LOCUS       NM_001408              11015 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens cadherin EGF LAG seven-pass G-type receptor 2
            (CELSR2), mRNA.
ACCESSION   NM_001408
VERSION     NM_001408.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11015)
  AUTHORS   Bui,D.L.H., Roach,A., Li,J., Bandekar,S.J., Orput,E., Raghavan,R.,
            Arac,D. and Sando,R.C.
  TITLE     The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via
            distinct activation mechanisms
  JOURNAL   Cell Rep 42 (6), 112552 (2023)
   PUBMED   37224017
  REMARK    GeneRIF: The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins
            via distinct activation mechanisms.
REFERENCE   2  (bases 1 to 11015)
  AUTHORS   Wen,Q., Weng,H., Liu,T., Yu,L., Zhao,T., Qin,J., Li,S., Wu,Q.,
            Tissir,F., Qu,Y. and Zhou,L.
  TITLE     Inactivating Celsr2 promotes motor axon fasciculation and
            regeneration in mouse and human
  JOURNAL   Brain 145 (2), 670-683 (2022)
   PUBMED   34983065
  REMARK    GeneRIF: Inactivating Celsr2 promotes motor axon fasciculation and
            regeneration in mouse and human.
REFERENCE   3  (bases 1 to 11015)
  AUTHORS   Tan,J., Che,Y., Liu,Y., Hu,J., Wang,W., Hu,L., Zhou,Q., Wang,H. and
            Li,J.
  TITLE     CELSR2 deficiency suppresses lipid accumulation in hepatocyte by
            impairing the UPR and elevating ROS level
  JOURNAL   FASEB J 35 (10), e21908 (2021)
   PUBMED   34478580
  REMARK    GeneRIF: CELSR2 deficiency suppresses lipid accumulation in
            hepatocyte by impairing the UPR and elevating ROS level.
REFERENCE   4  (bases 1 to 11015)
  AUTHORS   Noto,D., Cefalu,A.B., Martinelli,N., Giammanco,A., Spina,R.,
            Barbagallo,C.M., Caruso,M., Novo,S., Sarullo,F., Pernice,V.,
            Brucato,F., Ingrassia,V., Fayer,F., Altieri,G.I., Scrimali,C.,
            Misiano,G., Olivieri,O., Girelli,D. and Averna,M.R.
  TITLE     rs629301 CELSR2 polymorphism confers a ten-year equivalent risk of
            critical stenosis assessed by coronary angiography
  JOURNAL   Nutr Metab Cardiovasc Dis 31 (5), 1542-1547 (2021)
   PUBMED   33810964
  REMARK    GeneRIF: rs629301 CELSR2 polymorphism confers a ten-year equivalent
            risk of critical stenosis assessed by coronary angiography.
REFERENCE   5  (bases 1 to 11015)
  AUTHORS   Xu,M., Zhu,S., Xu,R. and Lin,N.
  TITLE     Identification of CELSR2 as a novel prognostic biomarker for
            hepatocellular carcinoma
  JOURNAL   BMC Cancer 20 (1), 313 (2020)
   PUBMED   32293343
  REMARK    GeneRIF: Identification of CELSR2 as a novel prognostic biomarker
            for hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 11015)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   7  (bases 1 to 11015)
  AUTHORS   Vincent,J.B., Skaug,J. and Scherer,S.W.
  TITLE     The human homologue of flamingo, EGFL2, encodes a brain-expressed
            large cadherin-like protein with epidermal growth factor-like
            domains, and maps to chromosome 1p13.3-p21.1
  JOURNAL   DNA Res 7 (3), 233-235 (2000)
   PUBMED   10907856
REFERENCE   8  (bases 1 to 11015)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     Large exons encoding multiple ectodomains are a characteristic
            feature of protocadherin genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3124-3129 (2000)
   PUBMED   10716726
REFERENCE   9  (bases 1 to 11015)
  AUTHORS   Wu,Q. and Maniatis,T.
  TITLE     A striking organization of a large family of human neural
            cadherin-like cell adhesion genes
  JOURNAL   Cell 97 (6), 779-790 (1999)
   PUBMED   10380929
REFERENCE   10 (bases 1 to 11015)
  AUTHORS   Nakayama,M., Nakajima,D., Nagase,T., Nomura,N., Seki,N. and
            Ohara,O.
  TITLE     Identification of high-molecular-weight proteins with multiple
            EGF-like motifs by motif-trap screening
  JOURNAL   Genomics 51 (1), 27-34 (1998)
   PUBMED   9693030
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL390252.9 and AF234887.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001408.2.
            
            Summary: The protein encoded by this gene is a member of the
            flamingo subfamily, part of the cadherin superfamily. The flamingo
            subfamily consists of nonclassic-type cadherins; a subpopulation
            that does not interact with catenins. The flamingo cadherins are
            located at the plasma membrane and have nine cadherin domains,
            seven epidermal growth factor-like repeats and two laminin A G-type
            repeats in their ectodomain. They also have seven transmembrane
            domains, a characteristic unique to this subfamily. It is
            postulated that these proteins are receptors involved in
            contact-mediated communication, with cadherin domains acting as
            homophilic binding regions and the EGF-like domains involved in
            cell adhesion and receptor-ligand interactions. The specific
            function of this particular member has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF234887.1, D87469.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271332.4/ ENSP00000271332.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AL390252.9         2789-3268
            481-3851            AL390252.9         3269-6639
            3852-5676           AF234887.1         3373-5197
            5677-5677           AL390252.9         17462-17462
            5678-5853           AF234887.1         5199-5374
            5854-5854           AL390252.9         17727-17727
            5855-9168           AF234887.1         5376-8689
            9169-9169           AL390252.9         26804-26804
            9170-9886           AF234887.1         8691-9407
            9887-11015          AL390252.9         27873-29001
FEATURES             Location/Qualifiers
     source          1..11015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.3"
     gene            1..11015
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /note="cadherin EGF LAG seven-pass G-type receptor 2"
                     /db_xref="GeneID:1952"
                     /db_xref="HGNC:HGNC:3231"
                     /db_xref="MIM:604265"
     exon            1..3851
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     CDS             542..9313
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /note="multiple epidermal growth factor-like domains 3;
                     EGF-like-domain, multiple 2; epidermal growth factor-like
                     2; EGF-like protein 2; flamingo homolog 3; cadherin family
                     member 10; multiple EGF-like domains protein 3; epidermal
                     growth factor-like protein 2; multiple epidermal growth
                     factor-like domains protein 3; cadherin, EGF LAG
                     seven-pass G-type receptor 2 (flamingo homolog,
                     Drosophila); adhesion G protein-coupled receptor C2;
                     multiple EGF like domains 3"
                     /codon_start=1
                     /product="cadherin EGF LAG seven-pass G-type receptor 2
                     precursor"
                     /protein_id="NP_001399.1"
                     /db_xref="CCDS:CCDS796.1"
                     /db_xref="GeneID:1952"
                     /db_xref="HGNC:HGNC:3231"
                     /db_xref="MIM:604265"
                     /translation="MRSPATGVPLPTPPPPLLLLLLLLLPPPLLGDQVGPCRSLGSRG
                     RGSSGACAPMGWLCPSSASNLWLYTSRCRDAGTELTGHLVPHHDGLRVWCPESEAHIP
                     LPPAPEGCPWSCRLLGIGGHLSPQGKLTLPEEHPCLKAPRLRCQSCKLAQAPGLRAGE
                     RSPEESLGGRRKRNVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEY
                     TMDALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLT
                     ILVTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGG
                     SPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDD
                     NDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLD
                     AQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVST
                     PFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAA
                     ELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAA
                     VGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYV
                     LAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED
                     TGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT
                     TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQG
                     GDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDV
                     NDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLD
                     IFSGELTALVDLDYEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVLGNFEILF
                     NNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRAL
                     DNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLL
                     GLFIQAVAATLATPPDHVVVFNVQRDTDAPGGHILNVSLSVGQPPGPGGGPPFLPSED
                     LQERLYLNRSLLTAISAQRVLPFDDNICLREPCENYMRCVSVLRFDSSAPFIASSSVL
                     FRPIHPVGGLRCRCPPGFTGDYCETEVDLCYSRPCGPHGRCRSREGGYTCLCRDGYTG
                     EHCEVSARSGRCTPGVCKNGGTCVNLLVGGFKCDCPSGDFEKPYCQVTTRSFPAHSFI
                     TFRGLRQRFHFTLALSFATKERDGLLLYNGRFNEKHDFVALEVIQEQVQLTFSAGEST
                     TTVSPFVPGGVSDGQWHTVQLKYYNKPLLGQTGLPQGPSEQKVAVVTVDGCDTGVALR
                     FGSVLGNYSCAAQGTQGGSKKSLDLTGPLLLGGVPDLPESFPVRMRQFVGCMRNLQVD
                     SRHIDMADFIANNGTVPGCPAKKNVCDSNTCHNGGTCVNQWDAFSCECPLGFGGKSCA
                     QEMANPQHFLGSSLVAWHGLSLPISQPWYLSLMFRTRQADGVLLQAITRGRSTITLQL
                     REGHVMLSVEGTGLQASSLRLEPGRANDGDWHHAQLALGASGGPGHAILSFDYGQQRA
                     EGNLGPRLHGLHLSNITVGGIPGPAGGVARGFRGCLQGVRVSDTPEGVNSLDPSHGES
                     INVEQGCSLPDPCDSNPCPANSYCSNDWDSYSCSCDPGYYGDNCTNVCDLNPCEHQSV
                     CTRKPSAPHGYTCECPPNYLGPYCETRIDQPCPRGWWGHPTCGPCNCDVSKGFDPDCN
                     KTSGECHCKENHYRPPGSPTCLLCDCYPTGSLSRVCDPEDGQCPCKPGVIGRQCDRCD
                     NPFAEVTTNGCEVNYDSCPRAIEAGIWWPRTRFGLPAAAPCPKGSFGTAVRHCDEHRG
                     WLPPNLFNCTSITFSELKGFAERLQRNESGLDSGRSQQLALLLRNATQHTAGYFGSDV
                     KVAYQLATRLLAHESTQRGFGLSATQDVHFTENLLRVGSALLDTANKRHWELIQQTEG
                     GTAWLLQHYEAYASALAQNMRHTYLSPFTIVTPNIVISVVRLDKGNFAGAKLPRYEAL
                     RGEQPPDLETTVILPESVFRETPPVVRPAGPGEAQEPEELARRQRRHPELSQGEAVAS
                     VIIYRTLAGLLPHNYDPDKRSLRVPKRPIINTPVVSISVHDDEELLPRALDKPVTVQF
                     RLLETEERTKPICVFWNHSILVSGTGGWSARGCEVVFRNESHVSCQCNHMTSFAVLMD
                     VSRRENGEILPLKTLTYVALGVTLAALLLTFFFLTLLRILRSNQHGIRRNLTAALGLA
                     QLVFLLGINQADLPFACTVIAILLHFLYLCTFSWALLEALHLYRALTEVRDVNTGPMR
                     FYYMLGWGVPAFITGLAVGLDPEGYGNPDFCWLSIYDTLIWSFAGPVAFAVSMSVFLY
                     ILAARASCAAQRQGFEKKGPVSGLQPSFAVLLLLSATWLLALLSVNSDTLLFHYLFAT
                     CNCIQGPFIFLSYVVLSKEVRKALKLACSRKPSPDPALTTKSTLTSSYNCPSPYADGR
                     LYQPYGDSAGSLHSTSRSGKSQPSYIPFLLREESALNPGQGPPGLGDPGSLFLEGQDQ
                     QHDPDTDSDSDLSLEDDQSGSYASTHSSDSEEEEEEEEEEAAFPGEQGWDSLLGPGAE
                     RLPLHSTPKDGGPGPGKAPWPGDFGTTAKESSGNGAPEERLRENGDALSREGSLGPLP
                     GSSAQPHKGILKKKCLPTISEKSSLLRLPLEQCTGSSRGSSASEGSRGGPPPRPPPRQ
                     SLQEQLNGVMPIAMSIKAGTVDEDSSGSEFLFFNFLH"
     exon            3852..4499
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            4500..4722
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            4723..4838
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            4839..4927
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            4928..5085
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            5086..5249
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            5250..5375
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            5376..5542
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            5543..5830
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            5831..6005
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            6006..6147
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            6148..6268
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            6269..6452
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            6453..6554
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            6555..6649
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            6650..6859
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            6860..7043
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            7044..7172
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            7173..7353
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            7354..7521
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            7522..7648
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            7649..7849
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            7850..8024
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            8025..8137
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            8138..8217
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            8218..8344
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            8345..8467
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            8468..8595
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            8596..8684
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            8685..8879
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            8880..9050
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            9051..9285
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     exon            9286..11015
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10993..10998
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /note="hexamer: AATAAA"
     polyA_site      11015
                     /gene="CELSR2"
                     /gene_synonym="ADGRC2; CDHF10; EGFL2; Flamingo1; MEGF3"
                     /note="major polyA site"
ORIGIN      
        1 gcagagctcg cccgcccgcc ggggaggcga gggagcgcgg ggctgggccc ggggccgcgg
       61 cgacaggcag cagccgcggc ggggacgcgg ggcgcgagcg ggcggcgcgg gaccgtcggg
      121 ggccgccggg gccgggccgg ggtcggggcg cacggctacg cgggcgcagg tgggcgatcc
      181 cataggggcg gagggggcac cccggctccg gaacccgggg cccggcaagg ccaggggcgc
      241 cgcggggccc ccgggcgcag gtggtgagtg cccggagcgc aggtggaggc gcggcggcag
      301 cccgcggtgc tcagggtgac ccgggagcgg gtctggctca gggggcagtg ggagcccggg
      361 ctcgtcggag ggtgcagcgc ggggtcccgc cgagccatcc agacgcaggc cccgcggggc
      421 gcacgggagg cccccgggga ctggcgccct ggcccgggca tgaggcgcgg cggggccggc
      481 aggagccgga ggaggagccg ccgccgccgt tgacccggcc gccggccggg agctgggaga
      541 gatgcggagc ccggccaccg gcgtccccct cccaacgccg ccgccgccgc tgctgctgct
      601 gttgctgctg ctgctgccgc cgccactatt gggagaccaa gtggggccct gtcgttcctt
      661 ggggtccagg ggacgaggct cttcgggggc ctgcgccccc atgggctggc tctgtccatc
      721 ctcagcgtcg aacctctggc tctacaccag ccgctgcagg gatgcgggca ctgagctgac
      781 tggccacctg gtaccccacc acgatggcct gagggtttgg tgtccagaat ccgaggccca
      841 tattccccta ccaccagctc ctgaaggctg cccctggagc tgtcgcctcc tgggcattgg
      901 aggccacctt tccccacagg gcaagctcac actgcccgag gagcacccgt gcttaaaggc
      961 tccacggctc agatgccagt cctgcaagct ggcacaggcc cccgggctca gggcagggga
     1021 aaggtcacca gaagagtccc tgggtgggcg tcggaaaagg aatgtaaata cagcccccca
     1081 gttccagccc cccagctacc aggccacagt gccggagaac cagccagcag gcacccctgt
     1141 tgcatccctg agggccatcg acccggacga gggtgaggca ggtcgactgg agtacaccat
     1201 ggatgccctc tttgatagcc gctccaacca gttcttctcc ctggacccag tcactggtgc
     1261 agtaaccaca gccgaggagc tggatcgtga gaccaagagc acccacgtct tcagggtcac
     1321 ggcgcaggac cacggcatgc cccgacgaag tgccctggct acactcacca tcttggttac
     1381 tgacaccaat gaccatgacc ctgtgttcga gcagcaggag tacaaggaga gcctcaggga
     1441 gaacctggag gttggctatg aggtgctcac tgtcagggcc acggatggtg atgcccctcc
     1501 caatgccaat attctgtacc gcctgctgga ggggtctggg ggcagcccct ctgaagtctt
     1561 tgagatcgac cctcgctctg gggtgatccg aacccgtggc cctgtggatc gggaagaggt
     1621 ggaatcctac cagctgacgg tagaggcaag tgaccagggt cgggacccgg gtcctcggag
     1681 taccacagcc gctgttttcc tttctgtgga ggatgacaat gataatgccc cccagtttag
     1741 tgagaagcgc tatgtggtcc aggtgaggga ggatgtgact ccaggggccc cagtactccg
     1801 agtcacagcc tcggatcgag acaaggggag caatgccgtg gtgcactata gcatcatgag
     1861 tggcaatgct cggggacagt tttatctgga tgcccagact ggagctctgg atgtggtgag
     1921 ccctcttgac tatgagacga ccaaggagta caccctacgg gtgcgagcac aggatggtgg
     1981 ccgtccccca ctctctaatg tctctggctt ggtgacagta caggtcctgg atatcaacga
     2041 caatgccccc atcttcgtca gcaccccttt ccaggctact gtcctggaga gtgtcccctt
     2101 aggctacctg gttctccatg tccaggctat cgacgctgat gctggtgaca atgcccgcct
     2161 ggaataccgc cttgctgggg tgggacatga cttccccttc accatcaaca atggcacagg
     2221 ctggatctct gtggctgctg aactggaccg ggaggaagtt gatttctaca gctttggggt
     2281 agaagctcga gaccatggca ctccagcact cactgcctcg gccagtgtca gcgtgactgt
     2341 cctggatgtc aacgacaaca atccaacctt tacccaacca gagtacacag tgcggctcaa
     2401 tgaggatgca gctgtgggca ccagcgtggt gacggtgtca gctgtggacc gtgatgctca
     2461 tagtgtcatc acctaccaga tcaccagtgg caatactcga aaccgcttct ccatcaccag
     2521 ccaaagtggt ggtgggctgg tatcccttgc cctgccactg gactacaaac ttgagcggca
     2581 gtatgtgttg gctgttaccg cctccgatgg cactcggcag gacacggcac agattgtggt
     2641 gaatgtcacc gacgccaaca cccatcgtcc tgtctttcag agctcccact atacagtgaa
     2701 tgttaatgag gaccggccgg caggcaccac ggtggtgctg atcagcgcca cggatgagga
     2761 cacaggtgag aatgcccgca tcacctactt catggaggac agcatccccc agttccgcat
     2821 cgatgcagac acgggggctg tcaccaccca ggctgagctg gactatgaag accaagtgtc
     2881 ttacaccctg gccattactg ctcgggacaa tggcattccc cagaagtccg acaccaccta
     2941 cctggagatc ctggtgaacg acgtgaatga caatgcccct cagttcctgc gagactccta
     3001 ccagggcagt gtctatgagg atgtgccacc cttcactagc gtcctgcaga tctcagccac
     3061 tgatcgtgat tctggactta atggcagggt cttctacacc ttccaaggag gcgacgatgg
     3121 agacggtgac tttattgttg agtccacgtc aggcatcgtg cgaacgctac ggaggctgga
     3181 tcgagagaac gtggcccagt atgtcttgcg ggcatatgca gtggacaagg ggatgccccc
     3241 agcccgcaca cctatggaag tgacagtcac tgtgttggat gtgaatgaca atccccctgt
     3301 ctttgagcag gatgagtttg atgtgtttgt ggaagagaac agccccattg ggctagccgt
     3361 ggcccgggtc acagccactg accccgatga aggcaccaat gcccagatta tgtaccagat
     3421 tgtggagggc aacatccctg aggtctttca gctggacatc ttctccgggg agctgacagc
     3481 cctggtagac ttagactacg aggaccggcc tgagtacgtc ctggtcatcc aggccacgtc
     3541 agctcctctg gtgagccggg ctacagtcca cgtccgcctc cttgaccgca atgacaaccc
     3601 accagtgctg ggcaactttg agatcctttt caacaactat gtcaccaatc gctcaagcag
     3661 cttccctggg ggtgccattg gccgagtacc tgcccatgac cctgatatct cagatagtct
     3721 gacttacagc tttgagcggg gaaatgaact cagcctggtc ctgctcaatg cctccacggg
     3781 tgagctgaag ctaagccgcg cactggacaa caaccggcct ctggaggcca tcatgagcgt
     3841 gctggtgtca gacggcgtac acagcgtgac cgcccagtgc gcgctgcgtg tgaccatcat
     3901 caccgatgag atgctcaccc acagcatcac gctgcgcctg gaggacatgt cacccgagcg
     3961 cttcctgtca ccactgctag gcctcttcat ccaggcggtg gccgccacgc tggccacgcc
     4021 accggaccac gtggtggtct tcaacgtaca gcgggacacc gacgcccccg ggggccacat
     4081 cctcaacgtg agcctgtcgg tgggccagcc gccagggccc gggggcgggc cgcccttcct
     4141 gccctctgag gacctgcagg agcgcctata cctcaaccgc agcctgctga cggccatctc
     4201 ggcacagcgc gtgctgccct tcgacgacaa catctgcctg cgggagccct gcgagaacta
     4261 catgcgctgc gtgtcggtgc tgcgcttcga ctcctccgcg cccttcatcg cctcctcctc
     4321 cgtgctcttc cggcccatcc accccgtcgg agggctgcgc tgccgctgcc cgcccggctt
     4381 cacgggtgac tactgcgaga ccgaggtgga cctctgctac tcgcggccct gtggccccca
     4441 cgggcgctgc cgcagccgcg agggcggcta cacctgcctc tgtcgtgatg gctacacggg
     4501 tgagcactgt gaggtgagtg ctcgctcagg ccgttgcacc ccgggtgtct gcaagaatgg
     4561 gggcacctgt gtcaacctgc tggtgggcgg tttcaagtgc gattgcccat ctggagactt
     4621 cgagaagccc tactgccagg tgaccacgcg cagcttcccc gcccactcct tcatcacctt
     4681 tcgcggcctg cgccagcgtt tccacttcac cctggccctc tcgtttgcca caaaggagcg
     4741 cgacgggttg ctgttgtaca atgggcgttt caatgagaag catgactttg tggccctcga
     4801 ggtgatccag gagcaggtcc agctcacctt ctctgcaggg gagtcaacca ccacggtgtc
     4861 cccattcgtg cccggaggag tcagtgatgg ccagtggcat acggtgcagc tgaaatacta
     4921 caataagcca ctgttgggtc agacagggct cccacagggc ccatcagagc agaaggtggc
     4981 tgtggtgacc gtggatggct gtgacacagg agtggccttg cgcttcggat ctgtcctggg
     5041 caactactcc tgtgctgccc agggcaccca gggtggcagc aagaagtctc tggatctgac
     5101 ggggcccctg ctactaggcg gggtgcctga cctgcccgag agcttcccag tccgaatgcg
     5161 gcagttcgtg ggctgcatgc ggaacctgca ggtggacagc cggcacatag acatggctga
     5221 cttcattgcc aacaatggca ccgtgcctgg ctgccctgcc aagaagaacg tgtgtgacag
     5281 caacacttgc cacaatgggg gcacttgcgt gaaccagtgg gacgcgttca gctgcgagtg
     5341 ccccctgggc tttgggggca agagctgcgc ccaggaaatg gccaatccac agcacttcct
     5401 gggcagcagc ctggtggcct ggcatggcct ctcgctgccc atctcccaac cctggtacct
     5461 cagcctcatg ttccgcacgc gccaggccga cggtgtcctg ctgcaggcca tcaccagggg
     5521 gcgcagcacc atcaccctac agctacgaga gggccacgtg atgctgagcg tggagggcac
     5581 agggcttcag gcctcctctc tccgtctgga gccaggccgg gccaatgacg gtgactggca
     5641 ccatgcacag ctggcactgg gagccagcgg ggggcccggc catgccattc tgtccttcga
     5701 ttatgggcag cagagagcag agggcaacct gggcccccgg ctgcatggtc tgcacctgag
     5761 caacataaca gtgggcggaa tacctgggcc agccggcggt gtggcccgtg gctttcgggg
     5821 ctgtttgcag ggtgtgcggg tgagcgatac gccggagggg gttaacagcc tggatcccag
     5881 ccatggggag agcatcaacg tggagcaagg ctgtagcctg cctgaccctt gtgactcaaa
     5941 cccgtgtcct gctaacagct attgcagcaa cgactgggac agctattcct gcagctgtga
     6001 tccaggttac tatggtgaca actgtactaa tgtgtgtgac ctgaacccgt gtgagcacca
     6061 gtctgtgtgt acccgcaagc ccagtgcccc ccatggctat acctgcgagt gtcccccaaa
     6121 ttaccttggg ccatactgtg agaccaggat tgaccagcct tgtccccgtg gctggtgggg
     6181 acatcccaca tgtggcccat gcaactgtga tgtcagcaaa ggctttgacc cagactgcaa
     6241 caagacaagc ggcgagtgcc actgcaagga gaaccactac cggcccccag gcagccccac
     6301 ctgcctcttg tgtgactgct accccacagg ctccttgtcc agagtctgtg accctgagga
     6361 tggccagtgt ccatgcaagc caggtgtcat cgggcgtcag tgtgaccgct gtgacaaccc
     6421 ttttgctgag gtcaccacca atggctgtga agtgaattat gacagctgcc cacgagcgat
     6481 tgaggctggg atctggtggc cccgtacccg cttcgggctg cctgctgctg ctccctgtcc
     6541 caaaggctcc tttgggactg ctgtgcgcca ctgtgatgag cacagggggt ggctcccccc
     6601 aaacctcttc aactgcacgt ccatcacctt ctcagaactg aagggcttcg ctgagcggct
     6661 acagcggaat gagtcaggcc tagactcagg gcgctcccag cagctagccc tgctcctgcg
     6721 caacgccacg cagcacacag ctggctactt cggcagcgac gtcaaggtgg cctaccagct
     6781 ggccacgcgg ctgctggccc acgagagcac ccagcggggc tttgggctgt ctgccacaca
     6841 ggacgtgcac ttcactgaga atctgctgcg ggtgggcagc gccctcctgg acacagccaa
     6901 caagcggcac tgggagctga tccagcagac agagggtggc accgcctggc tgctccagca
     6961 ctatgaggcc tacgccagtg ccctggccca gaacatgcgg cacacctacc taagcccctt
     7021 caccatcgtc acgcccaaca ttgtcatctc cgtagtgcgc ttggacaaag ggaactttgc
     7081 tggggccaag ctgccccgct acgaggccct gcgtggggag cagcccccgg accttgagac
     7141 aacagtcatt ctgcctgagt ctgtcttcag agagacgccc cccgtggtca ggcccgcagg
     7201 ccccggagag gcccaggagc cagaggagct ggcacggcga cagcgacggc acccggagct
     7261 gagccagggt gaggctgtgg ccagcgtcat catctaccgc accctggccg ggctactgcc
     7321 tcataactat gaccctgaca agcgcagctt gagagtcccc aaacgcccga tcatcaacac
     7381 acccgtggtg agcatcagcg tccatgatga tgaggagctt ctgccccggg ccctggacaa
     7441 acccgtcacg gtgcagttcc gcctgctgga gacagaggag cggaccaagc ccatctgtgt
     7501 cttctggaac cattcaatcc tggtcagtgg cacaggtggc tggtcggcca gaggctgtga
     7561 agtcgtcttc cgcaatgaga gccacgtcag ctgccagtgc aaccacatga cgagcttcgc
     7621 tgtgctcatg gacgtttctc ggcgggagaa tggggagatc ctgccactga agacactgac
     7681 atacgtggct ctaggtgtca ccttggctgc ccttctgctc accttcttct tcctcactct
     7741 cttgcgtatc ctgcgctcca accaacacgg catccgacgt aacctgacag ctgccctggg
     7801 cctggctcag ctggtcttcc tcctgggaat caaccaggct gacctccctt ttgcctgcac
     7861 agtcattgcc atcctgctgc acttcctgta cctctgcacc ttttcctggg ctctgctgga
     7921 ggccttgcac ctgtaccggg cactcactga ggtgcgcgat gtcaacaccg gccccatgcg
     7981 cttctactac atgctgggct ggggcgtgcc tgccttcatc acagggctag ccgtgggcct
     8041 ggaccccgag ggctacggga accctgactt ctgctggctc tccatctatg acacgctcat
     8101 ctggagtttt gctggcccgg tggcctttgc cgtctcgatg agtgtcttcc tgtacatcct
     8161 ggcggcccgg gcctcctgtg ctgcccagcg gcagggcttt gagaagaaag gtcctgtctc
     8221 gggcctgcag ccctccttcg ccgtcctcct gctgctgagc gccacgtggc tgctggcact
     8281 gctctctgtc aacagcgaca ccctcctctt ccactacctc tttgctacct gcaattgcat
     8341 ccagggcccc ttcatcttcc tctcctatgt ggtgcttagc aaggaggtcc ggaaagcact
     8401 caagcttgcc tgcagccgca agcccagccc tgaccctgct ctgaccacca agtccaccct
     8461 gacctcgtcc tacaactgcc ccagccccta cgcagatggg cggctgtacc agccctacgg
     8521 agactcggcc ggctctctgc acagcaccag tcgctcgggc aagagtcagc ccagctacat
     8581 ccccttcttg ctgagggagg agtccgcact gaaccctggc caagggcccc ctggcctggg
     8641 ggatccaggc agcctgttcc tggaaggtca agaccagcag catgatcctg acacggactc
     8701 cgacagtgac ctgtccttag aagacgacca gagtggctcc tatgcctcta cccactcatc
     8761 agacagtgag gaggaagaag aggaggagga agaggaggcc gccttccctg gagagcaggg
     8821 ctgggatagc ctgctggggc ctggagcaga gagactgccc ctgcacagta ctcccaagga
     8881 tgggggccca gggcctggca aggccccctg gccaggagac tttgggacca cagcaaaaga
     8941 gagtagtggc aacggggccc ctgaggagcg gctgcgggag aatggagatg ccctgtctcg
     9001 agaggggtcc ctaggccccc ttccaggctc ttctgcccag cctcacaaag gcatccttaa
     9061 gaagaagtgt ctgcccacca tcagcgagaa gagcagcctc ctgcggctcc ccctggagca
     9121 atgcacaggg tcttcccggg gctcctccgc tagtgagggc agccggggag gcccccctcc
     9181 ccgcccaccg ccccggcaga gcctccagga gcagctgaac ggggtcatgc ccatcgccat
     9241 gagcatcaag gcaggcacgg tggatgagga ctcgtcaggc tccgaatttc tcttctttaa
     9301 cttcctgcat taaccctggg ccgtggttcc tacgcccgag gctcccttcc cttccccagc
     9361 cgcactcatg ccctgctcct gtcttgtgct ttatcctgcc ccgctcccca tcgcctgccc
     9421 gcagcagcga cgaaacgtcc atctgaggag cctgggcctt gccgggaggg gtactcaccc
     9481 cacctaaggc catctagtgc caactccccc cccaccattc ccctcactgc actttggacc
     9541 cctggggcca acatctccaa gacaaagttt ttcagaaaag aggaaaaaaa gaatttaaaa
     9601 aaggatctcc actcttcatg acttcaggga ttcatttttt ttatacgctg gaaattgact
     9661 cccctttccc ttcccaaaga ggataggacc tcccaggatg cttcccagcc tctcctcagt
     9721 ttcccatctg ctgtgcctct gggaggagag ggactcctgg ggggcctgcc cctcatacgc
     9781 catcaccaaa aggaaaggac aaagccacac gcagccaggg cttcacaccc ttcaggctgc
     9841 acccgggcag gcctcagaac ggtgaggggc cagggcaaag ggtgtgcctc gtcctgcccg
     9901 cactgcctct cccaggaact ggaaaagccc tgtccggtga gggggcagaa ggactcagcg
     9961 cccctggacc cccaaatgct gcatgaacac attttcaggg gagcctgtgc ccccaggcgg
    10021 gggtcgggca gccccagccc ctctcctttt cctggactct ggccgtgcgc ggcagcccag
    10081 gtgtttgctc agttgctgac ccaaaagtgc ttcatttttc gtgcccgccc cgcgccccgg
    10141 gcaggccagt catgtgttaa gttgcgcttc tttgctgtga tgtgggtggg ggaggaagag
    10201 taaacacagt gctggctcgg ctgccctgag ggtgctcaat caagcacagg tttcaagtct
    10261 gggttctggt gtccactcac ccaccccacc ccccaaaatc agacaaatgc tactttgtct
    10321 aacctgctgt ggcctctgag acatgttcta tttttaaccc cttcttggaa ttggctctct
    10381 tcttcaaagg accaggtcct gttcctcttt ctccccgact ccaccccagc tccctgtgaa
    10441 gagagagtta atatatttgt tttatttatt tgctttttgt gttgggatgg gttcgtgtcc
    10501 agtcccgggg gtctgatatg gccatcacag gctgggtgtt cccagcagcc ctggcttggg
    10561 ggcttgacgc ccttcccctt gccccaggcc atcatctccc cacctctcct cccctctcct
    10621 cagttttgcc gactgctttt catctgagtc accatttact ccaagcatgt attccagact
    10681 tgtcactgac tttccttctg gagcaggtgg ctagaaaaag aggctgtggg caggaaagaa
    10741 aggctcctgt ttctcatttg tgaggccagc ctctggcttt tctgccgtgg attctccccc
    10801 gtcttctccc ctcagcaatt cctgcaaagg gttaaaaatt taactggttt ttactactga
    10861 tgacttgatt taaaaaaaat acaaagatgc tggatgctaa cttggtacta accatcagat
    10921 tgtacagttt ggttgttgct gtaaataggg tagcgttttg ttgttgttgt tttttcatgc
    10981 cccatactac tgaataaact agttctgtgc gggta
//
