LOCUS       NM_001376390            8045 bp    mRNA    linear   PRI 24-JUN-2024
DEFINITION  Homo sapiens CUGBP Elav-like family member 1 (CELF1), transcript
            variant 28, mRNA.
ACCESSION   NM_001376390
VERSION     NM_001376390.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8045)
  AUTHORS   Kikuchi,M., Viet,J., Nagata,K., Sato,M., David,G., Audic,Y.,
            Silverman,M.A., Yamamoto,M., Akatsu,H., Hashizume,Y., Takeda,S.,
            Akamine,S., Miyamoto,T., Uozumi,R., Gotoh,S., Mori,K., Ikeda,M.,
            Paillard,L. and Morihara,T.
  TITLE     Gene-gene functional relationships in Alzheimer's disease: CELF1
            regulates KLC1 alternative splicing
  JOURNAL   Biochem Biophys Res Commun 721, 150025 (2024)
   PUBMED   38768546
  REMARK    GeneRIF: Gene-gene functional relationships in Alzheimer's disease:
            CELF1 regulates KLC1 alternative splicing.
REFERENCE   2  (bases 1 to 8045)
  AUTHORS   David,G., Reboutier,D., Deschamps,S., Mereau,A., Taylor,W.,
            Padilla-Parra,S., Tramier,M., Audic,Y. and Paillard,L.
  TITLE     The RNA-binding proteins CELF1 and ELAVL1 cooperatively control the
            alternative splicing of CD44
  JOURNAL   Biochem Biophys Res Commun 626, 79-84 (2022)
   PUBMED   35973378
  REMARK    GeneRIF: The RNA-binding proteins CELF1 and ELAVL1 cooperatively
            control the alternative splicing of CD44.
REFERENCE   3  (bases 1 to 8045)
  AUTHORS   Zhao,X., Wang,J., Zhu,R., Zhang,J. and Zhang,Y.
  TITLE     DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin
            resistance of lung squamous cell carcinoma through modulating
            miR-181a-5p/miR-382-5p/CELF1 axis
  JOURNAL   Sci Rep 11 (1), 21014 (2021)
   PUBMED   34697393
  REMARK    GeneRIF: DLX6-AS1 activated by H3K4me1 enhanced secondary cisplatin
            resistance of lung squamous cell carcinoma through modulating
            miR-181a-5p/miR-382-5p/CELF1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8045)
  AUTHORS   Liu,C., Wang,H., Tang,L., Huang,H., Xu,M., Lin,Y., Zhou,L., Ho,L.,
            Lu,J. and Ai,X.
  TITLE     LncRNA BACE1-AS enhances the invasive and metastatic capacity of
            hepatocellular carcinoma cells through mediating miR-377-3p/CELF1
            axis
  JOURNAL   Life Sci 275, 119288 (2021)
   PUBMED   33667514
  REMARK    GeneRIF: LncRNA BACE1-AS enhances the invasive and metastatic
            capacity of hepatocellular carcinoma cells through mediating
            miR-377-3p/CELF1 axis.
REFERENCE   5  (bases 1 to 8045)
  AUTHORS   Jin,H., Liang,G., Yang,L., Liu,L., Wang,B. and Yan,F.
  TITLE     SP1-induced AFAP1-AS1 contributes to proliferation and invasion by
            regulating miR-497-5p/CELF1 pathway in nasopharyngeal carcinoma
  JOURNAL   Hum Cell 34 (2), 491-501 (2021)
   PUBMED   33400247
  REMARK    GeneRIF: SP1-induced AFAP1-AS1 contributes to proliferation and
            invasion by regulating miR-497-5p/CELF1 pathway in nasopharyngeal
            carcinoma.
REFERENCE   6  (bases 1 to 8045)
  AUTHORS   Michalowski,S., Miller,J.W., Urbinati,C.R., Paliouras,M.,
            Swanson,M.S. and Griffith,J.
  TITLE     Visualization of double-stranded RNAs from the myotonic dystrophy
            protein kinase gene and interactions with CUG-binding protein
  JOURNAL   Nucleic Acids Res 27 (17), 3534-3542 (1999)
   PUBMED   10446244
REFERENCE   7  (bases 1 to 8045)
  AUTHORS   Roberts,R., Timchenko,N.A., Miller,J.W., Reddy,S., Caskey,C.T.,
            Swanson,M.S. and Timchenko,L.T.
  TITLE     Altered phosphorylation and intracellular distribution of a (CUG)n
            triplet repeat RNA-binding protein in patients with myotonic
            dystrophy and in myotonin protein kinase knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 94 (24), 13221-13226 (1997)
   PUBMED   9371827
REFERENCE   8  (bases 1 to 8045)
  AUTHORS   Timchenko,L.T., Miller,J.W., Timchenko,N.A., DeVore,D.R.,
            Datar,K.V., Lin,L., Roberts,R., Caskey,C.T. and Swanson,M.S.
  TITLE     Identification of a (CUG)n triplet repeat RNA-binding protein and
            its expression in myotonic dystrophy
  JOURNAL   Nucleic Acids Res 24 (22), 4407-4414 (1996)
   PUBMED   8948631
REFERENCE   9  (bases 1 to 8045)
  AUTHORS   Bhagavati,S., Ghatpande,A. and Leung,B.
  TITLE     Identification of two nuclear proteins which bind to RNA CUG
            repeats: significance for myotonic dystrophy
  JOURNAL   Biochem Biophys Res Commun 228 (1), 55-62 (1996)
   PUBMED   8912635
  REMARK    Erratum:[Biochem Biophys Res Commun. 2008 Jun;370(3):530. Bhagwati,
            S [corrected to Bhagavati, S]]
REFERENCE   10 (bases 1 to 8045)
  AUTHORS   Timchenko,L.T., Timchenko,N.A., Caskey,C.T. and Roberts,R.
  TITLE     Novel proteins with binding specificity for DNA CTG repeats and RNA
            CUG repeats: implications for myotonic dystrophy
  JOURNAL   Hum Mol Genet 5 (1), 115-121 (1996)
   PUBMED   8789448
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090559.7.
            
            Summary: Members of the CELF/BRUNOL protein family contain two
            N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM
            domain, and a divergent segment of 160-230 aa between the second
            and third RRM domains. Members of this protein family regulate
            pre-mRNA alternative splicing and may also be involved in mRNA
            editing, and translation. This gene may play a role in myotonic
            dystrophy type 1 (DM1) via interactions with the dystrophia
            myotonica-protein kinase (DMPK) gene. Alternative splicing results
            in multiple transcript variants encoding different isoforms.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2136530.1,
                                           SRR18074969.1924148.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC090559.7         177465-177605       c
            142-293             AC090559.7         123926-124077       c
            294-481             AC090559.7         113310-113497       c
            482-564             AC090559.7         111632-111714       c
            565-613             AC090559.7         111223-111271       c
            614-748             AC090559.7         108862-108996       c
            749-828             AC090559.7         107926-108005       c
            829-990             AC090559.7         107168-107329       c
            991-1054            AC090559.7         103350-103413       c
            1055-1183           AC090559.7         101770-101898       c
            1184-1294           AC090559.7         101319-101429       c
            1295-1480           AC090559.7         99809-99994         c
            1481-1624           AC090559.7         97561-97704         c
            1625-8045           AC090559.7         90410-96830         c
FEATURES             Location/Qualifiers
     source          1..8045
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..8045
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /note="CUGBP Elav-like family member 1"
                     /db_xref="GeneID:10658"
                     /db_xref="HGNC:HGNC:2549"
                     /db_xref="MIM:601074"
     exon            1..141
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            142..293
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1752
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /note="isoform 9 is encoded by transcript variant 28; CUG
                     RNA-binding protein; embryo deadenylation element binding
                     protein; nuclear polyadenylated RNA-binding protein,
                     50-kD; bruno-like 2; CUG-BP- and ETR-3-like factor 1;
                     EDEN-BP homolog; bruno-like protein 2; deadenylation
                     factor CUG-BP; RNA-binding protein BRUNOL-2; CUG triplet
                     repeat RNA-binding protein 1; 50 kDa nuclear
                     polyadenylated RNA-binding protein; embryo deadenylation
                     element-binding protein homolog"
                     /codon_start=1
                     /product="CUGBP Elav-like family member 1 isoform 9"
                     /protein_id="NP_001363319.1"
                     /db_xref="GeneID:10658"
                     /db_xref="HGNC:HGNC:2549"
                     /db_xref="MIM:601074"
                     /translation="MAAFKLDFLPEMMVDHCSLNSSPVSKKMNGTLDHPDQPDLDAIK
                     MFVGQVPRTWSEKDLRELFEQYGAVYEINVLRDRSQNPPQSKGCCFVTFYTRKAALEA
                     QNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQ
                     IEECRILRGPDGLSRGCAFVTFTTRAMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKD
                     KEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALLQQTASSGNLNTLSSLHPM
                     GGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVLTSSGSSPSSSSSNSVNP
                     IASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQY
                     AAAALPTLYNQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNV
                     VSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKP
                     Y"
     exon            294..481
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            482..564
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            565..613
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            614..748
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            749..828
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            829..990
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1054
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1183
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1294
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1480
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1624
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..8045
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8026..8031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /note="hexamer: ATTAAA"
     polyA_site      8045
                     /gene="CELF1"
                     /gene_synonym="BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP;
                     hNab50; NAB50; NAPOR"
                     /note="major polyA site"
ORIGIN      
        1 gtgttctgct ctggcggcag cggcagcggc ggcgggacgc ggaggctccc ccgggattcg
       61 gcctcagcag cgaggcggcg gcggcggctg cggaggcgca ggcagcaact gaggcagcgg
      121 caggctcagg tgcagccgct ggaagctaaa gctgtgtgta tttgtggatc agacaagtgc
      181 agcaagttaa tatcattggc ttctgaaggg gagagtgagg tgatggctgc gtttaagttg
      241 gatttccttc cagaaatgat ggtggatcat tgctctttga attccagtcc cgtctcaaag
      301 aaaatgaacg gcaccctgga ccacccagac caaccagatc ttgatgctat caagatgttt
      361 gtgggccagg ttccaaggac ctggtctgaa aaggacttgc gggaactctt cgaacagtat
      421 ggtgctgtgt atgaaatcaa cgtcctaagg gataggagcc aaaacccgcc tcagagcaaa
      481 gggtgctgtt ttgttacatt ttacacccgt aaagctgcat tagaagctca gaatgctctt
      541 cacaacatga aagtcctccc agggatgcat caccctatac agatgaaacc tgctgacagt
      601 gagaagaaca atgcagtgga agacaggaag ctgtttattg gtatgatttc caagaagtgc
      661 actgaaaatg acatccgagt catgttctct tcgtttggac agattgaaga atgccggata
      721 ttgcggggac ctgatggcct gagccgaggt tgtgcatttg tgacttttac aacaagagcc
      781 atggcacaga cggctatcaa ggcaatgcac caagcacaga ccatggaggg ttgctcatca
      841 cccatggtgg taaaatttgc tgatacacag aaggacaaag aacagaagag aatggcccag
      901 cagctccagc agcagatgca gcaaatcagc gcagcatctg tgtggggaaa ccttgctggt
      961 ctaaatactc ttggacccca gtatttagca ctccttcagc agactgcctc ctctgggaac
     1021 ctcaacaccc tgagcagcct ccacccaatg ggagggttga atgcaatgca gttacagaat
     1081 ttggctgcac tagctgctgc agctagtgca gctcagaaca caccaagtgg taccaatgct
     1141 ctcactacat ccagcagtcc cctcagcgtg ctcactagtt cagggtcctc acctagctct
     1201 agcagcagta attctgtcaa ccccatagcc tcacttggag ccctgcagac attagctgga
     1261 gcaacggctg gcctcaatgt tggctctttg gcaggaatgg ctgctttaaa tggtggcctg
     1321 ggcagcagtg gcctttccaa tggcaccggg agcaccatgg aggccctcac tcaggcctac
     1381 tcgggtatcc agcaatatgc tgctgctgcg ctccccactc tgtacaacca gaatcttctg
     1441 acacagcaga gtattggtgc tgctggaagc cagaaggaag gtccagaggg agccaacctg
     1501 ttcatctacc acctgcccca ggagtttggt gatcaggacc tgctgcagat gtttatgccc
     1561 tttgggaatg tcgtgtctgc caaggttttc atagacaagc agacaaacct gagcaagtgt
     1621 tttggttttg taagttacga caatcctgtt tcggcccaag ctgccatcca gtccatgaac
     1681 ggctttcaga ttggcatgaa gcggcttaaa gtgcagctca aacgttcgaa gaatgacagc
     1741 aagccctact gagcgtgctc ccctctgaga ctggagtgag agggtcttct ggtaagtggg
     1801 ggaggagcac ccttaatgat tcgaagccct gaggctgtgt gttgacagcc ctggaccctg
     1861 atccctgcca ctctcgcagg cacagcttgc cctgaagact cggctactgc cttctgtggg
     1921 agtttcgctt cgtacagagg acaagtttgt gctttggttt ccagtgtttt actttggagt
     1981 ttaggtgcca tatcctgagg ttttttttgt ttttgttttt gtttctcctt tatttaaagt
     2041 ttgctgtgtt tgtaaccagt gtgtgttgag aaggaccaac accaaaccac cctggggaag
     2101 ggggacaggg aaacatttaa cacagacgat gatcaggatt tgccccaaac caccccaaga
     2161 gagaggactg agtggaacaa aaaagtgacc cccagaacct ctcttagtgt gagggtgggt
     2221 agaatgagaa ctgacacctg ggagctgtgg ggagcagagc ggctttgggg aagagtggag
     2281 tgactagaca cctaatgccc tggcagctgg agactcaaac tcctgtacag ctaccttctg
     2341 ggaaatagtt tttgacacct atttttcaga ttcttgtccg gaatttctgc tgctcttttc
     2401 aaaaaagggc attaacaatt ctctggaaat aaagcacctg ttagcctgac atatgcaaaa
     2461 agcagggcgg catcacccat tacgagctcc cccagccagc agtcagtatt ggattggcct
     2521 tgcctggctg gtggcagttt gggagaaaca gccaaagagg ttagtttatt tcaacaccaa
     2581 attagaccat ggcccatttc caacgggtct ctttaaaggc ctctatggaa tacattgcct
     2641 ggtttccttc tttgcagttc accacagcaa ggaatgtcac ctccatccca agccaccatt
     2701 ttctcatgaa ggcaaatcca agaagggctt gcagttcttg ctgaaggggg taccatttgt
     2761 gggcagagtg atcaatacca tctagttggg ggaggaggag cttatttctt ggtgtacttg
     2821 aatcagaagg tccctgcaag ccagtatgct tcatttgcca gtggccagaa attctccctt
     2881 gcctccttga ttgaggtgtc ccagatgtag tattcccaca ggggtctggc aggcccctcc
     2941 tgtaaccact ccagtcacat tttctgctct tgaggcagag gtgacatcag gacgtttaca
     3001 gcctccacat gaattgagtg ttcatttacc tcagtattac cgtgttcatt tttgtcctcg
     3061 tgctacagtt agctccctgc cgcctcttgc aggtcttact tcagctcttg cctgtgaccc
     3121 acacagcttc tgggctctgc ctctgctcta agaagtgctg tgggggtaga gaaccaggaa
     3181 ggacatgctg ttgggaatgt acacctgggc agaggtggcc ctgttaagat gtgactgtag
     3241 ccacagccag ggatgggatc cctgggtctc tggaatctga aacctcaaca aataccagtc
     3301 ttgaccccta gcagcagaga taagaataaa ggggttggtt tgctattaag tcagatgggg
     3361 gctctctcct tgtcatgctg tccctgtggg taacagacag ggattgacca tcttactgtt
     3421 gtacaggtag ctggtggtgt tggattatcc cattgaagct gggacagctg ttcctttctc
     3481 atagtgataa cttgggtctg ttgtcctcta aggaacgtga aacatacact tcttaagctg
     3541 aaccacgtaa acttgaaatt ctgcgcactg ggagaaatgt gtcctgtgtt tcaaaggata
     3601 aaactgttct aaaggcttcc agggtcatga tgggattttt taaataaatg caaaaaataa
     3661 aaataaaaaa gaaaaaagaa aacaaaaaaa aaaaagaaaa aaatgctagg ttggggaggc
     3721 gctgttctga atcccaaccg gctggaacca agaatgtcgt ttctattttt atagaagttt
     3781 tatacagctc cggggtggag aatatttatt acctaaatta tatctctgga aaaggccagg
     3841 attttgtaga atccagaatg tgattgttat acacacaggg tgctgtgtat gattgaaact
     3901 actgactttc tgtggcccgt ttgcagccca gctaacctgc ccaaggggaa ggtgttaatg
     3961 ctgtgaattg gcagaggaga gagctgtgct ccatagggtg ctgccggtgc tgtgctccct
     4021 agccttctgt tctgtcttcc tccttagcca gaacgccact cccttcccac atccccttct
     4081 tctctccgcc ttcccccatc tcaccattat ttgtccatgg atttgtcctg ggctctggga
     4141 ccttatgaaa cccctttcct aatgacataa gaggccaagg tgcaatccac ccacctttga
     4201 taccagaccc tgagggcttc atacctgctg atgggttttc ttttctaaaa ggaatgctcg
     4261 ccccagcagg gtcctgggct gcttgagcag ccagctggtg agaccatgca cttctctgtt
     4321 ctctcctccc cctgcccagt gagttagcac agcagtagca ctgcccttga gcacagttct
     4381 ttccccaggc caaagatggt tttgtgaaga agctgctccc ctacaagtct cacgtgtgaa
     4441 agggctcagc tcagagtgga gactcgctgt caagtcttaa gcaatccttt tctgttgtgt
     4501 gaaggtttca cttacaatgt gttttctgct gtagttttgt ttcttacttg ggttacatca
     4561 tgaaattgat ttgccttgaa tgcagccaga ccactgtctc ctgggttccc cttgagtggc
     4621 cagggcctgg atggaagcta agagcttgga tttctgggaa caaagggcca tccccataag
     4681 attgagcaga aattctggtc ctcttccctg aaaaattttc cccaccccag ccagcatctt
     4741 ctgcttcccc ttgggttgtg accagggagt ggggagagag gctgaggctc tgctcccctg
     4801 gagaccttct cttaggagtt gggtgcttca tggaaaatcc aagccttagg ttcccttctg
     4861 tctctggcaa ttagatgtgt tcttggtgtc ctccatgtcc tttttgactt ttccctgtgt
     4921 ccattgttag catgtgcaaa agttccctgt cattacccaa cccctgcccg cccacctcat
     4981 ttcagggctg tacacacagt gagtgttcct gttctctctc tctttgtttg gatgtattgc
     5041 tctgtgtaac tcagtgggtc tccctctttc tggtttgttt ttttttctag attcctgccg
     5101 tttgttcatc gttgtgccta aagcatgtcg atgtggcgtc aagtacatcg tccaaatccc
     5161 tgtctcttca gcttctctga tgcttgaact ctcacctttg accttgtgtt gacctttgat
     5221 gctgatgtgt atttttatta tgtttgtttc tttcttcgtt tttttttctt tttttctttc
     5281 cttttttttt ccttttgtgc tgccaaattg gttttgctag aacgactgct gaaggggaaa
     5341 tatttaaact tgcatttgaa tataaaaaaa atctattttt ctagaacttc ataagataac
     5401 cacttgattt tgtgattcca attctttgta attgtcttca gagcagccct actagcacat
     5461 accgcgtggt gtttgtattt ctgtgaacac acagccagtc cgtttctagg ctttgtttct
     5521 ctgtgtgctt agttttaaag acaactttga agtaaacaat gaaataaaag atgtcactaa
     5581 aacctctgag gctcctgagc acattttgct gatacagtct gtggggcttg aggagaccgc
     5641 atgtattgtt ctttcttttg tttttcttct gagttctcaa ctgcggagag cacctgaacc
     5701 ccctttcctt tttgaccgca ggctgcactt tgggccccag ccagcccttt ttctttttct
     5761 ttttcttttg tggttcttcc ctggagcgac tctggggagt cctggatatc ccgcctgccc
     5821 cttcccctca gccccatgct tgttccaaca gtctccacag caaaatgtga tgctttgatt
     5881 tttttgttgt tgtttttgtt tttgtattgt ttttgtgttt ttgttttgaa ttttttcctt
     5941 tcctactaag attatgccca gaaaaaagtt ttgcatgttt cctgctgttt cttcacacct
     6001 tcgtatatat caccttcacc tctctgtttt ctatagtttg tgcaaaaact gatcgattta
     6061 aaagggtttc aaagaagctg ttttaaattg ttgtagggtt gattattttt ttcaagattg
     6121 tattgtttaa ttttgaagtg gcaactttct cctctattgc ccttagagcg tttgcctgtg
     6181 cacttagact gtcacttcgt gtggcctcca ggtcttaccg gggcttccgg gaggctggct
     6241 gctttgctca gagagggtgg gaagggggcc tggagagaca cgagaagcag aggtagagcc
     6301 tagaaggtgg cagcaggtgg gtaagaggct tatttagcac attaggggca gtgagcacct
     6361 ggaggaagga gggcgctccc aatcacccgt aggaggccat ctgcacacca agcggcaatt
     6421 cacctgctgg cgcttttcct aggtgacaag cacaatacta cagtcttcac actgtttaca
     6481 gccctgggca ccagccaccc ggcactggct cttcatcaca gctctgctct tgcttagcta
     6541 gtggggtggg ggaaagggca gggatttgtt tttttaattg ggtggagagc caaacagcta
     6601 ctgtccctgg gtgccaagca agccagtttt ttggttccct gagggaaact gaccctcctc
     6661 tcttgtggca ccatccagcc tcagggtctt ggagacttga gtaagaatgt gagtggaggg
     6721 ggagaggtga ggagaggagc acagggtgga tctgtggagg gaagaggtta cagggggagg
     6781 agctgatgat agatcccacc cagacttaag ctgctggtgg gtgggtgagc tgggaagtag
     6841 gactgtccag ggaagggtgg agagatgtag ctaggggctg gggaggggga ggtggaagcg
     6901 ctattgagca tcctccacac caaggttgat gaaggaaggg atcccagcag ggtttctgct
     6961 ctggggctgg caggttgcct ggtattatgc ccaaggccgc tctgcctggg ggaaagggca
     7021 gccaggcaga ggcccagtgt ctggtaggct gctgaatttc ctggaagggg tgattggatg
     7081 gaaagaggcc agaaacccca gcctgagaga ctgctgtgca ccccacagtc tgactgcaca
     7141 gagccgcctc tgttggcagg aggcactgag gctccccttc ctgtgtattg agaagcagtg
     7201 tttgccaata tattttgctt tcaattccaa gaggagctct gggaaaacct gtggataaaa
     7261 ccaaatgcca aatgttggac gttgtttcct tttccttttc tctctctgat tgttttaatt
     7321 gttctgtggt ggttttaatg gatttgagac cctggagcgg cagctgcctt tctgatttcc
     7381 agctgctttt tgtgaataat ttaaaaagaa aaaaaaaaag aaactttaca ttttggagac
     7441 aaacctgtgt gagtttttta ttggtacaaa cgttgtattt aacactaggg gttttgtaca
     7501 gttttttgcc ttttctacta gaaaacaatg taaagtgatt tcacaatgtg aagagaaaaa
     7561 aaaattgcca ctatgaccaa acgcacagtc tgttctgcag caacaacggg attcaatcaa
     7621 ctcagtcgtg attcagccgt agaaatgctt ttcctttatc ttgtttgagc ttttcctttc
     7681 tttcctgttt tgatttgcaa aagaaaatgt cttttttgtg tgaacttgtg ttgtactctg
     7741 tagaaaatta tggattttac tttaatggtt taaaaaaagg caaggagagc cctcgtcgct
     7801 tttcttacct aatcacagag tttgtgtagt gaatttaaaa agaaaaaaaa attgttataa
     7861 gtttggagca agggagtatg tgtttcaaag gaatctcctt cctttttttg tgtgtttttc
     7921 cttttgtccc aatggggaac ctaaatctgt tttaattgca cagacacatg gacaaaaagt
     7981 cattttgtat ctgccaagtg tggtaccttc ctttgtttat ttgctattaa actgtttgag
     8041 aagaa
//
