LOCUS       NM_001407              11933 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens cadherin EGF LAG seven-pass G-type receptor 3
            (CELSR3), mRNA.
ACCESSION   NM_001407
VERSION     NM_001407.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11933)
  AUTHORS   Wu,Z., Zhu,Z., Wu,W., Hu,S., Cao,J., Huang,X., Xie,Q. and Deng,C.
  TITLE     CELSR3 is a prognostic marker in HNSCC and correlates with immune
            cell infiltration in the tumor microenvironment
  JOURNAL   Eur Arch Otorhinolaryngol 281 (6), 3143-3156 (2024)
   PUBMED   38507078
  REMARK    GeneRIF: CELSR3 is a prognostic marker in HNSCC and correlates with
            immune cell infiltration in the tumor microenvironment.
REFERENCE   2  (bases 1 to 11933)
  AUTHORS   Bui,D.L.H., Roach,A., Li,J., Bandekar,S.J., Orput,E., Raghavan,R.,
            Arac,D. and Sando,R.C.
  TITLE     The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via
            distinct activation mechanisms
  JOURNAL   Cell Rep 42 (6), 112552 (2023)
   PUBMED   37224017
  REMARK    GeneRIF: The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins
            via distinct activation mechanisms.
REFERENCE   3  (bases 1 to 11933)
  AUTHORS   Sun,Y., Chen,G., He,J., Li,J.X., Gan,X.Y., Ji,S.F., Huang,Y.,
            Chen,X.H., He,M.L. and Huang,Z.G.
  TITLE     Clinical Significance and Underlying Mechanisms of CELSR3 in
            Metastatic Prostate Cancer Based on Immunohistochemistry, Data
            Mining, and In Silico Analysis
  JOURNAL   Cancer Biother Radiopharm 37 (6), 466-479 (2022)
   PUBMED   34582697
  REMARK    GeneRIF: Clinical Significance and Underlying Mechanisms of CELSR3
            in Metastatic Prostate Cancer Based on Immunohistochemistry, Data
            Mining, and In Silico Analysis.
REFERENCE   4  (bases 1 to 11933)
  AUTHORS   Zheng,K., Lan,T., Li,G.P., Huang,L., Chen,Y.P., Su,B.H., Zhang,S.
            and Zheng,D.L.
  TITLE     Evaluated expression of CELSR3 in oral squamous cell carcinoma is
            associated with perineural invasion and poor prognosis
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 133 (5), 564-573 (2022)
   PUBMED   35165064
  REMARK    GeneRIF: Evaluated expression of CELSR3 in oral squamous cell
            carcinoma is associated with perineural invasion and poor
            prognosis.
REFERENCE   5  (bases 1 to 11933)
  AUTHORS   Li,J., Lin,S.M., Qiao,J.D., Liu,X.R., Wang,J., Jiang,M., Zhang,J.,
            Zhong,M., Chen,X.Q., Zhu,J., He,N., Su,T., Shi,Y.W., Yi,Y.H. and
            Liao,W.P.
  CONSRTM   China Epilepsy Gene 1.0 Project
  TITLE     CELSR3 variants are associated with febrile seizures and epilepsy
            with antecedent febrile seizures
  JOURNAL   CNS Neurosci Ther 28 (3), 382-389 (2022)
   PUBMED   34951123
  REMARK    GeneRIF: CELSR3 variants are associated with febrile seizures and
            epilepsy with antecedent febrile seizures.
REFERENCE   6  (bases 1 to 11933)
  AUTHORS   Bjarnadottir,T.K., Fredriksson,R., Hoglund,P.J., Gloriam,D.E.,
            Lagerstrom,M.C. and Schioth,H.B.
  TITLE     The human and mouse repertoire of the adhesion family of
            G-protein-coupled receptors
  JOURNAL   Genomics 84 (1), 23-33 (2004)
   PUBMED   15203201
REFERENCE   7  (bases 1 to 11933)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
REFERENCE   8  (bases 1 to 11933)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 11933)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   10 (bases 1 to 11933)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC121252.4, AF231023.1,
            AB011536.1 and BU738328.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001407.2.
            
            Summary: This gene belongs to the flamingo subfamily, which is
            included in the cadherin superfamily. The flamingo cadherins
            consist of nonclassic-type cadherins that do not interact with
            catenins. They are plasma membrane proteins containing seven
            epidermal growth factor-like repeats, nine cadherin domains and two
            laminin A G-type repeats in their ectodomain. They also have seven
            transmembrane domains, a characteristic feature of their subfamily.
            The encoded protein may be involved in the regulation of
            contact-dependent neurite growth and may play a role in tumor
            formation. [provided by RefSeq, Jun 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF231023.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000164024.5/ ENSP00000164024.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-290               AC121252.4         101045-101334       c
            291-9374            AF231023.1         320-9403
            9375-11927          AB011536.1         3280-5832
            11928-11933         BU738328.1         13-18               c
FEATURES             Location/Qualifiers
     source          1..11933
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..11933
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /note="cadherin EGF LAG seven-pass G-type receptor 3"
                     /db_xref="GeneID:1951"
                     /db_xref="HGNC:HGNC:3230"
                     /db_xref="MIM:604264"
     exon            1..4000
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4651
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4652..4877
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4878..4993
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            4994..5082
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5083..5240
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5241..5404
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5405..5530
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5531..5700
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5701..5886
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            5887..6003
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6004..6175
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6176..6317
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6318..6438
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6439..6622
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6623..6724
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6725..6819
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            6820..7029
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7030..7225
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7226..7381
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7382..7547
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7548..7715
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7716..7842
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            7843..8049
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8050..8224
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8225..8337
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8338..8417
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8418..8541
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8542..8658
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8659..8807
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8808..8917
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            8918..9076
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            9077..9277
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            9278..10163
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     exon            10164..11933
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11913..11918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /note="hexamer: AATAAA"
     polyA_site      11933
                     /gene="CELSR3"
                     /gene_synonym="ADGRC3; CDHF11; EGFL1; FMI1; HFMI1; MEGF2;
                     RESDA1"
                     /note="major polyA site"
ORIGIN      
        1 gttggagcgg cgggaggcgg cagcagcgtc ggggatgctg tggtgggggc ggaaaaagcc
       61 agggccgcac gccggagggg ctccggccgc ggagtagatg gtgcccagag ggcggcgggg
      121 gtgcggagag acaggcggag gggcgggggc ccggggcggc ggcaggggcc cgggaggggg
      181 cccgagcggc ggggccagcc caaggcccgg accggggcgg ggggcggtgg aggccgtgca
      241 gggaggcggg ggatgatggc gaggcggccg ccgtggcggg gcctcggggg acggtcgacc
      301 cccatactcc tgctccttct cctctctttg ttccccctca gccaggagga gctggggggc
      361 ggtgggcacc agggctggga cccaggctta gctgccacta cggggccaag ggcgcatatc
      421 ggtggcggag ccttagctct ttgtccggag tcttccgggg tccgggagga tggggggcct
      481 ggcctggggg tcagggagcc tatcttcgtg gggctccgag ggagaaggca aagcgcccgg
      541 aatagtcgag ggccccctga gcagccgaat gaggagctgg ggattgaaca cggcgtccag
      601 ccattgggca gccgcgaacg agagacagga cagggaccag ggtctgtgtt atactggcgc
      661 ccagaggtct cctcttgcgg gcggacagga cctttgcaaa gaggtagtct gtcaccaggg
      721 gctctgtcct caggggtccc gggctcgggg aacagctcgc ccctcccttc agactttttg
      781 attcggcacc acggtcccaa gccggtgtcc tcccagcgga acgctgggac aggctcccgc
      841 aaaagagtgg gcaccgcgcg ctgctgtggg gaattatggg caacagggag caagggtcag
      901 ggcgagagag ccacgacatc cggagcagaa aggacagccc cccggcggaa ctgtcttcca
      961 ggggcctcgg gatctggccc cgagctggat tcagcaccac gcacggcgag gacagctcct
     1021 gcatcaggtt cagcaccccg cgagtctcgg acagctcccg agccggcgcc caagcgcatg
     1081 cgctcccggg gtctcttccg ctgccgcttc ctcccgcagc gccccgggcc gcgtcccccg
     1141 ggactcccgg cccgtcctga agccaggaaa gtaacctcgg cgaaccgggc acgctttcgt
     1201 cgcgccgcaa accgccaccc gcagtttccg cagtacaact accagacgct ggtgccggag
     1261 aatgaggcag caggcaccgc ggtgctacgc gtggttgctc aggacccgga cgccggcgag
     1321 gccgggcgcc tagtctactc gctggcggca ctcatgaaca gccgctcgct ggagctgttc
     1381 agcatcgacc cgcagagcgg ccttatccgt acggcggcag ctctggaccg cgagagcatg
     1441 gagcgtcact acctgcgtgt gaccgcgcag gaccacgggt cgccgcgcct ctcggccacc
     1501 acgatggtgg ccgtgacagt agccgaccgc aacgaccact cgccggtttt tgagcaagcg
     1561 cagtaccggg agacccttcg cgagaatgtg gaggagggct accctatcct gcagctgcgt
     1621 gccactgacg gcgacgcgcc ccccaacgcc aacctgcgct accgcttcgt ggggccgcca
     1681 gctgcgcgcg ctgcagctgc cgccgccttc gagattgatc cacgctccgg cctcatcagc
     1741 accagcggcc gagtggaccg cgagcacatg gaaagctatg agctggtggt ggaagccagc
     1801 gaccagggcc aggaacccgg gccgcgctcg gccactgtgc gcgtacacat aactgtgcta
     1861 gacgagaacg acaatgctcc tcagttcagc gagaagcgct acgtggcgca ggtgcgcgag
     1921 gatgtgcgcc cccacacagt cgtgctgcgc gtcacggcca ctgaccggga caaggacgcc
     1981 aacggattgg tgcactacaa catcatcagt ggcaatagcc gtggacactt tgccatcgac
     2041 agcctcactg gcgagatcca ggtggtggca cctctggact tcgaggcaga gagagagtat
     2101 gccttgcgca tcagggcgca ggatgctggc cggccaccgc tgtccaacaa cacgggcctg
     2161 gccagcatcc aggtggtgga catcaatgac cacattccta tttttgtcag cacgcccttc
     2221 caagtttctg tcttggaaaa tgctcccttg ggtcactcag tcatccacat tcaggcagtc
     2281 gatgcagacc atggggagaa tgccagattg gagtactccc taactggtgt ggcacctgat
     2341 actccttttg tgataaacag cgccactggc tgggtctctg tgagtggtcc cctggaccgt
     2401 gagtctgtgg agcattactt ctttggtgtg gaggctcgag accatggctc acccccactc
     2461 tctgcctcag ccagtgtcac cgtgactgtg ctggacgtta atgacaatcg gcctgagttc
     2521 acaatgaagg agtaccacct acgactgaat gaggatgcag ctgtgggcac cagtgtggtc
     2581 agcgtgaccg cagtagaccg tgatgccaac agtgccatca gctaccagat cacaggcggc
     2641 aacacccgga atcgctttgc catcagcacc caggggggtg tgggtctggt gactctggct
     2701 ctgccactgg actacaagca ggaacgctac ttcaagctgg tactaactgc atctgaccgt
     2761 gcccttcatg atcactgcta tgtgcacatc aacatcacag atgccaacac tcatcggccg
     2821 gtctttcaaa gtgcccacta ctcagtgagt gtgaatgaag atcggccaat gggtagcacc
     2881 atagtggtca tcagtgcctc tgatgatgac gtgggtgaga atgctcgtat cacctatctc
     2941 ctggaggaca acctgcccca gttccgcatt gatgcagact caggagccat tacattacag
     3001 gccccattag actatgagga ccaggtgacc tacaccctgg ctatcacagc tcgggacaat
     3061 ggcatcccac agaaggcaga cactacttat gtggaggtga tggtcaatga cgtgaatgac
     3121 aatgctccac aatttgtggc ctcccactat acagggctgg tctctgagga tgccccacct
     3181 ttcaccagtg tcctgcagat ctcagccact gaccgggatg ctcatgccaa tggccgggtc
     3241 cagtacactt tccagaatgg tgaagatggg gatggagatt ttaccattga gcccacctct
     3301 ggaattgtcc gtacagtaag gcggctagac cgggaggcag tatcagtgta tgagttgact
     3361 gcctacgcag tggacagagg tgtgccccca ctccggactc cagtcagtat ccaggtgatg
     3421 gtgcaggatg tgaacgacaa tgcacctgtc ttcccagctg aggagtttga ggtgcgggtg
     3481 aaagagaata gcattgtggg ctcagtggtg gcccagatca ctgcagtgga ccctgacgaa
     3541 ggccccaatg cccatataat gtaccagatc gtggagggga acatccctga gctgttccaa
     3601 atggacatct tctctggaga actgacggca ctcattgacc tagactatga ggctcgccaa
     3661 gaatatgtga ttgtggtgca ggccacatct gctcctttgg tcagccgggc cactgtgcac
     3721 gtccgcctgg ttgaccagaa tgacaacagc cctgtgctca acaacttcca gatcctcttc
     3781 aacaactatg tatccaaccg ttcagacacc ttcccgtcgg gcattattgg gcgcatccca
     3841 gcttatgacc ccgatgtctc cgaccacctc ttctactcct ttgagcgtgg caatgagctg
     3901 cagctgctgg tagtcaacca gaccagtggg gagctgcgac tcagccgaaa gctagacaat
     3961 aaccgcccac tggtggcctc catgttggtg actgtcacag atggcctgca cagcgtgacg
     4021 gcgcagtgtg tgctgcgcgt ggtcatcatc acggaggagt tgctggccaa cagcctgacc
     4081 gtgcgccttg agaacatgtg gcaggagcgc ttcctgtcac cgctgctggg ccgcttcctc
     4141 gagggcgtgg ctgcggtgct cgctacgccc gctgaggacg tcttcatctt caacatccag
     4201 aacgacacag acgtaggggg caccgtgctc aatgtgagtt tctcggcgct agctccacgt
     4261 ggggccgggg cgggcgctgc agggccctgg ttcagctccg aggagctgca ggagcagttg
     4321 tacgtgcgcc gggcggcgct ggcggctcgc tccctgctcg acgtactgcc cttcgacgac
     4381 aacgtgtgcc tgcgagagcc ctgtgagaac tacatgaaat gcgtgtccgt gctccgcttt
     4441 gactcgtccg cgcccttcct ggcctcggcc tccacgctgt tccgacccat ccagcccatc
     4501 gctggcctgc gctgccgctg cccgcccgga ttcacgggag acttttgcga gaccgagctc
     4561 gacctctgct actccaaccc atgtcgcaac ggcggagcct gcgcgcggcg cgagggaggc
     4621 tacacgtgcg tctgccgccc gcgcttcacc ggagaggact gcgagctgga caccgaggcc
     4681 ggccgctgcg tgccgggcgt ctgccgcaac gggggcacct gcaccgacgc gcccaacggc
     4741 ggctttcgct gccagtgccc ggcaggcggc gccttcgagg gcccgcgctg cgaggtggct
     4801 gcgcgctcct tcccgcccag ttcgttcgtc atgtttcgcg gcctgcggca gcgattccac
     4861 cttacgctgt ccctctcgtt cgcgacagtg cagcagagcg ggctgctctt ctacaacggg
     4921 cgcctgaacg agaagcacga cttcctggcc ctggaactcg tggctggcca agtgcggctc
     4981 acatattcca cgggtgaatc caacaccgtg gtcagcccca cagttccagg gggcttgagt
     5041 gacgggcaat ggcatacagt gcatctgaga tactacaaca agccccggac agatgcccta
     5101 gggggtgcac agggcccctc caaggacaag gtggctgtgc taagcgtgga tgattgtgat
     5161 gtggccgtgg ctctgcagtt tggtgctgag attggcaact actcatgcgc ggctgctggt
     5221 gtgcaaacaa gctccaagaa gtccctggac ctgacgggcc ctcttcttct gggaggtgtc
     5281 cccaacctcc ccgagaactt ccccgtatcc cataaggact tcatcggctg tatgcgggac
     5341 ctgcacattg atggccgccg agtggacatg gcggcttttg tcgcaaataa tggcaccatg
     5401 gcaggctgcc aagccaagct acacttttgt gactcaggcc cctgcaagaa cagtggcttc
     5461 tgctcggagc gctggggcag cttcagctgc gactgccctg tgggcttcgg cggcaaagac
     5521 tgtcagctta ctatggccca tccccaccat ttccgtggca acggcacact gagctggaac
     5581 tttggaagtg acatggctgt gtctgtgcca tggtacctgg ggctggcatt tcggacacgg
     5641 gcaacgcagg gggtcctgat gcaagtgcag gctgggccac acagcacgct cctttgccag
     5701 ctagatcggg ggttactgtc tgtgacagtg accaggggct cgggccgtgc ttcccatctc
     5761 cttctggacc aggtgactgt cagtgatggc cggtggcacg atctgcggct ggagttgcag
     5821 gaggaaccag gtggccggcg gggccaccat gtccttatgg tctcactgga ctttagcctc
     5881 ttccaggaca ccatggcggt ggggagtgag ctgcagggcc tgaaggtaaa gcagctccac
     5941 gtgggaggcc tgccccccgg cagtgcagag gaggctcctc agggtctggt tggctgcatc
     6001 cagggggtgt ggctcggctc cacaccctct ggctccccgg ccctgctacc ccccagccac
     6061 cgagtgaatg cggagcctgg ctgtgttgtg accaacgcct gtgcctctgg gccctgccca
     6121 cctcacgcag actgccggga cctctggcag accttttctt gcacctgcca gccaggttac
     6181 tacggcccag gctgtgtgga tgcctgcctc ctgaacccct gtcagaacca gggatcatgc
     6241 cggcacctgc caggagcccc ccatggctat acctgtgact gtgtgggtgg ctatttcggg
     6301 caccactgtg agcacaggat ggaccagcag tgcccacggg gctggtgggg gagcccaacc
     6361 tgtggcccct gcaactgtga tgttcacaaa ggttttgatc ccaactgcaa caagacaaat
     6421 gggcagtgtc actgcaagga gttccactac cgaccgcggg gcagtgactc ttgcctccca
     6481 tgtgactgct accctgtggg ctccacctcg cgctcatgtg caccccacag cgggcagtgc
     6541 ccctgtcgcc caggagccct tggccgccag tgcaacagct gtgacagtcc cttcgcagag
     6601 gtgacagcca gcggctgccg ggtgctctat gatgcctgcc ctaagtccct gagatctggt
     6661 gtgtggtggc cccagacaaa gtttggcgtc ctggccacag tgccctgtcc ccggggggcc
     6721 ctgggtgctg ctgtgcggct gtgtgatgag gcccagggtt ggctggagcc cgacctcttc
     6781 aactgtacct cccctgcctt tcgagagctc agtctgctgc tggatggcct agagctgaac
     6841 aagacggcac tggataccat ggaggccaag aagctggctc agcggctacg ggaggtgact
     6901 ggccacactg accactattt tagccaagat gttcgagtca ctgcccgcct gctggcccac
     6961 ctgctggcct tcgagagcca tcagcagggc ttcgggctga cagccacaca ggatgcccac
     7021 ttcaatgaga atctgctgtg ggccggctct gcactgcttg ccccagagac aggggacttg
     7081 tgggcggcgc tggggcagcg ggcccctggg ggctccccag gcagcgcggg actggtgagg
     7141 cacctggagg agtatgcagc cacactcgca aggaatatgg aactcacata cctgaatccc
     7201 atggggctgg tgacgcctaa tatcatgctc agcattgacc gcatggagca ccccagttct
     7261 ccccgggggg cccgtcgcta ccctcgctac catagcaacc tctttcgagg ccaggatgcc
     7321 tgggatcctc acacccatgt gctgctgcct tcccagtccc cacggccatc cccatctgaa
     7381 gttctgccca caagcagcag catagaaaac tccaccacct caagtgtggt ccccccacca
     7441 gccccgccag agccagagcc tgggatctcc attatcattc tcctcgttta ccgcacctta
     7501 gggggactgc tccctgccca gttccaggca gaacgccgag gtgccaggct tcctcagaac
     7561 cccgtcatga actccccggt ggtcagcgtg gctgtgttcc acggacgcaa cttcctaagg
     7621 ggaatcctgg agtcccccat cagcctagag tttcgcctgc tacagacagc gaatcggagc
     7681 aaggcgatct gtgtgcagtg ggacccacct ggcctggcgg agcagcatgg tgtgtggaca
     7741 gcacgggact gcgagctggt gcacaggaat gggtcccacg cacggtgtcg ctgcagccgg
     7801 acagggacct ttggggtcct catggatgcc tctccccgtg agaggctgga gggcgacctg
     7861 gagctgctgg ctgtgttcac ccacgtggtc gtggctgtgt ctgtggctgc gctggtgctg
     7921 actgcagcca tcctgctgag cctgcgcagc ctcaagtcca atgtgcgtgg gatccatgcc
     7981 aatgtggcag ccgccctggg ggtggcagag ctcctcttcc tgctggggat tcacaggacc
     8041 cacaatcagc tggtgtgcac tgcagtcgcc atcctcctgc actacttctt cctcagcacc
     8101 ttcgcgtggc tcttcgtgca ggggctgcac ctctaccgca tgcaggttga gccacgcaac
     8161 gtggaccgcg gcgccatgcg cttctaccat gccctgggct ggggcgtccc tgctgtgctg
     8221 ctgggccttg ctgtgggcct ggaccctgag ggctatggga accctgactt ctgctggatc
     8281 tcagtccacg agcccctcat ctggagcttt gctggccctg ttgtcctggt catagtgatg
     8341 aacgggacca tgtttctcct cgctgcccgc acatcctgct ccacagggca gagggaggcc
     8401 aagaagacct ctgcactgac ccttcgcagc tccttcctgc tgcttctgct ggtcagtgcc
     8461 tcctggctct ttgggctcct ggcagtcaac cacagcatcc tagccttcca ctacctccat
     8521 gctggactct gcggcctcca gggcctggcg gtgctgctgc tcttctgtgt cctaaatgca
     8581 gatgctcggg ctgcctggat gccagcctgt ctgggcagga aggcagcgcc tgaggaggca
     8641 aggccagcac ctgggctggg acctggggcc tacaacaaca cggctctctt tgaggagagt
     8701 ggcctcatcc gcatcactct gggcgcctcc accgtctcct ctgtgagcag tgcccgctcc
     8761 ggccggaccc aggaccagga cagccagcgg ggccgcagct acctcaggga caatgtcctg
     8821 gttcgacatg gctcagccgc tgaccacact gaccacagcc tccaggctca tgctggcccc
     8881 actgacctgg acgtggccat gttccatcga gatgctggcg cagactccga ctctgacagt
     8941 gacctgtcct tggaggagga gaggagtctc tccattccat cttcagaaag cgaggacaat
     9001 ggccggacgc gggggcgctt ccaacggcca ctctgccgag cagcccagag tgagaggctc
     9061 ctcacccacc ccaaagatgt ggatggcaat gacctcctgt cctactggcc agccctgggg
     9121 gagtgcgagg cagccccctg tgctctgcag acttggggct ctgaaaggcg cctggggctg
     9181 gacaccagca aggatgcagc taacaacaac cagccagacc cggccctgac cagtggggat
     9241 gagacttctc tgggccgggc ccagcgccag aggaaaggca tcctgaagaa ccggttgcaa
     9301 tacccactgg tgccacagac ccgaggtgcc cctgagctgt cctggtgccg tgcagccacc
     9361 ttgggccacc gtgctgtgcc agctgcctct tacggtcgca tctatgctgg cgggggcacg
     9421 ggcagccttt cacagccagc cagccgctac tcttctagag aacagctgga cctgctcctc
     9481 cggcggcaac tgagccgtga gcgactagag gaagcccctg cccctgttct acgtcccctg
     9541 agccggccag ggtcccagga atgcatggat gctgcaccag gccgactgga gcccaaagat
     9601 cggggcagca ccctgccacg gaggcagcca cctcgggact accctggcgc catggctggc
     9661 cgcttcgggt cacgggatgc gctcgactta ggggcacctc gagagtggtt gagcacgctg
     9721 cctccgcccc gccgcacccg ggaccttgac ccacagcccc cacctctgcc cctgtctccc
     9781 cagcggcaac tctcaaggga ccccctcttg ccatcccggc cgctggactc tctgtctagg
     9841 agctcgaact ctcgggagca gctggaccag gtgcctagcc ggcacccctc acgagaagcc
     9901 cttgggccac tcccgcagct gctcagagct agggaggact cggtcagtgg ccccagccat
     9961 ggcccctcca cagaacagtt ggacattctt tcctccatcc ttgcctcttt caactcctcg
    10021 gccctctcct ctgtgcaatc ttcaagcaca cccttgggcc ctcacaccac tgccacacct
    10081 tctgccacag cctctgtgct tgggccctcc acgccacgtt ctgccacgtc tcacagcatc
    10141 tcggagctgt cgccagactc agaagttccc agaagtgagg gtcactcctg aggggatgac
    10201 ggcgtggacg aggaacagct gagggcgaca gaggatctag gctaacagga gagactccag
    10261 gagtgggggc agatcccaag gcagcctcct gctccccagt ggtgggtgcc ccagctctac
    10321 ctggtgtggc agggctgagg ctccatgtgc atctgtgagc atgcgtgtga caggtgcaga
    10381 gacgggggac tggagggaga cttttatacg ttttgtacct ttgtaaccag agagatgctt
    10441 atgttatttt tcagcttttc tgtctcctgg ggggtttgag gctgggctgg gagggggagg
    10501 gagatagagg gagagatgca gtttgacccc atttgggtcc tgagcaaacc ctatgctcat
    10561 ctctctctcc ttcctggggt ggactcagat gggtgggaca catgccttcc tccccctatt
    10621 ccacccccaa gttgatctga gtatcgtcag gggcccaaag tacagaattg ttctttgctt
    10681 tttattgaat gctccaaagg ccaaacttct ggggctgggg gttggtcttg gaaacagggg
    10741 tcctctgact tcctcatggg ggcttgctca taccgcccct cctggtggat gtgtgtgttt
    10801 attatgtgga gtccctgcca cttactgcct tatgacctag gactgatgct gtggggtgct
    10861 ggtggagcag ctgatgtcgt gtttacagag caaggcttcc ctgtctccca cggggagggg
    10921 ctcgggcctc tagtcagaca ttcctgcaga gggtcggtgg aggggtcatt cacctgcccc
    10981 tgcagcaagc aaaagttgtc tgtggtgcca tttgattccc tgacactgcc ccctgcttga
    11041 attgattccg aagggtaggg tgggaaggtg agcaaaggga gcagaaacaa gggaattcaa
    11101 gacccagaat gtaggtgcca ctgcctccta tgtttacagg atcctccgtg gccctaggca
    11161 cctgggctgc aggaagtgac tccgttccac tcctccttta ttcccttaaa aagggaaaaa
    11221 tgactgttac gaccctgttc acaaaactct tacttttgct attttgtctg ctgtccagaa
    11281 ctgaagactt taaaattttg ttactgttta caagtccaga ttcaaaaaat gtttttactt
    11341 tgtttacaac tcaaaacttt gagttttaca ctttgtttac agtagataat tttttttcct
    11401 ttgtttccaa gtgaaaggta gggaaagtgg gagagggact tggaggaccc acctgtgagg
    11461 accctgacct ggccatcttg aggggttttc taacccccag gtctcccagg ccgaaggtca
    11521 gccttgagtc ccgtttaaca gcagatccag aagaccttga gagtaggcgt cctctaacca
    11581 cgggggagag tggctgtgca gggctggggg gtggtctgtg cagacacctc ctcacccacc
    11641 accccatgca tactcttggg aagcagcttc ctgggagatt agaaattcta cttccctgac
    11701 tggagctaaa tcccaccagc caggacccaa actctcctta ccgagaagga ccccagctct
    11761 tgaagggctg agtggcctgc tgggggtggg agggtgtctt tactatgtcc taggtttcgt
    11821 agatgcccct ctctggggtt cccctcctcc agcccagcgg ccctctttcc tgtctgtgta
    11881 aattgttccg tgaagccgcg ctctgttttg ggaataaact tctatagaaa aca
//
