LOCUS       NM_001290047           10030 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens CECR2 histone acetyl-lysine reader (CECR2), transcript
            variant 1, mRNA.
ACCESSION   NM_001290047 XM_006724077
VERSION     NM_001290047.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10030)
  AUTHORS   Zhang,M., Liu,Z.Z., Aoshima,K., Cai,W.L., Sun,H., Xu,T., Zhang,Y.,
            An,Y., Chen,J.F., Chan,L.H., Aoshima,A., Lang,S.M., Tang,Z.,
            Che,X., Li,Y., Rutter,S.J., Bossuyt,V., Chen,X., Morrow,J.S.,
            Pusztai,L., Rimm,D.L., Yin,M. and Yan,Q.
  TITLE     CECR2 drives breast cancer metastasis by promoting NF-kappaB
            signaling and macrophage-mediated immune suppression
  JOURNAL   Sci Transl Med 14 (630), eabf5473 (2022)
   PUBMED   35108062
  REMARK    GeneRIF: CECR2 drives breast cancer metastasis by promoting
            NF-kappaB signaling and macrophage-mediated immune suppression.
REFERENCE   2  (bases 1 to 10030)
  AUTHORS   Wang,X., Xu,C., Wang,S., Huang,W., Liu,Y., Zhang,X., Li,N., Gao,Z.,
            Wang,F., Zhang,N., Guan,J., Yi,H. and Liu,F.
  TITLE     A novel tumor suppressor CECR2 down regulation links glutamine
            metabolism contributes tumor growth in laryngeal squamous cell
            carcinoma
  JOURNAL   Clin Transl Oncol 23 (9), 1942-1954 (2021)
   PUBMED   33826083
  REMARK    GeneRIF: A novel tumor suppressor CECR2 down regulation links
            glutamine metabolism contributes tumor growth in laryngeal squamous
            cell carcinoma.
REFERENCE   3  (bases 1 to 10030)
  AUTHORS   Raich,L., Meier,K., Gunther,J., Christ,C.D., Noe,F. and Olsson,S.
  TITLE     Discovery of a hidden transient state in all bromodomain families
  JOURNAL   Proc Natl Acad Sci U S A 118 (4) (2021)
   PUBMED   33468647
  REMARK    GeneRIF: Discovery of a hidden transient state in all bromodomain
            families.
REFERENCE   4  (bases 1 to 10030)
  AUTHORS   Olson,N.M., Kroc,S., Johnson,J.A., Zahid,H., Ycas,P.D., Chan,A.,
            Kimbrough,J.R., Kalra,P., Schonbrunn,E. and Pomerantz,W.C.K.
  TITLE     NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential
            Binding Interactions with the Bromodomain of the NURF Nucleosome
            Remodeling Complex
  JOURNAL   Biochemistry 59 (20), 1871-1880 (2020)
   PUBMED   32356653
  REMARK    GeneRIF: NMR Analyses of Acetylated H2A.Z Isoforms Identify
            Differential Binding Interactions with the Bromodomain of the NURF
            Nucleosome Remodeling Complex.
REFERENCE   5  (bases 1 to 10030)
  AUTHORS   Flynn,E.M., Huang,O.W., Poy,F., Oppikofer,M., Bellon,S.F., Tang,Y.
            and Cochran,A.G.
  TITLE     A Subset of Human Bromodomains Recognizes Butyryllysine and
            Crotonyllysine Histone Peptide Modifications
  JOURNAL   Structure 23 (10), 1801-1814 (2015)
   PUBMED   26365797
  REMARK    GeneRIF: The bromodomains of BRD9, CECR2, and the second
            bromodomain of TAF1 recognize the longer butyryl mark on histones.
            In addition, the TAF1 second bromodomain is capable of binding
            crotonyl marks.
REFERENCE   6  (bases 1 to 10030)
  AUTHORS   Erdel,F. and Rippe,K.
  TITLE     Chromatin remodelling in mammalian cells by ISWI-type
            complexes--where, when and why?
  JOURNAL   FEBS J 278 (19), 3608-3618 (2011)
   PUBMED   21810179
  REMARK    Review article
REFERENCE   7  (bases 1 to 10030)
  AUTHORS   Banting,G.S., Barak,O., Ames,T.M., Burnham,A.C., Kardel,M.D.,
            Cooch,N.S., Davidson,C.E., Godbout,R., McDermid,H.E. and
            Shiekhattar,R.
  TITLE     CECR2, a protein involved in neurulation, forms a novel chromatin
            remodeling complex with SNF2L
  JOURNAL   Hum Mol Genet 14 (4), 513-524 (2005)
   PUBMED   15640247
REFERENCE   8  (bases 1 to 10030)
  AUTHORS   Liu,L., Amy,V., Liu,G. and McKeehan,W.L.
  TITLE     Novel complex integrating mitochondria and the microtubular
            cytoskeleton with chromosome remodeling and tumor suppressor RASSF1
            deduced by in silico homology analysis, interaction cloning in
            yeast, and colocalization in cultured cells
  JOURNAL   In Vitro Cell Dev Biol Anim 38 (10), 582-594 (2002)
   PUBMED   12762840
REFERENCE   9  (bases 1 to 10030)
  AUTHORS   Liu,L. and McKeehan,W.L.
  TITLE     Sequence analysis of LRPPRC and its SEC1 domain interaction
            partners suggests roles in cytoskeletal organization, vesicular
            trafficking, nucleocytosolic shuttling, and chromosome activity
  JOURNAL   Genomics 79 (1), 124-136 (2002)
   PUBMED   11827465
REFERENCE   10 (bases 1 to 10030)
  AUTHORS   Footz,T.K., Brinkman-Mills,P., Banting,G.S., Maier,S.A.,
            Riazi,M.A., Bridgland,L., Hu,S., Birren,B., Minoshima,S.,
            Shimizu,N., Pan,H., Nguyen,T., Fang,F., Fu,Y., Ray,L., Wu,H.,
            Shaull,S., Phan,S., Yao,Z., Chen,F., Huan,A., Hu,P., Wang,Q.,
            Loh,P., Qi,S., Roe,B.A. and McDermid,H.E.
  TITLE     Analysis of the cat eye syndrome critical region in humans and the
            region of conserved synteny in mice: a search for candidate genes
            at or near the human chromosome 22 pericentromere
  JOURNAL   Genome Res 11 (6), 1053-1070 (2001)
   PUBMED   11381032
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF336133.1, FO681548.4,
            AL832377.1, AK308330.1 and AC007666.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001290047.1.
            
            Summary: This gene encodes a bromodomain-containing protein that is
            involved in chromatin remodeling, and may additionally play a role
            in DNA damage response. The encoded protein functions as part of an
            ATP-dependent complex that is involved in neurulation. This gene is
            a candidate gene for Cat Eye Syndrome. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2145743,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262608.13/ ENSP00000262608.11
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                AF336133.1         95-174
            81-82               FO681548.4         15265-15266
            83-407              AF336133.1         177-501
            408-450             FO681548.4         15592-15634
            451-1379            AL832377.1         23-951
            1380-1512           AK308330.1         1006-1138
            1513-4585           AL832377.1         1085-4157
            4586-6024           AF336133.1         4740-6178
            6025-10030          AC007666.12        65940-69945
FEATURES             Location/Qualifiers
     source          1..10030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.1-q11.21"
     gene            1..10030
                     /gene="CECR2"
                     /note="CECR2 histone acetyl-lysine reader"
                     /db_xref="GeneID:27443"
                     /db_xref="HGNC:HGNC:1840"
                     /db_xref="MIM:607576"
     exon            1..450
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..4719
                     /gene="CECR2"
                     /note="isoform 1 is encoded by transcript variant 1; cat
                     eye syndrome critical region protein 2; cat eye syndrome
                     chromosome region, candidate 2; chromatin remodeling
                     regulator CECR2"
                     /codon_start=1
                     /product="chromatin remodeling regulator CECR2 isoform 1"
                     /protein_id="NP_001276976.1"
                     /db_xref="CCDS:CCDS93111.1"
                     /db_xref="GeneID:27443"
                     /db_xref="HGNC:HGNC:1840"
                     /db_xref="MIM:607576"
                     /translation="MCPEEGGAAGLGELRSWWEVPAIAHFCSLFRTAFRLPDFEIEEL
                     EAALHRDDVEFISDLIACLLQGCYQRRDITPQTFHSYLEDIINYRWELEEGKPNPLRE
                     ASFQDLPLRTRVEILHRLCDYRLDADDVFDLLKGLDADSLRVEPLGEDNSGALYWYFY
                     GTRMYKEDPVQGKSNGELSLSRESEGQKNVSSIPGKTGKRRGRPPKRKKLQEEILLSE
                     KQEENSLASEPQTRHGSQGPGQGTWWLLCQTEEEWRQVTESFRERTSLRERQLYKLLS
                     EDFLPEICNMIAQKGKRPQRTKAELHPRWMSDHLSIKPVKQEETPVLTRIEKQKRKEE
                     EEERQILLAVQKKEQEQMLKEERKRELEEKVKAVEDRAKRRKLREERAWLLAQGKELP
                     PELSHLDPNSPMREEKKTKDLFELDDDFTAMYKVLDVVKAHKDSWPFLEPVDESYAPN
                     YYQIIKAPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLE
                     RCFHRAMMKHFPGEDGDTDEEFWIREDEKREKRRSRAGRSGGSHVWTRSRDPEGSSRK
                     QQPMENGGKSLPPTRRAPSSGDDQSSSSTQPPREVGTSNGRGFSHPLHCGGTPSQAPF
                     LNQMRPAVPGTFGPLRGSDPATLYGSSGVPEPHPGEPVQQRQPFTMQPPVGINSLRGP
                     RLGTPEEKQMCGGLTHLSNMGPHPGSLQLGQISGPSQDGSMYAPAQFQPGFIPPRHGG
                     APARPPDFPESSEIPPSHMYRSYKYLNRVHSAVWNGNHGATNQGPLGPDEKPHLGPGP
                     SHQPRTLGHVMDSRVMRPPVPPNQWTEQSGFLPHGVPSSGYMRPPCKSAGHRLQPPPV
                     PAPSSLFGAPAQALRGVQGGDSMMDSPEMIAMQQLSSRVCPPGVPYHPHQPAHPRLPG
                     PFPQVAHPMSVTVSAPKPALGNPGRAPENSEAQEPENDQAEPLPGLEEKPPGVGTSEG
                     VYLTQLPHPTPPLQTDCTRQSSPQERETVGPELKSSSSESADNCKAMKGKNPWPSDSS
                     YPGPAAQGCVRDLSTVADRGALSENGVIGEASPCGSEGKGLGSSGSEKLLCPRGRTLQ
                     ETMPCTGQNAATPPSTDPGLTGGTVSQFPPLYMPGLEYPNSAAHYHISPGLQGVGPVM
                     GGKSPASHPQHFPPRGFQSNHPHSGGFPRYRPPQGMRYSYHPPPQPSYHHYQRTPYYA
                     CPQSFSDWQRPLHPQGSPSGPPASQPPPPRSLFSDKNAMASLQGCETLNAALTSPTRM
                     DAVAAKVPNDGQNPGPEEEKLDESMERPESPKEFLDLDNHNAATKRQSSLSASEYLYG
                     TPPPLSSGMGFGSSAFPPHSVMLQTGPPYTPQRPASHFQPRAYSSPVAALPPHHPGAT
                     QPNGLSQEGPIYRCQEEGLGHFQAVMMEQIGTRSGIRGPFQEMYRPSGMQMHPVQSQA
                     SFPKTPTAATSQEEVPPHKPPTLPLDQS"
     exon            451..545
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..729
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            730..869
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..974
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1024
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1194
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1278
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..1432
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1562
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1563..1600
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1692
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1819
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..2208
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2209..2337
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2338..3184
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..4601
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4602..4713
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4714..10030
                     /gene="CECR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5795..5800
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CECR2"
                     /note="hexamer: AATAAA"
     polyA_site      5827
                     /gene="CECR2"
                     /note="major polyA site"
     regulatory      10005..10010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CECR2"
                     /note="hexamer: TATAAA"
     polyA_site      10030
                     /gene="CECR2"
                     /note="major polyA site"
ORIGIN      
        1 atctgtttct ccggcgggga ctcgattata ttgtagggga ctgggggcgg ccgccgccgc
       61 agccgcggga tggggcgagc gcgcggaccc cgcgggcagc cgcagccgca gccgcctcag
      121 tagttcgggc ccccgcgccg ccgccccccg cccggcgccc gccctcggct cctgcactcg
      181 ccgagcggcg gcagcagcgg gaggagcgcc ccgccgcccc cgccgaggac cgcgcggagg
      241 ctgcggcgct gccgcggcgg gagtcccagg tcggcgggca gagcgcgggc agcgaggggc
      301 cgccgcctgt gccgcagcgg ggagatgtgc ccagaggagg gcggcgcggc cgggctgggc
      361 gagctccgct cctggtggga ggtcccggcc atcgcgcact tctgctcgct ctttcgcacc
      421 gcgttccgcc tgcccgactt cgagatcgag gagttagaag ccgctcttca cagagatgac
      481 gtggagttta tcagtgacct gattgcctgc ctgcttcagg gctgctatca acgaagagat
      541 atcacgcctc agacattcca cagctaccta gaggacatca tcaactaccg ctgggagctc
      601 gaagaaggga agcccaaccc tctgagggaa gccagtttcc aggacctgcc tcttcgcaca
      661 cgggtggaga tcctgcaccg actctgtgat taccggctgg atgcagacga tgtcttcgat
      721 cttctaaagg gcctggatgc agacagtctc cgtgtggagc cattgggtga agacaattct
      781 ggggcactat attggtattt ctatggaaca cgaatgtaca aagaggaccc ggtgcaagga
      841 aaatccaatg gagaactctc tttgagcagg gaaagtgaag gacaaaaaaa tgtctcaagt
      901 attcctggaa aaacgggaaa aagaagagga agacccccaa aacggaagaa actgcaggag
      961 gagattctgt tgagtgaaaa gcaggaagaa aattccttgg catccgagcc acagacaaga
     1021 catgggtccc aagggccagg ccaaggtact tggtggctcc tgtgccagac agaagaggaa
     1081 tggagacagg tcaccgagag ttttcgcgag aggacctccc ttcgagaacg gcagctctac
     1141 aagctcctca gtgaggactt cctgcctgag atctgcaaca tgatcgccca gaagggaaaa
     1201 cgtccacagc gcacaaaggc agagttgcat cctaggtgga tgtctgacca cctgtccatc
     1261 aaacccgtca agcaagagga gactcctgtg ctgaccagaa tagaaaaaca aaagcgcaaa
     1321 gaggaggaag aagagcgtca gattcttcta gcagtgcaga agaaggagca ggagcagatg
     1381 ctaaaggaag agaggaaacg cgagttggag gagaaggtca aggcagtgga agatcgagcg
     1441 aagaggagaa agctcaggga agaaagggca tggctgctgg ctcaaggaaa ggagctccct
     1501 ccagaacttt cccatctgga ccccaattcc cccatgagag aggaaaaaaa gactaaagac
     1561 ctctttgagt tggatgatga tttcactgct atgtataaag ttctagacgt ggtaaaggct
     1621 cacaaggatt cctggccctt cttggaacct gtggatgaat cttatgcccc taactattat
     1681 cagattatta aggcccccat ggatatttcc agcatggaga agaaactgaa tggaggttta
     1741 tactgtacca aggaggaatt tgtaaatgac atgaagacca tgttcaggaa ttgtcgaaag
     1801 tataatgggg aaagtagtga gtataccaag atgtctgata atttagagag gtgtttccat
     1861 cgggcaatga tgaaacattt tcctggagaa gatggagaca cagatgaaga attttggatt
     1921 cgagaggatg aaaagcggga gaaaagacgg agtcgggctg ggcgaagtgg tgggagccat
     1981 gtttggaccc gctccaggga cccagaaggg tccagcagga aacagcagcc catggagaat
     2041 ggaggaaagt cgttgccccc cacacgccga gcgccctctt ctggggacga tcagagcagc
     2101 agctccacac agcccccgcg ggaggtgggc acttccaatg gccgaggttt ttctcatccc
     2161 ctgcattgtg gtgggacacc cagccaggca ccctttttaa accagatgag gccagcagta
     2221 ccaggaacat ttggccctct gcgaggatca gatcctgcca ccttgtatgg ctcctctgga
     2281 gtcccggagc cacaccccgg ggagcctgtg cagcagcgtc agcctttcac catgcagcct
     2341 ccagttggaa ttaacagcct ccgaggaccc aggctaggca caccagagga gaagcaaatg
     2401 tgcggggggc tgacacacct ttctaacatg ggcccacacc ctggatcctt gcagcttggg
     2461 cagataagtg gcccaagtca ggatggaagc atgtatgctc cagctcagtt ccagccagga
     2521 ttcattcctc cccggcatgg gggggctcca gcccggccac cagactttcc tgaaagctca
     2581 gaaattcctc ccagccatat gtatcgatcg tacaagtacc tgaatcgagt acactctgcc
     2641 gtctggaatg ggaaccatgg tgctacgaac caaggaccct tgggcccaga tgagaagccc
     2701 cacctggggc caggaccctc tcaccagcct cgcactctcg gtcacgtgat ggattcccga
     2761 gtcatgagac cacctgtccc ccccaaccag tggactgaac aatcaggctt cctacctcat
     2821 ggagttcctt cctcagggta catgcgaccg ccctgcaagt ctgccggaca tcggttacag
     2881 ccacctccag tgccagcacc cagttctttg tttggagcac ctgcccaggc tcttcggggg
     2941 gtgcagggag gggactccat gatggacagc ccagagatga ttgcgatgca gcagctctcc
     3001 tcccgcgtct gccccccagg tgtgccttac cacccccacc agcctgcaca cccccgttta
     3061 cctggccctt ttccgcaggt agctcaccca atgtcagtca ctgtgtcagc ccccaagcct
     3121 gccctgggca accctgggag ggcaccggag aacagtgaag cacaagagcc tgagaatgac
     3181 caagcagagc cgttgcctgg ccttgaagag aaaccaccag gtgttggtac ttcagagggg
     3241 gtctacctca cacaactacc tcaccccaca cctcccctgc agactgactg caccaggcag
     3301 agctcaccac aagaaaggga aacagtgggc ccggagctca aaagcagctc ctccgaatct
     3361 gcggacaact gtaaagcaat gaagggcaag aatccctggc cctcggatag cagctacccc
     3421 ggcccagccg cccaagggtg cgtgagagac ctctccacgg tggcagacag gggcgctcta
     3481 tccgagaacg gagtcattgg ggaagcatct ccttgtggat cggaggggaa gggccttggt
     3541 agcagtggtt ccgaaaagct gctctgcccc agaggcagaa cgttgcagga aaccatgcca
     3601 tgcacgggac agaacgcagc gacaccgccc agcacagacc ccggtttgac gggaggcact
     3661 gtgagccagt ttcccccgct gtatatgcct ggcctagagt acccgaattc agctgcccat
     3721 taccacatca gtccaggcct gcagggtgtg ggccctgtga tgggagggaa gtccccagca
     3781 tcccatcccc agcattttcc cccaaggggc tttcagtcta accacccaca ttctggaggc
     3841 tttccccggt atcgcccccc acaaggaatg aggtattcct accacccacc gccacagcct
     3901 tcctaccacc actatcagcg aactccttac tatgcctgtc cacagagctt ttctgactgg
     3961 cagagacctc tccatcccca gggaagccca agcggacccc cagccagtca gcctccccca
     4021 ccaaggtccc tcttctcaga taagaatgcc atggccagtc tgcaaggctg tgagacactg
     4081 aatgctgcct taacttctcc aacccgtatg gatgcagtgg ctgctaaagt cccaaatgac
     4141 gggcagaatc ctggtccaga ggaagagaag ctggatgaat ctatggagag gccagagagt
     4201 cccaaagaat ttttagacct ggacaaccat aacgcagcta ccaagcggca gagctcgttg
     4261 tcagccagcg agtatctcta tggaactcct ccgcctctga gttcaggaat gggatttggt
     4321 tcatctgcat ttccacccca cagtgtgatg ctgcagacgg ggcctcccta tacccctcag
     4381 cggccggcca gtcactttca gcccagggct tactcttccc ctgtggctgc cctcccacct
     4441 caccacccag gggccaccca gcccaacggc ctctctcagg agggtcccat ctatcgctgc
     4501 caggaagaag gcctgggtca ctttcaagct gtgatgatgg aacaaattgg cactagaagt
     4561 ggaataagag gacctttcca ggaaatgtac agaccatcag gaatgcagat gcacccggtc
     4621 cagtcgcagg cctcgttccc aaagaccccc acagcagcaa catcacagga ggaggtgccg
     4681 cctcataagc ctccaacact tcccctggat cagagctagt ccaaggagga aatgagcccc
     4741 aagcaatgga aagctgcaca cgaagactgg aatgtggaga actggggagt gccctgtcag
     4801 ctctattccc atcacctgct ccaccccttc acggcgaccc actcgtgcca tacttgagct
     4861 ggagccagtc acgggcccta aaaggacact ccttagatga ctgacacaca gattgcaaag
     4921 gtcctcggcc agggatctct tgcacagctg atgtagacag tcaggcaaaa ctaatgaacg
     4981 tggagttaat gatgactttt ccaaatcctg agacactttt cagggaaaat cactttaaac
     5041 ttgggggagg gggtatactc aagaatggag tggtgctttt aaactttgat gagcagctaa
     5101 actcaggtat atatttgggg aagggactac tcttagtatt aatggttttg gagctgggtc
     5161 cagtttacag aattttcatg ttgcctttta aaataatttt tgttggtggt gaatgtattg
     5221 tacataaagt gggaagggtg ggtggggatg cggaagaaat gggggtccta actggtgggc
     5281 acacagcact ggagtgattt ttatctgttt acaatcatgt cacactgaat acttatggga
     5341 gccggagatg agggtaggaa aggtttgatc ttgtaatatg tcactgtgtt tccttagtgg
     5401 ccagccagcc ttcagaatag ctaaaggcct tccttccttc cagtcagcct gagagagaac
     5461 acctgtcccc taagcacctg gtgtctccat tggaggcaga ctgctctcag gagactacta
     5521 gaagcttcag cccggaagac aggctgctct ctcatgctgg tggcccaaat tgagaaagtg
     5581 gtgtcccttc ctgattttgc caccagccct accgaatagt tgtaaaccag tatcaggaat
     5641 tgggatcgct agagtgtttc acgtattaga agatgaatcg tcctcatcac agacctccct
     5701 gtcaggactg tgatctagaa ggcatcacac acagctttct ggcacgaatc acattttgtg
     5761 gaagtgacta ctcaggtttg tatattttag tatcaataaa gaattgcaca ggtttgaata
     5821 ggaaaaatgt attctataga tttacagttt gaatttagga atatttcagt atatatagtt
     5881 tttattcgtt ttaagtgaat catagtaaaa tcagtcatgg tgatttaaaa tagctatcaa
     5941 gaacaagttc ttggaattat ctgttgtatc tgtgatagga aaccatttta cagtattaaa
     6001 ttactttatt acagttgtag agttgaatta cactggattc tccctcgtta gcattctgta
     6061 tttgatttta gctgaaaggt caccaaagtt aggacccatg ttttaaactt ttgaatattc
     6121 cacaaaagaa aaaactaagg aaaatactga aattacaggt ctttgtaaag aatagcatat
     6181 ttttaagcat gcttttggga tagtagaaga gtctctatga aatattaatc tgccctagtt
     6241 tcttataaat tcagctgtgg gaggggccag tagagtgttt ccctccaatt ccaggattcc
     6301 tagtgaagca tggaactgtc gtgtttacag tttgctaaac atatgctgtc cgtggaaaag
     6361 gaagctaatc ggaagcatcc atgatacaga gaaatgaaag ccaagacacc agttccagga
     6421 tgatggaagt tcatatccgt acgcaaatgc tgaacctggt gctgctgcct agggctcagg
     6481 cagatttgag agttgagtag ggaacacagg tgcctctaag gtataatgca caaaaataca
     6541 gattttctct cagagaggtt ttaattttaa atttgatgta tttgcaagtg gattgagttt
     6601 tgagcctgtg ttctcactgg atcctaattc ttgttagaaa cctatcactg gcataacctg
     6661 gtttagaaga gtgaagagga cagaaggatt gtggatgggt ctgcccttta gctagtatcc
     6721 gctaacatgg ggcattacta cttcagtttc tgtgtttgtg cagaagcagg gaggaggtaa
     6781 aaagctagtt tggagctggt tagacctggt ctaggcccag agaatttggc cactgacagc
     6841 ctttctcttt tcctggtaat gctggtttga atcagaggcc tctcacttct ccttaacagg
     6901 agcactgaca ctgtgggcct ctccccatga ctaccccagg ggcctgggtg ggagtggctg
     6961 taagcagcag ttgggccatt gccccctttc cttctgccct cgtggtcctt gagcagttgt
     7021 gtgcacactc ttccaggtaa tcctgtctcc tctctctccc agtgaccgcc ccaatcagct
     7081 gttgctagag cgatgctgtg aacgatacag gaaaagtcag taaatccctt tatccttaat
     7141 ctcccttctt ggttttcgac agaaaatatt aaggaagagc aataggaaat agaactactg
     7201 tattataaca ctgtgaacaa gaacatcagc agcagcagaa ttgtcagcct tcctgcgtcc
     7261 tgtgtgggaa tgtgtccatg ccttataggt actagtgctt cgtccattgt ccagggagtg
     7321 tcctgagctt tcactggtct ttgaagtgca gatctgctat aagctgtctg gagctgcaag
     7381 gttgcaggaa tccacaggag cgtgagctgc tgtgaacccc tagcccaccc atccccaagc
     7441 aggatcttct tctcaccttt tcttcctcct ctagcacttc tctttccaag tgtcttaagc
     7501 agatgcaatg tcttaaagca gatgcaaatg catttgccat cttctccatt aggaaaatga
     7561 tggttatgtg atatgttata tttaggaagt agtgtgtaag gtatcctgaa aaggtttgct
     7621 ctcaagctag aaggacattt caccctgtgg gtcactgtca ccttgtcagc gtgccggctc
     7681 tcagtggtcc ccaggaggat ggggatagct gagatcgtgg agaatgggaa ataccattgc
     7741 atctctttga tttaacactc atggctcacc tttagtagag ttgttaataa gttagaaact
     7801 tgtgtcccta aggcccaaga gaaaagatga gcttcttggg aggattctgg gtttgttttc
     7861 ccctcagaat taaaaaatag tttttaattc agctactttt tcccctcagt taaaaggtag
     7921 caggagctat tggctgaaat ttgttacagt gaatgaatgt ggagaataaa taagaacaaa
     7981 ccctgtagga ttcttgttga cgtaactttc catcccacct ctccgcctct ccttcatcac
     8041 cagccttcat caggttggtt tagtttacct ggccgtacac acgagctgct catcaacagt
     8101 tcgtatcttc tcactgagcc cgggccagat gctctcagaa ggccttctca tgctcctctt
     8161 cgttaggctt agtgaaaacc ttaagacctg cagtttgtgc ccctcagttc agtcagacct
     8221 cagctttaaa tgtcgattta ctctgtcttg ttccctgaaa gtgtttcttg tgactaagca
     8281 tttggtgtca ttatcccatg ccatttatct gctgtatagt tactatatta tttttgctga
     8341 ttcctactgc tggcagatgc catcccaggc ccacaaaatc ccagtgttgc agtcaccaca
     8401 gctgtcagaa acaagtttgc aatccatact tcttggttca attttttttt ttaatggaca
     8461 ttcaaatctg taaatactac actgctctta agacctgatt tgaaatttca caggaaggcc
     8521 taatcctata gtcacaaggt aaggacagtt gagtagtgta agaaccccaa cctgcttgca
     8581 gagaaccttg gttttcatag aaaggaaagg ctgaaggttt tctagcattg ttgcccttct
     8641 ttgtctgtca gtcagttcac cctctgtgat tctccatgga cccgcattgc agaaaatcag
     8701 tcccatatat tagtgagcca tgtactgccc aatccggggg ctcctggggt gtggtgtgtc
     8761 caccagtgac tctccggaca ctagcttcag taaggatact tcttatttcg gttgagaatg
     8821 cagaggcttt tattcgtgga ctcacatcac tgcatagcac aaagaatgtg attgccattt
     8881 gctgcgtgag aaaaagctgg gctccctatt tcttttttgg gttggactct gccgtgcagc
     8941 cataggacac caagcctcac gcactttccc cttgggacag tagtgtttgg gtgaatgtta
     9001 ctgcatcccg ttttttttct tttctttttt tttttttttt ttttgagacg aaatcttgct
     9061 cttgtccccc agactggagt gcaatggcac gatctcggct cactgcaacc tccacctccc
     9121 aggttcaagg gattcgtctg cctcggcctc ccaagtagct gggactacaa gcgcgcacca
     9181 ccactcccag ctaatttttg tatttttagt agaggcgggg tttcaccatg ttggccaggc
     9241 tggtctcaaa ctcctgacct caggtgatcc acccgccttg gcctcccaac atgctgggat
     9301 tacaggcgtg agccaacaca ccggaccttc attttttaaa ttaagctggg acacaagttt
     9361 tgcctccagg ctggatgttg atcctgctct gtgctagaca gatgtgcgga gggactgttc
     9421 cgggctcggc ttgacctttt cctacctagt ttctccctct tgtcctgcac aagaggacta
     9481 actgaactct aacgtcagaa cggctgacga gcagttgatt gtccttgctt gtgttgttga
     9541 caggggtggg tggggtggga gcaggggtat ggatattgca taagttattg aaatgctgac
     9601 ccccgttcag gaaaccatgc agccccttcc cttcccttcc cttcccttcc tttcccttcc
     9661 ctagccaggg ctcaggtacc tcactctcct gccttgtgcg tagctcctgg ggccccggtc
     9721 agtccccagc agccttggca cacagtgtct ggagcctctg ctcctgctgc aaaagcagaa
     9781 accatgtgaa ccttctggcc agtactggaa aggggaatgc tatttatttt tatattgtgt
     9841 atattttgtc gtggtctgct gattccctgt ttcactgaga gcgacactta cctcaatagt
     9901 tagttcaata ttgtgtgttg gataattttt taaaagaact ttttaaaaag ctttttgatc
     9961 cttggaggtc tgtagattta tttccatatg aactggttat tttgtataaa gtacatgctt
    10021 aaaatagcaa
//
