LOCUS       NM_001326342            9406 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens CUGBP Elav-like family member 2 (CELF2), transcript
            variant 29, mRNA.
ACCESSION   NM_001326342
VERSION     NM_001326342.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9406)
  AUTHORS   Huang,P., Meng,L., Pang,J., Huang,H., Ma,J., He,L. and Lin,X.
  TITLE     miR-208a-3p regulated by circUQCRC2 suppresses
            ischemia/reperfusion-induced acute kidney injury by inhibiting
            CELF2-mediated tubular epithelial cell apoptosis, inflammation and
            ferroptosis
  JOURNAL   Shock 61 (6), 942-950 (2024)
   PUBMED   38664873
  REMARK    GeneRIF: miR-208a-3p regulated by circUQCRC2 suppresses
            ischemia/reperfusion-induced acute kidney injury by inhibiting
            CELF2-mediated tubular epithelial cell apoptosis, inflammation and
            ferroptosis.
REFERENCE   2  (bases 1 to 9406)
  AUTHORS   Li,J., Xian,L., Zhu,Z., Wang,Y., Zhang,W., Zheng,R., Xue,W. and
            Li,J.
  TITLE     Role of CELF2 in ferroptosis: Potential targets for cancer therapy
            (Review)
  JOURNAL   Int J Mol Med 52 (4) (2023)
   PUBMED   37594127
  REMARK    GeneRIF: Role of CELF2 in ferroptosis: Potential targets for cancer
            therapy (Review).
            Review article
REFERENCE   3  (bases 1 to 9406)
  AUTHORS   Tuo,H., Liu,R., Wang,Y., Yang,W. and Liu,Q.
  TITLE     Hypoxia-induced lncRNA MRVI1-AS1 accelerates hepatocellular
            carcinoma progression by recruiting RNA-binding protein CELF2 to
            stabilize SKA1 mRNA
  JOURNAL   World J Surg Oncol 21 (1), 111 (2023)
   PUBMED   36973749
  REMARK    GeneRIF: Hypoxia-induced lncRNA MRVI1-AS1 accelerates
            hepatocellular carcinoma progression by recruiting RNA-binding
            protein CELF2 to stabilize SKA1 mRNA.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9406)
  AUTHORS   Yang,Y., Cheng,Y., Mou,Y., Tang,X. and Mu,X.
  TITLE     Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses
            Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability
            via Interaction with CELF2
  JOURNAL   Crit Rev Eukaryot Gene Expr 33 (1), 67-77 (2022)
   PUBMED   36374812
  REMARK    GeneRIF: Natural Antisense Long Noncoding RNA HHIP-AS1 Suppresses
            Non-Small-Cell Lung Cancer Progression by Increasing HHIP Stability
            via Interaction with CELF2.
REFERENCE   5  (bases 1 to 9406)
  AUTHORS   Ramalingam,S., Natarajan,G., Schafer,C., Subramaniam,D., May,R.,
            Ramachandran,I., Queimado,L., Houchen,C.W. and Anant,S.
  TITLE     Novel intestinal splice variants of RNA-binding protein CUGBP2:
            isoform-specific effects on mitotic catastrophe
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 294 (4), G971-G981 (2008)
   PUBMED   18258790
  REMARK    GeneRIF: Data demonstrate that cells expressing CUGBP2 variant 1
            undergo apoptosis during mitosis, suggesting mitotic catastrophe.
REFERENCE   6  (bases 1 to 9406)
  AUTHORS   Li,D., Bachinski,L.L. and Roberts,R.
  TITLE     Genomic organization and isoform-specific tissue expression of
            human NAPOR (CUGBP2) as a candidate gene for familial
            arrhythmogenic right ventricular dysplasia
  JOURNAL   Genomics 74 (3), 396-401 (2001)
   PUBMED   11414768
REFERENCE   7  (bases 1 to 9406)
  AUTHORS   Good,P.J., Chen,Q., Warner,S.J. and Herring,D.C.
  TITLE     A family of human RNA-binding proteins related to the Drosophila
            Bruno translational regulator
  JOURNAL   J Biol Chem 275 (37), 28583-28592 (2000)
   PUBMED   10893231
REFERENCE   8  (bases 1 to 9406)
  AUTHORS   Choi,D.K., Ito,T., Tsukahara,F., Hirai,M. and Sakaki,Y.
  TITLE     Developmentally-regulated expression of mNapor encoding an
            apoptosis-induced ELAV-type RNA binding protein
  JOURNAL   Gene 237 (1), 135-142 (1999)
   PUBMED   10524244
REFERENCE   9  (bases 1 to 9406)
  AUTHORS   Lu,X., Timchenko,N.A. and Timchenko,L.T.
  TITLE     Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG
            repeats expanded in myotonic dystrophy
  JOURNAL   Hum Mol Genet 8 (1), 53-60 (1999)
   PUBMED   9887331
REFERENCE   10 (bases 1 to 9406)
  AUTHORS   Hwang,D.M., Hwang,W.S. and Liew,C.C.
  TITLE     Single pass sequencing of a unidirectional human fetal heart cDNA
            library to discover novel genes of the cardiovascular system
  JOURNAL   J Mol Cell Cardiol 26 (10), 1329-1333 (1994)
   PUBMED   7869393
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL162408.8, AL136320.7,
            AL157704.10, AC026887.9 and KF573678.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001326342.1.
            
            Summary: Members of the CELF/BRUNOL protein family contain two
            N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM
            domain, and a divergent segment of 160-230 aa between the second
            and third RRM domains. Members of this protein family regulate
            pre-mRNA alternative splicing and may also be involved in mRNA
            editing, and translation. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.94881.1,
                                           SRR1803616.190052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000633077.2/ ENSP00000488690.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-292               AL162408.8         7386-7677
            293-489             AL136320.7         28395-28591
            490-572             AL157704.10        26783-26865
            573-621             AC026887.9         180373-180421       c
            622-756             AC026887.9         171702-171836       c
            757-836             AC026887.9         162897-162976       c
            837-995             AC026887.9         158750-158908       c
            996-1059            AC026887.9         154454-154517       c
            1060-1194           AC026887.9         141022-141156       c
            1195-1314           AC026887.9         115316-115435       c
            1315-1512           AC026887.9         108188-108385       c
            1513-1656           AC026887.9         103595-103738       c
            1657-5147           AC026887.9         97158-100648        c
            5148-5493           KF573678.1         1-346               c
            5494-9406           AC026887.9         92863-96775         c
FEATURES             Location/Qualifiers
     source          1..9406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p14"
     gene            1..9406
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /note="CUGBP Elav-like family member 2"
                     /db_xref="GeneID:10659"
                     /db_xref="HGNC:HGNC:2550"
                     /db_xref="MIM:602538"
     exon            1..292
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             219..1784
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /note="isoform 2 is encoded by transcript variant 29;
                     ELAV-type RNA-binding protein 3; CUG-BP- and ETR-3-like
                     factor 2; neuroblastoma apoptosis-related RNA-binding
                     protein; bruno-like protein 3; RNA-binding protein
                     BRUNOL-3; CUG triplet repeat RNA-binding protein 2;
                     KDM2B/CELF2 fusion"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 2 isoform 2"
                     /protein_id="NP_001313271.1"
                     /db_xref="CCDS:CCDS44355.1"
                     /db_xref="GeneID:10659"
                     /db_xref="HGNC:HGNC:2550"
                     /db_xref="MIM:602538"
                     /translation="MTSAFKLDFLPDMMVEGRLLVPDRINGTANKMNGALDHSDQPDP
                     DAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKA
                     ALEAQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFS
                     PFGQIEECRILRGPDGLSRGCAFVTFSTRAMAQNAIKAMHQSQTMEGCSSPIVVKFAD
                     TQKDKEQRRLQQQLAQQMQQLNTATWGNLTGLGGLTPQYLALLQQATSSSNLGAFSGI
                     QQMAGMNALQLQNLATLAAAAAAAQTSATSTNANPLSTTSSALGALTSPVAASTPNST
                     AGAAMNSLTSLGTLQGLAGATVGLNNINALAVAQMLSGMAALNGGLGATGLTNGTAGT
                     MDALTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQ
                     DILQMFMPFGNVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLK
                     VQLKRSKNDSKPY"
     exon            293..489
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            490..572
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            573..621
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            622..756
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            757..836
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            837..995
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1059
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1194
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1314
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1512
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1656
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..9406
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7070..7075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /note="hexamer: ATTAAA"
     polyA_site      7089
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /note="major polyA site"
     regulatory      9229..9234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /note="hexamer: AATAAA"
     polyA_site      9247
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /note="major polyA site"
     regulatory      9383..9388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /note="hexamer: AATAAA"
     polyA_site      9406
                     /gene="CELF2"
                     /gene_synonym="BRUNOL3; CELF-2; CUG-BP2; CUGBP2; DEE97;
                     ETR-3; ETR3; NAPOR"
                     /note="major polyA site"
ORIGIN      
        1 gcccccgccc gccgcacctg gcgctcggca gccggccgcc ccggcgctgg atttcggagg
       61 ggattggcgg agcgcgagga gagaatgtga caagtgccgg ctcggcggcc gccgggggag
      121 gccgcgcgca cctgtccctg cccgtctcgc gccgcccgcg gccgctcgga cgcgcgcaga
      181 gccgcccccc gccgctgccg ccgcgtgcgc ccgcgaacat gacttctgcc ttcaagctgg
      241 atttcctccc ggacatgatg gtcgagggcc gcctgctcgt tcctgacaga attaacggca
      301 cagccaacaa gatgaacgga gctttggatc actcagacca accagaccca gatgccatta
      361 agatgtttgt cggacagatc ccccggtcat ggtcggaaaa ggagctgaaa gaactttttg
      421 agccttacgg agccgtctac cagatcaacg tcctccggga ccggagtcag aaccctccgc
      481 agagtaaagg ttgttgtttc gtaacatttt atacaagaaa agctgcactt gaggcccaga
      541 atgcactgca caatattaaa actttacctg ggatgcatca tcccattcag atgaaacctg
      601 cagatagtga aaagtccaac gctgtggaag acagaaaatt gttcatagga atggtatcga
      661 agaaatgtaa tgagaacgac atcagggtga tgttctctcc atttggccag atagaagaat
      721 gccggatcct ccggggacct gatgggctga gtcgaggctg tgcgtttgtc acattttcta
      781 caagggcaat ggcacagaat gcaatcaaag ccatgcatca gtctcagacc atggagggct
      841 gctcttcacc tatcgtggtg aagtttgctg acactcagaa ggacaaagag caaaggcgcc
      901 tccagcagca gctcgctcag cagatgcagc agctcaacac tgccacctgg gggaacctga
      961 cagggctggg cggactgacc ccacagtatc tggcgctcct gcagcaggcc acctcctcca
     1021 gcaacctggg tgcgttcagc ggcattcaac aaatggcagg catgaatgct ttacagttgc
     1081 agaacctggc gacgctggct gctgctgcag ctgcggccca gacctcagcc accagcacca
     1141 atgcaaaccc tctctctacc acgagcagcg ccctgggagc cctcacgagt cccgtggctg
     1201 cttcaacccc caactccact gctggtgcag ccatgaactc cttgacctct ctcgggactc
     1261 tgcaaggact ggctggagcc actgttggac tgaataatat taatgcacta gcagttgctc
     1321 aaatgctctc aggtatggcg gctctgaatg gaggacttgg cgccacaggc ttgacgaatg
     1381 gcacggctgg caccatggac gccctcaccc aggcctactc aggaattcaa cagtacgcag
     1441 ccgccgcgct gcccactctg tacagccaga gcctgctgca gcagcagagc gctgcaggca
     1501 gccagaagga aggtccagag ggggcaaacc tctttattta ccaccttcca caggaatttg
     1561 gagaccagga cattctgcag atgttcatgc cttttggaaa tgttatctct gctaaagtct
     1621 tcattgacaa acagaccaat ctgagcaagt gctttggttt tgttagctac gacaatccag
     1681 tctctgcaca agctgctatc caagctatga atggctttca gatcggcatg aaacgcttga
     1741 aggtgcagct gaagcgttcc aaaaacgaca gcaaacctta ctgatcctaa ccccagaggc
     1801 tccctgctct cattttagct ttcttagggt aagtcccacg agccagcctg tctcaacagg
     1861 gaaggcagag gaggaccaca ttgccaactt ttaccaagag agacggttat ttttacaata
     1921 aggcctccat gtccccaccc acttccccta cccagtttgc cataattaaa acttgggcta
     1981 ctttgtttct attgagtaat tcctcctcca gttgtgccac tgtattctcc tttgttttgc
     2041 gatttgaatc tccttttacc ttttttttta atttttttca tttttgcttt tttttaaaga
     2101 gaagcatata cacaaataaa tggcatcttg agaatttaaa aggcaaacaa acaaacgcta
     2161 atgtgcaatt ctaactctga aaccactggt gccccgagag cactgcctgg agaattcacc
     2221 cctccttgcc cggcgcccgc ccccggaggg agggcccggt gcttagaggt taacttggtg
     2281 gcctaggaga gggagaagcc aggagaagca cttactccaa ccacacgtct ttccactaca
     2341 tcggcttgtt ttactaagta ggattttatt ttagggttca aagaaacatg acatttattg
     2401 gtcaaaatat tacactggtt gtctattttg ttattgtttt attttagttt ttagaaagga
     2461 ttaatgtaca aaaagattta gagatctgtt tcttaaagct acagggttta aaaaataaaa
     2521 atgagtgaaa atacttgatg tttcttgaaa gataaattta ataataataa ataaatacat
     2581 aaatacataa ataaaaaaga aagccacagg cctgtaaatt ttatttgtaa aaaagcattt
     2641 ctatttttat acaaaatttt tactgcctca gaaataatgg aagttattta ttgcctattg
     2701 ttaacttatt gggtacctaa agagcagttc tctgtctagc tagaaccttc tgaagtagtc
     2761 tctagaggaa ttgttctagg aatgggcttt ttttcaccgt tgaaccctag acctgaagtt
     2821 catgctttat cctctcgttg tttgtatctg tctgattatt ttgtttgtaa cttccattat
     2881 ctagtttaca gttcagtcgt ctgactttcc ccgtatgtca catttgttga aactggacct
     2941 tctccccctg tccctcaccc caaaacaccc ggaatccatc ccgtttcgct ctctccagat
     3001 ggattctctt ggggtttcat tgtgctgtgg ataaggagtg taagaaatgc aaattatgtg
     3061 aatggctcgg agactcccta atgacctaag atttgcatta gtttttctcc tgcaccctta
     3121 aaagtgattt tgttgccgct gcatagattc tgtgtaactt tttactcttc cttgtttttt
     3181 ccctagacat cttcatgccc gttagttcat cgtttgccta gcatgtccct gtggcgtctc
     3241 aaaaaaaagt ttcatcgtcc cgtcattgtt tctgatgtct ttctgacctc acatcatatt
     3301 tggttctcct actgaccttt gatctagttt gacctttgaa atttgcatgt gacctcatct
     3361 agctatgaat tctgggaagt caatgtgaaa aacattgctg cattcatgca agactgaaat
     3421 ttattattag acaaattcat tatagaaaaa acctgtggca aaaacgtttc tttcttattt
     3481 tttttctttt cctaaaacag acttgaaagt attatacagg gattggcatt cttcccggtc
     3541 actggtaaca atagcaatat gtgtccaggg acacagaatg ttggtttcta acagactact
     3601 tccaaaaaca gtttgagaaa aaaactgtct gattttaagt ctctagaggt ctgtaatagt
     3661 ttttacattt ttcaggcagt gtaaagtttt ttgataaggc cattttaggt ggctcacttt
     3721 ctcattaaga tatatatata gaaccacttt ttgtagatta gtataagaaa aatatttacc
     3781 ctgttttggg gcaaatgcta cctatttgtg tcaccttttg ctgaactcac agttagacaa
     3841 tccatggttt aatgcacatg aaattaccta tattttatac tgtttcaatg tacaggagaa
     3901 aggttactgt aaactgtgtt atgttggtgc ttctgtgaat taagttgtgg tttcatcatg
     3961 agtcttaatg ttctttgttg ataagacaag tttagaattg gtttacttaa tacaaaaaaa
     4021 aaaaaaagaa tttcaaaaaa aaaagttgtt tgcttaaaaa aaatttcatg tgagggaaaa
     4081 aaaaaaaacc tattccagaa taagttttgt gttggcttgt gaagcattga tgtcattttt
     4141 tttaattgtg gactatttag atgtgtttgt gttcagcaaa atgtgatgtt tttttctttt
     4201 aaagaaaaaa agtgaaaata tatagtgcca aattccaaag gtacttcctt cctagagctt
     4261 cagtgtgttt cttgtgagaa gtaatttgat aacatgggta ttttattatg tgttttgtat
     4321 aaatccctaa tatttaaaaa aaaaaacaaa acaaaaaaag gttacaaagt ttgttaactt
     4381 gctatcctgt ggtcttgttg cctgaaattg ttattgtttg ttatttctct ctgatgtttt
     4441 ttgtaagaca ttgtataagt gcccatgtcc cactttttta accactccgc acatcagtgc
     4501 tgtgaaggca acctcaccat gtattttctt cataatctat ggaaacctct aaggtgagaa
     4561 agttttgaac ttttaaccct ttctacccag agctatctgg aatgttgatg actttttata
     4621 ctgtcatgat ttgagtttgt tttggggtgt ttccaatttg gatttttttc cctgcatcta
     4681 tcctctaagt tgtttcggtt tgactacttt gttctttggt taagatccaa aagaaaacag
     4741 aaaacaattc cacgaggcca atctaaaggg aaaaaatcct acactacttt tactactttt
     4801 gattatttct catttttggg aaaagaattc ctaatgtgct actagaattc cttcttcagt
     4861 tttaacgagt aattggataa accctgaggg aaaacggagg tagattcagc acctaacaat
     4921 cctgtatgct tttgagatca cgtttagtgc tatgtcctag tctagaatat tttcatatac
     4981 cttgcagtaa aacgactttg tggcaggaca gtctcttgag gggttttgtt tctgtttcct
     5041 aaatactcct aaataatatt tctaatcagc cattatgctg gggcatctct gatcccagta
     5101 ggtacctctg aatataccag gtgtctggag ttagaagccc atagcccttt cccagccttt
     5161 ttggtttttt taattgaaca catttcatct aagtaaagct cagttcttta tcacaattta
     5221 ctgaccaaat acctagcacc agttcctgct gccacttttt aaagtgccat atgactttct
     5281 acgaacaggt accttgctgt cttgacaaat cctaatgtca cgcctacagc cccaacacaa
     5341 gctccagtct tcctcttcgg catgccctgg aagcttcttg gcctcagctc cccttccccg
     5401 ctcagcaccc tgttaggatc agtgtgtgtg gatgggatag ccctgggatg gaaaggacta
     5461 gcctctactg atgcaaaaaa acaaaaagca acacaaacgt ttccttctta tagcacatgc
     5521 acttccttac aatgacatga tttgtattat cctcacatgt gtttactact gctggggcct
     5581 tccttcatcc tctgagggct attttgtact ttctgcagca atcagcttaa taacaacact
     5641 tattgcacct gtctctctct gagaacacgg tgtgtctcga cacgtaccac gtacgtggaa
     5701 acacaagagc ccaccacttg aatttctaag accatttcat tctgaaactt cttatcaatt
     5761 acctaaatct caacgaaaaa caatttactg aagccgactc ccctccccat ctccctctca
     5821 acctcaaccc acctgcatgc atctccccca gaggaaacac tgagggtagg ggacaggagg
     5881 ctcaggacgc gccctctgaa tcgagtgttt cttcttcaca agtcaccaag agaggacatg
     5941 agggggaaag tcctttttgc ccttctccaa aaaataacct tccacagaga caaactgtcc
     6001 ttctatccac ttttatcttt taataaatat caaaaggaaa aagctgcaag ggtgcaaagg
     6061 gcctgtgcca gaagaaaaca cacacaggga aaccgctttt tttaatcaat tgtagagaat
     6121 agtcattttt aatctaaatt agagaattgt gatacaatgg cagtcctcaa aggcgtaacg
     6181 agttcatctt tctttcacca taggggttat agttggcttg tgctactctg gaatcatttt
     6241 actgtttgtt tttattatct taagtgctaa ttaaaaaaaa aataaaattt taaaaaaacc
     6301 tgtagtttca ttaccttttt gaataatgtc atacaaaaaa tgtatttgtt tttttgtgct
     6361 gtgagaattg atgtttgtag attaataatc attttgttta gaattacaaa atagttttta
     6421 aatattgtct gagaaaagcc aaagttaatg caacctagtg gaaactgtaa gaccatttga
     6481 gtattgtttg ttttattgat gcatttggat tttgttgttt gatggaattt gagccaaaaa
     6541 aaaaatacgc aggctttcct atttctacaa ctgattgtac ttatgcattt tgtaccagtg
     6601 gaacttttta tactggagat taaaaaaaaa atggaaattt ttgtggcttg ctctggtggg
     6661 cccctgacaa tgactgattt caagtttgat ttcgggttga ttgattgatt gattgataga
     6721 aagaaagttg cttttctttt gagaattaaa aactttggct tgatttcttt tttccctttg
     6781 cttatatcta gcattagaat tttgtcttaa aataacagcg gtaagtttca ctttttattc
     6841 tgtattgtgc agttacacaa taaggtaatt agatttagaa gtactcagtc actttaagtg
     6901 gataaatgta ttagttaaaa ctttagggtt tgcttttttg ctgtttagat caaagttttt
     6961 tctgattctt ctgtcctcat tgtgaacata accgtgtagt tgaaacagtc aaacttattt
     7021 ttgtaatgta tgttattgtg tgatgcagtt ttttgcttct gtctccaata ttaaaccatt
     7081 ttcctaatac ttgtttctct ctctgcgtgt tgtattgttg gtagtcatta tatgttggtg
     7141 atacatctgc acacctcact gtttcacgta tctgtttttt tctctatgtt gtgtaaaaag
     7201 atacagtcga ttccacttaa gtgaatatct gatttgggga agaggaaact gcacagcagc
     7261 cacctttgat ttatgtacaa ccgcccactt gaactcctgc ttccaagatt tatacacttt
     7321 tttcctacag ttcacctcag taactgcctt tggggttgga tttgccaagg tgttttacgg
     7381 tcttttgacc acacaggtta atttcccctt ctctcccctc cctcatgagt ctatccacgc
     7441 agttcttaac atacattcca aactgctgcg gggtttcctc tccacaccca cgaggccaaa
     7501 cccgcatcat tacagtccaa ctcttcttag acactaatca ctttctaaaa gaagtgagtt
     7561 ctccagggaa gaaaaatcaa cttagccagt gaaaagggtt aaacttaagt ctattatttg
     7621 ttgccctcaa tcaaaagata tgtatagaaa agtcatttaa attatttatt tctacaagct
     7681 aattgaatcc aggagcagct ttaattatta acactaacgg aagagaaaag aagtatttcc
     7741 aagggctcaa atggaagctg tactcagtcc ggtggaggca gggggaggta aagtttctca
     7801 cactcaagtc gtcttcatag tttactgtcc ttttccaaac aaaagctaat aacgccatac
     7861 gcatccacac actccctcct ggatgaacct aagtctcgtc cccactgtca ccccaaggcc
     7921 agttatcaaa aactgttcct tctctgccct caaagactga agccgcaggc cctgttctgc
     7981 ctctgctcag gaatctgatt gctcttaaag tgctcttaca agattccgtc gatgtttgct
     8041 ccctctgtct tatctctcct tccagtattt tcagacgcac aagctctgac tcaggccacc
     8101 cagcacctgg cagccttcct ctgcgtgcca gtgaaatctc tcccagtagg tgctcaggct
     8161 cttcaccctc tcgttgcagc agcccctctg gcccgagatt gtattttcta gtctgctcaa
     8221 gaacagaggg gcctggcgag gtggaggaag ggaggctccc tccccggggc tggccgcctc
     8281 agtgatggtg atgccaccag ctccagcctg cacggatgga gctcacttcc taccatcact
     8341 tctgctttca gtctcctcat agccttcggc agtctcctct gaaaacacac tgcctacgtt
     8401 agtgggaaag gatggctaag ggtgtgattt ctttttatta gggaggtggg agggggatgt
     8461 tgggaggcat ggggggtgat taaattatca tttccaaggt gcaagtgttt atttttcaaa
     8521 tctataagta catagttcca ccattttggc acaagacaaa atactcatgc taagcaaagg
     8581 aagagaaaga caaagccagt ttttgttgct tttctaaagc aacaaataat tctccaaaga
     8641 aggggatgaa aatgctagtt cctttaagca cttactgact gtaaagttgg tccctgctta
     8701 aattcatacc catagttttg agtcggtatg acaccactgc agtgtgagca aggtgaatcc
     8761 gtgtgccatg catggaccac cttgggatac cgcagcacca tcaacatccg ccttgctgat
     8821 ggaagccaca cacgctgccc agcccacagc agtcgcacgc agccgatggg ctcggactct
     8881 tagctggcag gctaggacac acagtgaaca ttaatgtact gtgaatcgtt cctgataagt
     8941 gaataaaaca ttgtgaccaa acaatcagct tattcactta tcaggaatcg actgttctgc
     9001 taatttgctg ttgttgtttt tcatctctgt tgtagttcac tatttttgct gtgttctgtt
     9061 ttctcctctc atgcttgggc aaatcactgg gaatattatc ttcatgtgac catgaaacgt
     9121 ttctattgag tgaaaatgat atcttaacaa aatctatgca cttgctatca ggaacacaat
     9181 actggatgtg tcttatatat attgaactat atagtactcg atttcttaaa taaagcttaa
     9241 gaaaggactc tgttgtgtgt aaagttaatg tgattatttt tcaaagcagt gtttctaagg
     9301 ggtatttttg ttcttttaag tcttgagtga tacaggatat ttttcattaa aattatatca
     9361 ctggctttat gacttaatat tcaataaatt gactttggaa acaaaa
//
