LOCUS       NM_001293298            7353 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cell migration inducing hyaluronidase 1 (CEMIP),
            transcript variant 1, mRNA.
ACCESSION   NM_001293298
VERSION     NM_001293298.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7353)
  AUTHORS   Gao,L., Qiao,L., Li,Y., Jia,L., Cui,W., Yang,J., Wu,C. and Wang,L.
  TITLE     ALKBH5 regulates paclitaxel resistance in NSCLC via inhibiting
            CEMIP-mediated EMT
  JOURNAL   Toxicol Appl Pharmacol 483, 116807 (2024)
   PUBMED   38199493
  REMARK    GeneRIF: ALKBH5 regulates paclitaxel resistance in NSCLC via
            inhibiting CEMIP-mediated EMT.
REFERENCE   2  (bases 1 to 7353)
  AUTHORS   Sato,S., Miyazaki,M., Fukuda,S., Mizutani,Y., Mizukami,Y.,
            Higashiyama,S. and Inoue,S.
  TITLE     Human TMEM2 is not a catalytic hyaluronidase, but a regulator of
            hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2
            expression
  JOURNAL   J Biol Chem 299 (6), 104826 (2023)
   PUBMED   37196767
  REMARK    GeneRIF: Human TMEM2 is not a catalytic hyaluronidase, but a
            regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and
            HAS2 expression.
REFERENCE   3  (bases 1 to 7353)
  AUTHORS   Li,L., Shen,X., Mo,X., Chen,Z., Yu,F., Mo,X., Song,J., Huang,G.,
            Liang,K., Luo,Z., Mao,N. and Yang,J.
  TITLE     CEMIP-mediated hyaluronan metabolism facilitates SCLC metastasis by
            activating TLR2/c-Src/ERK1/2 axis
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1870 (5), 119451 (2023)
   PUBMED   36931608
  REMARK    GeneRIF: CEMIP-mediated hyaluronan metabolism facilitates SCLC
            metastasis by activating TLR2/c-Src/ERK1/2 axis.
REFERENCE   4  (bases 1 to 7353)
  AUTHORS   Mo,X., Shen,X., Mo,X., Yu,F., Tan,W., Deng,Z., He,J., Luo,Z.,
            Chen,Z. and Yang,J.
  TITLE     CEMIP promotes small cell lung cancer proliferation by activation
            of glutamine metabolism via FBXW7/c-Myc-dependent axis
  JOURNAL   Biochem Pharmacol 209, 115446 (2023)
   PUBMED   36746261
  REMARK    GeneRIF: CEMIP promotes small cell lung cancer proliferation by
            activation of glutamine metabolism via FBXW7/c-Myc-dependent axis.
REFERENCE   5  (bases 1 to 7353)
  AUTHORS   Xu,G., Zhao,L., Hua,Q., Wang,L., Liu,H., Lin,Z., Jin,M., Wang,J.,
            Zhou,P., Yang,K., Wu,G., Yu,D., Zhang,D. and Zhang,T.
  TITLE     CEMIP, acting as a scaffold protein for bridging GRAF1 and MIB1,
            promotes colorectal cancer metastasis via activating CDC42/MAPK
            pathway
  JOURNAL   Cell Death Dis 14 (2), 167 (2023)
   PUBMED   36849460
  REMARK    GeneRIF: CEMIP, acting as a scaffold protein for bridging GRAF1 and
            MIB1, promotes colorectal cancer metastasis via activating
            CDC42/MAPK pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7353)
  AUTHORS   Abe,S., Katagiri,T., Saito-Hisaminato,A., Usami,S., Inoue,Y.,
            Tsunoda,T. and Nakamura,Y.
  TITLE     Identification of CRYM as a candidate responsible for nonsyndromic
            deafness, through cDNA microarray analysis of human cochlear and
            vestibular tissues
  JOURNAL   Am J Hum Genet 72 (1), 73-82 (2003)
   PUBMED   12471561
REFERENCE   7  (bases 1 to 7353)
  AUTHORS   Abe,S., Usami,S. and Nakamura,Y.
  TITLE     Mutations in the gene encoding KIAA1199 protein, an inner-ear
            protein expressed in Deiters' cells and the fibrocytes, as the
            cause of nonsyndromic hearing loss
  JOURNAL   J Hum Genet 48 (11), 564-570 (2003)
   PUBMED   14577002
  REMARK    GeneRIF: three possibly disease-causing point mutations
REFERENCE   8  (bases 1 to 7353)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   9  (bases 1 to 7353)
  AUTHORS   Krause,A., Liepke,C., Meyer,M., Adermann,K., Forssmann,W.G. and
            Maronde,E.
  TITLE     Human natriuretic peptides exhibit antimicrobial activity
  JOURNAL   Eur J Med Res 6 (5), 215-218 (2001)
   PUBMED   11410403
REFERENCE   10 (bases 1 to 7353)
  AUTHORS   Wines,M.E., Lee,L., Katari,M.S., Zhang,L., DeRossi,C., Shi,Y.,
            Perkins,S., Feldman,M., McCombie,W.R. and Holdener,B.C.
  TITLE     Identification of mesoderm development (mesd) candidate genes by
            comparative mapping and genome sequence analysis
  JOURNAL   Genomics 72 (1), 88-98 (2001)
   PUBMED   11247670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA220969.1, AY581148.1, AB103330.1, AL049389.1 and AC027808.9.
            
            On Nov 23, 2018 this sequence version replaced NM_001293298.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY581148.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1968189,
                                           SAMEA2149876 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394685.8/ ENSP00000378177.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DA220969.1         33-33
            2-2390              AY581148.1         1-2389
            2391-7240           AB103330.1         2231-7080
            7241-7244           AL049389.1         2307-2310
            7245-7353           AC027808.9         203531-203639
FEATURES             Location/Qualifiers
     source          1..7353
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..7353
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /note="cell migration inducing hyaluronidase 1"
                     /db_xref="GeneID:57214"
                     /db_xref="HGNC:HGNC:29213"
                     /db_xref="MIM:608366"
     exon            1..245
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            246..404
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            405..514
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..4506
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /EC_number="3.2.1.35"
                     /note="colon cancer secreted protein 1; cell
                     migration-inducing and hyaluronan-binding protein; cell
                     migration inducing protein, hyaluronan binding;
                     hyaluronan-binding protein involved in hyaluronan
                     depolymerization; cell migration inducing hyaluronan
                     binding protein"
                     /codon_start=1
                     /product="cell migration-inducing and hyaluronan-binding
                     protein precursor"
                     /protein_id="NP_001280227.1"
                     /db_xref="CCDS:CCDS10315.1"
                     /db_xref="GeneID:57214"
                     /db_xref="HGNC:HGNC:29213"
                     /db_xref="MIM:608366"
                     /translation="MGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQ
                     PWNPGHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILID
                     NGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLS
                     WTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESER
                     LVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKG
                     NPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKV
                     SQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGR
                     ACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQ
                     AEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKC
                     YPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVD
                     ERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNT
                     FDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNL
                     INCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIID
                     NGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHGAWLRG
                     GDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWG
                     PGGLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAW
                     QSCPHNNVTGIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSY
                     LTKNDNWLVRHPDCINVPDWRGAICSGCYAQMYIQAYKTSNLRMKIIKNDFPSHPLYL
                     EGALTRSTHYQQYQPVVTLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCYPRGT
                     TFSILSDVHNRLLKQTSKTGVFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFLKLKAQN
                     EREKFAFCSMKGCERIKIKALIPKNAGVSDCTATAYPKFTERAVVDVPMPKKLFGSQL
                     KTKDHFLEVKMESSKQHFFHLWNDFAYIEVDGKKYPSSEDGIQVVVIDGNQGRVVSHT
                     SFRNSILQGIPWQLFNYVATIPDNSIVLMASKGRYVSRGPWTRVLEKLGADRGLKLKE
                     QMAFVGFKGSFRPIWVTLDTEDHKAKIFQVVPIPVVKKKKL"
     exon            515..661
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            662..800
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            801..1037
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1217
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1288
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1384
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1506
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1639
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1831
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..2007
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2217
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2423
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2493
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2494..2622
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2708
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2709..2840
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2841..2876
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            2877..3032
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3033..3213
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3214..3429
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3430..3641
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3642..3827
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            3828..4032
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4119
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            4120..4277
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            4278..4378
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     exon            4379..7353
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7218..7223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /note="hexamer: AATAAA"
     polyA_site      7241
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /note="major polyA site"
     regulatory      7332..7337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /note="hexamer: AGTAAA"
     polyA_site      7353
                     /gene="CEMIP"
                     /gene_synonym="CCSP1; CEMIP1; HYBID; KIAA1199; TMEM2L"
                     /note="major polyA site"
ORIGIN      
        1 ggagctagcg ctcaagcaga gcccagcgcg gtgctatcgg acagagcctg gcgagcgcaa
       61 gcggcgcggg gagccagcgg ggctgagcgc ggccagggtc tgaacccaga tttcccagac
      121 tagctaccac tccgcttgcc cacgccccgg gagctcgcgg cgcctggcgg tcagcgacca
      181 gacgtccggg gccgctgcgc tcctggcccg cgaggcgtga cactgtctcg gctacagacc
      241 cagagagaaa agcttcattc tggaggggaa ggagttttga gtgccaagga tgaaattcca
      301 cccatcactc ggtctctgag ctgcaggaca caggcaggac aacggtagga ttttcatgcc
      361 ccgatctgcc tggccttgag ttgtggcagc tggggaagcc actgggagca cactgccagg
      421 atgggagctg ctgggaggca ggacttcctc ttcaaggcca tgctgaccat cagctggctc
      481 actctgacct gcttccctgg ggccacatcc acagtggctg ctgggtgccc tgaccagagc
      541 cctgagttgc aaccctggaa ccctggccat gaccaagacc accatgtgca tatcggccag
      601 ggcaagacac tgctgctcac ctcttctgcc acggtctatt ccatccacat ctcagaggga
      661 ggcaagctgg tcattaaaga ccacgacgag ccgattgttt tgcgaacccg gcacatcctg
      721 attgacaacg gaggagagct gcatgctggg agtgccctct gccctttcca gggcaatttc
      781 accatcattt tgtatggaag ggctgatgaa ggtattcagc cggatcctta ctatggtctg
      841 aagtacattg gggttggtaa aggaggcgct cttgagttgc atggacagaa aaagctctcc
      901 tggacatttc tgaacaagac ccttcaccca ggtggcatgg cagaaggagg ctattttttt
      961 gaaaggagct ggggccaccg tggagttatt gttcatgtca tcgaccccaa atcaggcaca
     1021 gtcatccatt ctgaccggtt tgacacctat agatccaaga aagagagtga acgtctggtc
     1081 cagtatttga acgcggtgcc cgatggcagg atcctttctg ttgcagtgaa tgatgaaggt
     1141 tctcgaaatc tggatgacat ggccaggaag gcgatgacca aattgggaag caaacacttc
     1201 ctgcaccttg gatttagaca cccttggagt tttctaactg tgaaaggaaa tccatcatct
     1261 tcagtggaag accatattga atatcatgga catcgaggct ctgctgctgc ccgggtattc
     1321 aaattgttcc agacagagca tggcgaatat ttcaatgttt ctttgtccag tgagtgggtt
     1381 caagacgtgg agtggacgga gtggttcgat catgataaag tatctcagac taaaggtggg
     1441 gagaaaattt cagacctctg gaaagctcac ccaggaaaaa tatgcaatcg tcccattgat
     1501 atacaggcca ctacaatgga tggagttaac ctcagcaccg aggttgtcta caaaaaaggc
     1561 caggattata ggtttgcttg ctacgaccgg ggcagagcct gccggagcta ccgtgtacgg
     1621 ttcctctgtg ggaagcctgt gaggcccaaa ctcacagtca ccattgacac caatgtgaac
     1681 agcaccattc tgaacttgga ggataatgta cagtcatgga aacctggaga taccctggtc
     1741 attgccagta ctgattactc catgtaccag gcagaagagt tccaggtgct tccctgcaga
     1801 tcctgcgccc ccaaccaggt caaagtggca gggaaaccaa tgtacctgca catcggggag
     1861 gagatagacg gcgtggacat gcgggcggag gttgggcttc tgagccggaa catcatagtg
     1921 atgggggaga tggaggacaa atgctacccc tacagaaacc acatctgcaa tttctttgac
     1981 ttcgatacct ttgggggcca catcaagttt gctctgggat ttaaggcagc acacttggag
     2041 ggcacggagc tgaagcatat gggacagcag ctggtgggtc agtacccgat tcacttccac
     2101 ctggccggtg atgtagacga aaggggaggt tatgacccac ccacatacat cagggacctc
     2161 tccatccatc atacattctc tcgctgcgtc acagtccatg gctccaatgg cttgttgatc
     2221 aaggacgttg tgggctataa ctctttgggc cactgcttct tcacggaaga tgggccggag
     2281 gaacgcaaca cttttgacca ctgtcttggc ctccttgtca agtctggaac cctcctcccc
     2341 tcggaccgtg acagcaagat gtgcaagatg atcacagagg actcctaccc ggggtacatc
     2401 cccaagccca ggcaagactg caatgctgtg tccaccttct ggatggccaa tcccaacaac
     2461 aacctcatca actgtgccgc tgcaggatct gaggaaactg gattttggtt tatttttcac
     2521 cacgtaccaa cgggcccctc cgtgggaatg tactccccag gttattcaga gcacattcca
     2581 ctgggaaaat tctataacaa ccgagcacat tccaactacc gggctggcat gatcatagac
     2641 aacggagtca aaaccaccga ggcctctgcc aaggacaagc ggccgttcct ctcaatcatc
     2701 tctgccagat acagccctca ccaggacgcc gacccgctga agccccggga gccggccatc
     2761 atcagacact tcattgccta caagaaccag gaccacgggg cctggctgcg cggcggggat
     2821 gtgtggctgg acagctgccg gtttgctgac aatggcattg gcctgaccct ggccagtggt
     2881 ggaaccttcc cgtatgacga cggctccaag caagagataa agaacagctt gtttgttggc
     2941 gagagtggca acgtggggac ggaaatgatg gacaatagga tctggggccc tggcggcttg
     3001 gaccatagcg gaaggaccct ccctataggc cagaattttc caattagagg aattcagtta
     3061 tatgatggcc ccatcaacat ccaaaactgc actttccgaa agtttgtggc cctggagggc
     3121 cggcacacca gcgccctggc cttccgcctg aataatgcct ggcagagctg cccccataac
     3181 aacgtgaccg gcattgcctt tgaggacgtt ccgattactt ccagagtgtt cttcggagag
     3241 cctgggccct ggttcaacca gctggacatg gatggggata agacatctgt gttccatgac
     3301 gtcgacggct ccgtgtccga gtaccctggc tcctacctca cgaagaatga caactggctg
     3361 gtccggcacc cagactgcat caatgttccc gactggagag gggccatttg cagtgggtgc
     3421 tatgcacaga tgtacattca agcctacaag accagtaacc tgcgaatgaa gatcatcaag
     3481 aatgacttcc ccagccaccc tctttacctg gagggggcgc tcaccaggag cacccattac
     3541 cagcaatacc aaccggttgt caccctgcag aagggctaca ccatccactg ggaccagacg
     3601 gcccccgccg aactcgccat ctggctcatc aacttcaaca agggcgactg gatccgagtg
     3661 gggctctgct acccgcgagg caccacattc tccatcctct cggatgttca caatcgcctg
     3721 ctgaagcaaa cgtccaagac gggcgtcttc gtgaggacct tgcagatgga caaagtggag
     3781 cagagctacc ctggcaggag ccactactac tgggacgagg actcagggct gttgttcctg
     3841 aagctgaaag ctcagaacga gagagagaag tttgctttct gctccatgaa aggctgtgag
     3901 aggataaaga ttaaagctct gattccaaag aacgcaggcg tcagtgactg cacagccaca
     3961 gcttacccca agttcaccga gagggctgtc gtagacgtgc cgatgcccaa gaagctcttt
     4021 ggttctcagc tgaaaacaaa ggaccatttc ttggaggtga agatggagag ttccaagcag
     4081 cacttcttcc acctctggaa cgacttcgct tacattgaag tggatgggaa gaagtacccc
     4141 agttcggagg atggcatcca ggtggtggtg attgacggga accaagggcg cgtggtgagc
     4201 cacacgagct tcaggaactc cattctgcaa ggcataccat ggcagctttt caactatgtg
     4261 gcgaccatcc ctgacaattc catagtgctt atggcatcaa agggaagata cgtctccaga
     4321 ggcccatgga ccagagtgct ggaaaagctt ggggcagaca ggggtctcaa gttgaaagag
     4381 caaatggcat tcgttggctt caaaggcagc ttccggccca tctgggtgac actggacact
     4441 gaggatcaca aagccaaaat cttccaagtt gtgcccatcc ctgtggtgaa gaagaagaag
     4501 ttgtgaggac agctgccgcc cggtgccacc tcgtggtaga ctatgacggt gactcttggc
     4561 agcagaccag tgggggatgg ctgggtcccc cagcccctgc cagcagctgc ctgggaaggc
     4621 cgtgtttcag ccctgatggg ccaagggaag gctatcagag accctggtgc tgccacctgc
     4681 ccctactcaa gtgtctacct ggagcccctg gggcggtgct ggccaatgct ggaaacattc
     4741 actttcctgc agcctcttgg gtgcttctct cctatctgtg cctcttcagt gggggtttgg
     4801 ggaccatatc aggagacctg ggttgtgctg acagcaaaga tccactttgg caggagccct
     4861 gacccagcta ggaggtagtc tggagggctg gtcattcaca gatccccatg gtcttcagca
     4921 gacaagtgag ggtggtaaat gtaggagaaa gagccttggc cttaaggaaa tctttactcc
     4981 tgtaagcaag agccaacctc acaggattag gagctggggt agaactggct atccttgggg
     5041 aagaggcaag ccctgcctct ggccgtgtcc acctttcagg agactttgag tggcaggttt
     5101 ggacttggac tagatgactc tcaaaggccc ttttagttct gagattccag aaatctgctg
     5161 catttcacat ggtacctgga acccaacagt tcatggatat ccactgatat ccatgatgct
     5221 gggtgcccca gcgcacacgg gatggagagg tgagaactaa tgcctagctt gaggggtctg
     5281 cagtccagta gggcaggcag tcaggtccat gtgcactgca atgccaggtg gagaaatcac
     5341 agagaggtaa aatggaggcc agtgccattt cagaggggag gctcaggaag gcttcttgct
     5401 tacaggaatg aaggctgggg gcattttgct ggggggagat gaggcagcct ctggaatggc
     5461 tcagggattc agccctccct gccgctgcct gctgaagctg gtgactacgg ggtcgccctt
     5521 tgctcacgtc tctctggccc actcatgatg gagaagtgtg gtcagagggg agcaatgggc
     5581 tttgctgctt atgagcacag aggaattcag tccccaggca gccctgcctc tgactccaag
     5641 agggtgaagt ccacagaagt gagctcctgc cttagggcct catttgctct tcatccaggg
     5701 aactgagcac agggggcctc caggagaccc tagatgtgct cgtactccct cggcctggga
     5761 tttcagagct ggaaatatag aaaatatcta gcccaaagcc ttcattttaa cagatgggga
     5821 aagtgagccc ccaagatggg aaagaaccac acagctaagg gagggcctgg ggagccccac
     5881 cctagccctt gctgccacac cacattgcct caacaaccgg ccccagagtg cccaggcact
     5941 cctgaggtag cttctggaaa tggggacaag tcccctcgaa ggaaaggaaa tgactagagt
     6001 agaatgacag ctagcagatc tcttccctcc tgctcccagc gcacacaaac ccgccctccc
     6061 cttggtgttg gcggtccctg tggccttcac tttgttcact acctgtcagc ccagcctggg
     6121 tgcacagtag ctgcaactcc ccattggtgc tacctggctc tcctgtctct gcagctctac
     6181 aggtgaggcc cagcagaggg agtagggctc gccatgtttc tggtgagcca atttggctga
     6241 tcttgggtgt ctgaacagct attgggtcca ccccagtccc tttcagctgc tgcttaatgc
     6301 cctgctctct ccctggccca ccttatagag agcccaaaga gctcctgtaa gagggagaac
     6361 tctatctgtg gtttataatc ttgcacgagg caccagagtc tccctgggtc ttgtgatgaa
     6421 ctacatttat cccctttcct gccccaacca caaactcttt ccttcaaaga gggcctgcct
     6481 ggctccctcc acccaactgc acccatgaga ctcggtccaa gagtccattc cccaggtggg
     6541 agccaactgt cagggaggtc tttcccacca aacatctttc agctgctggg aggtgaccat
     6601 agggctctgc ttttaaagat atggctgctt caaaggccag agtcacagga aggacttctt
     6661 ccagggagat tagtggtgat ggagaggaga gttaaaatga cctcatgtcc ttcttgtcca
     6721 cggttttgtt gagttttcac tcttctaatg caagggtctc acactgtgaa ccacttagga
     6781 tgtgatcact ttcaggtggc caggaatgtt gaatgtcttt ggctcagttc atttaaaaaa
     6841 gatatctatt tgaaagttct cagagttgta catatgtttc acagtacagg atctgtacat
     6901 aaaagtttct ttcctaaacc attcaccaag agccaatatc taggcatttt cttggtagca
     6961 caaattttct tattgcttag aaaattgtcc tccttgttat ttctgtttgt aagacttaag
     7021 tgagttaggt ctttaaggaa agcaacgctc ctctgaaatg cttgtctttt ttctgttgcc
     7081 gaaatagctg gtcctttttc gggagttaga tgtatagagt gtttgtatgt aaacatttct
     7141 tgtaggcatc accatgaaca aagatatatt ttctatttat ttattatatg tgcacttcaa
     7201 gaagtcactg tcagagaaat aaagaattgt cttaaatgtc atgattggag atgtcctttg
     7261 cattgcttgg aaggggtgta cctagagcca aggaaattgg ctctggtttg gaaaaatttt
     7321 gctgttatta tagtaaacat acaaaggatg tca
//
