LOCUS       NM_021938               1896 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens CUGBP Elav-like family member 5 (CELF5), transcript
            variant 1, mRNA.
ACCESSION   NM_021938
VERSION     NM_021938.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1896)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1896)
  AUTHORS   Wang,K.S., Liu,X.F. and Aragam,N.
  TITLE     A genome-wide meta-analysis identifies novel loci associated with
            schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 124 (1-3), 192-199 (2010)
   PUBMED   20889312
REFERENCE   3  (bases 1 to 1896)
  AUTHORS   Wu,J., Li,C., Zhao,S. and Mao,B.
  TITLE     Differential expression of the Brunol/CELF family genes during
            Xenopus laevis early development
  JOURNAL   Int J Dev Biol 54 (1), 209-214 (2010)
   PUBMED   19757395
REFERENCE   4  (bases 1 to 1896)
  AUTHORS   Ladd,A.N., Charlet,N. and Cooper,T.A.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   5  (bases 1 to 1896)
  AUTHORS   Good,P.J., Chen,Q., Warner,S.J. and Herring,D.C.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005331.2, BC028101.1 and
            BC047522.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021938.3.
            
            Summary: This gene encodes a member of the the CELF/BRUNOL protein
            family, which contain two N-terminal RNA recognition motif (RRM)
            domains, one C-terminal RRM domain, and a divergent segment of
            160-230 aa between the second and third RRM domains. Members of
            this protein family regulate pre-mRNA alternative splicing and may
            also be involved in mRNA editing and translation. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jan 2012].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028101.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292672.7/ ENSP00000292672.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC005331.2         18050-18091
            43-237              BC028101.1         1-195
            238-238             BC047522.1         162-162
            239-1857            BC028101.1         197-1815
            1858-1896           BC028101.1         1817-1855
FEATURES             Location/Qualifiers
     source          1..1896
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1896
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /note="CUGBP Elav-like family member 5"
                     /db_xref="GeneID:60680"
                     /db_xref="HGNC:HGNC:14058"
                     /db_xref="MIM:612680"
     exon            1..338
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1537
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     RNA-binding protein BRUNOL-5; CUG-BP and ETR-3 like factor
                     5; bruno-like 5 RNA binding protein"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 5 isoform 1"
                     /protein_id="NP_068757.2"
                     /db_xref="CCDS:CCDS12106.1"
                     /db_xref="GeneID:60680"
                     /db_xref="HGNC:HGNC:14058"
                     /db_xref="MIM:612680"
                     /translation="MARLTESEARRQQQQLLQPRPSPVGSSGPEPPGGQPDGMKDLDA
                     IKLFVGQIPRHLDEKDLKPLFEQFGRIYELTVLKDPYTGMHKGCAFLTYCARDSAIKA
                     QTALHEQKTLPGMARPIQVKPADSESRGGRDRKLFVGMLNKQQSEEDVLRLFQPFGVI
                     DECTVLRGPDGSSKGCAFVKFSSHTEAQAAIHALHGSQTMPGASSSLVVKFADTDKER
                     TLRRMQQMVGQLGILTPSLTLPFSPYSAYAQALMQQQTTVLSTSGSYLSPGVAFSPCH
                     IQQIGAVSLNGLPATPIAPASGLHSPPLLGTTAVPGLVAPITNGFAGVVPFPGGHPAL
                     ETVYANGLVPYPAQSPTVAETLHPAFSGVQQYTAMYPTAAITPIAHSVPQPPPLLQQQ
                     QREGPEGCNLFIYHLPQEFGDTELTQMFLPFGNIISSKVFMDRATNQSKCFGFVSFDN
                     PASAQAAIQAMNGFQIGMKRLKVQLKRPKDPGHPY"
     exon            339..421
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            422..473
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            474..602
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            603..682
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            683..829
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            830..971
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1118
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1181
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1265
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1409
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..1577
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1896
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1875..1880
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /note="hexamer: AATAAA"
     polyA_site      1896
                     /gene="CELF5"
                     /gene_synonym="BRUNOL-5; BRUNOL5; CELF-5"
                     /note="major polyA site"
ORIGIN      
        1 gggaggcgcg gccgccgctc cagctgcgag tccgcccgcc gcccgccgcc gccgccgccg
       61 gctcggtccc gcgcccgcca tggcccgcct gacggagagc gaggcgcgcc ggcagcagca
      121 gcagctcctg cagccgcggc cctcgcccgt gggcagcagc gggcccgagc cccccggggg
      181 gcagcccgac ggcatgaagg acctggacgc catcaaactc ttcgtgggcc agatcccgcg
      241 gcacctggac gagaaggacc tcaagccgct cttcgagcag ttcggccgca tctacgagct
      301 cacggtgctc aaagacccct acacggggat gcacaaaggc tgtgccttcc tcacctactg
      361 tgccagggat tccgccatca aagctcagac tgccctgcac gagcagaaga ccttgcccgg
      421 aatggcgcgg ccaatccagg tgaagcctgc ggacagtgaa agccgcggag gtagggaccg
      481 gaagctgttc gtggggatgc tgaacaagca gcagtcggag gaggacgtgc tgcggctgtt
      541 ccagcccttc ggggtcattg acgagtgcac cgtgctccgg gggcctgacg gcagcagcaa
      601 aggctgtgct ttcgtgaagt tctcctccca cacggaggcg caggcggcca tccacgcctt
      661 gcatgggagc cagaccatgc cgggagcctc ctccagcctg gtggtcaagt tcgccgacac
      721 ggacaaggag cggacgctcc ggcgcatgca gcagatggtg ggccagctgg gcatcctgac
      781 gccgtccctc acattgccct tcagccccta cagtgcctac gcccaggctc tcatgcaaca
      841 gcagacaaca gtcctgtcca cctcgggcag ctacctgagt cccggcgtgg ccttctcacc
      901 ctgtcacatc cagcagatag gcgccgtcag cctcaacggg ctgcctgcca cacccatcgc
      961 tcctgcctct gggctgcact cacccccgct gctgggcacc accgctgtgc ctggcctcgt
     1021 ggctcccatc accaatggct ttgcaggtgt cgtgcccttt ccaggtgggc accctgccct
     1081 ggaaaccgtc tatgccaatg gccttgtgcc ctacccagct cagagcccga ctgtggccga
     1141 gacactgcat cctgccttct ccggagtcca gcagtacaca gccatgtacc ccaccgcggc
     1201 catcacgccc atcgcgcaca gcgtccccca gccgccgccc ctcctgcagc agcagcagcg
     1261 agaaggtccc gagggctgta acctgtttat ctaccacctc ccccaggagt ttggagacac
     1321 ggagctgacg cagatgttcc tacccttcgg caatatcatt tcctccaagg tgtttatgga
     1381 tcgagctacc aaccagagca agtgtttcgg cttcgtgagc tttgataacc cggccagcgc
     1441 ccaggcagcc atccaggcca tgaacggctt ccagatcggc atgaagaggc tcaaagtcca
     1501 gctgaagcgg cccaaagacc cgggacaccc ctactgaccg cgcccacagc cgccctgagg
     1561 ctgtaggcat ggcccagacc tgcgtgattt gtacaatgta ctttatttct gctacgagta
     1621 atttcatgaa gtttcaactt gcaaactgac ttttgggaca aaccaacaca cacacagaag
     1681 agaaagcaaa gaacttggaa ctttgggttg actcggtttg agttttgtgt caaagaagat
     1741 ttcccgcggc tgaagaggtt ggtgttcctg ttacgtgttt caggtgagaa gcagcaaagc
     1801 gtcttaatgt tcaaaacgcc tctctttggt ctggagaaaa aaaaaaaaaa aaaaaaacaa
     1861 ctaaaaattt atttaataaa agttttactt gctaaa
//
