LOCUS       NM_007185               5582 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens CUGBP Elav-like family member 3 (CELF3), transcript
            variant 1, mRNA.
ACCESSION   NM_007185
VERSION     NM_007185.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5582)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5582)
  AUTHORS   Zhou,B. and Guo,R.
  TITLE     Integrative analysis of significant RNA-binding proteins in
            colorectal cancer metastasis
  JOURNAL   J Cell Biochem 119 (12), 9730-9741 (2018)
   PUBMED   30132996
  REMARK    GeneRIF: CELF3 expression is associated with colorectal cancer
            metastasis.
REFERENCE   3  (bases 1 to 5582)
  AUTHORS   Ishizuka,A., Hasegawa,Y., Ishida,K., Yanaka,K. and Nakagawa,S.
  TITLE     Formation of nuclear bodies by the lncRNA Gomafu-associating
            proteins Celf3 and SF1
  JOURNAL   Genes Cells 19 (9), 704-721 (2014)
   PUBMED   25145264
  REMARK    GeneRIF: Gomafu indirectly modulates the function of the splicing
            factors SF1 and Celf3 by sequestering these proteins into separate
            nuclear bodies.
REFERENCE   4  (bases 1 to 5582)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 5582)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5582)
  AUTHORS   Chapple,J.P., Anthony,K., Martin,T.R., Dev,A., Cooper,T.A. and
            Gallo,J.M.
  TITLE     Expression, localization and tau exon 10 splicing activity of the
            brain RNA-binding protein TNRC4
  JOURNAL   Hum Mol Genet 16 (22), 2760-2769 (2007)
   PUBMED   17725984
REFERENCE   7  (bases 1 to 5582)
  AUTHORS   Wang,J., Gao,Q.S., Wang,Y., Lafyatis,R., Stamm,S. and Andreadis,A.
  TITLE     Tau exon 10, whose missplicing causes frontotemporal dementia, is
            regulated by an intricate interplay of cis elements and trans
            factors
  JOURNAL   J Neurochem 88 (5), 1078-1090 (2004)
   PUBMED   15009664
REFERENCE   8  (bases 1 to 5582)
  AUTHORS   Ladd,A.N., Charlet,N. and Cooper,T.A.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (bases 1 to 5582)
  AUTHORS   Good,P.J., Chen,Q., Warner,S.J. and Herring,D.C.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (bases 1 to 5582)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL589765.19 and KF455029.1.
            
            On May 17, 2019 this sequence version replaced NM_007185.6.
            
            Summary: Members of the CELF/BRUNOL protein family contain two
            N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM
            domain, and a divergent segment of 160-230 aa between the second
            and third RRM domains. Members of this protein family regulate
            pre-mRNA alternative splicing and may also be involved in mRNA
            editing, and translation. Multiple alternatively spliced transcript
            variants encoding different isoforms have been identified in this
            gene. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.110253.1, AY165003.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000290583.9/ ENSP00000290583.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-928               AL589765.19        38251-39178         c
            929-1011            AL589765.19        36969-37051         c
            1012-1060           AL589765.19        32118-32166         c
            1061-1189           AL589765.19        31595-31723         c
            1190-1269           AL589765.19        31373-31452         c
            1270-1413           AL589765.19        30167-30310         c
            1414-1555           AL589765.19        29882-30023         c
            1556-1705           AL589765.19        29520-29669         c
            1706-1771           AL589765.19        29044-29109         c
            1772-1909           AL589765.19        28599-28736         c
            1910-2053           AL589765.19        28197-28340         c
            2054-2191           AL589765.19        27406-27543         c
            2192-2536           AL589765.19        25479-25823         c
            2537-2894           KF455029.1         1-358
            2895-5582           AL589765.19        22433-25120         c
FEATURES             Location/Qualifiers
     source          1..5582
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..5582
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="CUGBP Elav-like family member 3"
                     /db_xref="GeneID:11189"
                     /db_xref="HGNC:HGNC:11967"
                     /db_xref="MIM:612678"
     exon            1..928
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             784..2181
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     expanded repeat domain, CAG/CTG 4; CAG repeat domain;
                     trinucleotide repeat containing 4; CUG-BP- and ETR-3-like
                     factor 3; CAG repeat protein 4; bruno-like protein 1;
                     RNA-binding protein BRUNOL-1; ELAV-type RNA-binding
                     protein 1; expanded repeat domain protein CAG/CTG 4;
                     trinucleotide repeat-containing gene 4 protein"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 3 isoform 1"
                     /protein_id="NP_009116.3"
                     /db_xref="CCDS:CCDS1002.1"
                     /db_xref="GeneID:11189"
                     /db_xref="HGNC:HGNC:11967"
                     /db_xref="MIM:612678"
                     /translation="MKEPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYT
                     GLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGML
                     GKQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAFVKFQTHAEAQAAINTLHSSRT
                     LPGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIALQFGAYSAYTQALMQQQAAL
                     VAAHSAYLSPMATMAAVQMQHMAAINANGLIATPITPSSGTSTPPAIAATPVSAIPAA
                     LGVNGYSPVPTQPTGQPAPDALYPNGVHPYPAQSPAAPVDPLQQAYAGMQHYTAAYPA
                     AYSLVAPAFPQPPALVAQQPPPPPQQQQQQQQQQQQQQQREGPDGCNIFIYHLPQEFT
                     DSEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKR
                     LKVQLKRPKDANRPY"
     exon            929..1011
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1060
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1189
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1269
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1413
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1555
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1705
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1771
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1909
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2053
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2191
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..5582
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3217..3222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="hexamer: AAGAAA"
     polyA_site      3236
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="major polyA site"
     regulatory      5555..5560
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="hexamer: AATAAA"
     polyA_site      5582
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
ORIGIN      
        1 ggtttttgtt gaggagagcg cggccggaga gcagagctcc gggacccagg tgaccgggaa
       61 agcaggcagc cccagcggcg ggagcagccg gcagcagccc aggcccgggg actggggtgg
      121 gggtgggagg ggggctgagg ggaggacctg aaggggggcg gcagggcaaa agggacccct
      181 ggagccctgc cgccatcaga gatcaagcat ctggcatcag ggatcttcgg acccagcaga
      241 aggatccgcc acaggggagg tgtcctccca gggaagccaa cgagagattc acctgcccca
      301 catcaggagt gggcccccct tactgacgct gctggcaacc atagcaggcc ccttaacccc
      361 tcagtctcct ccccatcacc ctcctcaggc cctttccccg cctccagctc tcatctcaac
      421 tcccagttcc cagccctcta agccctagca cccccggcta ccacctaacc ctccaggtct
      481 tggccatact cacccccatc ctgggacatt tgccagatct ctgggaggga gatcgtttgt
      541 ttaggcgatg ccccctggtg gcatgacagc gtctgcctag acccctgacc cctagcactc
      601 aactccctgg gcctcctttg tgtgaagagc cgcccctctg cttagcagcg tggttggggg
      661 ccaaagggaa agccagcccc agctgggccc ccgggcccca ccacttatct ccttgctggg
      721 cagctcccct tggcctttgg gcctctccct gctcccctcg gcccctcctc ctgggccgcc
      781 tcaatgaagg agccggatgc catcaagctg tttgtggggc agatcccgag gcatctggag
      841 gagaaggacc tgaagcccat cttcgaacag tttggtcgga tctttgagct gactgtcatc
      901 aaggacaagt acaccgggct gcacaaggga tgtgccttcc tgacatactg tgcccgggat
      961 tcagccctga aggcccagag cgccctgcac gaacagaaga cgcttccagg gatgaacagg
     1021 ccgatccagg tcaagccagc cgacagcgag agccgaggag aagaccggaa gctctttgtg
     1081 gggatgctag ggaagcagca gacagatgag gacgtccgga agatgtttga gcccttcggg
     1141 accatcgacg agtgcactgt gctccggggg ccagatggca ccagcaaagg ctgcgccttc
     1201 gtgaagttcc agacccacgc tgaggcccag gcggccatca acacccttca cagcagccgg
     1261 accctgccag gtgcctcgtc cagcctggtg gtgaagtttg ctgacactga gaaggagcga
     1321 ggtctccgcc gcatgcagca ggtggccacc cagttgggca tgttcagccc catcgccctc
     1381 cagtttggag cctacagcgc ctacacccag gccctgatgc agcagcaggc ggccctggta
     1441 gcggctcaca gtgcctacct cagccccatg gccaccatgg ctgccgtgca gatgcagcac
     1501 atggctgcca tcaatgccaa tggcctcatc gccaccccca tcaccccatc ctcaggaacc
     1561 agcacccctc ctgccatcgc tgccacgcct gtctctgcca ttccggctgc cctgggcgtc
     1621 aacggctaca gcccggtgcc cacccagccc actgggcagc ctgcccctga tgctctgtat
     1681 cccaacgggg ttcaccccta cccagcccag agccccgcgg cccccgtgga ccccctgcag
     1741 caggcctacg cggggatgca gcactacaca gcagcctacc cagcagccta cagcctggtt
     1801 gcacctgcgt tcccgcagcc tccagccctg gtcgcccagc agcccccacc accacctcaa
     1861 cagcagcagc agcagcagca gcagcaacag cagcagcagc aaagagaagg ccctgatggc
     1921 tgcaacatct tcatctacca cctgccccag gagttcactg actcagagat cctccagatg
     1981 tttgtcccct ttggccacgt catctcagcc aaagtctttg ttgaccgagc caccaatcaa
     2041 agcaaatgtt ttggctttgt gagtttcgac aatccggcca gtgcccaggc tgccatccag
     2101 gccatgaatg gcttccagat cggcatgaag cgcctcaaag tccagctaaa gcggcctaag
     2161 gatgccaacc ggccctactg agggccccca ggtctggaga tcccagagga aggggcgcct
     2221 cacaccctct tcccacgact ggccccggcc ctctccgcac acctgccctg ggccttgact
     2281 gggttctggg gcaaacgctg cttcgtggcc cccgggggca caagacaccg gcccctccca
     2341 cccccctgcc tctctgaagg gccatggcta tgcttccctg gctccaaggg cccatttcct
     2401 cctagatgcc cttttggcct ttgtgaggga gcgaggaaca ggctcgaagg ctccggggta
     2461 tctgccttct gctgggctcc tgtgacaggc cttctgtacc cagcgtttgt acttgcctcc
     2521 cccaacagtg ggcctgttct acccgtgcag gccccaggag agccgcaggg gcctgccaca
     2581 cactcccagc tcaccctcac cccagcctct tccccacatt aggggtttct tggaagctgg
     2641 ctctcactcc cctccaccct cagctagagg taggatatcc ctgattcctg ggctcccagc
     2701 cctaaaactc actgcctccc ccaagggccc cctctaagga gggtgtgggg gagccctgag
     2761 ggctgcctct ctgccagtca gccacagaga ccctcctcct ttcacgagga aaagaccttc
     2821 ccctgaaccc ctaaaaatgt ttacagtctc tgctggttcc ctctgtgtaa ataccactac
     2881 cacccgtgcg ttatccagcc cgcccggcct ggcccggacg ctgccatctc tctttctggg
     2941 agtttagaca atgttgccct tggatttttt tctctctctt aatttctccc tttgctttgg
     3001 ggggtaattg ggtattggga ggaggggtgt ggggaggggt caaggggttt attacctgat
     3061 cattttcttt aggaagaggt tttagggaaa agaaaatggg gtgggggtgg gggtggtaag
     3121 gggagaccgg ggagtcagtt tcagacagtt ctctatgctt aacttattta tttattgcat
     3181 tttactttta aagagttggt cttttctgtc taaataaaga aaaaagttta aaagcatcaa
     3241 ataagagtct tggaaggttg agggtagggg attgttccct acccacactg ggaaggggga
     3301 gggaggtaga gaatgaggtt tgagagagaa aatcccatca gggaaggccg ggcccttgct
     3361 tttgagcagc atccaggcct tgttcatggc ttcatgatcc tgtccttcag cccttctttg
     3421 gggcttaatt ctggaatgtc ctgcagagtt cggcacaagg agatctcccc tgtcgggggc
     3481 tctcccctgt atccagctct gtccctctga aggctgagga cttgcagtct cacatctgga
     3541 cctccatttc tgcacagagg ccagtgtgga tactgggagc cagttgtgac accaccattt
     3601 actaaccact gctccatatg tgattctgtt ccaagtcctt attgtgcatt tcctcatttt
     3661 acctcctaac aaccttgtga ggcaggctat agtttattta ttttacttat ttactttgaa
     3721 acagggtctc actctgtcac tcaagctgga gtgtgatggt gagatcatag ctcactgcaa
     3781 ccttgaactc ctggttcagg ggatcctcct gtctcagcct cccaagtagt taggactata
     3841 agcggctgca ccaccacgcc cagctcattt ttaaaaatgg tgtttttttt tgtagacagg
     3901 gtcttgctat gttgcccagg ctggtctcga acccctgggc tcaagcaaac ctcctgcctt
     3961 ggcctcccga agtgctcaga ttacaggcat gagccaccac gcccagccta ggtaggatat
     4021 aattttatag atgggaaaag gaggcttgga aggttaacta acttccctgg agtcacaaag
     4081 ccagtaaggc atggctgtag gagttgaacc cagtttgtca gattccaaag cccatgatgt
     4141 tctcttctta cctgttcttt gacctgaggc aaagatccca agaagtagca agcaggctta
     4201 ggagtgagtc cttcaggtag agggtggact gcataagccc taagtccctc cacttcctag
     4261 attcttctct gtgagctgct ttagggcagg ctcaggatca cacaggtgtc ttctttgact
     4321 tcatagaaca tgtgcttcta ggctgctacc ccaccctctg tcttcatcat tagtaagcag
     4381 caccactagg tacctactca agccaaaact tggattacac cctttctctc atgtctcctc
     4441 cccaatccaa ctgcaaagcc ctaccaagtc tacctctaaa gtattcagct gatttactta
     4501 ctcatgtctc tgcatctcca cagccatcaa cactgtccac gtcacattgc tctcatctgt
     4561 ctccatgttt cttttcctgc tctcctacaa tttgttctcc caagaagcca agagtcatct
     4621 tttaaaagtt aattcaccaa catttactac ccagtctgct ttgtccagca ctgtatcctg
     4681 gtcaccctaa acagtgcccc aaatattaga cattgcttag taaataagaa atgactgttg
     4741 gacatctata ctggacttcc catccatatc tacatcatca tagggccaat gctaaaactt
     4801 tctcccataa agtcctgact catatatttc tattttctag tcacatagac agaaaacctc
     4861 aagagttttt agtactttcg cataaactca atggtattaa atcatttaag atttcacttc
     4921 cacaaacttt ctcatatcat ttccctcttt tcaattatca ctgcctacac ttattaactg
     4981 agtaatcata gcaatttcct aattggtcct tctgtctatg ttctgaagca tcaatctttc
     5041 taaactgcag ctaataaaaa acaaaacttc tctgctgctg ttttttgttg tttttcatag
     5101 aacacctcag cctggcattc aaggctcttc gaagccttac tttccacttc attcctacac
     5161 atacccaaat agaactattc attgttctct aggcaagttt ggtccctttt ctcccatgtc
     5221 ttttcattcc cagttactac agtgtctggc acataacggc tcaataaatg tttgttgaat
     5281 gccttcttgt tgaaatcctt ctcacactaa aacagttcac cttaaacact actttcttca
     5341 tgaaaatctt aacggccctc atccacaggt ctttctcctt ccttttctag tccttatggc
     5401 acttaaacct ttcactgctg tgtatcatgg ccatgcgtaa gtgtctcatt cttctgtgag
     5461 cctgtaagct ggcagaaatg tttctttctt tgcttttgtg tctgttgcag tatctcaaac
     5521 aatctcccca ccccaccccc aacagcagat acctaataaa tgtttgactt taaccactgt
     5581 aa
//
