LOCUS       NM_013390               6152 bp    mRNA    linear   PRI 05-MAY-2024
DEFINITION  Homo sapiens cell migration inducing hyaluronidase 2 (CEMIP2),
            transcript variant 1, mRNA.
ACCESSION   NM_013390
VERSION     NM_013390.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6152)
  AUTHORS   Zhao,X., Liu,D., Zhao,Y., Wang,Z., Wang,Y., Chen,Z., Ning,S.,
            Wang,G., Meng,L., Yao,J. and Tian,X.
  TITLE     HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated
            apoptosis through a non-canonical pathway in intestinal
            ischemia/reperfusion
  JOURNAL   Cell Death Dis 15 (2), 154 (2024)
   PUBMED   38378757
  REMARK    GeneRIF: HRD1-induced TMEM2 ubiquitination promotes ER
            stress-mediated apoptosis through a non-canonical pathway in
            intestinal ischemia/reperfusion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6152)
  AUTHORS   Narita,T., Tobisawa,Y., Bobkov,A., Jackson,M., Ohyama,C., Irie,F.
            and Yamaguchi,Y.
  TITLE     TMEM2 is a bona fide hyaluronidase possessing intrinsic catalytic
            activity
  JOURNAL   J Biol Chem 299 (9), 105120 (2023)
   PUBMED   37527776
  REMARK    GeneRIF: TMEM2 is a bona fide hyaluronidase possessing intrinsic
            catalytic activity.
REFERENCE   3  (bases 1 to 6152)
  AUTHORS   Sato,S., Miyazaki,M., Fukuda,S., Mizutani,Y., Mizukami,Y.,
            Higashiyama,S. and Inoue,S.
  TITLE     Human TMEM2 is not a catalytic hyaluronidase, but a regulator of
            hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2
            expression
  JOURNAL   J Biol Chem 299 (6), 104826 (2023)
   PUBMED   37196767
  REMARK    GeneRIF: Human TMEM2 is not a catalytic hyaluronidase, but a
            regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and
            HAS2 expression.
REFERENCE   4  (bases 1 to 6152)
  AUTHORS   Shiozawa,J., de Vega,S., Yoshinaga,C., Ji,X., Negishi,Y.,
            Momoeda,M., Nakamura,T., Yoshida,H., Kaneko,H., Ishijima,M. and
            Okada,Y.
  TITLE     Expression and regulation of recently discovered hyaluronidases,
            HYBID and TMEM2, in chondrocytes from knee osteoarthritic cartilage
  JOURNAL   Sci Rep 12 (1), 17242 (2022)
   PUBMED   36241903
  REMARK    GeneRIF: Expression and regulation of recently discovered
            hyaluronidases, HYBID and TMEM2, in chondrocytes from knee
            osteoarthritic cartilage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6152)
  AUTHORS   Kudo,Y., Sato,N., Oba,T., Adachi,Y., Amaike,T., Koga,A., Kohi,S.,
            Noguchi,H., Nakayama,T. and Hirata,K.
  TITLE     Concurrent Overexpression of Two Hyaluronidases, KIAA1199 and
            TMEM2, Strongly Predicts Shorter Survival After Resection in
            Pancreatic Ductal Adenocarcinoma
  JOURNAL   Pancreas 51 (7), 800-807 (2022)
   PUBMED   36395406
  REMARK    GeneRIF: Concurrent Overexpression of Two Hyaluronidases, KIAA1199
            and TMEM2, Strongly Predicts Shorter Survival After Resection in
            Pancreatic Ductal Adenocarcinoma.
REFERENCE   6  (bases 1 to 6152)
  AUTHORS   Lee,H., Goodarzi,H., Tavazoie,S.F. and Alarcon,C.R.
  TITLE     TMEM2 Is a SOX4-Regulated Gene That Mediates Metastatic Migration
            and Invasion in Breast Cancer
  JOURNAL   Cancer Res 76 (17), 4994-5005 (2016)
   PUBMED   27328729
  REMARK    GeneRIF: our findings lead us to propose that TMEM2 may not only
            mediate the pathologic effects of SOX4 on cancer progression but
            also potentially its contributions to embryonic development
REFERENCE   7  (bases 1 to 6152)
  AUTHORS   Zhu,X., Xie,C., Li,Y.M., Huang,Z.L., Zhao,Q.Y., Hu,Z.X., Wang,P.P.,
            Gu,Y.R., Gao,Z.L. and Peng,L.
  TITLE     TMEM2 inhibits hepatitis B virus infection in HepG2 and HepG2.2.15
            cells by activating the JAK-STAT signaling pathway
  JOURNAL   Cell Death Dis 7 (6), e2239 (2016)
   PUBMED   27253403
  REMARK    GeneRIF: TMEM2 inhibits Hepatitis b virus infection in HepG2 and
            HepG2.2.15 by activating the JAK-STAT signaling pathway.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 6152)
  AUTHORS   Zhao,Q., Peng,L., Huang,W., Li,Q., Pei,Y., Yuan,P., Zheng,L.,
            Zhang,Y., Deng,J., Zhong,C., Hu,B., Ding,H., Fang,W., Li,R.,
            Liao,Q., Lin,C., Deng,W., Yan,H., Hou,J., Wu,Q., Xu,T., Liu,J.,
            Hu,L., Peng,T., Chen,S., Lai,K.N., Yuen,M.F., Wang,Y., Maini,M.K.,
            Li,C., Li,M., Wang,J., Zhang,X., Sham,P.C., Wang,J., Gao,Z.L. and
            Wang,Y.
  TITLE     Rare inborn errors associated with chronic hepatitis B virus
            infection
  JOURNAL   Hepatology 56 (5), 1661-1670 (2012)
   PUBMED   22610944
  REMARK    GeneRIF: Results showed that missense mutations in transmembrane
            protein 2 p.Ser1254Asn, interferon alpha 2 p.Ala120Thr, its
            regulator NLR family member X1 p.Arg707Cys, and complement
            component 2 p.Glu318Asp were associated with chronic hepatitis B.
REFERENCE   9  (bases 1 to 6152)
  AUTHORS   Siegrist,F., Ebeling,M. and Certa,U.
  TITLE     The small interferon-induced transmembrane genes and proteins
  JOURNAL   J Interferon Cytokine Res 31 (1), 183-197 (2011)
   PUBMED   21166591
  REMARK    Review article
REFERENCE   10 (bases 1 to 6152)
  AUTHORS   Scott,D.A., Drury,S., Sundstrom,R.A., Bishop,J., Swiderski,R.E.,
            Carmi,R., Ramesh,A., Elbedour,K., Srikumari Srisailapathy,C.R.,
            Keats,B.J., Sheffield,V.C. and Smith,R.J.
  TITLE     Refining the DFNB7-DFNB11 deafness locus using intragenic
            polymorphisms in a novel gene, TMEM2
  JOURNAL   Gene 246 (1-2), 265-274 (2000)
   PUBMED   10767548
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA865249.1, AB037833.2,
            AK075370.1 and CA418327.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_013390.2.
            
            Summary: This gene encodes a type II transmembrane protein that
            belongs to the interferon-induced transmembrane (IFITM) protein
            superfamily. The encoded protein functions as a cell surface
            hyaluronidase that cleaves extracellular high molecular weight
            hyaluronan into intermediate size fragments before internalization
            and degradation in the lysosome. It also has an interferon-mediated
            antiviral function in humans through activation of the JAK STAT
            signaling pathway. The activation of this gene by transcription
            factor SOX4 in breast cancer cells has been shown to mediate the
            pathological effects of SOX4 on cancer progression. Naturally
            occurring mutations in this gene are associated with autosomal
            recessive non-syndromic hearing loss. [provided by RefSeq, Mar
            2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.27090.1, AF137030.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377044.9/ ENSP00000366243.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                DA865249.1         35-70
            37-5713             AB037833.2         1-5677
            5714-5933           AK075370.1         3813-4032
            5934-6152           CA418327.1         18-236              c
FEATURES             Location/Qualifiers
     source          1..6152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..6152
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /note="cell migration inducing hyaluronidase 2"
                     /db_xref="GeneID:23670"
                     /db_xref="HGNC:HGNC:11869"
                     /db_xref="MIM:605835"
     exon            1..157
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            158..500
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..4321
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /EC_number="3.2.1.35"
                     /note="isoform a is encoded by transcript variant 1; cell
                     surface hyaluronidase; transmembrane protein 2; cell
                     surface hyaluronidase CEMIP2"
                     /codon_start=1
                     /product="cell surface hyaluronidase CEMIP2 isoform a"
                     /protein_id="NP_037522.1"
                     /db_xref="CCDS:CCDS6638.1"
                     /db_xref="GeneID:23670"
                     /db_xref="HGNC:HGNC:11869"
                     /db_xref="MIM:605835"
                     /translation="MYATDSRGHSPAFLQPQNGNSRHPSGYVPGKVVPLRPPPPPKSQ
                     ASAKFTSIRREDRATFAFSPEEQQAQRESQKQKRHKNTFICFAITSFSFFIALAIILG
                     ISSKYAPDENCPDQNPRLRNWDPGQDSAKQVVIKEGDMLRLTSDATVHSIVIQDGGLL
                     VFGDNKDGSRNITLRTHYILIQDGGALHIGAEKCRYKSKATITLYGKSDEGESMPTFG
                     KKFIGVEAGGTLELHGARKASWTLLARTLNSSGLPFGSYTFEKDFSRGLNVRVIDQDT
                     AKILESERFDTHEYRNESRRLQEFLRFQDPGRIVAIAVGDSAAKSLLQGTIQMIQERL
                     GSELIQGLGYRQAWALVGVIDGGSTSCNESVRNYENHSSGGKALAQREFYTVDGQKFS
                     VTAYSEWIEGVSLSGFRVEVVDGVKLNLLDDVSSWKPGDQIVVASTDYSMYQAEEFTL
                     LPCSECSHFQVKVKETPQFLHMGEIIDGVDMRAEVGILTRNIVIQGEVEDSCYAENQC
                     QFFDYDTFGGHIMIMKNFTSVHLSYVELKHMGQQQMGRYPVHFHLCGDVDYKGGYRHA
                     TFVDGLSIHHSFSRCITVHGTNGLLIKDTIGFDTLGHCFFLEDGIEQRNTLFHNLGLL
                     TKPGTLLPTDRNNSMCTTMRDKVFGNYIPVPATDCMAVSTFWIAHPNNNLINNAAAGS
                     QDAGIWYLFHKEPTGESSGLQLLAKPELTPLGIFYNNRVHSNFKAGLFIDKGVKTTNS
                     SAADPREYLCLDNSARFRPHQDANPEKPRVAALIDRLIAFKNNDNGAWVRGGDIIVQN
                     SAFADNGIGLTFASDGSFPSDEGSSQEVSESLFVGESRNYGFQGGQNKYVGTGGIDQK
                     PRTLPRNRTFPIRGFQIYDGPIHLTRSTFKKYVPTPDRYSSAIGFLMKNSWQITPRNN
                     ISLVKFGPHVSLNVFFGKPGPWFEDCEMDGDKNSIFHDIDGSVTGYKDAYVGRMDNYL
                     IRHPSCVNVSKWNAVICSGTYAQVYVQTWSTQNLSMTITRDEYPSNPMVLRGINQKAA
                     FPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKNDWIRVGLCYPSNTSFQVTFGYL
                     QRQNGSLSKIEEYEPVHSLEELQRKQSERKFYFDSSTGLLFLYLKAKSHRHGHSYCSS
                     QGCERVKIQAATDSKDISNCMAKAYPQYYRKPSVVKRMPAMLTGLCQGCGTRQVVFTS
                     DPHKSYLPVQFQSPDKAETQRGDPSVISVNGTDFTFRSAGVLLLVVDPCSVPFRLTEK
                     TVFPLADVSRIEEYLKTGIPPRSIVLLSTRGEIKQLNISHLLVPLGLAKPAHLYDKGS
                     TIFLGFSGNFKPSWTKLFTSPAGQGLGVLEQFIPLQLDEYGCPRATTVRRRDLELLKQ
                     ASKAH"
     exon            501..641
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            642..1203
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1373
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1562
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1732
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1942
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2148
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2149..2218
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2347
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2436
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2437..2568
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2569..2604
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2605..2760
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2938
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2939..3154
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3363
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3546
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3547..3766
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3767..3865
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..4020
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4021..4124
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4125..6152
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6126..6131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /note="hexamer: AATAAA"
     polyA_site      6152
                     /gene="CEMIP2"
                     /gene_synonym="TMEM2"
                     /note="major polyA site"
ORIGIN      
        1 agttgagtac gagcggcagc tgcgggcgcc ggcaatcgag tggcttcctg gccatggaga
       61 ggagatctgg acccgaggac gccagggact cctctccgtc tccctggacc gctgtgtagg
      121 cacctgagtt aacggacgct aagcggggta ggggaagtaa cagtgtatca tgtatgccac
      181 tgattccagg ggacactccc ctgctttcct ccaacctcag aatggaaata gtcgtcaccc
      241 atctggctat gttccaggga aggttgtccc attgcgtccc cctcctcctc caaagagtca
      301 agcttcagcc aaatttacct ccatcagacg agaagaccgg gcaaccttcg cattctcacc
      361 tgaagaacag caagcccaga gagaaagtca aaagcaaaag agacacaaaa atactttcat
      421 ttgttttgct attactagtt tctcattttt tattgcactt gcaatcattt taggaatatc
      481 ctcaaaatat gctccagatg aaaattgccc agatcaaaat cctcgtctca ggaattggga
      541 tccaggacaa gattctgcaa agcaagttgt tatcaaggag ggagatatgc tccgtctgac
      601 ctcagacgcc accgtgcatt ctatagtcat tcaggatgga ggactgcttg tatttgggga
      661 caataaagat ggatccagaa atattacttt gaggactcat tacatcctga tccaggatgg
      721 tggggcgctt catattggag cagaaaaatg ccgctataaa tccaaagcga caattacctt
      781 gtatggcaag tcagatgaag gtgaaagtat gccaacattt ggcaaaaagt ttattggtgt
      841 ggaagctggc gggacactgg agttacatgg ggcacggaag gcatcgtgga cgttgttggc
      901 aaggaccctg aattcctcag gcttgccctt tgggtcctat acctttgaaa aggacttttc
      961 ccggggcctc aatgtgaggg tcattgacca agacacggcc aaaattttgg aaagtgagag
     1021 atttgatacc catgaatacc gcaatgagag caggcggctt caggagtttc tgagattcca
     1081 ggatccaggt cggattgttg ccatagctgt cggggattca gccgctaaaa gtctcttaca
     1141 aggaaccatc cagatgatcc aggaacggtt gggaagtgaa ctgatccaag gactgggcta
     1201 caggcaagct tgggctttag ttggtgtcat tgatggtgga agcacttctt gcaatgaatc
     1261 cgtgagaaac tatgaaaatc atagcagtgg cgggaaggct cttgcccaaa gagaatttta
     1321 tactgtggat ggccagaagt tctctgtgac agcttatagt gaatggattg aaggcgtttc
     1381 tctttcagga ttccgggtag aggttgtaga tggagtgaag ctaaatttgc tagatgatgt
     1441 tagtagttgg aaacctggag accagattgt ggtcgcaagc acagactatt ccatgtacca
     1501 agcagaggag ttcactcttc ttccctgttc tgaatgcagc cattttcagg tcaaagtcaa
     1561 agaaacccct cagttcctgc acatgggtga gatcatagac ggtgtagaca tgagagctga
     1621 ggttggaatt cttacccgga atattgtgat ccaaggagaa gtggaggact catgctacgc
     1681 agaaaatcag tgccaatttt ttgattatga tacctttggg ggacacatta tgataatgaa
     1741 aaattttact tcagtccatc tttcttatgt ggaattgaaa cacatgggtc agcagcagat
     1801 ggggcgatac cctgttcatt ttcacctgtg tggtgacgtg gattataaag gaggatacag
     1861 acatgcaaca tttgtggacg gcctgtctat tcatcacagc ttctcaaggt gcatcactgt
     1921 gcatgggaca aatggcttgc taataaaaga caccattggg tttgacacac taggtcattg
     1981 tttctttttg gaagatggta ttgaacagag gaatactttg ttccacaatc tgggactcct
     2041 caccaagccg ggtactctcc tgcccaccga taggaacaac tccatgtgta ccaccatgcg
     2101 agataaagtg tttggaaatt acattcctgt gcctgctact gactgtatgg ctgtttcaac
     2161 tttctggatt gctcatccca acaataatct gattaataat gcagctgcag gctcacagga
     2221 tgctggaata tggtatttat tccacaagga accaactggg gaatccagtg gattgcagct
     2281 cttggcaaaa ccagaactca ctccattggg tatattttat aacaacaggg tccattcaaa
     2341 ttttaaggct ggcttattta ttgacaaagg tgtcaaaaca accaactcta gtgctgctga
     2401 cccaagggaa tacctctgtt tggacaatag tgcaagattt cgacctcatc aggatgcaaa
     2461 ccccgaaaaa ccacgtgttg ctgctctaat tgacaggctc attgctttta aaaataatga
     2521 taatggagct tgggtcagag gaggagatat tatcgttcaa aattcagcat ttgcagataa
     2581 tggaatagga ctgacctttg ccagtgatgg aagcttccca agtgatgaag gttccagcca
     2641 agaggtatct gaatctctct ttgttgggga gagcaggaat tacggctttc agggtggtca
     2701 gaacaagtat gtaggcactg gaggaataga ccagaagcct cgaacattac ccaggaacag
     2761 gacgttccca attagaggct ttcagattta tgatgggccc attcatctca caaggagcac
     2821 tttcaaaaaa tatgtgccaa ctccagatag gtacagcagt gcaattggct tcctcatgaa
     2881 gaattcctgg cagataaccc ccaggaataa tatctccctc gtgaagtttg gtccacatgt
     2941 ctctctgaat gtcttttttg gaaagcctgg tccctggttt gaagattgtg agatggatgg
     3001 tgataagaac tccatattcc atgacattga tggctctgtg acaggataca aggatgctta
     3061 tgtgggaaga atggacaact acctgatccg ccatccaagc tgtgtaaatg tgtctaagtg
     3121 gaatgcagtg atctgcagtg ggacctatgc acaggtctat gtacagacat ggagcactca
     3181 gaatctttct atgaccatta cacgagatga gtatccgtcc aaccctatgg tgctccgagg
     3241 tattaatcag aaggctgcct ttccacagta ccagcctgtc gtcatgctgg agaagggtta
     3301 taccatccac tggaatgggc cggcaccacg gactacattt ctatacctcg tcaacttcaa
     3361 caagaatgac tggattcgag ttggcctttg ctatccatca aacacaagtt ttcaagttac
     3421 ctttggctat ttgcagcggc agaatggctc attatccaaa atcgaagaat atgagcctgt
     3481 gcattcactg gaagaactgc aaagaaagca atccgagagg aaattctatt ttgactccag
     3541 cacggggtta ctgtttttgt atctcaaagc caaaagccac aggcatggcc acagttactg
     3601 ttcatctcag ggatgtgaaa gagtcaagat ccaagcagcc acagactcaa aggacatcag
     3661 taactgcatg gccaaagcat acccacagta ctacagaaag ccgtcagtgg tcaagcggat
     3721 gccggccatg ctcactggac tctgtcaagg ctgtggcact cggcaggtgg tgtttactag
     3781 tgatcctcat aaaagttacc tccctgtgca attccagtca cctgataaag cagaaaccca
     3841 gcgtggagac ccgtctgtta tttctgtcaa tggcactgac tttaccttcc gaagtgcagg
     3901 cgtcctcctc cttgttgtgg atccgtgcag cgttccattc cgcttgacgg aaaaaacggt
     3961 ttttcctctt gctgatgtca gtcgcattga agagtattta aaaacaggca tccctccaag
     4021 gtccattgtt ctgttgagca caagaggaga aataaagcag ttaaacattt cacacttact
     4081 agtacctctg ggattagcca aaccagctca tctttatgac aaagggagta ccatattttt
     4141 gggattcagt ggaaacttta aaccatcatg gactaagcta tttaccagtc ctgctggaca
     4201 gggccttggg gtgcttgaac aattcatacc tttgcagctg gacgaatatg gttgtcccag
     4261 agccaccact gtccgcagaa gagacctgga actgctaaag caagcttcaa aagcacatta
     4321 gagactaact gtaacttaag tgctggggga aaaaaaatgt gaactaactt atttaattta
     4381 tggcatttta aaatgacact gttaacccaa cggaaccatt ttccagtttg atacagaatg
     4441 gggagaaaag aaagcgtttg aaattattgc ttggatacca gcttcatgca ccttctagtt
     4501 gtacaaaatg ttaaagacgt tgtttgtatt tgtaaggctg gtgtattcag agagcagatc
     4561 tcttattcct cactttccac ccccgtattt tgtaatgacc atgagcaatg tttttacttt
     4621 ttgtataatg gggtggggtg gagtgggggc ttctgagagt cagcctgagg tctttagagg
     4681 accagctatt gtagcacctt ggatacttga agtttaatgc tcagttgggt cgggtggcag
     4741 ttgacttggt ggctggcatg ttcagcagtg cctggggccc tgtttctggg cagcctttga
     4801 ggattttcta tgatattgaa tgacagtttt aagtggcaac tcaggcccag ctcatgccct
     4861 tttttgcctg gacatgtgct atttttattc acttatatat caattacttg taagggttaa
     4921 actttcaaac aggaagtata ttgggacaaa agggctcttg gggattagat atccctttaa
     4981 tctgtgacca ttgggcaaaa aattttcctg cagcaaaagt ctgaggctgt tgggaccatt
     5041 tttgcagctt taatccttag cctcttttga ctgtatattt gtgtttaaaa tgcagagctc
     5101 aactgaatat ttcctttttt gttttgtttt gttttgtttt aagaagtagg ttgttttcct
     5161 gaaccgtaaa cttgtatcat tttaacttgc acaaaggaag tctgttcttg gtattgctct
     5221 tgcacttggg ttttttgtta ttgttttgtg tggatttttt aaagcttttc tgttcaccct
     5281 cctgccagga aaatcccaga aagcttaatg ataccccaaa atgattacac ccagggagga
     5341 aaaaaaggag cgctttctag ggtcagaatc gtggagagaa tactcagaaa tgaacctctt
     5401 taaagccttg caggaatgag tcactcttac ttaatgaaat gttaaagcca attaaaaagc
     5461 atgctgtgat gcccagcttc cctttccaca gggtgcatgc gtctcctgct ggtgaatcac
     5521 atgcggcaag aggcaactgg ctccacagcc tgggatgctg ccgtaccaag aggaaagaag
     5581 cagcaaaatg cctttacgtt gttctaaacc cccgacgcat aaagtgtaga ggagggatgg
     5641 ccaagggtgg gtggtagaaa gtgtgttcag gctgacactg gcaatgagta cagataattt
     5701 cactttcctc ttctaggggc aaaggctgat ggcctctacc tttgtatcca ggagaaactg
     5761 cagagcagcc ctgtgacttt acaaaatatg ctacctcaaa gtgctaccga taaacctttc
     5821 taattgtaag tgcccttact aagggcacat gtcttaatca aagttagttt tttgttttct
     5881 ggtttgtttt ttttttttgt atattgatga atgagatctt acctattaaa tatattattg
     5941 gattatggtt cctgaaggtc attagagtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgttt
     6001 tatgacttaa atatctttac gtgtgttttt tagagcttgg ttctttaaag atttggagaa
     6061 gatatgtaaa ttaccaaggc acttggtttt tctgttttat atactaataa tcagggccta
     6121 agttaaataa aaatatgtgt gcatgtattt ta
//
