LOCUS       NM_198489               1254 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens centrosomal AT-AC splicing factor (CENATAC),
            transcript variant 1, mRNA.
ACCESSION   NM_198489 XM_290495
VERSION     NM_198489.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1254)
  AUTHORS   de Wolf,B., Oghabian,A., Akinyi,M.V., Hanks,S., Tromer,E.C., van
            Hooff,J.J.E., van Voorthuijsen,L., van Rooijen,L.E., Verbeeren,J.,
            Uijttewaal,E.C.H., Baltissen,M.P.A., Yost,S., Piloquet,P.,
            Vermeulen,M., Snel,B., Isidor,B., Rahman,N., Frilander,M.J. and
            Kops,G.J.P.L.
  TITLE     Chromosomal instability by mutations in the novel minor spliceosome
            component CENATAC
  JOURNAL   EMBO J 40 (14), e106536 (2021)
   PUBMED   34009673
  REMARK    GeneRIF: Chromosomal instability by mutations in the novel minor
            spliceosome component CENATAC.
REFERENCE   2  (bases 1 to 1254)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1254)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1254)
  AUTHORS   Wang,T., Zou,Y., Huang,N., Teng,J. and Chen,J.
  TITLE     CCDC84 Acetylation Oscillation Regulates Centrosome Duplication by
            Modulating HsSAS-6 Degradation
  JOURNAL   Cell Rep 29 (7), 2078-2091 (2019)
   PUBMED   31722219
  REMARK    GeneRIF: CCDC84 Acetylation Oscillation Regulates Centrosome
            Duplication by Modulating HsSAS-6 Degradation.
REFERENCE   5  (bases 1 to 1254)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY073607.1, AB094093.1 and
            BU733365.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_198489.2.
            
            Summary: This gene encodes a protein thought to contain a coiled
            coil motif. No function has been determined for the encoded
            protein. A pseudogene of this gene is located on chromosome 20.
            Alternate splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.72242.1, AB094093.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334418.6/ ENSP00000334767.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 HY073607.1         8-11
            5-1206              AB094093.1         1-1202
            1207-1254           BU733365.1         16-63               c
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..1254
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /note="centrosomal AT-AC splicing factor"
                     /db_xref="GeneID:338657"
                     /db_xref="HGNC:HGNC:30460"
                     /db_xref="MIM:620142"
     exon            1..180
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1059
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /note="coiled-coil domain-containing protein 84;
                     coiled-coil domain containing 84"
                     /codon_start=1
                     /product="centrosomal AT-AC splicing factor"
                     /protein_id="NP_940891.1"
                     /db_xref="CCDS:CCDS8405.1"
                     /db_xref="GeneID:338657"
                     /db_xref="HGNC:HGNC:30460"
                     /db_xref="MIM:620142"
                     /translation="MAPAQRCPLCRQTFFCGRGHVYSRKHQRQLKEALERLLPQVEAA
                     RKAIRAAQVERYVPEHERCCWCLCCGCEVREHLSHGNLTVLYGGLLEHLASPEHKKAT
                     NKFWWENKAEVQMKEKFLVTPQDYARFKKSMVKGLDSYEEKEDKVIKEMAAQIREVEQ
                     SRQEVVRSVLEPQAVPDPEEGSSAPRSWKGMNSQVASSLQQPSNLDLPPAPELDWMET
                     GPSLTFIGHQDIPGVGNIHSGATPPWMIQDEEYIAGNQEIGPSYEEFLKEKEKQKLKK
                     LPPDRVGANFDHSSRTSAGWLPSFGRVWNNGRRWQSRHQFKTEAAAMKKQSHTEKS"
     exon            181..344
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     exon            345..443
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     exon            444..510
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     exon            511..573
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     exon            574..638
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     exon            639..744
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     exon            745..775
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     exon            776..865
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     exon            866..998
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1254
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1181..1186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /note="hexamer: AATAAA"
     polyA_site      1206
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /note="major polyA site"
     regulatory      1232..1237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
                     /note="hexamer: ATTAAA"
     polyA_site      1254
                     /gene="CENATAC"
                     /gene_synonym="CCDC84; DLNB14; MVA4"
ORIGIN      
        1 agaggccgcc ggatggcgta ggatcggccg ctggtggtgg tgataccggg tacccgggct
       61 atggcgccgg cgcagcgctg ccctctgtgc cgccagacct tcttctgtgg tcgcgggcac
      121 gtttacagcc gcaagcacca gcggcagctg aaggaggctt tggagaggct cctgccccag
      181 gtggaggcgg cccgcaaggc catccgcgcc gctcaggtgg agcgctatgt gcccgaacac
      241 gagcgatgct gctggtgcct gtgctgcggc tgtgaggtgc gggaacacct gagccatgga
      301 aacctgacgg tgctgtacgg ggggctgctg gagcatctgg ccagcccaga gcacaagaaa
      361 gcaaccaaca aattctggtg ggagaacaaa gctgaggtcc agatgaaaga gaagtttctg
      421 gtcactcccc aggattatgc gcgattcaag aaatccatgg tgaaaggttt ggattcctat
      481 gaagaaaagg aggataaagt gatcaaggag atggcagctc agatccgtga ggtggagcag
      541 agccgacagg aggtggttcg gtctgtctta gagcctcagg cagtgccaga cccagaagag
      601 ggctcttcag cacctagaag ctggaaaggg atgaacagcc aagtagcttc cagcttacag
      661 cagccctcaa atttggacct gccaccagct ccagagcttg actggatgga gacaggacca
      721 tctctgacat tcattggcca tcaggatata ccaggagttg gtaacatcca ctcaggtgcc
      781 acacctccct ggatgatcca agatgaagaa tacattgctg ggaaccaaga aataggacca
      841 tcctatgaag aatttcttaa agaaaaggaa aaacagaagt tgaaaaaact ccccccagac
      901 cgagttgggg ccaactttga tcacagctcc aggaccagtg caggctggct gccctctttt
      961 ggccgcgtct ggaataatgg acgccgctgg cagtccagac atcaattcaa aactgaagct
     1021 gcagcaatga agaagcagtc acatacagaa aaaagctaat catgctctct accaactacc
     1081 atgaggctaa aagcaaagtc aacaaacccc tattatacct tccaccaaat tctttatcat
     1141 tgtctttctt aggaaacaga catactcatt catttgattt aataaagttt tatttttcca
     1201 aatgtacagc tggttggacc tgtaaaaaaa aattaaaaga atcagaacca taaa
//
