LOCUS       NM_001048212            1374 bp    mRNA    linear   PRI 04-JUN-2024
DEFINITION  Homo sapiens cementum protein 1 (CEMP1), mRNA.
ACCESSION   NM_001048212 NM_001048216
VERSION     NM_001048212.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1374)
  AUTHORS   Wang,M., He,M., Xu,X., Wu,Z., Tao,J., Yin,F., Luo,K. and Jiang,J.
  TITLE     Cementum protein 1 gene-modified adipose-derived mesenchymal stem
            cell sheets enhance periodontal regeneration in osteoporosis rat
  JOURNAL   J Periodontal Res 58 (4), 755-768 (2023)
   PUBMED   37154214
  REMARK    GeneRIF: Cementum protein 1 gene-modified adipose-derived
            mesenchymal stem cell sheets enhance periodontal regeneration in
            osteoporosis rat.
REFERENCE   2  (bases 1 to 1374)
  AUTHORS   Rovai,E.S., Alves,T., Gasparoni,L.M., Franca,B.N., Sipert,C.R.,
            Kantarci,A. and Holzhausen,M.
  TITLE     Protease-activated receptor type 1 (PAR1) increases CEMP1 gene
            expression through MAPK/ERK pathway
  JOURNAL   Braz Oral Res 36, e048 (2022)
   PUBMED   35442377
  REMARK    GeneRIF: Protease-activated receptor type 1 (PAR1) increases CEMP1
            gene expression through MAPK/ERK pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1374)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1374)
  AUTHORS   Arroyo,R., Lopez,S., Romo,E., Montoya,G., Hoz,L., Pedraza,C.,
            Garfias,Y. and Arzate,H.
  TITLE     Carboxy-Terminal Cementum Protein 1-Derived Peptide 4 (cemp1-p4)
            Promotes Mineralization through wnt/beta-catenin Signaling in Human
            Oral Mucosa Stem Cells
  JOURNAL   Int J Mol Sci 21 (4), 1307 (2020)
   PUBMED   32075221
  REMARK    GeneRIF: Carboxy-Terminal Cementum Protein 1-Derived Peptide 4
            (cemp1-p4) Promotes Mineralization through wnt/beta-catenin
            Signaling in Human Oral Mucosa Stem Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1374)
  AUTHORS   Diercke,K., Konig,A., Kohl,A., Lux,C.J. and Erber,R.
  TITLE     Human primary cementoblasts respond to combined IL-1beta
            stimulation and compression with an impaired BSP and CEMP-1
            expression
  JOURNAL   Eur J Cell Biol 91 (5), 402-412 (2012)
   PUBMED   22349547
  REMARK    GeneRIF: human primary cementoblasts subjected to compression and
            IL-1beta stimulation impeded BSP and CEMP-1 expression, proteins
            that are associated with cementogenesis.
REFERENCE   6  (bases 1 to 1374)
  AUTHORS   Hoz,L., Romo,E., Zeichner-David,M., Sanz,M., Nunez,J., Gaitan,L.,
            Mercado,G. and Arzate,H.
  TITLE     Cementum protein 1 (CEMP1) induces differentiation by human
            periodontal ligament cells under three-dimensional culture
            conditions
  JOURNAL   Cell Biol Int 36 (2), 129-136 (2012)
   PUBMED   21929512
REFERENCE   7  (bases 1 to 1374)
  AUTHORS   Komaki,M., Iwasaki,K., Arzate,H., Narayanan,A.S., Izumi,Y. and
            Morita,I.
  TITLE     Cementum protein 1 (CEMP1) induces a cementoblastic phenotype and
            reduces osteoblastic differentiation in periodontal ligament cells
  JOURNAL   J Cell Physiol 227 (2), 649-657 (2012)
   PUBMED   21465469
  REMARK    GeneRIF: These data demonstrate for the first time that the CEMP1
            is not only a marker protein for cementoblast-related cells, but it
            also regulates cementoblast commitment in periodontal ligament
            cells
REFERENCE   8  (bases 1 to 1374)
  AUTHORS   Villarreal-Ramirez,E., Moreno,A., Mas-Oliva,J.,
            Chavez-Pacheco,J.L., Narayanan,A.S., Gil-Chavarria,I.,
            Zeichner-David,M. and Arzate,H.
  TITLE     Characterization of recombinant human cementum protein 1 (hrCEMP1):
            primary role in biomineralization
  JOURNAL   Biochem Biophys Res Commun 384 (1), 49-54 (2009)
   PUBMED   19393626
  REMARK    GeneRIF: CEMP1 plays a role during the biomineralization process by
            promoting octacalcium phosphate crystal nucleation.
REFERENCE   9  (bases 1 to 1374)
  AUTHORS   Carmona-Rodriguez,B., Alvarez-Perez,M.A., Narayanan,A.S.,
            Zeichner-David,M., Reyes-Gasga,J., Molina-Guarneros,J.,
            Garcia-Hernandez,A.L., Suarez-Franco,J.L., Chavarria,I.G.,
            Villarreal-Ramirez,E. and Arzate,H.
  TITLE     Human Cementum Protein 1 induces expression of bone and cementum
            proteins by human gingival fibroblasts
  JOURNAL   Biochem Biophys Res Commun 358 (3), 763-769 (2007)
   PUBMED   17509525
  REMARK    GeneRIF: CEMP1 might participate in differentiation and
            mineralization of nonosteogenic cells, and it might have a
            potential function in cementum and bone formation
REFERENCE   10 (bases 1 to 1374)
  AUTHORS   Alvarez-Perez,M.A., Narayanan,S., Zeichner-David,M., Rodriguez
            Carmona,B. and Arzate,H.
  TITLE     Molecular cloning, expression and immunolocalization of a novel
            human cementum-derived protein (CP-23)
  JOURNAL   Bone 38 (3), 409-419 (2006)
   PUBMED   16263347
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY584596.1.
            
            On Dec 7, 2010 this sequence version replaced NM_001048212.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY584596.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000567119.1/ ENSP00000457380.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1374              AY584596.1         1-1374
FEATURES             Location/Qualifiers
     source          1..1374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..1374
                     /gene="CEMP1"
                     /gene_synonym="CP-23; CP23"
                     /note="cementum protein 1"
                     /db_xref="GeneID:752014"
                     /db_xref="HGNC:HGNC:32553"
                     /db_xref="MIM:611113"
     exon            1..1374
                     /gene="CEMP1"
                     /gene_synonym="CP-23; CP23"
                     /inference="alignment:Splign:2.1.0"
     CDS             336..1079
                     /gene="CEMP1"
                     /gene_synonym="CP-23; CP23"
                     /note="cementum protein 23"
                     /codon_start=1
                     /product="cementoblastoma-derived protein 1"
                     /protein_id="NP_001041677.1"
                     /db_xref="CCDS:CCDS42108.1"
                     /db_xref="GeneID:752014"
                     /db_xref="HGNC:HGNC:32553"
                     /db_xref="MIM:611113"
                     /translation="MGTSSTDSQQAGHRRCSTSNTSAENLTCLSLPGSPGKTAPLPGP
                     AQAGAGQPLPKGCAAVKAEVGIPAPHTSQEVRIHIRRLLSWAAPGACGLRSTPCALPQ
                     ALPQARPCPGRWFFPGCSLPTGGAQTILSLWTWRHFLNWALQQREENSGRARRVPPVP
                     RTAPVSKGEGSHPPQNSNGEKVKTITPDVGLHQSLTSDPTVAVLRAKRAPEAHPPRSC
                     SGSLTARVCHMGVCQGQGDTEDGRMTLMG"
ORIGIN      
        1 ttacttttgt tatgtatttt accacaattt ttaaaaagca aaccaaaacc aaccaagagt
       61 gcttccccca cacctcaaaa tcatcctgca gcagctccct ggcccagctc tctctcaccc
      121 tgaccctggg cccctctccc accacccagg gctagccctg tggaccaacc atctctgcca
      181 gcccctcccc gaccctccag ccagggaggt ggggcgctgg ccggtgaatg gggcaggcca
      241 ggcccaaagg ctggcccagg gctcaccagc tctggactgg gcgtcccgtc tgaggtgggg
      301 atgaccaaca tgccagctct gggttttagc tgaggatggg cacatcaagc actgacagcc
      361 agcaagctgg gcacaggcga tgctcaacct ctaacacatc ggctgagaac ctcacctgcc
      421 tctccctgcc tgggagccct ggcaagacag ctcctctccc aggcccagca caggcaggcg
      481 ctggacagcc acttcctaag gggtgcgcgg ccgtcaaggc agaggtgggt atccctgcac
      541 ctcacacctc tcaggaggtc aggatccaca tccgtcgcct gctttcctgg gctgcccctg
      601 gggcttgtgg gctgagatca accccttgtg ccctgcccca ggccctccct caggcgaggc
      661 cctgcccagg caggtggttc ttccctggct gttcccttcc aacaggtggg gcccagacca
      721 tcctatctct ttggacctgg agacatttcc ttaactgggc tttgcagcag agggaagaga
      781 acagtggcag agccaggcgc gtacctcctg tgcccaggac agcacctgta agcaaggggg
      841 aagggagcca cccaccccag aactcaaatg gagagaaagt caagacaatc acccctgacg
      901 tggggctgca ccaatccctg acgtctgacc ccactgtggc tgtcctcaga gccaagaggg
      961 ctccagaagc ccacccgcct cgaagctgtt cagggagcct cacggcccgt gtttgccaca
     1021 tgggtgtgtg ccagggccaa ggggacacag aagatggcag gatgacacta atggggtgag
     1081 cagggcacac tggtgcctcc catactgccc tccagcacca ggcagggtca ccacagccgg
     1141 caagcactgg gcctggggat gtgtgaagag atagggttat tgagaagaga aaacagaacg
     1201 ctggtcatcc gtggcactca gggctaggca gtccagggag cagaaaacag gggtcccggg
     1261 cccagtctcc ctcctggagg tcagagcgga gcccctggca ctgtgccctg gcccagaacc
     1321 aggctgtggg ctccacgctg cacaccccaa ctcaggagca gaaagcaaac ccct
//
