LOCUS       NM_001378328           11559 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens cadherin EGF LAG seven-pass G-type receptor 1
            (CELSR1), transcript variant 1, mRNA.
ACCESSION   NM_001378328 XM_006724383
VERSION     NM_001378328.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 11559)
  AUTHORS   de Koning,M.A., Pimienta Ramirez,P.A., Haak,M.C., Han,X.,
            Ruiterkamp-Versteeg,M.H., de Leeuw,N., Schatz,U.A., Shoukier,M.,
            Rieger-Fackeldey,E., Ortiz,J.U., van Duinen,S.G., Klein,W.M.,
            Witlox,R.S.G.M., Finnell,R.H., Santen,G.W.E., Lei,Y. and Suerink,M.
  TITLE     De novo heterozygous missense variants in CELSR1 as cause of fetal
            pleural effusions and progressive fetal hydrops
  JOURNAL   J Med Genet 61 (6), 549-552 (2024)
   PUBMED   38272662
  REMARK    GeneRIF: De novo heterozygous missense variants in CELSR1 as cause
            of fetal pleural effusions and progressive fetal hydrops.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 11559)
  AUTHORS   Tamilselvan,E. and Sotomayor,M.
  TITLE     CELSR1, a core planar cell polarity protein, features a weakly
            adhesive and flexible cadherin ectodomain
  JOURNAL   Structure 32 (4), 476-491 (2024)
   PUBMED   38307021
  REMARK    GeneRIF: CELSR1, a core planar cell polarity protein, features a
            weakly adhesive and flexible cadherin ectodomain.
REFERENCE   3  (bases 1 to 11559)
  AUTHORS   Zuo,J., Zheng,A., Wang,X., Luo,Z., Chen,Y., Cheng,X., Zhao,Y.,
            Zhou,X., Tang,K.F. and Du,X.
  TITLE     Upregulation of CELSR1 expression promotes ovarian cancer cell
            proliferation, migration, and invasion
  JOURNAL   Med Oncol 41 (1), 10 (2023)
   PUBMED   38070011
  REMARK    GeneRIF: Upregulation of CELSR1 expression promotes ovarian cancer
            cell proliferation, migration, and invasion.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 11559)
  AUTHORS   Alpaslan,M., Mestre-Godin,S., Lay,A., Giacalone,G., Helaers,R.,
            Adham,S., Kovacsik,H., Guillemard,S., Mercier,E., Boon,L.,
            Revencu,N., Brouillard,P., Quere,I. and Vikkula,M.
  TITLE     Ureteropelvic junction obstruction with primary lymphoedema
            associated with CELSR1 variants
  JOURNAL   J Med Genet 60 (12), 1161-1168 (2023)
   PUBMED   37225411
  REMARK    GeneRIF: Ureteropelvic junction obstruction with primary
            lymphoedema associated with CELSR1 variants.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 11559)
  AUTHORS   Smith,M.S., Sarasua,S.M., Rogers,C., Phelan,K. and Boccuto,L.
  TITLE     Lymphedema is associated with CELSR1 in Phelan-McDermid syndrome
  JOURNAL   Clin Genet 104 (4), 472-478 (2023)
   PUBMED   37232218
  REMARK    GeneRIF: Lymphedema is associated with CELSR1 in Phelan-McDermid
            syndrome.
REFERENCE   6  (bases 1 to 11559)
  AUTHORS   Georgieva,L., Nikolov,I., Poriazova,N., Jones,G., Toncheva,D.,
            Kirov,G. and Owen,M.J.
  TITLE     Genetic variation in the seven-pass transmembrane cadherin CELSR1:
            lack of association with schizophrenia
  JOURNAL   Psychiatr Genet 13 (2), 103-106 (2003)
   PUBMED   12782967
  REMARK    GeneRIF: Variations in the nine ectodomains of CELSR1 do not
            increase susceptibility to schizophrenia.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 11559)
  AUTHORS   Gross,J., Grimm,O., Ortega,G., Teuber,I., Lesch,K.P. and Meyer,J.
  TITLE     Mutational analysis of the neuronal cadherin gene CELSR1 and
            exclusion as a candidate for catatonic schizophrenia in a large
            family
  JOURNAL   Psychiatr Genet 11 (4), 197-200 (2001)
   PUBMED   11807409
  REMARK    GeneRIF: exclusion as a candidate gene for schizophrenia-- a
            cadhrin gene
REFERENCE   8  (bases 1 to 11559)
  AUTHORS   Ghosh,A.
  TITLE     Dentritic growth: don't go says flamingo
  JOURNAL   Neuron 28 (1), 3-4 (2000)
   PUBMED   11086974
REFERENCE   9  (bases 1 to 11559)
  AUTHORS   Nollet,F., Kools,P. and van Roy,F.
  TITLE     Phylogenetic analysis of the cadherin superfamily allows
            identification of six major subfamilies besides several solitary
            members
  JOURNAL   J Mol Biol 299 (3), 551-572 (2000)
   PUBMED   10835267
  REMARK    Review article
REFERENCE   10 (bases 1 to 11559)
  AUTHORS   Hadjantonakis,A.K., Sheward,W.J., Harmar,A.J., de Galan,L.,
            Hoovers,J.M. and Little,P.F.
  TITLE     Celsr1, a neural-specific gene encoding an unusual seven-pass
            transmembrane receptor, maps to mouse chromosome 15 and human
            chromosome 22qter
  JOURNAL   Genomics 45 (1), 97-104 (1997)
   PUBMED   9339365
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL021392.5, AL031597.7 and
            AL031588.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 7, 2020 this sequence version replaced XM_006724383.3.
            
            Summary: The protein encoded by this gene is a member of the
            flamingo subfamily, part of the cadherin superfamily. The flamingo
            subfamily consists of nonclassic-type cadherins; a subpopulation
            that does not interact with catenins. The flamingo cadherins are
            located at the plasma membrane and have nine cadherin domains,
            seven epidermal growth factor-like repeats and two laminin A G-type
            repeats in their ectodomain. They also have seven transmembrane
            domains, a characteristic unique to this subfamily. It is
            postulated that these proteins are receptors involved in
            contact-mediated communication, with cadherin domains acting as
            homophilic binding regions and the EGF-like domains involved in
            cell adhesion and receptor-ligand interactions. This particular
            member is a developmentally regulated, neural-specific gene which
            plays an unspecified role in early embryogenesis. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1537087.1,
                                           SRR14038194.2205577.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000674500.2/ ENSP00000501367.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3994              AL021392.5         110613-114606
            3995-4633           AL031597.7         63782-64420
            4634-4856           AL031597.7         88716-88938
            4857-4972           AL031597.7         91838-91953
            4973-5061           AL031597.7         94646-94734
            5062-5219           AL031588.1         18372-18529
            5220-5383           AL031588.1         19570-19733
            5384-5509           AL031588.1         20251-20376
            5510-5676           AL031588.1         20969-21135
            5677-5862           AL031588.1         30229-30414
            5863-5976           AL031588.1         31494-31607
            5977-6151           AL031588.1         32283-32457
            6152-6293           AL031588.1         33385-33526
            6294-6414           AL031588.1         35869-35989
            6415-6598           AL031588.1         38315-38498
            6599-6700           AL031588.1         38844-38945
            6701-6795           AL031588.1         39645-39739
            6796-7005           AL031588.1         40632-40841
            7006-7189           AL031588.1         43546-43729
            7190-7333           AL031588.1         45445-45588
            7334-7538           AL031588.1         48081-48285
            7539-7706           AL031588.1         49176-49343
            7707-7833           AL031588.1         51414-51540
            7834-8034           AL031588.1         52870-53070
            8035-8209           AL031588.1         57074-57248
            8210-8322           AL031588.1         60327-60439
            8323-8402           AL031588.1         60873-60952
            8403-8529           AL031588.1         62276-62402
            8530-8655           AL031588.1         63013-63138
            8656-8750           AL031588.1         63651-63745
            8751-8854           AL031588.1         64442-64545
            8855-9004           AL031588.1         64751-64900
            9005-9229           AL031588.1         65395-65619
            9230-9485           AL031588.1         65880-66135
            9486-11559          AL031588.1         66884-68957
FEATURES             Location/Qualifiers
     source          1..11559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..11559
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /note="cadherin EGF LAG seven-pass G-type receptor 1"
                     /db_xref="GeneID:9620"
                     /db_xref="HGNC:HGNC:1850"
                     /db_xref="MIM:604523"
     exon            1..3994
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..9510
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protocadherin flamingo 2; cadherin, EGF LAG
                     seven-pass G-type receptor 1 (flamingo homolog,
                     Drosophila); adhesion G protein-coupled receptor C1;
                     flamingo homolog 2; cadherin family member 9"
                     /codon_start=1
                     /product="cadherin EGF LAG seven-pass G-type receptor 1
                     isoform 1 precursor"
                     /protein_id="NP_001365257.1"
                     /db_xref="CCDS:CCDS93179.1"
                     /db_xref="GeneID:9620"
                     /db_xref="HGNC:HGNC:1850"
                     /db_xref="MIM:604523"
                     /translation="MAPPPPPVLPVLLLLAAAAALPAMGLRAAAWEPRVPGGTRAFAL
                     RPGCTYAVGAACTPRAPRELLDVGRDGRLAGRRRVSGAGRPLPLQVRLVARSAPTALS
                     RRLRARTHLPGCGARARLCGTGARLCGALCFPVPGGCAAAQHSALAAPTTLPACRCPP
                     RPRPRCPGRPICLPPGGSVRLRLLCALRRAAGAVRVGLALEAATAGTPSASPSPSPPL
                     PPNLPEARAGPARRARRGTSGRGSLKFPMPNYQVALFENEPAGTLILQLHAHYTIEGE
                     EERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRS
                     ATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTIRASDRDSPINANLRYRV
                     LGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRNPGPLSATATVYIEVE
                     DENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFY
                     LHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV
                     SSPFQATVLENVPLGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAP
                     TPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVND
                     NDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRG
                     GGLITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSV
                     SEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQV
                     AYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQV
                     SATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVD
                     RGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGP
                     NAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLVSRATVH
                     ILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGN
                     ELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIHSVTAFCTLRVTIITDDMLT
                     NSITVRLENMSQEKFLSPLLALFVEGVAAVLSTTKDDVFVFNVQNDTDVSSNILNVTF
                     SALLPGGVRGQFFPSEDLQEQIYLNRTLLTTISTQRVLPFDDNICLREPCENYMKCVS
                     VLRFDSSAPFLSSTTVLFRPIHPINGLRCRCPPGFTGDYCETEIDLCYSDPCGANGRC
                     RSREGGYTCECFEDFTGEHCEVDARSGRCANGVCKNGGTCVNLLIGGFHCVCPPGEYE
                     RPYCEVTTRSFPPQSFVTFRGLRQRFHFTISLTFATQERNGLLLYNGRFNEKHDFIAL
                     EIVDEQVQLTFSAGETTTTVAPKVPSGVSDGRWHSVQVQYYNKPNIGHLGLPHGPSGE
                     KMAVVTVDDCDTTMAVRFGKDIGNYSCAAQGTQTGSKKSLDLTGPLLLGGVPNLPEDF
                     PVHNRQFVGCMRNLSVDGKNVDMAGFIANNGTREGCAARRNFCDGRRCQNGGTCVNRW
                     NMYLCECPLRFGGKNCEQAMPHPQLFSGESVVSWSDLNIIISVPWYLGLMFRTRKEDS
                     VLMEATSGGPTSFRLQILNNYLQFEVSHGPSDVESVMLSGLRVTDGEWHHLLIELKNV
                     KEDSEMKHLVTMTLDYGMDQNKADIGGMLPGLTVRSVVVGGASEDKVSVRRGFRGCMQ
                     GVRMGGTPTNVATLNMNNALKVRVKDGCDVDDPCTSSPCPPNSRCHDAWEDYSCVCDK
                     GYLGINCVDACHLNPCENMGACVRSPGSPQGYVCECGPSHYGPYCENKLDLPCPRGWW
                     GNPVCGPCHCAVSKGFDPDCNKTNGQCQCKENYYKLLAQDTCLPCDCFPHGSHSRTCD
                     MATGQCACKPGVIGRQCNRCDNPFAEVTTLGCEVIYNGCPKAFEAGIWWPQTKFGQPA
                     AVPCPKGSVGNAVRHCSGEKGWLPPELFNCTTISFVDLRAMNEKLSRNETQVDGARAL
                     QLVRALRSATQHTGTLFGNDVRTAYQLLGHVLQHESWQQGFDLAATQDADFHEDVIHS
                     GSALLAPATRAAWEQIQRSEGGTAQLLRRLEGYFSNVARNVRRTYLRPFVIVTANMIL
                     AVDIFDKFNFTGARVPRFDTIHEEFPRELESSVSFPADFFRPPEEKEGPLLRPAGRRT
                     TPQTTRPGPGTEREAPISRRRRHPDDAGQFAVALVIIYRTLGQLLPERYDPDRRSLRL
                     PHRPIINTPMVSTLVYSEGAPLPRPLERPVLVEFALLEVEERTKPVCVFWNHSLAVGG
                     TGGWSARGCELLSRNRTHVACQCSHTASFAVLMDISRRENGEVLPLKIVTYAAVSLSL
                     AALLVAFVLLSLVRMLRSNLHSIHKHLAVALFLSQLVFVIGINQTENPFLCTVVAILL
                     HYIYMSTFAWTLVESLHVYRMLTEVRNIDTGPMRFYYVVGWGIPAIVTGLAVGLDPQG
                     YGNPDFCWLSLQDTLIWSFAGPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLL
                     RTAFLLLLLISATWLLGLLAVNRDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHL
                     KGVLGGRKLHLEDSATTRATLLTRSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEG
                     IQKLGVSSGLVRGSHGEPDASLMPRSCKDPPGHDSDSDSELSLDEQSSSYASSHSSDS
                     EDDGVGAEEKWDPARGAVHSTPKGDAVANHVPAGWPDQSLAESDSEDPSGKPRLKVET
                     KVSVELHREEQGSHRGEYPPDQESGGAARLASSQPPEQRKGILKNKVTYPPPLTLTEQ
                     TLKGRLREKLADCEQSPTSSRTSSLGSGGPDCAITVKSPGREPGRDHLNGVAMNVRTG
                     SAQADGSDSEGSNETSI"
     exon            3995..4633
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            4634..4856
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            4857..4972
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            4973..5061
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            5062..5219
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            5220..5383
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            5384..5509
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            5510..5676
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            5677..5862
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            5863..5976
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            5977..6151
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            6152..6293
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            6294..6414
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            6415..6598
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            6599..6700
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            6701..6795
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            6796..7005
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            7006..7189
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            7190..7333
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            7334..7538
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            7539..7706
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            7707..7833
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            7834..8034
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            8035..8209
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            8210..8322
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            8323..8402
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            8403..8529
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            8530..8655
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            8656..8750
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            8751..8854
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            8855..9004
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            9005..9229
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            9230..9485
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     exon            9486..11559
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11534..11539
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /note="hexamer: AATAAA"
     polyA_site      11559
                     /gene="CELSR1"
                     /gene_synonym="ADGRC1; CDHF9; FMI2; HFMI2; LMPHM9; ME2"
                     /note="major polyA site"
ORIGIN      
        1 aagcgcaccg cccaggcagc agccggccgc cggggtctgc gcggcgcgga gctgcccagc
       61 ccgctccggg aactcagccc ccgccccgcg ccgggcccgc cccgcttccc acgcccgtcc
      121 ggccgagccc gcgccggagc cacctggagc cgcctggagc cgccgccgcc gccgcaggtt
      181 gatgcgcggc gccctcccgg gacgcgcgga ggagccatct tgaaaccaac ttcgcaaact
      241 ttcgcaaagt gctctcgaag tggaagctgc gggggaggcc gggcgcgtgg tccccacagt
      301 ccccgccagg gcccccgggg aggcgggacg cggaccgccc cgagggccgg gcgcccggga
      361 gccgctcccc ggcctcgccg ggtggatgcg gaggcgcgcc gggtgcatgg attgtgttcg
      421 ggcgcccggc tcgggctcgg gctccgggcc atggcgccgc cgccgccgcc cgtgctgccc
      481 gtgctgctgc tcctggccgc cgccgccgcc ctgccggcga tggggctgcg agcggccgcc
      541 tgggagccgc gcgtacccgg cgggacccgc gccttcgccc tccggcccgg ctgtacctac
      601 gcggtgggcg ccgcttgcac gccccgggcg ccgcgggagc tgctggacgt gggccgcgat
      661 gggcggctgg caggacgtcg gcgcgtctcg ggcgcggggc gcccgctgcc gctgcaagtc
      721 cgcttggtgg cccgcagtgc cccgacggcg ctgagccgcc gcctgcgggc gcgcacgcac
      781 cttcccggct gcggagcccg tgcccggctc tgcggaaccg gtgcccggct ctgcggggcg
      841 ctctgcttcc ccgtccccgg cggctgcgcg gccgcgcagc attcggcgct cgcagctccg
      901 accaccttac ccgcctgccg ctgcccgccg cgccccaggc cccgctgtcc cggccgtccc
      961 atctgcctgc cgccgggcgg ctcggtccgc ctgcgtctgc tgtgcgccct gcggcgcgcg
     1021 gctggcgccg tccgggtggg actggcgctg gaggccgcca ccgcggggac gccctccgcg
     1081 tcgccatccc catcgccgcc cctgccgccg aacttgcccg aagcccgggc ggggccggcg
     1141 cgacgggccc ggcggggcac gagcggcaga gggagcctga agtttccgat gcccaactac
     1201 caggtggcgt tgtttgagaa cgaaccggcg ggcaccctca tcctccagct gcacgcgcac
     1261 tacaccatcg agggcgagga ggagcgcgtg agctattaca tggaggggct gttcgacgag
     1321 cgctcccggg gctacttccg aatcgactct gccacgggcg ccgtgagcac ggacagcgta
     1381 ctggaccgcg agaccaagga gacgcacgtc ctcagggtga aagccgtgga ctacagtacg
     1441 ccgccgcgct cggccaccac ctacatcact gtcttggtca aagacaccaa cgaccacagc
     1501 ccggtcttcg agcagtcgga gtaccgcgag cgcgtgcggg agaacctgga ggtgggctac
     1561 gaggtgctga ccatccgcgc cagcgaccgc gactcgccca tcaacgccaa cttgcgttac
     1621 cgcgtgttgg ggggcgcgtg ggacgtcttc cagctcaacg agagctctgg cgtggtgagc
     1681 acacgggcgg tgctggaccg ggaggaggcg gccgagtacc agctcctggt ggaggccaac
     1741 gaccaggggc gcaatccggg cccgctcagt gccacggcca ccgtgtacat cgaggtggag
     1801 gacgagaacg acaactaccc ccagttcagc gagcagaact acgtggtcca ggtgcccgag
     1861 gacgtggggc tcaacacggc tgtgctgcga gtgcaggcca cggaccggga ccagggccag
     1921 aacgcggcca ttcactacag catcctcagc gggaacgtgg ccggccagtt ctacctgcac
     1981 tcgctgagcg ggatcctgga tgtgatcaac cccttggatt tcgaggatgt ccagaaatac
     2041 tcgctgagca ttaaggccca ggatgggggc cggcccccgc tcatcaattc ttcaggggtg
     2101 gtgtctgtgc aggtgctgga tgtcaacgac aacgagccta tctttgtgag cagccccttc
     2161 caggccacgg tgctggagaa tgtgcccctg ggctaccccg tggtgcacat tcaggcggtg
     2221 gacgcggact ctggagagaa cgcccggctg cactatcgcc tggtggacac ggcctccacc
     2281 tttctggggg gcggcagcgc tgggcctaag aatcctgccc ccacccctga cttccccttc
     2341 cagatccaca acagctccgg ttggatcaca gtgtgtgccg agctggaccg cgaggaggtg
     2401 gagcactaca gcttcggggt ggaggcggtg gaccacggct cgccccccat gagctcctcc
     2461 accagcgtgt ccatcacggt gctggacgtg aatgacaacg acccggtgtt cacgcagccc
     2521 acctacgagc ttcgtctgaa tgaggatgcg gccgtgggga gcagcgtgct gaccctgcag
     2581 gcccgcgacc gtgacgccaa cagtgtgatt acctaccagc tcacaggcgg caacacccgg
     2641 aaccgctttg cactcagcag ccagagaggg ggcggcctca tcaccctggc gctacctctg
     2701 gactacaagc aggagcagca gtacgtgctg gcggtgacag catccgacgg cacacggtcg
     2761 cacactgcgc atgtcctaat caacgtcact gatgccaaca cccacaggcc tgtctttcag
     2821 agctcccatt acacagtgag tgtcagtgag gacaggcctg tgggcacctc cattgctacc
     2881 ctcagtgcca acgatgagga cacaggagag aatgcccgca tcacctacgt gattcaggac
     2941 cccgtgccgc agttccgcat tgaccccgac agtggcacca tgtacaccat gatggagctg
     3001 gactatgaga accaggtcgc ctacacgctg accatcatgg cccaggacaa cggcatcccg
     3061 cagaaatcag acaccaccac cctagagatc ctcatcctcg atgccaatga caatgcaccc
     3121 cagttcctgt gggatttcta ccagggttcc atctttgagg atgctccacc ctcgaccagc
     3181 atcctccagg tctctgccac ggaccgggac tcaggtccca atgggcgtct gctgtacacc
     3241 ttccagggtg gggacgacgg cgatggggac ttctacatcg agcccacgtc cggtgtgatt
     3301 cgcacccagc gccggctgga ccgggagaat gtggccgtgt acaacctttg ggctctggct
     3361 gtggatcggg gcagtcccac tccccttagc gcctcggtag aaatccaggt gaccatcttg
     3421 gacattaatg acaatgcccc catgtttgag aaggacgaac tggagctgtt tgttgaggag
     3481 aacaacccag tggggtcggt ggtggcaaag attcgtgcta acgaccctga tgaaggccct
     3541 aatgcccaga tcatgtatca gattgtggaa ggggacatgc ggcatttctt ccagctggac
     3601 ctgctcaacg gggacctgcg tgccatggtg gagctggact ttgaggtccg gcgggagtat
     3661 gtgctggtgg tgcaggccac gtcggctccg ctggtgagcc gagccacggt gcacatcctt
     3721 ctcgtggacc agaatgacaa cccgcctgtg ctgcccgact tccagatcct cttcaacaac
     3781 tatgtcacca acaagtccaa cagtttcccc accggcgtga tcggctgcat cccggcccat
     3841 gaccccgacg tgtcagacag cctcaactac accttcgtgc agggcaacga gctgcgcctg
     3901 ttgctgctgg accccgccac gggcgaactg cagctcagcc gcgacctgga caacaaccgg
     3961 ccgctggagg cgctcatgga ggtgtctgtg tctgatggca tccacagcgt cacggccttc
     4021 tgcaccctgc gtgtcaccat catcacggac gacatgctga ccaacagcat cactgtccgc
     4081 ctggagaaca tgtcccagga gaagttcctg tccccgctgc tggccctctt cgtggagggg
     4141 gtggccgccg tgctgtccac caccaaggac gacgtcttcg tcttcaacgt ccagaacgac
     4201 accgacgtca gctccaacat cctgaacgtg accttctcgg cgctgctgcc tggcggcgtc
     4261 cgcggccagt tcttcccgtc ggaggacctg caggagcaga tctacctgaa tcggacgctg
     4321 ctgaccacca tctccacgca gcgcgtgctg cccttcgacg acaacatctg cctgcgcgag
     4381 ccctgcgaga actacatgaa gtgcgtgtcc gttctgcgat tcgacagctc cgcgcccttc
     4441 ctcagctcca ccaccgtgct cttccggccc atccacccca tcaacggcct gcgctgccgc
     4501 tgcccgcccg gcttcaccgg cgactactgc gagacggaga tcgacctctg ctactccgac
     4561 ccgtgcggcg ccaacggccg ctgccgcagc cgcgagggcg gctacacctg cgagtgcttc
     4621 gaggacttca ctggagagca ctgtgaggtg gatgcccgct caggccgctg tgccaacggg
     4681 gtgtgcaaga acgggggcac ctgcgtgaac ctgctcatcg gcggcttcca ctgcgtgtgt
     4741 cctcctggcg agtatgagag gccctactgt gaggtgacca ccaggagctt cccgccccag
     4801 tccttcgtca ccttccgggg cctgagacag cgcttccact tcaccatctc cctcacgttt
     4861 gccactcagg aaaggaacgg cttgcttctc tacaacggcc gcttcaatga gaagcacgac
     4921 ttcatcgccc tggagatcgt ggacgagcag gtgcagctca ccttctctgc aggcgagaca
     4981 acaacgaccg tggcaccgaa ggttcccagt ggtgtgagtg acgggcggtg gcactctgtg
     5041 caggtgcagt actacaacaa gcccaatatt ggccacctgg gcctgcccca tgggccgtcc
     5101 ggggaaaaga tggccgtggt gacagtggat gattgtgaca caaccatggc tgtgcgcttt
     5161 ggaaaggaca tcgggaacta cagctgcgct gcccagggca ctcagaccgg ctccaagaag
     5221 tccctggatc tgaccggccc tctactcctg gggggtgtcc ccaacctgcc agaagacttc
     5281 ccagtgcaca accggcagtt cgtgggctgc atgcggaacc tgtcagtcga cggcaaaaat
     5341 gtggacatgg ccggattcat cgccaacaat ggcacccggg aaggctgcgc tgctcggagg
     5401 aacttctgcg atgggaggcg gtgtcagaat ggaggcacct gtgtcaacag gtggaatatg
     5461 tatctgtgtg agtgtccact ccgattcggc gggaagaact gtgagcaagc catgcctcac
     5521 ccccagctct tcagcggtga gagcgtcgtg tcctggagtg acctgaacat catcatctct
     5581 gtgccctggt acctggggct catgttccgg acccggaagg aggacagcgt tctgatggag
     5641 gccaccagtg gtgggcccac cagctttcgc ctccagatcc tgaacaacta cctccagttt
     5701 gaggtgtccc acggcccctc cgatgtggag tccgtgatgc tgtccgggtt gcgggtgacc
     5761 gacggggagt ggcaccacct gctgatcgag ctgaagaatg ttaaggagga cagtgagatg
     5821 aagcacctgg tcaccatgac cttggactat gggatggacc agaacaaggc agatatcggg
     5881 ggcatgcttc ccgggctgac ggtaaggagc gtggtggtcg gaggcgcctc tgaagacaag
     5941 gtctccgtgc gccgtggatt ccgaggctgc atgcagggag tgaggatggg ggggacgccc
     6001 accaacgtcg ccaccctgaa catgaacaac gcactcaagg tcagggtgaa ggacggctgt
     6061 gatgtggacg acccctgtac ctcgagcccc tgtcccccca atagccgctg ccacgacgcc
     6121 tgggaggact acagctgcgt ctgtgacaaa gggtaccttg gaataaactg tgtggatgcc
     6181 tgtcacctga acccctgcga gaacatgggg gcctgcgtgc gctcccccgg ctccccgcag
     6241 ggctacgtgt gcgagtgtgg gcccagtcac tacgggccgt actgtgagaa caaactcgac
     6301 cttccgtgcc ccagaggctg gtgggggaac cccgtctgtg gaccctgcca ctgtgccgtc
     6361 agcaaaggct ttgatcccga ctgtaataag accaacggcc agtgccaatg caaggagaat
     6421 tactacaagc tcctagccca ggacacctgt ctgccctgcg actgcttccc ccatggctcc
     6481 cacagccgca cttgcgacat ggccaccggg cagtgtgcct gcaagcccgg cgtcatcggc
     6541 cgccagtgca accgctgcga caacccgttt gccgaggtca ccacgctcgg ctgtgaagtg
     6601 atctacaatg gctgtcccaa agcatttgag gccggcatct ggtggccaca gaccaagttc
     6661 gggcagccgg ctgcggtgcc atgccctaag ggatccgttg gaaatgcggt ccgacactgc
     6721 agcggggaga agggctggct gcccccagag ctctttaact gtaccaccat ctccttcgtg
     6781 gacctcaggg ccatgaatga gaagctgagc cgcaatgaga cgcaggtgga cggcgccagg
     6841 gccctgcagc tggtgagggc gctgcgcagt gctacacagc acacgggcac gctctttggc
     6901 aatgacgtgc gcacggccta ccagctgctg ggccacgtcc ttcagcacga gagctggcag
     6961 cagggcttcg acctggcagc cacgcaggac gccgactttc acgaggacgt catccactcg
     7021 ggcagcgccc tcctggcccc agccaccagg gcggcgtggg agcagatcca gcggagcgag
     7081 ggcggcacgg cacagctgct ccggcgcctc gagggctact tcagcaacgt ggcacgcaac
     7141 gtgcggcgga cgtacctgcg gcccttcgtc atcgtcaccg ccaacatgat tcttgctgtc
     7201 gacatctttg acaagttcaa ctttacggga gccagggtcc cgcgattcga caccatccat
     7261 gaagagttcc ccagggagct ggagtcctcc gtctccttcc cagccgactt cttcagacca
     7321 cctgaagaaa aagaaggccc cctgctgagg ccggctggcc ggaggaccac cccgcagacc
     7381 acgcgcccgg ggcctggcac cgagagggag gccccgatca gcaggcggag gcgacaccct
     7441 gatgacgctg gccagttcgc cgtcgctctg gtcatcattt accgcaccct ggggcagctc
     7501 ctgcccgagc gctacgaccc cgaccgtcgc agcctccggt tgcctcaccg gcccatcatt
     7561 aataccccga tggtgagcac gctggtgtac agcgaggggg ctccgctccc gagacccctg
     7621 gagaggcccg tcctggtgga gttcgccctg ctggaggtgg aggagcgaac caagcctgtc
     7681 tgcgtgttct ggaaccactc cctggccgtt ggtgggacgg gagggtggtc tgcccggggc
     7741 tgcgagctcc tgtccaggaa ccggacacat gtcgcctgcc agtgcagcca cacagccagc
     7801 tttgcggtgc tcatggatat ctccaggcgt gagaacgggg aggtcctgcc tctgaagatt
     7861 gtcacctatg ccgctgtgtc cttgtcactg gcagccctgc tggtggcctt cgtcctcctg
     7921 agcctggtcc gcatgctgcg ctccaacctg cacagcattc acaagcacct cgccgtggcg
     7981 ctcttcctct ctcagctggt gttcgtgatt gggatcaacc agacggaaaa cccgtttctg
     8041 tgcacagtgg ttgccatcct cctccactac atctacatga gcacctttgc ctggaccctc
     8101 gtggagagcc tgcatgtcta ccgcatgctg accgaggtgc gcaacatcga cacggggccc
     8161 atgcggttct actacgtcgt gggctggggc atcccggcca ttgtcacagg actggcggtc
     8221 ggcctggacc cccagggcta cgggaacccc gacttctgct ggctgtcgct tcaagacacc
     8281 ctgatttgga gctttgcggg gcccatcgga gctgttataa tcatcaacac agtcacttct
     8341 gtcctatctg caaaggtttc ctgccaaaga aagcaccatt attatgggaa aaaagggatc
     8401 gtctccctgc tgaggaccgc attcctcctg ctgctgctca tcagcgccac ctggctgctg
     8461 gggctgctgg ctgtgaaccg cgatgcactg agctttcact acctcttcgc catcttcagc
     8521 ggcttacagg gccccttcgt cctccttttc cactgcgtgc tcaaccagga ggtccggaag
     8581 cacctgaagg gcgtgctcgg cgggaggaag ctgcacctgg aggactccgc caccaccagg
     8641 gccaccctgc tgacgcgctc cctcaactgc aacaccacct tcggtgacgg gcctgacatg
     8701 ctgcgcacag acttgggcga gtccaccgcc tcgctggaca gcatcgtcag ggatgaaggg
     8761 atccagaagc tcggcgtgtc ctctgggctg gtgaggggca gccacggaga gccagacgcg
     8821 tccctcatgc ccaggagctg caaggatccc cctggccacg attccgactc agatagcgag
     8881 ctgtccctgg atgagcagag cagctcttac gcctcctcac actcgtcaga cagcgaggac
     8941 gatggggtgg gagctgagga aaaatgggac ccggccaggg gcgccgtcca cagcaccccc
     9001 aaaggggacg ctgtggccaa ccacgttccg gccggctggc ccgaccagag cctggctgag
     9061 agtgacagtg aggaccccag cggcaagccc cgcctgaagg tggagaccaa ggtcagcgtg
     9121 gagctgcacc gcgaggagca gggcagtcac cgtggagagt accccccgga ccaggagagc
     9181 gggggcgcag ccaggcttgc tagcagccag cccccagagc agaggaaagg catcttgaaa
     9241 aataaagtca cctacccgcc gccgctgacg ctgacggagc agacgctgaa gggccggctc
     9301 cgggagaagc tggccgactg tgagcagagc cccacatcct cgcgcacgtc ttccctgggc
     9361 tctggcggcc ccgactgcgc catcacagtc aagagccctg ggagggagcc ggggcgtgac
     9421 cacctcaacg gggtggccat gaatgtgcgc actgggagcg cccaggccga tggctccgac
     9481 tctgaaggca gtaatgaaac ttcaatttga accatcagta atgaaacttc aatttgaacc
     9541 atcaggaaac cgtgaggcaa gcccgtcacc ccacacaggc tgcggcatca ccctcagacc
     9601 ttggagccca aggggccact gcccttgaag tggagtgggc ccagagtgtg gcggtcccca
     9661 tggtggcagc cccccgactg atcatccaga cacaaaggtc ttggttctcc caggagctca
     9721 gggcctgtca gacctggtga caagtgccaa aggccacagg catgagggag gcgtggacca
     9781 ctgggccagc accgctgagt cctaagactg cagtcaaagc cagaactgag aggggacccc
     9841 agactgggcc cagaggctgg ccagagttca ggaacgccgg gcacagacca aagaccgcgg
     9901 tccagccccg cccaggcggg catctcatgg cagtgcggac ccgtggctgg cagcccgggc
     9961 agtcctttgc aaaggcaccc cttgtcttaa aatcacttcg ctatgtggga aaggtggaga
    10021 tacttttata tatttgtatg ggactctgag gaggtgcaac ctgtatatat attgcattcg
    10081 tgctgacttt gttatcccga gagatccatg caatgatctc ttgctgtctt ctctgtcaag
    10141 attgcacagt tgtacttgaa tctggcatgt gttgacgaaa ctggtgcccc agcagatcaa
    10201 aggtgggaaa tacgtcagca gtggggctaa aaccaagcgg ctagaagccc tacagctgcc
    10261 ttcggccagg aagtgaggat ggtgtgggcc ctccccgccg gccccctggg tccccagtgt
    10321 tcgctgtgtg tgcgtttgtc ctctgctgcc atctgccccg gctgtgtgaa ttcaagacag
    10381 ggcagtgcag cactaggcag gtgtgaggag ccctgctgag gtcactgtgg ggcacggttg
    10441 ccacacggct gtcatttttc acctggtcat tctgtgacca ccaccccctc ccctcaccgc
    10501 ctcccaggtg gcccgggagc tgcaggtggg gatggctttg tcctttgctc ctgctccccg
    10561 tgggacctgg gaccttaaag cgttgcaggt tcctgatttg gacagaggtg tggggccttc
    10621 caggccgtta catacctcct gccaattctc taactctctg agactgcgag gatctccagg
    10681 cagggttctc ccctctggag tctgaccaat tacttcattt tgcttcaaat ggccaattgt
    10741 gcagagggac aaagccacag ccacactctt caacggttac caaactgttt ttggaaattc
    10801 acaccaaggt cgggcccact gcaggcagct ggcacagcgt ggcccgaggg gctgtggaac
    10861 gggtcccgga actgtcagac atgtttgatt ttagcgtttc ctttgttctt caaatcaggt
    10921 gcccaaataa gtgatcagca cagctgcttc caaataggag aaaccataaa ataggatgaa
    10981 aatcaagtaa aatgcaaaga tgtccacact gttttaaact tgaccctgat gaaaatgtga
    11041 gcactgttag cagatgccta tgggagagga aaagcgtatc tgaaaatggt ccaggacagg
    11101 aggatgaaat gagatcccag agtcctcaca cctgaatgaa ttatacatgt gccttaccag
    11161 gtgagtggtc tttcgaagat aaaaaactct agtcccttta aacgtttgcc cctggcgttt
    11221 cctaagtacg aaaaggtttt taagtcttcg aacagtctcc tttcatgact ttaacaggat
    11281 tctgccccct gaggtgtaat ttttttgttc tatttttttc cacgtactcc acagccaaca
    11341 tcacgaggtg taatttttaa tttgatcaga actgttacca aaaaacaact gtcagtttta
    11401 ttgagatggg aaaaatgtaa acctattttt attacttaag actttatggg agagattaga
    11461 cactggaggt ttttaacaga acgtgtattt attaatgttc aaaacactgg aattacaaat
    11521 gagaagagtc tacaataaat taagattttt gaatttgta
//
