE   7  (bases 1 to 1605)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 1605)
  AUTHORS   Papadodima,O., Sergaki,M., Hurel,C., Mamalaki,A. and Matsas,R.
  TITLE     Characterization of the BM88 promoter and identification of an 88
            bp fragment sufficient to drive neurone-specific expression
  JOURNAL   J Neurochem 95 (1), 146-159 (2005)
   PUBMED   16181419
REFERENCE   9  (bases 1 to 1605)
  AUTHORS   Gaitanou,M., Buanne,P., Pappa,C., Georgopoulou,N., Mamalaki,A.,
            Tirone,F. and Matsas,R.
  TITLE     Cloning, expression and localization of human BM88 shows that it
            maps to chromosome 11p15.5, a region implicated in
            Beckwith-Wiedemann syndrome and tumorigenesis
  JOURNAL   Biochem J 355 (Pt 3), 715-724 (2001)
   PUBMED   11311134
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA066200.1 and AP006621.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016564.3.
            
            Summary: The protein encoded by this gene is a neuron-specific
            protein. The similar protein in pig enhances neuroblastoma cell
            differentiation in vitro and may be involved in neuronal
            differentiation in vivo. Multiple pseudogenes have been reported
            for this gene. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.171475.1,
                                           SRR3476690.390060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330106.5/ ENSP00000328336.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-526               DA066200.1         37-562
            527-1605            AP006621.1         82010-83088         c
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1605
                     /gene="CEND1"
                     /gene_synonym="BM88"
                     /note="cell cycle exit and neuronal differentiation 1"
                     /db_xref="GeneID:51286"
                     /db_xref="HGNC:HGNC:24153"
                     /db_xref="MIM:608213"
     exon            1..61
                     /gene="CEND1"
                     /gene_synonym="BM88"
                     /inference="alignment:Splign:2.1.0"
     exon            62..1605
                     /gene="CEND1"
                     /gene_synonym="BM88"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..593
                     /gene="CEND1"
                     /gene_synonym="BM88"
                     /note="BM88 antigen"
                     /codon_start=1
                     /product="cell cycle exit and neuronal differentiation
                     protein 1"
                     /protein_id="NP_057648.2"
                     /db_xref="CCDS:CCDS7714.1"
                     /db_xref="GeneID:51286"
                     /db_xref="HGNC:HGNC:24153"
                     /db_xref="MIM:608213"
                     /translation="MESRGKSASSPKPDTKVPQVTTEAKVPPAADGKAPLTKPSKKEA
                     PAEKQQPPAAPTTAPAKKTSAKADPALLNNHSNLKPAPTVPSSPDATPEPKGPGDGAE
                     EDEAASGGPGGRGPWSCENFNPLLVAGGVAVAAIALILGVAFLVRKK"
     regulatory      1586..1591
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEND1"
                     /gene_synonym="BM88"
                     /note="hexamer: AATAAA"
     polyA_site      1605
                     /gene="CEND1"
                     /gene_synonym="BM88"
                     /note="major polyA site"
ORIGIN      
        1 gcgttcgcag ccgccgtcat cccgcggagg agcgcgcagc cccggggagg ccggaggacg
       61 cgcccataga atgcccaggg gcgacaaact gtcctgagcc cctctggtgc agccacctgc
      121 ctgtcccata cgccccgccc accatggagt ccagagggaa gtcagccagc agccccaagc
      181 ccgacaccaa ggtgccccag gtcaccaccg aggccaaggt acccccggca gccgatggga
      241 aagccccctt gaccaagccc tcgaagaagg aggccccggc cgagaagcag cagccgccag
      301 cagcccccac cacggcacct gccaagaaga cctcggccaa ggccgaccct gcccttctca
      361 acaaccacag caacctgaag ccagccccca cggtccccag cagtcccgat gcaaccccgg
      421 agcccaaggg tcctggggac ggggcggagg aagatgaggc tgccagtggg gggcctgggg
      481 gccgaggtcc ctggtcctgt gagaacttca accccctgct ggtggctggg ggtgtggccg
      541 tggcagccat agccctgatt ctcggtgtgg ccttcctggt ccggaaaaaa taatacctgg
      601 gggccaggcg gggggcacgg agccacttcc tgtacagacc cgaggaagcc agtgcatgca
      661 gagttcaccc ttacctattc gtacacacgc acattcatta cacacctaca tacgccccca
      721 acacacgcgc acggtgaaga ggacgcccga gcccacccct gctgacccag gacttcccca
      781 acctccaggg cagaaagagc ccaggctccg gggtccacag cacaggatgt ggggcgaggg
      841 cacagctggg gaacggcaag aaaggaatgg accctgtgtg tggccccccc cacccctggc
      901 ggctgggtga tcctgggccc ccagggctgg tctgagtgca ggtgggggtg ccgggatggg
      961 ttgggcctgg gcccggccct cgtggggaca ttaaagggcg cggtggctcc actcgcccca
     1021 tttctgctct ttgcgtaccc cccgggggtc tgcctgggcg aatgcagtgg gacggacctg
     1081 gggtgggcac tcacctcagc agagcctcaa tgccacctcc ccacaccacc caagcctagc
     1141 tgggtgggaa gacggagccc tgaagcctgc gtgtggaggg ggtgctgccc aagggtcgcc
     1201 ttccccagct tgtgctccag gggagccccg acgccggcgg ggaggcaggg atgtcgaggg
     1261 cccctcacag ctgtgcccgc cctgccccgc tagactgccc ctccagcttg cacccagcac
     1321 cacctgagtc taaccagcgt ataatgcaat aacaggtaga gtagaactgc ttttggcggc
     1381 gaccgtcaca cactgtcctc agcccactgc acctggggaa gcccctcgtg cagcccctcc
     1441 ttagcacatc cagtcccagc gtggcccttg gcgcgcagca gcaggcgaac tcccagaagg
     1501 tggtggtggg cactgtgaga acgtggcctg ccctcactgg ccagtggcca caggaacccc
     1561 gggcctgagt ggaggctgag tctgaaataa actctgtcgt ctgaa
//
