LOCUS       NM_007352                906 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens chymotrypsin like elastase 3B (CELA3B), mRNA.
ACCESSION   NM_007352
VERSION     NM_007352.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Suzuki,M., Hirai,S., Sakurai,Y. and Shimizu,T.
  TITLE     Does the Complex of CELA3B Variants With Other Pancreatitis-Related
            Genes Affect Developing Childhood Pancreatitis?
  JOURNAL   J Pediatr Gastroenterol Nutr 77 (3), e62 (2023)
   PUBMED   37307306
  REMARK    GeneRIF: Does the Complex of CELA3B Variants With Other
            Pancreatitis-Related Genes Affect Developing Childhood
            Pancreatitis?
REFERENCE   2  (bases 1 to 906)
  AUTHORS   Gopi,S., Singh,N., Yegurla,J., Tabish,M., Agarwal,S., Qamar,S.,
            Gunjan,D. and Saraya,A.
  TITLE     Utility of Fecal Elastase-1 to diagnose severe exocrine
            insufficiency in chronic pancreatitis: Real world experience
  JOURNAL   Pancreatology 23 (2), 151-157 (2023)
   PUBMED   36610873
  REMARK    GeneRIF: Utility of Fecal Elastase-1 to diagnose severe exocrine
            insufficiency in chronic pancreatitis: Real world experience.
REFERENCE   3  (bases 1 to 906)
  AUTHORS   Masson,E., Rebours,V., Buscail,L., Frete,F., Pagenault,M.,
            Lachaux,A., Chevaux,J.B., Genin,E., Cooper,D.N., Ferec,C. and
            Chen,J.M.
  TITLE     The reversion variant (p.Arg90Leu) at the evolutionarily adaptive
            p.Arg90 site in CELA3B predisposes to chronic pancreatitis
  JOURNAL   Hum Mutat 42 (4), 385-391 (2021)
   PUBMED   33565216
  REMARK    GeneRIF: The reversion variant (p.Arg90Leu) at the evolutionarily
            adaptive p.Arg90 site in CELA3B predisposes to chronic
            pancreatitis.
REFERENCE   4  (bases 1 to 906)
  AUTHORS   Moore,P.C., Cortez,J.T., Chamberlain,C.E., Alba,D., Berger,A.C.,
            Quandt,Z., Chan,A., Cheng,M.H., Bautista,J.L., Peng,J.,
            German,M.S., Anderson,M.S. and Oakes,S.A.
  TITLE     Elastase 3B mutation links to familial pancreatitis with diabetes
            and pancreatic adenocarcinoma
  JOURNAL   J Clin Invest 129 (11), 4676-4681 (2019)
   PUBMED   31369399
  REMARK    GeneRIF: Elastase 3B mutation links to familial pancreatitis with
            diabetes and pancreatic adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 906)
  AUTHORS   Cabarkapa,V., Djeric,M., Mitrovic,M., Kojic-Damjanov,S., Isakov,I.,
            Vukovic,B. and Popovic,D.
  TITLE     Fecal pancreatic elastase-1 and erythrocyte magnesium levels in
            diabetes type 1 and type 2
  JOURNAL   Magnes Res 31 (1), 1-10 (2018)
   PUBMED   30106003
  REMARK    GeneRIF: The aim of this study was to examine the frequency of
            exocrine dysfunctions of the pancreas according to the level of
            fecal elastase-1 (FE-1) in patients with diabetes mellitus, type 1
            and diabetes mellitus, type 2.
REFERENCE   6  (bases 1 to 906)
  AUTHORS   Aviles,F.X., Pascual,R., Salva,M., Bonicel,J. and Puigserver,A.
  TITLE     Generation of a subunit III-like protein by autolysis of human and
            porcine proproteinase e in a binary complex with
            procarboxypeptidase A
  JOURNAL   Biochem Biophys Res Commun 163 (3), 1191-1196 (1989)
   PUBMED   2675835
REFERENCE   7  (bases 1 to 906)
  AUTHORS   Moulard,M., Kerfelec,B., Mallet,B. and Chapus,C.
  TITLE     Identification of a procarboxypeptidase A-truncated protease E
            binary complex in human pancreatic juice
  JOURNAL   FEBS Lett 250 (2), 166-170 (1989)
   PUBMED   2753124
REFERENCE   8  (bases 1 to 906)
  AUTHORS   Wendorf,P., Geyer,R., Sziegoleit,A. and Linder,D.
  TITLE     Localization and characterization of the glycosylation site of
            human pancreatic elastase 1
  JOURNAL   FEBS Lett 249 (2), 275-278 (1989)
   PUBMED   2737288
REFERENCE   9  (bases 1 to 906)
  AUTHORS   Shirasu,Y., Takemura,K., Yoshida,H., Sato,Y., Iijima,H.,
            Shimada,Y., Mikayama,T., Ozawa,T., Ikeda,N., Ishida,A. et al.
  TITLE     Molecular cloning of complementary DNA encoding one of the human
            pancreatic protease E isozymes
  JOURNAL   J Biochem 104 (2), 259-264 (1988)
   PUBMED   2460440
REFERENCE   10 (bases 1 to 906)
  AUTHORS   Cohen,A.B.
  TITLE     The interaction of alpha-1-antitrypsin with chymotrypsin, trypsin
            and elastase
  JOURNAL   Biochim Biophys Acta 391 (1), 193-200 (1975)
   PUBMED   1079736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC005216.1, BM129235.1 and
            BM128949.1.
            
            On May 17, 2019 this sequence version replaced NM_007352.3.
            
            Summary: Elastases form a subfamily of serine proteases that
            hydrolyze many proteins in addition to elastin. Humans have six
            elastase genes which encode the structurally similar proteins
            elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase
            3B has little elastolytic activity. Like most of the human
            elastases, elastase 3B is secreted from the pancreas as a zymogen
            and, like other serine proteases such as trypsin, chymotrypsin and
            kallikrein, it has a digestive function in the intestine. Elastase
            3B preferentially cleaves proteins after alanine residues. Elastase
            3B may also function in the intestinal transport and metabolism of
            cholesterol. Both elastase 3A and elastase 3B have been referred to
            as protease E and as elastase 1, and excretion of this protein in
            fecal material is frequently used as a measure of pancreatic
            function in clinical assays. [provided by RefSeq, May 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M18692.1, DRR138519.19030.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337107.11/ ENSP00000338369.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               BC005216.1         3-172
            171-289             BM129235.1         79-197
            290-455             BC005216.1         292-457
            456-906             BM128949.1         14-464              c
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..906
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /note="chymotrypsin like elastase 3B"
                     /db_xref="GeneID:23436"
                     /db_xref="HGNC:HGNC:15945"
                     /db_xref="MIM:618694"
     exon            1..61
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..831
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /EC_number="3.4.21.70"
                     /note="proteinase E; pancreatic endopeptidase E;
                     cholesterol-binding pancreatic protease; elastase 3B,
                     pancreatic; protease E; pancreatic elastase 1;
                     elastase-3B; elastase IIIB; fecal elastase 1; chymotrypsin
                     like elastase family member 3B"
                     /codon_start=1
                     /product="chymotrypsin-like elastase family member 3B
                     preproprotein"
                     /protein_id="NP_031378.1"
                     /db_xref="CCDS:CCDS219.1"
                     /db_xref="GeneID:23436"
                     /db_xref="HGNC:HGNC:15945"
                     /db_xref="MIM:618694"
                     /translation="MMLRLLSSLLLVAVASGYGPPSSRPSSRVVNGEDAVPYSWPWQV
                     SLQYEKSGSFYHTCGGSLIAPDWVVTAGHCISSSRTYQVVLGEYDRAVKEGPEQVIPI
                     NSGDLFVHPLWNRSCVACGNDIALIKLSRSAQLGDAVQLASLPPAGDILPNETPCYIT
                     GWGRLYTNGPLPDKLQEALLPVVDYEHCSRWNWWGSSVKKTMVCAGGDIRSGCNGDSG
                     GPLNCPTEDGGWQVHGVTSFVSAFGCNTRRKPTVFTRVSAFIDWIEETIASH"
     exon            62..147
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            148..245
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            246..380
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            381..517
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            518..660
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            661..813
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /inference="alignment:Splign:2.1.0"
     exon            814..906
                     /gene="CELA3B"
                     /gene_synonym="CBPP; ELA3B"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctatcatcg caaaactcat gatgctccgg ctgctcagtt ccctcctcct tgtggccgtt
       61 gcctcaggct atggcccacc ttcctctcgc ccttccagcc gcgttgtcaa tggtgaggat
      121 gcggtcccct acagctggcc ctggcaggtt tccctgcagt atgagaaaag cggaagcttc
      181 taccacacct gtggcggtag cctcatcgcc cccgactggg ttgtgactgc cggccactgc
      241 atctcgagct cccggaccta ccaggtggtg ttgggcgagt acgaccgtgc tgtgaaggag
      301 ggccccgagc aggtgatccc catcaactct ggggacctct ttgtgcatcc actctggaac
      361 cgctcgtgtg tggcctgtgg caatgacatc gccctcatca agctctcacg cagcgcccag
      421 ctgggagacg ccgtccagct cgcctcactc cctccggctg gtgacatcct tcccaacgag
      481 acaccctgct acatcaccgg ctggggccgt ctctatacca acgggccact cccagacaag
      541 ctgcaggagg ccctgctgcc ggtggtggac tatgaacact gctccaggtg gaactggtgg
      601 ggttcctccg tgaagaagac catggtgtgt gctggagggg acatccgctc cggctgcaat
      661 ggtgactctg gaggacccct caactgcccc acagaggatg gtggctggca ggtccatggc
      721 gtgaccagct ttgtttctgc ctttggctgc aacacccgca ggaagcccac ggtgttcact
      781 cgagtctccg ccttcattga ctggattgag gagaccatag caagccacta gaaccaaggc
      841 ccagctggca gtgctgatcg atcccacatc ctgaataaag aataaagatc tctcagaaaa
      901 ttccaa
//
