LOCUS       NM_005760               3346 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens CCAAT enhancer binding protein zeta (CEBPZ), mRNA.
ACCESSION   NM_005760
VERSION     NM_005760.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3346)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3346)
  AUTHORS   Herold,T., Metzeler,K.H., Vosberg,S., Hartmann,L., Rollig,C.,
            Stolzel,F., Schneider,S., Hubmann,M., Zellmeier,E., Ksienzyk,B.,
            Jurinovic,V., Pasalic,Z., Kakadia,P.M., Dufour,A., Graf,A.,
            Krebs,S., Blum,H., Sauerland,M.C., Buchner,T., Berdel,W.E.,
            Woermann,B.J., Bornhauser,M., Ehninger,G., Mansmann,U.,
            Hiddemann,W., Bohlander,S.K., Spiekermann,K. and Greif,P.A.
  TITLE     Isolated trisomy 13 defines a homogeneous AML subgroup with high
            frequency of mutations in spliceosome genes and poor prognosis
  JOURNAL   Blood 124 (8), 1304-1311 (2014)
   PUBMED   24923295
REFERENCE   3  (bases 1 to 3346)
  AUTHORS   Ripke,S., O'Dushlaine,C., Chambert,K., Moran,J.L., Kahler,A.K.,
            Akterin,S., Bergen,S.E., Collins,A.L., Crowley,J.J., Fromer,M.,
            Kim,Y., Lee,S.H., Magnusson,P.K., Sanchez,N., Stahl,E.A.,
            Williams,S., Wray,N.R., Xia,K., Bettella,F., Borglum,A.D.,
            Bulik-Sullivan,B.K., Cormican,P., Craddock,N., de Leeuw,C.,
            Durmishi,N., Gill,M., Golimbet,V., Hamshere,M.L., Holmans,P.,
            Hougaard,D.M., Kendler,K.S., Lin,K., Morris,D.W., Mors,O.,
            Mortensen,P.B., Neale,B.M., O'Neill,F.A., Owen,M.J.,
            Milovancevic,M.P., Posthuma,D., Powell,J., Richards,A.L.,
            Riley,B.P., Ruderfer,D., Rujescu,D., Sigurdsson,E., Silagadze,T.,
            Smit,A.B., Stefansson,H., Steinberg,S., Suvisaari,J., Tosato,S.,
            Verhage,M., Walters,J.T., Levinson,D.F., Gejman,P.V., Kendler,K.S.,
            Laurent,C., Mowry,B.J., O'Donovan,M.C., Owen,M.J., Pulver,A.E.,
            Riley,B.P., Schwab,S.G., Wildenauer,D.B., Dudbridge,F., Holmans,P.,
            Shi,J., Albus,M., Alexander,M., Campion,D., Cohen,D., Dikeos,D.,
            Duan,J., Eichhammer,P., Godard,S., Hansen,M., Lerer,F.B.,
            Liang,K.Y., Maier,W., Mallet,J., Nertney,D.A., Nestadt,G.,
            Norton,N., O'Neill,F.A., Papadimitriou,G.N., Ribble,R.,
            Sanders,A.R., Silverman,J.M., Walsh,D., Williams,N.M., Wormley,B.,
            Arranz,M.J., Bakker,S., Bender,S., Bramon,E., Collier,D.,
            Crespo-Facorro,B., Hall,J., Iyegbe,C., Jablensky,A., Kahn,R.S.,
            Kalaydjieva,L., Lawrie,S., Lewis,C.M., Lin,K., Linszen,D.H.,
            Mata,I., McIntosh,A., Murray,R.M., Ophoff,R.A., Powell,J.,
            Rujescu,D., Van Os,J., Walshe,M., Weisbrod,M., Wiersma,D.,
            Donnelly,P., Barroso,I., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A.P., Deloukas,P., Duncanson,A., Jankowski,J.,
            Markus,H.S., Mathew,C.G., Palmer,C.N., Plomin,R., Rautanen,A.,
            Sawcer,S.J., Trembath,R.C., Viswanathan,A.C., Wood,N.W.,
            Spencer,C.C., Band,G., Bellenguez,C., Freeman,C., Hellenthal,G.,
            Giannoulatou,E., Pirinen,M., Pearson,R.D., Strange,A., Su,Z.,
            Vukcevic,D., Donnelly,P., Langford,C., Hunt,S.E., Edkins,S.,
            Gwilliam,R., Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M.,
            Gray,E., Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M.,
            Tashakkori-Ghanbaria,A., Waller,M.J., Weston,P., Widaa,S.,
            Whittaker,P., Barroso,I., Deloukas,P., Mathew,C.G., Blackwell,J.M.,
            Brown,M.A., Corvin,A.P., McCarthy,M.I., Spencer,C.C., Bramon,E.,
            Corvin,A.P., O'Donovan,M.C., Stefansson,K., Scolnick,E.,
            Purcell,S., McCarroll,S.A., Sklar,P., Hultman,C.M. and
            Sullivan,P.F.
  CONSRTM   Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis
            Endophenotypes International Consortium; Wellcome Trust Case
            Control Consortium 2
  TITLE     Genome-wide association analysis identifies 13 new risk loci for
            schizophrenia
  JOURNAL   Nat Genet 45 (10), 1150-1159 (2013)
   PUBMED   23974872
REFERENCE   4  (bases 1 to 3346)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 3346)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 3346)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   7  (bases 1 to 3346)
  AUTHORS   Iouzalen,N., Andreae,S., Hannier,S. and Triebel,F.
  TITLE     LAP, a lymphocyte activation gene-3 (LAG-3)-associated protein that
            binds to a repeated EP motif in the intracellular region of LAG-3,
            may participate in the down-regulation of the CD3/TCR activation
            pathway
  JOURNAL   Eur J Immunol 31 (10), 2885-2891 (2001)
   PUBMED   11592063
REFERENCE   8  (bases 1 to 3346)
  AUTHORS   Imbriano,C., Bolognese,F., Gurtner,A., Piaggio,G. and Mantovani,R.
  TITLE     HSP-CBF is an NF-Y-dependent coactivator of the heat shock
            promoters CCAAT boxes
  JOURNAL   J Biol Chem 276 (28), 26332-26339 (2001)
   PUBMED   11306579
REFERENCE   9  (bases 1 to 3346)
  AUTHORS   Hoeppner,M.A., Gilbert,D.J., Copeland,N.G., Jenkins,N.A.,
            Linzer,D.I. and Wu,B.
  TITLE     Cloning and characterization of mouse CCAAT binding factor
  JOURNAL   Nucleic Acids Res 24 (6), 1091-1098 (1996)
   PUBMED   8604343
  REMARK    GeneRIF: Mouse and Human CCAAT binding factors are discussed in
            this citation.
REFERENCE   10 (bases 1 to 3346)
  AUTHORS   Lum,L.S., Sultzman,L.A., Kaufman,R.J., Linzer,D.I. and Wu,B.J.
  TITLE     A cloned human CCAAT-box-binding factor stimulates transcription
            from the human hsp70 promoter
  JOURNAL   Mol Cell Biol 10 (12), 6709-6717 (1990)
   PUBMED   2247079
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC034475.2 and AC007390.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005760.2.
            
            Summary: This gene belongs to the CBF/Mak21 family. The encoded
            protein plays a role in cellular response to environmental stimuli
            through a transcriptional process that involves heat shock factors,
            conserved DNA elements (heat shock elements or HSEs) and CCAAT
            boxes. The protein acts as a DNA-binding transcriptional activator
            and regulates the heat-shock protein 70 (HSP70) promoter in a
            CCAAT-dependent manner. The protein is also involved in cell growth
            and differentiation, particularly, hematopoietic differentiation.
            [provided by RefSeq, Nov 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.201620.1,
                                           SRR1660803.53522.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000234170.10/ ENSP00000234170.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3329              BC034475.2         6-3334
            3330-3346           AC007390.4         120388-120404
FEATURES             Location/Qualifiers
     source          1..3346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.2"
     gene            1..3346
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /note="CCAAT enhancer binding protein zeta"
                     /db_xref="GeneID:10153"
                     /db_xref="HGNC:HGNC:24218"
                     /db_xref="MIM:612828"
     exon            1..185
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..3194
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /note="CCAAT-box-binding transcription factor;
                     CCAAT/enhancer binding protein cebp family zeta;
                     CCAAT/enhancer binding protein (C/EBP), zeta;
                     CCAAT-binding transcription factor 2"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein zeta"
                     /protein_id="NP_005751.2"
                     /db_xref="CCDS:CCDS1787.1"
                     /db_xref="GeneID:10153"
                     /db_xref="HGNC:HGNC:24218"
                     /db_xref="MIM:612828"
                     /translation="MAAVKEPLEFHAKRPWRPEEAVEDPDEEDEDNTSEAENGFSLEE
                     VLRLGGTKQDYLMLATLDENEEVIDGGKKGAIDDLQQGELEAFIQNLNLAKYTKASLV
                     EEDEPAEKENSSKKEVKIPKINNKNTAESQRTSVNKVKNKNRPEPHSDENGSTTPKVK
                     KDKQNIFEFFERQTLLLRPGGKWYDLEYSNEYSLKPQPQDVVSKYKTLAQKLYQHEIN
                     LFKSKTNSQKGASSTWMKAIVSSGTLGDRMAAMILLIQDDAVHTLQFVETLVNLVKKK
                     GSKQQCLMALDTFKELLITDLLPDNRKLRIFSQRPFDKLEQLSSGNKDSRDRRLILWY
                     FEHQLKHLVAEFVQVLETLSHDTLVTTKTRALTVAHELLCNKPEEEKALLVQVVNKLG
                     DPQNRIATKASHLLETLLCKHPNMKGVVSGEVERLLFRSNISSKAQYYAICFLNQMAL
                     SHEESELANKLITVYFCFFRTCVKKKDVESKMLSALLTGVNRAYPYSQTGDDKVREQI
                     DTLFKVLHIVNFNTSVQALMLLFQVMNSQQTISDRYYTALYRKMLDPGLMTCSKQAMF
                     LNLVYKSLKADIVLRRVKAFVKRLLQVTCQQMPPFICGALYLVSEILKAKPGLRSQLD
                     DHPESDDEENFIDANDDEDMEKFTDADKETEIVKKLETEETVPETDVETKKPEVASWV
                     HFDNLKGGKQLNKYDPFSRNPLFCGAENTSLWELKKLSVHFHPSVALFAKTILQGNYI
                     QYSGDPLQDFTLMRFLDRFVYRNPKPHKGKENTDSVVMQPKRKHFIKDIRHLPVNSKE
                     FLAKEESQIPVDEVFFHRYYKKVAVKEKQKRDADEESIEDVDDEEFEELIDTFEDDNC
                     FSSGKDDMDFAGNVKKRTKGAKDNTLDEDSEGSDDELGNLDDDEVSLGSMDDEEFAEV
                     DEDGGTFMDVLDDESESVPELEVHSKVSTKKSKRKGTDDFDFAGSFQGPRKKKRNLND
                     SSLFVSAEEFGHLLDENMGSKFDNIGMNAMANKDNASLKQLRWEAERDDWLHNRDAKS
                     IIKKKKHFKKKRIKTTQKTKKQRK"
     exon            186..1678
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1910
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2094
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2183
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2237
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2340
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2409
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..2476
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2574
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2632
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2829
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2913
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2914..2972
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2973..3054
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3346
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3215..3220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /note="hexamer: ATTAAA"
     polyA_site      3237
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /note="major polyA site"
     regulatory      3311..3316
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /note="hexamer: AATAAA"
     regulatory      3322..3327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
                     /note="hexamer: AATAAA"
     polyA_site      3342
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
     polyA_site      3346
                     /gene="CEBPZ"
                     /gene_synonym="CBF; CBF2; HSP-CBF; NOC1"
ORIGIN      
        1 gagtttcacg cgcgtatgct ttgcccgcca tggccgcagt caaggagcct ttggagttcc
       61 atgccaagcg gccttggcgc cccgaggagg cagtagaaga tccggacgag gaggatgagg
      121 ataatactag tgaagccgag aatgggttct ccctggagga agtgttacgg ctcggaggca
      181 ccaagcaaga ttaccttatg ctggctactt tggatgagaa tgaggaagtg atagatggag
      241 gcaaaaaagg agcaatcgat gaccttcagc aaggtgaatt ggaagcattt attcaaaatc
      301 ttaatttggc gaagtataca aaagcttcct tagttgaaga agatgaacca gctgaaaaag
      361 aaaattccag caaaaaagaa gtaaaaatac ctaaaataaa taataaaaat acagcagaaa
      421 gtcaaaggac atcagttaat aaggtgaaaa ataagaatag gccagaacca cattctgatg
      481 agaatggcag taccacaccg aaagtaaaga aagataaaca gaacatcttt gaattttttg
      541 agagacagac tttgttactt aggcctggag gcaaatggta tgatctggag tacagcaatg
      601 aatattcttt gaaaccccag cctcaggatg ttgtatctaa gtacaaaacc cttgctcaga
      661 agctgtatca gcatgaaatc aacttattca aaagtaagac gaatagtcaa aagggagcct
      721 cttctacctg gatgaaggca attgtgtcat cggggacact aggtgacagg atggcagcca
      781 tgattcttct tattcaggat gatgccgttc acacacttca gtttgtagaa actcttgtga
      841 accttgttaa aaagaagggc agcaaacagc agtgccttat ggccttggat actttcaaag
      901 agttgcttat cacagacctt ttgccagaca atcggaagct gaggattttc agccagcgtc
      961 cttttgacaa actggaacag ttgtccagtg gcaacaagga ctcaagagat agaagactga
     1021 tattatggta ttttgaacac cagctgaaac acttagtggc tgaatttgtg caggtcttag
     1081 aaactttaag tcatgataca ttagtaacca ctaaaactcg agcccttacc gtggctcatg
     1141 agctgctttg taacaagcct gaggaagaaa aggctcttct tgtgcaagtg gtaaataaac
     1201 tgggagatcc tcagaacaga attgccacaa aagcatccca tctgttagag acattacttt
     1261 gtaaacatcc caatatgaaa ggagttgtgt ctggtgaagt agaaaggcta ctcttccgct
     1321 caaatatcag ctccaaagct caatattatg caatttgctt tttaaatcaa atggctctgt
     1381 cccatgaaga aagtgaattg gctaacaaat taataactgt ttacttttgc ttttttcgga
     1441 cttgtgtcaa aaaaaaagat gttgaatcaa aaatgcttag cgccctttta acaggtgtga
     1501 atagggcata cccttattcc cagactggtg atgacaaagt aagggagcag attgacacac
     1561 tgtttaaagt gttgcatatt gtgaatttta ataccagtgt ccaggcttta atgttgcttt
     1621 tccaagtaat gaattctcag cagacaatat cggatcgata ttacacagca ttatacagga
     1681 agatgttgga tccagggttg atgacgtgtt ccaagcaagc tatgtttctt aaccttgtct
     1741 acaaatctct gaaagctgac attgtgttgc gccgggtgaa ggcttttgtg aagaggttac
     1801 ttcaagttac ttgtcaacag atgccaccat ttatatgtgg agctttatat cttgtgtctg
     1861 agatccttaa agcaaaacca ggtttaagaa gccaactaga tgatcatccg gagtctgatg
     1921 atgaagaaaa ttttattgat gcaaatgatg atgaagacat ggaaaaattc actgatgcag
     1981 acaaagaaac agagatagtg aaaaaacttg agacagagga aacagttcct gaaactgatg
     2041 tagaaaccaa aaaaccagag gttgcttcct gggtgcactt tgataatttg aaaggtggga
     2101 aacagttaaa taaatacgat ccattcagta gaaaccctct gttctgtgga gctgaaaata
     2161 caagtctttg ggaactcaaa aagttatctg tgcattttca tccctccgtg gccctttttg
     2221 caaagaccat ccttcaggga aactatattc agtattcagg ggacccactg caggatttca
     2281 ctctaatgag atttttggat cgatttgtat accgaaatcc aaagccccat aaaggcaaag
     2341 aaaacacaga tagtgttgtg atgcagccga aaagaaaaca ttttattaag gatattcgtc
     2401 atcttcctgt gaacagtaag gagttccttg caaaagaaga aagccaaata ccagtggatg
     2461 aagtgttttt ccacaggtat tataaaaaag ttgctgttaa agagaaacaa aaacgggatg
     2521 cagatgaaga aagtatagaa gacgtggatg atgaagaatt tgaagagctg attgacacat
     2581 ttgaagatga taactgtttc agctctggaa aggatgatat ggattttgct ggaaacgtga
     2641 aaaagagaac aaaaggagct aaggataaca cattagatga agattcagaa ggtagtgatg
     2701 atgaacttgg taacctggat gacgatgaag tttctttagg aagtatggat gatgaagaat
     2761 ttgctgaagt tgatgaagat ggaggaacat tcatggatgt gttagatgat gaaagtgaga
     2821 gcgttccaga acttgaagtc cactccaaag tcagtactaa gaaaagcaag agaaaaggta
     2881 cagatgattt tgactttgct ggctcatttc aagggccaag aaaaaagaaa agaaacttaa
     2941 atgattccag cctatttgta tctgctgaag agtttggcca tctattggat gaaaatatgg
     3001 gatccaagtt tgataacatt ggcatgaatg ccatggctaa caaagataat gcaagtctca
     3061 aacagcttag atgggaggct gaacgtgatg actggctaca caacagagat gcaaaaagta
     3121 tcatcaagaa aaagaaacat tttaaaaaga agaggattaa aaccactcaa aaaactaaaa
     3181 aacaaaggaa atgagttatt aatgtaaatt atagattaaa attctactta catctaattt
     3241 ttgctgttca accatgtttt ttgatctagc tctctgattc catacattcc agacttctca
     3301 gtggatttgt aataaactat aaataaaaat agctctcatt tataaa
//
