LOCUS       NM_001291107            5579 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens CUGBP Elav-like family member 3 (CELF3), transcript
            variant 5, mRNA.
ACCESSION   NM_001291107 XM_005244858
VERSION     NM_001291107.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5579)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5579)
  AUTHORS   Zhou,B. and Guo,R.
  TITLE     Integrative analysis of significant RNA-binding proteins in
            colorectal cancer metastasis
  JOURNAL   J Cell Biochem 119 (12), 9730-9741 (2018)
   PUBMED   30132996
  REMARK    GeneRIF: CELF3 expression is associated with colorectal cancer
            metastasis.
REFERENCE   3  (bases 1 to 5579)
  AUTHORS   Ishizuka,A., Hasegawa,Y., Ishida,K., Yanaka,K. and Nakagawa,S.
  TITLE     Formation of nuclear bodies by the lncRNA Gomafu-associating
            proteins Celf3 and SF1
  JOURNAL   Genes Cells 19 (9), 704-721 (2014)
   PUBMED   25145264
  REMARK    GeneRIF: Gomafu indirectly modulates the function of the splicing
            factors SF1 and Celf3 by sequestering these proteins into separate
            nuclear bodies.
REFERENCE   4  (bases 1 to 5579)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 5579)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5579)
  AUTHORS   Chapple,J.P., Anthony,K., Martin,T.R., Dev,A., Cooper,T.A. and
            Gallo,J.M.
  TITLE     Expression, localization and tau exon 10 splicing activity of the
            brain RNA-binding protein TNRC4
  JOURNAL   Hum Mol Genet 16 (22), 2760-2769 (2007)
   PUBMED   17725984
REFERENCE   7  (bases 1 to 5579)
  AUTHORS   Wang,J., Gao,Q.S., Wang,Y., Lafyatis,R., Stamm,S. and Andreadis,A.
  TITLE     Tau exon 10, whose missplicing causes frontotemporal dementia, is
            regulated by an intricate interplay of cis elements and trans
            factors
  JOURNAL   J Neurochem 88 (5), 1078-1090 (2004)
   PUBMED   15009664
REFERENCE   8  (bases 1 to 5579)
  AUTHORS   Ladd,A.N., Charlet,N. and Cooper,T.A.
  TITLE     The CELF family of RNA binding proteins is implicated in
            cell-specific and developmentally regulated alternative splicing
  JOURNAL   Mol Cell Biol 21 (4), 1285-1296 (2001)
   PUBMED   11158314
REFERENCE   9  (bases 1 to 5579)
  AUTHORS   Good,P.J., Chen,Q., Warner,S.J. and Herring,D.C.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   10 (bases 1 to 5579)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL589765.19 and KF455029.1.
            
            On May 31, 2019 this sequence version replaced NM_001291107.1.
            
            Summary: Members of the CELF/BRUNOL protein family contain two
            N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM
            domain, and a divergent segment of 160-230 aa between the second
            and third RRM domains. Members of this protein family regulate
            pre-mRNA alternative splicing and may also be involved in mRNA
            editing, and translation. Multiple alternatively spliced transcript
            variants encoding different isoforms have been identified in this
            gene. [provided by RefSeq, Feb 2010].
            
            Transcript Variant: This variant (5) uses an alternate in-frame
            splice site in the coding region, compared to variant 1. The
            encoded protein (isoform 5) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.110240.1, BC143226.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-928               AL589765.19        38251-39178         c
            929-1011            AL589765.19        36969-37051         c
            1012-1060           AL589765.19        32118-32166         c
            1061-1186           AL589765.19        31595-31720         c
            1187-1266           AL589765.19        31373-31452         c
            1267-1410           AL589765.19        30167-30310         c
            1411-1552           AL589765.19        29882-30023         c
            1553-1702           AL589765.19        29520-29669         c
            1703-1768           AL589765.19        29044-29109         c
            1769-1906           AL589765.19        28599-28736         c
            1907-2050           AL589765.19        28197-28340         c
            2051-2188           AL589765.19        27406-27543         c
            2189-2533           AL589765.19        25479-25823         c
            2534-2891           KF455029.1         1-358
            2892-5579           AL589765.19        22433-25120         c
FEATURES             Location/Qualifiers
     source          1..5579
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..5579
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="CUGBP Elav-like family member 3"
                     /db_xref="GeneID:11189"
                     /db_xref="HGNC:HGNC:11967"
                     /db_xref="MIM:612678"
     exon            1..928
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             784..2178
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="isoform 5 is encoded by transcript variant 5;
                     expanded repeat domain, CAG/CTG 4; CAG repeat domain;
                     trinucleotide repeat containing 4; CUG-BP- and ETR-3-like
                     factor 3; CAG repeat protein 4; bruno-like protein 1;
                     RNA-binding protein BRUNOL-1; ELAV-type RNA-binding
                     protein 1; expanded repeat domain protein CAG/CTG 4;
                     trinucleotide repeat-containing gene 4 protein"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 3 isoform 5"
                     /protein_id="NP_001278036.1"
                     /db_xref="GeneID:11189"
                     /db_xref="HGNC:HGNC:11967"
                     /db_xref="MIM:612678"
                     /translation="MKEPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYT
                     GLHKGCAFLTYCARDSALKAQSALHEQKTLPGMNRPIQVKPADSESRGDRKLFVGMLG
                     KQQTDEDVRKMFEPFGTIDECTVLRGPDGTSKGCAFVKFQTHAEAQAAINTLHSSRTL
                     PGASSSLVVKFADTEKERGLRRMQQVATQLGMFSPIALQFGAYSAYTQALMQQQAALV
                     AAHSAYLSPMATMAAVQMQHMAAINANGLIATPITPSSGTSTPPAIAATPVSAIPAAL
                     GVNGYSPVPTQPTGQPAPDALYPNGVHPYPAQSPAAPVDPLQQAYAGMQHYTAAYPAA
                     YSLVAPAFPQPPALVAQQPPPPPQQQQQQQQQQQQQQQREGPDGCNIFIYHLPQEFTD
                     SEILQMFVPFGHVISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRL
                     KVQLKRPKDANRPY"
     exon            929..1011
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1060
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1186
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1266
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1410
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1552
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1702
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1768
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1906
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1907..2050
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2188
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..5579
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3214..3219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="hexamer: AAGAAA"
     polyA_site      3233
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="major polyA site"
     regulatory      5552..5557
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
                     /note="hexamer: AATAAA"
     polyA_site      5579
                     /gene="CELF3"
                     /gene_synonym="BRUNOL1; CAGH4; ERDA4; ETR-1; TNRC4"
ORIGIN      
        1 ggtttttgtt gaggagagcg cggccggaga gcagagctcc gggacccagg tgaccgggaa
       61 agcaggcagc cccagcggcg ggagcagccg gcagcagccc aggcccgggg actggggtgg
      121 gggtgggagg ggggctgagg ggaggacctg aaggggggcg gcagggcaaa agggacccct
      181 ggagccctgc cgccatcaga gatcaagcat ctggcatcag ggatcttcgg acccagcaga
      241 aggatccgcc acaggggagg tgtcctccca gggaagccaa cgagagattc acctgcccca
      301 catcaggagt gggcccccct tactgacgct gctggcaacc atagcaggcc ccttaacccc
      361 tcagtctcct ccccatcacc ctcctcaggc cctttccccg cctccagctc tcatctcaac
      421 tcccagttcc cagccctcta agccctagca cccccggcta ccacctaacc ctccaggtct
      481 tggccatact cacccccatc ctgggacatt tgccagatct ctgggaggga gatcgtttgt
      541 ttaggcgatg ccccctggtg gcatgacagc gtctgcctag acccctgacc cctagcactc
      601 aactccctgg gcctcctttg tgtgaagagc cgcccctctg cttagcagcg tggttggggg
      661 ccaaagggaa agccagcccc agctgggccc ccgggcccca ccacttatct ccttgctggg
      721 cagctcccct tggcctttgg gcctctccct gctcccctcg gcccctcctc ctgggccgcc
      781 tcaatgaagg agccggatgc catcaagctg tttgtggggc agatcccgag gcatctggag
      841 gagaaggacc tgaagcccat cttcgaacag tttggtcgga tctttgagct gactgtcatc
      901 aaggacaagt acaccgggct gcacaaggga tgtgccttcc tgacatactg tgcccgggat
      961 tcagccctga aggcccagag cgccctgcac gaacagaaga cgcttccagg gatgaacagg
     1021 ccgatccagg tcaagccagc cgacagcgag agccgaggag accggaagct ctttgtgggg
     1081 atgctaggga agcagcagac agatgaggac gtccggaaga tgtttgagcc cttcgggacc
     1141 atcgacgagt gcactgtgct ccgggggcca gatggcacca gcaaaggctg cgccttcgtg
     1201 aagttccaga cccacgctga ggcccaggcg gccatcaaca cccttcacag cagccggacc
     1261 ctgccaggtg cctcgtccag cctggtggtg aagtttgctg acactgagaa ggagcgaggt
     1321 ctccgccgca tgcagcaggt ggccacccag ttgggcatgt tcagccccat cgccctccag
     1381 tttggagcct acagcgccta cacccaggcc ctgatgcagc agcaggcggc cctggtagcg
     1441 gctcacagtg cctacctcag ccccatggcc accatggctg ccgtgcagat gcagcacatg
     1501 gctgccatca atgccaatgg cctcatcgcc acccccatca ccccatcctc aggaaccagc
     1561 acccctcctg ccatcgctgc cacgcctgtc tctgccattc cggctgccct gggcgtcaac
     1621 ggctacagcc cggtgcccac ccagcccact gggcagcctg cccctgatgc tctgtatccc
     1681 aacggggttc acccctaccc agcccagagc cccgcggccc ccgtggaccc cctgcagcag
     1741 gcctacgcgg ggatgcagca ctacacagca gcctacccag cagcctacag cctggttgca
     1801 cctgcgttcc cgcagcctcc agccctggtc gcccagcagc ccccaccacc acctcaacag
     1861 cagcagcagc agcagcagca gcaacagcag cagcagcaaa gagaaggccc tgatggctgc
     1921 aacatcttca tctaccacct gccccaggag ttcactgact cagagatcct ccagatgttt
     1981 gtcccctttg gccacgtcat ctcagccaaa gtctttgttg accgagccac caatcaaagc
     2041 aaatgttttg gctttgtgag tttcgacaat ccggccagtg cccaggctgc catccaggcc
     2101 atgaatggct tccagatcgg catgaagcgc ctcaaagtcc agctaaagcg gcctaaggat
     2161 gccaaccggc cctactgagg gcccccaggt ctggagatcc cagaggaagg ggcgcctcac
     2221 accctcttcc cacgactggc cccggccctc tccgcacacc tgccctgggc cttgactggg
     2281 ttctggggca aacgctgctt cgtggccccc gggggcacaa gacaccggcc cctcccaccc
     2341 ccctgcctct ctgaagggcc atggctatgc ttccctggct ccaagggccc atttcctcct
     2401 agatgccctt ttggcctttg tgagggagcg aggaacaggc tcgaaggctc cggggtatct
     2461 gccttctgct gggctcctgt gacaggcctt ctgtacccag cgtttgtact tgcctccccc
     2521 aacagtgggc ctgttctacc cgtgcaggcc ccaggagagc cgcaggggcc tgccacacac
     2581 tcccagctca ccctcacccc agcctcttcc ccacattagg ggtttcttgg aagctggctc
     2641 tcactcccct ccaccctcag ctagaggtag gatatccctg attcctgggc tcccagccct
     2701 aaaactcact gcctccccca agggccccct ctaaggaggg tgtgggggag ccctgagggc
     2761 tgcctctctg ccagtcagcc acagagaccc tcctcctttc acgaggaaaa gaccttcccc
     2821 tgaaccccta aaaatgttta cagtctctgc tggttccctc tgtgtaaata ccactaccac
     2881 ccgtgcgtta tccagcccgc ccggcctggc ccggacgctg ccatctctct ttctgggagt
     2941 ttagacaatg ttgcccttgg atttttttct ctctcttaat ttctcccttt gctttggggg
     3001 gtaattgggt attgggagga ggggtgtggg gaggggtcaa ggggtttatt acctgatcat
     3061 tttctttagg aagaggtttt agggaaaaga aaatggggtg ggggtggggg tggtaagggg
     3121 agaccgggga gtcagtttca gacagttctc tatgcttaac ttatttattt attgcatttt
     3181 acttttaaag agttggtctt ttctgtctaa ataaagaaaa aagtttaaaa gcatcaaata
     3241 agagtcttgg aaggttgagg gtaggggatt gttccctacc cacactggga agggggaggg
     3301 aggtagagaa tgaggtttga gagagaaaat cccatcaggg aaggccgggc ccttgctttt
     3361 gagcagcatc caggccttgt tcatggcttc atgatcctgt ccttcagccc ttctttgggg
     3421 cttaattctg gaatgtcctg cagagttcgg cacaaggaga tctcccctgt cgggggctct
     3481 cccctgtatc cagctctgtc cctctgaagg ctgaggactt gcagtctcac atctggacct
     3541 ccatttctgc acagaggcca gtgtggatac tgggagccag ttgtgacacc accatttact
     3601 aaccactgct ccatatgtga ttctgttcca agtccttatt gtgcatttcc tcattttacc
     3661 tcctaacaac cttgtgaggc aggctatagt ttatttattt tacttattta ctttgaaaca
     3721 gggtctcact ctgtcactca agctggagtg tgatggtgag atcatagctc actgcaacct
     3781 tgaactcctg gttcagggga tcctcctgtc tcagcctccc aagtagttag gactataagc
     3841 ggctgcacca ccacgcccag ctcattttta aaaatggtgt ttttttttgt agacagggtc
     3901 ttgctatgtt gcccaggctg gtctcgaacc cctgggctca agcaaacctc ctgccttggc
     3961 ctcccgaagt gctcagatta caggcatgag ccaccacgcc cagcctaggt aggatataat
     4021 tttatagatg ggaaaaggag gcttggaagg ttaactaact tccctggagt cacaaagcca
     4081 gtaaggcatg gctgtaggag ttgaacccag tttgtcagat tccaaagccc atgatgttct
     4141 cttcttacct gttctttgac ctgaggcaaa gatcccaaga agtagcaagc aggcttagga
     4201 gtgagtcctt caggtagagg gtggactgca taagccctaa gtccctccac ttcctagatt
     4261 cttctctgtg agctgcttta gggcaggctc aggatcacac aggtgtcttc tttgacttca
     4321 tagaacatgt gcttctaggc tgctacccca ccctctgtct tcatcattag taagcagcac
     4381 cactaggtac ctactcaagc caaaacttgg attacaccct ttctctcatg tctcctcccc
     4441 aatccaactg caaagcccta ccaagtctac ctctaaagta ttcagctgat ttacttactc
     4501 atgtctctgc atctccacag ccatcaacac tgtccacgtc acattgctct catctgtctc
     4561 catgtttctt ttcctgctct cctacaattt gttctcccaa gaagccaaga gtcatctttt
     4621 aaaagttaat tcaccaacat ttactaccca gtctgctttg tccagcactg tatcctggtc
     4681 accctaaaca gtgccccaaa tattagacat tgcttagtaa ataagaaatg actgttggac
     4741 atctatactg gacttcccat ccatatctac atcatcatag ggccaatgct aaaactttct
     4801 cccataaagt cctgactcat atatttctat tttctagtca catagacaga aaacctcaag
     4861 agtttttagt actttcgcat aaactcaatg gtattaaatc atttaagatt tcacttccac
     4921 aaactttctc atatcatttc cctcttttca attatcactg cctacactta ttaactgagt
     4981 aatcatagca atttcctaat tggtccttct gtctatgttc tgaagcatca atctttctaa
     5041 actgcagcta ataaaaaaca aaacttctct gctgctgttt tttgttgttt ttcatagaac
     5101 acctcagcct ggcattcaag gctcttcgaa gccttacttt ccacttcatt cctacacata
     5161 cccaaataga actattcatt gttctctagg caagtttggt cccttttctc ccatgtcttt
     5221 tcattcccag ttactacagt gtctggcaca taacggctca ataaatgttt gttgaatgcc
     5281 ttcttgttga aatccttctc acactaaaac agttcacctt aaacactact ttcttcatga
     5341 aaatcttaac ggccctcatc cacaggtctt tctccttcct tttctagtcc ttatggcact
     5401 taaacctttc actgctgtgt atcatggcca tgcgtaagtg tctcattctt ctgtgagcct
     5461 gtaagctggc agaaatgttt ctttctttgc ttttgtgtct gttgcagtat ctcaaacaat
     5521 ctccccaccc cacccccaac agcagatacc taataaatgt ttgactttaa ccactgtaa
//
