LOCUS       NM_001376430            7929 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens CUGBP Elav-like family member 1 (CELF1), transcript
            variant 58, mRNA.
ACCESSION   NM_001376430
VERSION     NM_001376430.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7929)
  AUTHORS   Kikuchi,M., Viet,J., Nagata,K., Sato,M., David,G., Audic,Y.,
            Silverman,M.A., Yamamoto,M., Akatsu,H., Hashizume,Y., Takeda,S.,
            Akamine,S., Miyamoto,T., Uozumi,R., Gotoh,S., Mori,K., Ikeda,M.,
            Paillard,L. and Morihara,T.
  TITLE     Gene-gene functional relationships in Alzheimer's disease: CELF1
            regulates KLC1 alternative splicing
  JOURNAL   Biochem Biophys Res Commun 721, 150025 (2024)
   PUBMED   38768546
  REMARK    GeneRIF: Gene-gene functional relationships in Alzheimer's disease:
            CELF1 regulates KLC1 alternative splicing.
REFERENCE   2  (bases 1 to 7929)
  AUTHORS   David,G., Reboutier,D., Deschamps,S., Mereau,A., Taylor,W.,
            Padilla-Parra,S., Tramier,M., Audic,Y. and Paillard,L.
  TITLE     The RNA-binding proteins CELF1 and ELAVL1 cooperatively control the
            alternative splicing of CD44
  JOURNAL   Biochem Biophys Res Commun 626, 79-84 (2022)
   PUBMED   35973378
  REMARK    GeneRIF: The RNA-binding proteins CELF1 and ELAVL1 cooperatively
            control the alternative splicing of CD44.
REFERENCE   3  (bases 1 to 7929)
  AUTHORS   Zhao,X., Wang,J., Zhu,R., Zhang,J. and Zhang,Y.
  TITLE     DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin
            resistance of lung squamous cell carcinoma through modulating
            miR-181a-5p/miR-382-5p/CELF1 axis
  JOURNAL   Sci Rep 11 (1), 21014 (2021)
   PUBMED   34697393
  REMARK    GeneRIF: DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin
            resistance of lung squamous cell carcinoma through modulating
            miR-181a-5p/miR-382-5p/CELF1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7929)
  AUTHORS   Liu,C., Wang,H., Tang,L., Huang,H., Xu,M., Lin,Y., Zhou,L., Ho,L.,
            Lu,J. and Ai,X.
  TITLE     LncRNA BACE1-AS enhances the invasive and metastatic capacity of
            hepatocellular carcinoma cells through mediating miR-377-3p/CELF1
            axis
  JOURNAL   Life Sci 275, 119288 (2021)
   PUBMED   33667514
  REMARK    GeneRIF: LncRNA BACE1-AS enhances the invasive and metastatic
            capacity of hepatocellular carcinoma cells through mediating
            miR-377-3p/CELF1 axis.
REFERENCE   5  (bases 1 to 7929)
  AUTHORS   Jin,H., Liang,G., Yang,L., Liu,L., Wang,B. and Yan,F.
  TITLE     SP1-induced AFAP1-AS1 contributes to proliferation and invasion by
            regulating miR-497-5p/CELF1 pathway in nasopharyngeal carcinoma
  JOURNAL   Hum Cell 34 (2), 491-501 (2021)
   PUBMED   33400247
  REMARK    GeneRIF: SP1-induced AFAP1-AS1 contributes to proliferation and
            invasion by regulating miR-497-5p/CELF1 pathway in nasopharyngeal
            carcinoma.
REFERENCE   6  (bases 1 to 7929)
  AUTHORS   Michalowski,S., Miller,J.W., Urbinati,C.R., Paliouras,M.,
            Swanson,M.S. and Griffith,J.
  TITLE     Visualization of double-stranded RNAs from the myotonic dystrophy
            protein kinase gene and interactions with CUG-binding protein
  JOURNAL   Nucleic Acids Res 27 (17), 3534-3542 (1999)
   PUBMED   10446244
REFERENCE   7  (bases 1 to 7929)
  AUTHORS   Roberts,R., Timchenko,N.A., Miller,J.W., Reddy,S., Caskey,C.T.,
            Swanson,M.S. and Timchenko,L.T.
  TITLE     Altered phosphorylation and intracellular distribution of a (CUG)n
            triplet repeat RNA-binding protein in patients with myotonic
            dystrophy and in myotonin protein kinase knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 13221-13226 (1997)
   PUBMED   9371827
REFERENCE   8  (bases 1 to 7929)
  AUTHORS   Timchenko,L.T., Miller,J.W., Timchenko,N.A., DeVore,D.R.,
            Datar,K.V., Lin,L., Roberts,R., Caskey,C.T. and Swanson,M.S.
  TITLE     Identification of a (CUG)n triplet repeat RNA-binding protein and
            its expression in myotonic dystrophy
  JOURNAL   Nucleic Acids Res 24 (22), 4407-4414 (1996)
   PUBMED   8948631
REFERENCE   9  (bases 1 to 7929)
  AUTHORS   Bhagavati,S., Ghatpande,A. and Leung,B.
  TITLE     Identification of two nuclear proteins which bind to RNA CUG
            repeats: significance for myotonic dystrophy
  JOURNAL   Biochem Biophys Res Commun 228 (1), 55-62 (1996)
   PUBMED   8912635
  REMARK    Erratum:[Biochem Biophys Res Commun. 2008 Jun;370(3):530. Bhagwati,
            S [corrected to Bhagavati, S]]
REFERENCE   10 (bases 1 to 7929)
  AUTHORS   Timchenko,L.T., Timchenko,N.A., Caskey,C.T. and Roberts,R.
  TITLE     Novel proteins with binding specificity for DNA CTG repeats and RNA
            CUG repeats: implications for myotonic dystrophy
  JOURNAL   Hum Mol Genet 5 (1), 115-121 (1996)
   PUBMED   8789448
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090559.7.
            
            Summary: Members of the CELF/BRUNOL protein family contain two
            N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM
            domain, and a divergent segment of 160-230 aa between the second
            and third RRM domains. Members of this protein family regulate
            pre-mRNA alternative splicing and may also be involved in mRNA
            editing, and translation. This gene may play a role in myotonic
            dystrophy type 1 (DM1) via interactions with the dystrophia
            myotonica-protein kinase (DMPK) gene. Alternative splicing results
            in multiple transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.267865.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-181               AC090559.7         148997-149177       c
            182-253             AC090559.7         125334-125405       c
            254-441             AC090559.7         113310-113497       c
            442-524             AC090559.7         111632-111714       c
            525-573             AC090559.7         111223-111271       c
            574-708             AC090559.7         108862-108996       c
            709-788             AC090559.7         107926-108005       c
            789-950             AC090559.7         107168-107329       c
            951-1026            AC090559.7         103350-103425       c
            1027-1155           AC090559.7         101770-101898       c
            1156-1266           AC090559.7         101319-101429       c
            1267-1452           AC090559.7         99809-99994         c
            1453-1596           AC090559.7         97561-97704         c
            1597-1763           AC090559.7         96664-96830         c
            1764-7929           AC090559.7         90410-96575         c
FEATURES             Location/Qualifiers
     source          1..7929
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..7929
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /note="CUGBP Elav-like family member 1"
                     /db_xref="GeneID:10658"
                     /db_xref="HGNC:HGNC:2549"
                     /db_xref="MIM:601074"
     exon            1..181
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            182..253
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            254..441
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             264..1724
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /note="isoform 3 is encoded by transcript variant 58; CUG
                     RNA-binding protein; embryo deadenylation element binding
                     protein; nuclear polyadenylated RNA-binding protein,
                     50-kD; bruno-like 2; CUG-BP- and ETR-3-like factor 1;
                     EDEN-BP homolog; bruno-like protein 2; deadenylation
                     factor CUG-BP; RNA-binding protein BRUNOL-2; CUG triplet
                     repeat RNA-binding protein 1; 50 kDa nuclear
                     polyadenylated RNA-binding protein; embryo deadenylation
                     element-binding protein homolog"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 1 isoform 3"
                     /protein_id="NP_001363359.1"
                     /db_xref="CCDS:CCDS31482.1"
                     /db_xref="GeneID:10658"
                     /db_xref="HGNC:HGNC:2549"
                     /db_xref="MIM:601074"
                     /translation="MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYE
                     INVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKN
                     NAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAM
                     AQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLA
                     GLNTLGPQYLALYLQLLQQTASSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQN
                     TPSGTNALTTSSSPLSVLTSSGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLA
                     GMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYNQNLLTQQSIGAAG
                     SQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYD
                     NPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY"
     exon            442..524
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            525..573
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            574..708
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            709..788
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            789..950
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1026
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1155
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1266
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1452
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1596
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1763
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..7929
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7910..7915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /note="hexamer: ATTAAA"
     polyA_site      7929
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /note="major polyA site"
ORIGIN      
        1 atatttgtac agcaacagca ggagcagccc actagctagg ccgtgtggcc accctttggc
       61 acccgcaccg gctcagacct gctcaggact cagccagggc acacagtttg tgttcttacg
      121 tgcatccatc tgtctgtctg tgtgcgtctc tgtggaggac tgaggttttc aagtgaaaga
      181 ggctgaacat aacttctttt tttcaaagtt ccctgtgttg tgaactgagc ttgggtgaag
      241 tgaaatcttt gagctcaaag aaaatgaacg gcaccctgga ccacccagac caaccagatc
      301 ttgatgctat caagatgttt gtgggccagg ttccaaggac ctggtctgaa aaggacttgc
      361 gggaactctt cgaacagtat ggtgctgtgt atgaaatcaa cgtcctaagg gataggagcc
      421 aaaacccgcc tcagagcaaa gggtgctgtt ttgttacatt ttacacccgt aaagctgcat
      481 tagaagctca gaatgctctt cacaacatga aagtcctccc agggatgcat caccctatac
      541 agatgaaacc tgctgacagt gagaagaaca atgcagtgga agacaggaag ctgtttattg
      601 gtatgatttc caagaagtgc actgaaaatg acatccgagt catgttctct tcgtttggac
      661 agattgaaga atgccggata ttgcggggac ctgatggcct gagccgaggt tgtgcatttg
      721 tgacttttac aacaagagcc atggcacaga cggctatcaa ggcaatgcac caagcacaga
      781 ccatggaggg ttgctcatca cccatggtgg taaaatttgc tgatacacag aaggacaaag
      841 aacagaagag aatggcccag cagctccagc agcagatgca gcaaatcagc gcagcatctg
      901 tgtggggaaa ccttgctggt ctaaatactc ttggacccca gtatttagca ctttatttgc
      961 agctccttca gcagactgcc tcctctggga acctcaacac cctgagcagc ctccacccaa
     1021 tgggagggtt gaatgcaatg cagttacaga atttggctgc actagctgct gcagctagtg
     1081 cagctcagaa cacaccaagt ggtaccaatg ctctcactac atccagcagt cccctcagcg
     1141 tgctcactag ttcagggtcc tcacctagct ctagcagcag taattctgtc aaccccatag
     1201 cctcacttgg agccctgcag acattagctg gagcaacggc tggcctcaat gttggctctt
     1261 tggcaggaat ggctgcttta aatggtggcc tgggcagcag tggcctttcc aatggcaccg
     1321 ggagcaccat ggaggccctc actcaggcct actcgggtat ccagcaatat gctgctgctg
     1381 cgctccccac tctgtacaac cagaatcttc tgacacagca gagtattggt gctgctggaa
     1441 gccagaagga aggtccagag ggagccaacc tgttcatcta ccacctgccc caggagtttg
     1501 gtgatcagga cctgctgcag atgtttatgc cctttgggaa tgtcgtgtct gccaaggttt
     1561 tcatagacaa gcagacaaac ctgagcaagt gttttggttt tgtaagttac gacaatcctg
     1621 tttcggccca agctgccatc cagtccatga acggctttca gattggcatg aagcggctta
     1681 aagtgcagct caaacgttcg aagaatgaca gcaagcccta ctgagcgtgc tcccctctga
     1741 gactggagtg agagggtctt ctggcacagc ttgccctgaa gactcggcta ctgccttctg
     1801 tgggagtttc gcttcgtaca gaggacaagt ttgtgctttg gtttccagtg ttttactttg
     1861 gagtttaggt gccatatcct gaggtttttt ttgtttttgt ttttgtttct cctttattta
     1921 aagtttgctg tgtttgtaac cagtgtgtgt tgagaaggac caacaccaaa ccaccctggg
     1981 gaagggggac agggaaacat ttaacacaga cgatgatcag gatttgcccc aaaccacccc
     2041 aagagagagg actgagtgga acaaaaaagt gacccccaga acctctctta gtgtgagggt
     2101 gggtagaatg agaactgaca cctgggagct gtggggagca gagcggcttt ggggaagagt
     2161 ggagtgacta gacacctaat gccctggcag ctggagactc aaactcctgt acagctacct
     2221 tctgggaaat agtttttgac acctattttt cagattcttg tccggaattt ctgctgctct
     2281 tttcaaaaaa gggcattaac aattctctgg aaataaagca cctgttagcc tgacatatgc
     2341 aaaaagcagg gcggcatcac ccattacgag ctcccccagc cagcagtcag tattggattg
     2401 gccttgcctg gctggtggca gtttgggaga aacagccaaa gaggttagtt tatttcaaca
     2461 ccaaattaga ccatggccca tttccaacgg gtctctttaa aggcctctat ggaatacatt
     2521 gcctggtttc cttctttgca gttcaccaca gcaaggaatg tcacctccat cccaagccac
     2581 cattttctca tgaaggcaaa tccaagaagg gcttgcagtt cttgctgaag ggggtaccat
     2641 ttgtgggcag agtgatcaat accatctagt tgggggagga ggagcttatt tcttggtgta
     2701 cttgaatcag aaggtccctg caagccagta tgcttcattt gccagtggcc agaaattctc
     2761 ccttgcctcc ttgattgagg tgtcccagat gtagtattcc cacaggggtc tggcaggccc
     2821 ctcctgtaac cactccagtc acattttctg ctcttgaggc agaggtgaca tcaggacgtt
     2881 tacagcctcc acatgaattg agtgttcatt tacctcagta ttaccgtgtt catttttgtc
     2941 ctcgtgctac agttagctcc ctgccgcctc ttgcaggtct tacttcagct cttgcctgtg
     3001 acccacacag cttctgggct ctgcctctgc tctaagaagt gctgtggggg tagagaacca
     3061 ggaaggacat gctgttggga atgtacacct gggcagaggt ggccctgtta agatgtgact
     3121 gtagccacag ccagggatgg gatccctggg tctctggaat ctgaaacctc aacaaatacc
     3181 agtcttgacc cctagcagca gagataagaa taaaggggtt ggtttgctat taagtcagat
     3241 gggggctctc tccttgtcat gctgtccctg tgggtaacag acagggattg accatcttac
     3301 tgttgtacag gtagctggtg gtgttggatt atcccattga agctgggaca gctgttcctt
     3361 tctcatagtg ataacttggg tctgttgtcc tctaaggaac gtgaaacata cacttcttaa
     3421 gctgaaccac gtaaacttga aattctgcgc actgggagaa atgtgtcctg tgtttcaaag
     3481 gataaaactg ttctaaaggc ttccagggtc atgatgggat tttttaaata aatgcaaaaa
     3541 ataaaaataa aaaagaaaaa agaaaacaaa aaaaaaaaag aaaaaaatgc taggttgggg
     3601 aggcgctgtt ctgaatccca accggctgga accaagaatg tcgtttctat ttttatagaa
     3661 gttttataca gctccggggt ggagaatatt tattacctaa attatatctc tggaaaaggc
     3721 caggattttg tagaatccag aatgtgattg ttatacacac agggtgctgt gtatgattga
     3781 aactactgac tttctgtggc ccgtttgcag cccagctaac ctgcccaagg ggaaggtgtt
     3841 aatgctgtga attggcagag gagagagctg tgctccatag ggtgctgccg gtgctgtgct
     3901 ccctagcctt ctgttctgtc ttcctcctta gccagaacgc cactcccttc ccacatcccc
     3961 ttcttctctc cgccttcccc catctcacca ttatttgtcc atggatttgt cctgggctct
     4021 gggaccttat gaaacccctt tcctaatgac ataagaggcc aaggtgcaat ccacccacct
     4081 ttgataccag accctgaggg cttcatacct gctgatgggt tttcttttct aaaaggaatg
     4141 ctcgccccag cagggtcctg ggctgcttga gcagccagct ggtgagacca tgcacttctc
     4201 tgttctctcc tccccctgcc cagtgagtta gcacagcagt agcactgccc ttgagcacag
     4261 ttctttcccc aggccaaaga tggttttgtg aagaagctgc tcccctacaa gtctcacgtg
     4321 tgaaagggct cagctcagag tggagactcg ctgtcaagtc ttaagcaatc cttttctgtt
     4381 gtgtgaaggt ttcacttaca atgtgttttc tgctgtagtt ttgtttctta cttgggttac
     4441 atcatgaaat tgatttgcct tgaatgcagc cagaccactg tctcctgggt tccccttgag
     4501 tggccagggc ctggatggaa gctaagagct tggatttctg ggaacaaagg gccatcccca
     4561 taagattgag cagaaattct ggtcctcttc cctgaaaaat tttccccacc ccagccagca
     4621 tcttctgctt ccccttgggt tgtgaccagg gagtggggag agaggctgag gctctgctcc
     4681 cctggagacc ttctcttagg agttgggtgc ttcatggaaa atccaagcct taggttccct
     4741 tctgtctctg gcaattagat gtgttcttgg tgtcctccat gtcctttttg acttttccct
     4801 gtgtccattg ttagcatgtg caaaagttcc ctgtcattac ccaacccctg cccgcccacc
     4861 tcatttcagg gctgtacaca cagtgagtgt tcctgttctc tctctctttg tttggatgta
     4921 ttgctctgtg taactcagtg ggtctccctc tttctggttt gttttttttt ctagattcct
     4981 gccgtttgtt catcgttgtg cctaaagcat gtcgatgtgg cgtcaagtac atcgtccaaa
     5041 tccctgtctc ttcagcttct ctgatgcttg aactctcacc tttgaccttg tgttgacctt
     5101 tgatgctgat gtgtattttt attatgtttg tttctttctt cgtttttttt tctttttttc
     5161 tttccttttt ttttcctttt gtgctgccaa attggttttg ctagaacgac tgctgaaggg
     5221 gaaatattta aacttgcatt tgaatataaa aaaaatctat ttttctagaa cttcataaga
     5281 taaccacttg attttgtgat tccaattctt tgtaattgtc ttcagagcag ccctactagc
     5341 acataccgcg tggtgtttgt atttctgtga acacacagcc agtccgtttc taggctttgt
     5401 ttctctgtgt gcttagtttt aaagacaact ttgaagtaaa caatgaaata aaagatgtca
     5461 ctaaaacctc tgaggctcct gagcacattt tgctgataca gtctgtgggg cttgaggaga
     5521 ccgcatgtat tgttctttct tttgtttttc ttctgagttc tcaactgcgg agagcacctg
     5581 aacccccttt cctttttgac cgcaggctgc actttgggcc ccagccagcc ctttttcttt
     5641 ttctttttct tttgtggttc ttccctggag cgactctggg gagtcctgga tatcccgcct
     5701 gccccttccc ctcagcccca tgcttgttcc aacagtctcc acagcaaaat gtgatgcttt
     5761 gatttttttg ttgttgtttt tgtttttgta ttgtttttgt gtttttgttt tgaatttttt
     5821 cctttcctac taagattatg cccagaaaaa agttttgcat gtttcctgct gtttcttcac
     5881 accttcgtat atatcacctt cacctctctg ttttctatag tttgtgcaaa aactgatcga
     5941 tttaaaaggg tttcaaagaa gctgttttaa attgttgtag ggttgattat ttttttcaag
     6001 attgtattgt ttaattttga agtggcaact ttctcctcta ttgcccttag agcgtttgcc
     6061 tgtgcactta gactgtcact tcgtgtggcc tccaggtctt accggggctt ccgggaggct
     6121 ggctgctttg ctcagagagg gtgggaaggg ggcctggaga gacacgagaa gcagaggtag
     6181 agcctagaag gtggcagcag gtgggtaaga ggcttattta gcacattagg ggcagtgagc
     6241 acctggagga aggagggcgc tcccaatcac ccgtaggagg ccatctgcac accaagcggc
     6301 aattcacctg ctggcgcttt tcctaggtga caagcacaat actacagtct tcacactgtt
     6361 tacagccctg ggcaccagcc acccggcact ggctcttcat cacagctctg ctcttgctta
     6421 gctagtgggg tgggggaaag ggcagggatt tgttttttta attgggtgga gagccaaaca
     6481 gctactgtcc ctgggtgcca agcaagccag ttttttggtt ccctgaggga aactgaccct
     6541 cctctcttgt ggcaccatcc agcctcaggg tcttggagac ttgagtaaga atgtgagtgg
     6601 agggggagag gtgaggagag gagcacaggg tggatctgtg gagggaagag gttacagggg
     6661 gaggagctga tgatagatcc cacccagact taagctgctg gtgggtgggt gagctgggaa
     6721 gtaggactgt ccagggaagg gtggagagat gtagctaggg gctggggagg gggaggtgga
     6781 agcgctattg agcatcctcc acaccaaggt tgatgaagga agggatccca gcagggtttc
     6841 tgctctgggg ctggcaggtt gcctggtatt atgcccaagg ccgctctgcc tgggggaaag
     6901 ggcagccagg cagaggccca gtgtctggta ggctgctgaa tttcctggaa ggggtgattg
     6961 gatggaaaga ggccagaaac cccagcctga gagactgctg tgcaccccac agtctgactg
     7021 cacagagccg cctctgttgg caggaggcac tgaggctccc cttcctgtgt attgagaagc
     7081 agtgtttgcc aatatatttt gctttcaatt ccaagaggag ctctgggaaa acctgtggat
     7141 aaaaccaaat gccaaatgtt ggacgttgtt tccttttcct tttctctctc tgattgtttt
     7201 aattgttctg tggtggtttt aatggatttg agaccctgga gcggcagctg cctttctgat
     7261 ttccagctgc tttttgtgaa taatttaaaa agaaaaaaaa aaagaaactt tacattttgg
     7321 agacaaacct gtgtgagttt tttattggta caaacgttgt atttaacact aggggttttg
     7381 tacagttttt tgccttttct actagaaaac aatgtaaagt gatttcacaa tgtgaagaga
     7441 aaaaaaaatt gccactatga ccaaacgcac agtctgttct gcagcaacaa cgggattcaa
     7501 tcaactcagt cgtgattcag ccgtagaaat gcttttcctt tatcttgttt gagcttttcc
     7561 tttctttcct gttttgattt gcaaaagaaa atgtcttttt tgtgtgaact tgtgttgtac
     7621 tctgtagaaa attatggatt ttactttaat ggtttaaaaa aaggcaagga gagccctcgt
     7681 cgcttttctt acctaatcac agagtttgtg tagtgaattt aaaaagaaaa aaaaattgtt
     7741 ataagtttgg agcaagggag tatgtgtttc aaaggaatct ccttcctttt tttgtgtgtt
     7801 tttccttttg tcccaatggg gaacctaaat ctgttttaat tgcacagaca catggacaaa
     7861 aagtcatttt gtatctgcca agtgtggtac cttcctttgt ttatttgcta ttaaactgtt
     7921 tgagaagaa
//
