LOCUS       NM_052840               3373 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CUGBP Elav-like family member 6 (CELF6), transcript
            variant 1, mRNA.
ACCESSION   NM_052840
VERSION     NM_052840.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3373)
  AUTHORS   Ma,H., Liu,G., Yu,B., Wang,J., Qi,Y., Kou,Y., Hu,Y., Wang,S.,
            Wang,F. and Chen,D.
  TITLE     RNA-binding protein CELF6 modulates transcription and splicing
            levels of genes associated with tumorigenesis in lung cancer A549
            cells
  JOURNAL   PeerJ 10, e13800 (2022)
   PUBMED   35910766
  REMARK    GeneRIF: RNA-binding protein CELF6 modulates transcription and
            splicing levels of genes associated with tumorigenesis in lung
            cancer A549 cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3373)
  AUTHORS   Zheng,Z., Tan,J., Zhang,J., Wu,M., Chen,G., Li,Z., Shi,X., Fu,W.,
            Zhou,H., Lao,Y., Zhang,L. and Xu,H.
  TITLE     The natural compound neobractatin inhibits cell proliferation
            mainly by regulating the RNA binding protein CELF6
  JOURNAL   Food Funct 13 (4), 1741-1750 (2022)
   PUBMED   35088780
  REMARK    GeneRIF: The natural compound neobractatin inhibits cell
            proliferation mainly by regulating the RNA binding protein CELF6.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3373)
  AUTHORS   Rieger,M.A., King,D.M., Crosby,H., Liu,Y., Cohen,B.A. and
            Dougherty,J.D.
  TITLE     CLIP and Massively Parallel Functional Analysis of CELF6 Reveal a
            Role in Destabilizing Synaptic Gene mRNAs through Interaction with
            3' UTR Elements
  JOURNAL   Cell Rep 33 (12), 108531 (2020)
   PUBMED   33357440
  REMARK    GeneRIF: CLIP and Massively Parallel Functional Analysis of CELF6
            Reveal a Role in Destabilizing Synaptic Gene mRNAs through
            Interaction with 3' UTR Elements.
REFERENCE   4  (bases 1 to 3373)
  AUTHORS   Yang,X., Zhao,L., Pei,J., Wang,Z., Zhang,J. and Wang,B.
  TITLE     CELF6 modulates triple-negative breast cancer progression by
            regulating the stability of FBP1 mRNA
  JOURNAL   Breast Cancer Res Treat 183 (1), 71-82 (2020)
   PUBMED   32601971
  REMARK    GeneRIF: CELF6 modulates triple-negative breast cancer progression
            by regulating the stability of FBP1 mRNA.
REFERENCE   5  (bases 1 to 3373)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3373)
  AUTHORS   Liu,G., Zhang,Q., Xia,L., Shi,M., Cai,J., Zhang,H., Li,J., Lin,G.,
            Xie,W., Zhang,Y. and Xu,N.
  TITLE     RNA-binding protein CELF6 is cell cycle regulated and controls
            cancer cell proliferation by stabilizing p21
  JOURNAL   Cell Death Dis 10 (10), 688 (2019)
   PUBMED   31534127
  REMARK    GeneRIF: RNA-binding protein CELF6 is cell cycle regulated and
            controls cancer cell proliferation by stabilizing p21.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3373)
  AUTHORS   Dougherty,J.D., Maloney,S.E., Wozniak,D.F., Rieger,M.A.,
            Sonnenblick,L., Coppola,G., Mahieu,N.G., Zhang,J., Cai,J.,
            Patti,G.J., Abrahams,B.S., Geschwind,D.H. and Heintz,N.
  TITLE     The disruption of Celf6, a gene identified by translational
            profiling of serotonergic neurons, results in autism-related
            behaviors
  JOURNAL   J Neurosci 33 (7), 2732-2753 (2013)
   PUBMED   23407934
  REMARK    GeneRIF: Analysis of common variants near the corresponding genes
            implicated the RNA binding protein CELF6 in autism risk
REFERENCE   8  (bases 1 to 3373)
  AUTHORS   Ladd,A.N., Nguyen,N.H., Malhotra,K. and Cooper,T.A.
  TITLE     CELF6, a member of the CELF family of RNA-binding proteins,
            regulates muscle-specific splicing enhancer-dependent alternative
            splicing
  JOURNAL   J Biol Chem 279 (17), 17756-17764 (2004)
   PUBMED   14761971
  REMARK    GeneRIF: CELF6 is a member of the CELF family of RNA-binding
            proteins that regulates muscle-specific splicing enhancer-dependent
            alternative splicing
REFERENCE   9  (bases 1 to 3373)
  AUTHORS   Wistow,G., Bernstein,S.L., Wyatt,M.K., Fariss,R.N., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of human RPE/choroid for the
            NEIBank Project: over 6000 non-redundant transcripts, novel genes
            and splice variants
  JOURNAL   Mol Vis 8, 205-220 (2002)
   PUBMED   12107410
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3373)
  AUTHORS   Good,P.J., Chen,Q., Warner,S.J. and Herring,D.C.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA393931.1, AF401233.1,
            AK131098.1, BU732838.1 and BM681937.1.
            
            On Nov 22, 2018 this sequence version replaced NM_052840.4.
            
            Summary: Members of the CELF/BRUNOL protein family contain two
            N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM
            domain, and a divergent segment of 160-230 aa between the second
            and third RRM domains. Members of this protein family regulate
            pre-mRNA alternative splicing and may also be involved in mRNA
            editing, and translation. Multiple alternatively spliced transcript
            variants encoding different isoforms have been identified in this
            gene. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030835.1, SRR14038196.2586877.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287202.10/ ENSP00000287202.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                CA393931.1         28-55
            29-2147             AF401233.1         1-2119
            2148-2529           AK131098.1         3324-3705
            2530-3063           BU732838.1         19-552              c
            3064-3373           BM681937.1         19-328              c
FEATURES             Location/Qualifiers
     source          1..3373
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..3373
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /note="CUGBP Elav-like family member 6"
                     /db_xref="GeneID:60677"
                     /db_xref="HGNC:HGNC:14059"
                     /db_xref="MIM:612681"
     exon            1..545
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1729
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /EC_number="3.2.1.52"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein BRUNOL-6; Bruno -like 6, RNA binding
                     protein; CUG-BP- and ETR-3-like factor 6; bruno-like
                     protein 6; bruno-like 6, RNA binding protein"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 6 isoform 1"
                     /protein_id="NP_443072.3"
                     /db_xref="CCDS:CCDS10242.1"
                     /db_xref="GeneID:60677"
                     /db_xref="HGNC:HGNC:14059"
                     /db_xref="MIM:612681"
                     /translation="MAAAPGGSAQPAGPGPRLGFSTADSGVGMSGLNPGPAVPMKDHD
                     AIKLFVGQIPRGLDEQDLKPLFEEFGRIYELTVLKDRLTGLHKGCAFLTYCARDSALK
                     AQSALHEQKTLPGMNRPIQVKPAASEGRGEDRKLFVGMLGKQQGEEDVRRLFQPFGHI
                     EECTVLRSPDGTSKGCAFVKFGSQGEAQAAIRGLHGSRTMAGASSSLVVKLADTDRER
                     ALRRMQQMAGHLGAFHPAPLPLGACGAYTTAILQHQAALLAAAQGPGLGPVAAVAAQM
                     QHVAAFSLVAAPLLPAAAANSPPGSGPGTLPGLPAPIGVNGFGPLTPQTNGQPGSDTL
                     YNNGLSPYPAQSPGVADPLQQAYAGMHHYAAAYPSAYAPVSTAFPQQPSALPQQQREG
                     PEGCNLFIYHLPQEFGDAELIQTFLPFGAVVSAKVFVDRATNQSKCFGFVSFDNPTSA
                     QTAIQAMNGFQIGMKRLKVQLKRPKDANRPY"
     exon            546..628
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            629..677
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            678..806
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            807..886
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1030
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1163
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1313
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1376
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1457
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1601
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1757
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..3373
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3040..3045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /note="hexamer: TATAAA"
     polyA_site      3062
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /note="major polyA site"
     regulatory      3351..3356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /note="hexamer: AAGAAA"
     polyA_site      3373
                     /gene="CELF6"
                     /gene_synonym="BRUNOL6"
                     /note="major polyA site"
ORIGIN      
        1 gagctcgggc gggagcccag agagagccgc acggggacct caagccagac cccagcgttc
       61 agccgccacc tcggcccggg cccgccccgc cccggccccg cccctttcct gcccgcccca
      121 ccccctctac gcccctccac ccggaccccg ccccctgggc agccccccgc cctctccgcc
      181 cgggctccgc cccctccccc tggccctcgc caccggtcca gggaggggac ggcgggacag
      241 gcgggaccag tgggaccggc gggagggctg acagggcggg gacatggccg cggcgccggg
      301 agggtcagcg cagcccgctg gccccggccc gcgcctgggt ttcagcaccg cggacagcgg
      361 cgtcggcatg agcgggctaa accccggtcc cgccgtaccc atgaaggacc acgacgccat
      421 caagctcttc gtggggcaga tcccgcgggg cttggacgag caggacctca agccgctgtt
      481 cgaggagttc ggccgcatct acgagctgac ggtgctgaag gaccggctca ccggcctcca
      541 caaaggctgt gccttcctca cctactgcgc ccgggactct gctctcaagg cccagagtgc
      601 actgcacgag cagaagaccc tgccagggat gaatcgtccg atccaagtga agccagctgc
      661 cagtgagggc cgaggagagg accgaaagct gtttgtgggg atgctgggca agcagcaggg
      721 tgaggaggac gtcagacgcc tgttccagcc ctttggccac atcgaggagt gcacggtcct
      781 gcggagtcct gacggcacca gtaaaggctg tgcctttgtg aagttcggga gtcaagggga
      841 agctcaggcg gccatccggg gtctgcacgg cagccggacc atggcgggcg cctcgtccag
      901 cctcgtggtc aagctggcgg acaccgaccg ggagcgcgcg ctgcggcgga tgcagcagat
      961 ggccggccac ctgggcgcct tccaccccgc gccactgccg ctaggggcct gcggcgccta
     1021 caccacggcg atcctgcagc accaggcggc cctgctggcg gcggcacagg gcccaggcct
     1081 aggcccggtg gcggcagtgg cggcccagat gcaacacgtg gcggccttta gcctggtagc
     1141 tgcgcctctg ttgcccgcgg cagcagccaa ctccccgcct ggcagcggcc ctggcaccct
     1201 cccaggtctt ccggcgccca tcggggtcaa tggattcggc cctctgaccc cccagaccaa
     1261 tggccagccg ggctccgaca cgctctacaa taacgggctc tccccttatc cagcccagag
     1321 ccccggcgtg gctgaccccc tgcagcaggc ctacgctggg atgcaccact acgcagcagc
     1381 ctatccgtcg gcctatgccc cagtgagcac agcttttccc cagcagcctt cagccctgcc
     1441 ccagcagcag agagaaggcc ccgaaggctg taacctcttc atctatcacc tgcctcagga
     1501 gtttggtgat gcggaactca tacagacatt cctgcccttt ggagccgttg tctctgctaa
     1561 agtctttgtg gatcgagcca ccaaccagag caagtgtttt gggtttgtta gttttgacaa
     1621 tccaactagt gcccagactg ctattcaggc gatgaatggc tttcaaattg gcatgaagag
     1681 gctcaaggtc cagctaaagc ggcccaagga tgccaaccgg ccttactgac ctgctttcac
     1741 tgaccagcca cagaaagaaa cagaagagtg agaagaaagg agaggaaaag cacagaaacg
     1801 cttgagcagc ccttcccgaa ggagcagctg cggacggagg tggatcggac ccaaggctgg
     1861 tgcctggggc taaggccact ctaaggattg tttttatcaa gtgggttgtt ctgtgcctgc
     1921 agcatagagc gcaggctggc agagcaaata gggctggtga ggagtgactg tccaggggaa
     1981 ccagcagagg gcgttggggg tgccaagggc ttctccgcaa gggaagccca gatttacttc
     2041 tttcaaaatc atatcattcc ttagagttta gggaccaaag gactattgct tttttaagaa
     2101 tatatatatc tatataaatt aaaacaaaga aacaaacaaa caaaaaacaa gacaaacaac
     2161 tacaaaaaaa gacagtatag agtctcataa aagctgcctt taaatatccc taggagacag
     2221 ggtgaaggag acccttgaca gccccagcct aggcagatgg gggctgtgga aagattgttc
     2281 tgtgtctcat tccctcttaa gccactcccc caccctgccc ttttaaaaat aattaaggat
     2341 ttgaggtcta ggctcacatg caggtaatga gaacgttatg gaagcagtga acccacaatc
     2401 cacaatcccc aaactcagag tgcatcccag aagaggcccc aggcagagct caggttggcc
     2461 ctggcctttg ccatcccggg aggcccccta gccagcaaga gtgggattgc ctttcctgtg
     2521 gaaccactgc ttccccaggc gggaagaaag agggagttct ggccacctga gcctttccct
     2581 tgccaatcca ggtagacaga ggccctgcct ttggctgagc tgagacacct cctgtttccc
     2641 ttccccttga accagtccca gtgtcccctt gctccaggct accttctgtc tcttagtcta
     2701 agtttgccca cctgtaaagt agattcagga tatctgtaga gggctgtgac aacagacttg
     2761 gaaggtttgc tactgtatat actgccattg agaaggggaa atttttcaat atgtagaagc
     2821 ttcagaatta gaggtccctc tttaccccag acctgggagg gaagtagatg ttttgccaaa
     2881 atacttcttc attcctttaa aaactacatc tttcctatgc aagagtgtct cacatgtgct
     2941 taaccgaggt gcttctagtt ggtgagcagt gttgagctta gaagtggtgt gtgctctgtc
     3001 tgtctgtctt tgtctgtctg ttgtatacag tgggtgccat ataaagctga tcaatggtgg
     3061 tgcttcctgc ctgcttctgt gagatgggca aaagattcag cttagaacac catgactcac
     3121 cttgccttgg tcagcctttc ctgggcctgt agggccttgc acatattttt cccaggagga
     3181 tttcccctcc accccacagg catggatcag cttggtctga ggccccagct gtgtggggtc
     3241 cctctaatcc ccagatgttg ctgaggctga aggcctctga tctgataaca tgtcagatag
     3301 taaaagatgt gggggtgggg gtggagggct cctccttcat aacagtttct aagaaaactt
     3361 gttcccacct gtt
//
