LOCUS       NM_001806               3730 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens CCAAT enhancer binding protein gamma (CEBPG),
            transcript variant 1, mRNA.
ACCESSION   NM_001806
VERSION     NM_001806.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3730)
  AUTHORS   Hartl,L., Roelofs,J.J.T.H., Dijk,F., Bijlsma,M.F., Duitman,J. and
            Spek,C.A.
  TITLE     C/EBP-Family Redundancy Determines Patient Survival and Lymph Node
            Involvement in PDAC
  JOURNAL   Int J Mol Sci 24 (2), 1537 (2023)
   PUBMED   36675048
  REMARK    GeneRIF: C/EBP-Family Redundancy Determines Patient Survival and
            Lymph Node Involvement in PDAC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3730)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3730)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   4  (bases 1 to 3730)
  AUTHORS   Yan,C., Zhang,L., Yang,L., Zhang,Q. and Wang,X.
  TITLE     C/EBPgamma is a critical negative regulator of LPS-/IgG immune
            complex-induced acute lung injury through the downregulation of
            C/EBPbeta-/C/EBPdelta-dependent C/EBP transcription activation
  JOURNAL   FASEB J 34 (10), 13696-13710 (2020)
   PUBMED   32786052
  REMARK    GeneRIF: C/EBPgamma is a critical negative regulator of LPS-/IgG
            immune complex-induced acute lung injury through the downregulation
            of C/EBPbeta-/C/EBPdelta-dependent C/EBP transcription activation.
REFERENCE   5  (bases 1 to 3730)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 3730)
  AUTHORS   Cooper,C., Henderson,A., Artandi,S., Avitahl,N. and Calame,K.
  TITLE     Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP
            family transcriptional activators
  JOURNAL   Nucleic Acids Res 23 (21), 4371-4377 (1995)
   PUBMED   7501458
REFERENCE   7  (bases 1 to 3730)
  AUTHORS   Thomassin,H., Hamel,D., Bernier,D., Guertin,M. and Belanger,L.
  TITLE     Molecular cloning of two C/EBP-related proteins that bind to the
            promoter and the enhancer of the alpha 1-fetoprotein gene. Further
            analysis of C/EBP beta and C/EBP gamma
  JOURNAL   Nucleic Acids Res 20 (12), 3091-3098 (1992)
   PUBMED   1377818
REFERENCE   8  (bases 1 to 3730)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
REFERENCE   9  (bases 1 to 3730)
  AUTHORS   Williams,S.C., Cantwell,C.A. and Johnson,P.F.
  TITLE     A family of C/EBP-related proteins capable of forming covalently
            linked leucine zipper dimers in vitro
  JOURNAL   Genes Dev 5 (9), 1553-1567 (1991)
   PUBMED   1884998
REFERENCE   10 (bases 1 to 3730)
  AUTHORS   Nishizawa,M., Wakabayashi-Ito,N. and Nagata,S.
  TITLE     Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP,
            a nuclear protein which binds to granulocyte colony-stimulating
            factor promoter element 1
  JOURNAL   FEBS Lett 282 (1), 95-97 (1991)
   PUBMED   1709121
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC007582.1, BC013128.1 and
            AC008744.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001806.3.
            
            Summary: The C/EBP family of transcription factors regulates viral
            and cellular CCAAT/enhancer element-mediated transcription. C/EBP
            proteins contain the bZIP region, which is characterized by two
            motifs in the C-terminal half of the protein: a basic region
            involved in DNA binding and a leucine zipper motif involved in
            dimerization. The C/EBP family consist of several related proteins,
            C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form
            homodimers and that form heterodimers with each other.
            CCAAT/enhancer binding protein gamma may cooperate with Fos to bind
            PRE-I enhancer elements. Two transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Nov
            2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.218451.1,
                                           SRR1660803.202134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284000.9/ ENSP00000284000.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BC007582.1         380-421
            43-2547             BC013128.1         1-2505
            2548-2548           AC008744.6         78511-78511
            2549-3730           BC013128.1         2507-3688
FEATURES             Location/Qualifiers
     source          1..3730
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..3730
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="CCAAT enhancer binding protein gamma"
                     /db_xref="GeneID:1054"
                     /db_xref="HGNC:HGNC:1837"
                     /db_xref="MIM:138972"
     exon            1..187
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            188..3730
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..736
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="CCAAT/enhancer binding protein (C/EBP), gamma;
                     c/EBP gamma"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein gamma"
                     /protein_id="NP_001797.1"
                     /db_xref="CCDS:CCDS12432.1"
                     /db_xref="GeneID:1054"
                     /db_xref="HGNC:HGNC:1837"
                     /db_xref="MIM:138972"
                     /translation="MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGK
                     AVAPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENE
                     RLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ"
     regulatory      1017..1022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1036
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="major polyA site"
     regulatory      3705..3710
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="hexamer: AATAAA"
     polyA_site      3730
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcggcc ccggcgagca ggggaagccg gtggccgcgg ctgcggaacg ggcggaggct
       61 gccggtttcg taaccgtcgc tcctcctcgc tgactcgcgg gctgtgaggc ctgggtcggc
      121 tcgggccgca ccgcgcgggg ccgctcggag tggaggccgc ctgggggcag gcgggctaga
      181 ggagcaggta catgtgaaga ttttttggca gcttagcgtg gaaaccattg atcaccctgc
      241 tctcatttct acctgttctg tgttggcaag ggagagtgcc caaatgagca agatatcgca
      301 gcaaaacagc actccagggg tgaacggaat tagtgttatc catacccagg cacatgccag
      361 cggcttacag caggttcctc agctggtgcc tgctggccct gggggaggag gcaaagctgt
      421 ggctcccagc aagcagagca aaaagagttc gcccatggat cgaaacagtg acgagtatcg
      481 gcaacgccga gagaggaaca acatggctgt gaaaaagagc cggttgaaaa gcaagcagaa
      541 agcacaagac acactgcaga gagtcaatca gctcaaagaa gagaatgaac ggttggaagc
      601 aaaaatcaaa ttgctgacca aggaattaag tgtactcaaa gatttgtttc ttgagcatgc
      661 acacaacctt gcagacaacg tacagtccat tagcactgaa aatacgacag cagatggcga
      721 caatgcagga cagtagacct caccctttcc agactttaga gcttgtggct tgaatgttaa
      781 aggtgtgacc accgacacca ctcatgtcaa tggctgaaag ttgtccattt ccatgactca
      841 aagacccatt ggaggctatt ttctgggatc agcactgaag agttgattag ctaaaaatgt
      901 tagccttgta attcgaatat ctggttttaa atgatagagg tttttgtggg aatcaaaatc
      961 ccccaaatgt taaggtatat ggtaaaaaaa gaaatatctg ggatcccgat gttcttaata
     1021 aatcctgact tcccaagaaa tgcttctttt ttaagttgac aaaaggaatg gggaactggc
     1081 aggccgcgca gaaggttctt ggttttaatg gataggctga attggattaa gaaaagttga
     1141 atgccaccta tggtaatcta tttgtgattt tcttctaaat tatgtattat aaattcgtag
     1201 agctatagaa agcaatgagt gtgtaatttg gagtgatttt atatatggca taaactttgt
     1261 tttaacataa ttagtactgt tttcccccaa aagtacaagt ttttgagtag caatgtcagg
     1321 ttaagtaaag aaacttcatc acatcttata ggtagtgtgt ggccaattga cttaaaaaat
     1381 acaaataaca tttaggaagc aaatagatta aacacaaaaa taaaactaaa gcataggaat
     1441 tatgtttttg agataccttt gggcttagat tggcattgtt ttattctaaa aacccaactc
     1501 agtggtgtag agaaacttgt gtaccaaaat tttagtttct gcagatgcta gtgttttttt
     1561 ggatacaatt ttgacaacca agttagtaaa caaaatatct taacagtttg atgacacaag
     1621 ctactgatga gggtttggaa tattaattca gaaggtagtt tctcttgtgt tcaaaatagc
     1681 tgccatgggg ctgttacttt taaagtcaaa attttcttct gaaggctcat tttggtattt
     1741 gatcttaacc aagtgattat tagagaaatg tatcaactcc atgccatctc ccaaaataat
     1801 tgtctaagaa aacttgaaag tgtaaggttt taacctttaa tttatttctc ttaaatacat
     1861 cttttgatat tgttgttgtg acatttcttt ttctggttag tgggctttcc agactttgta
     1921 ccactgcttc tgtttattca tttatatgct tttgtgtccc ataaattatt tcagaaaatg
     1981 ctgataaaac tcaggatatt gacatttttg ttgagactaa aaaatggcag tcgctaaagt
     2041 agggactcta gagtctggct tacgtcagtg ttggtagttt agattgtctt tgtcaacgtt
     2101 ttttcttctc tcttttgctt tcttttcttt ctcttttttt cttagcacag ttctagctca
     2161 aatttgtgta ttttttgtgt gcctgggctg gagatgagag actgagtcat aactgattta
     2221 aaagtttgtg ttatcaggta tcttatttga acatggtcat ttttggccac attgctgttt
     2281 catactagga cttgggatga tgtagccaga ataaaactca agttgcaccc tccggttggt
     2341 ggaagattgc tgaccgtgcc gtttctgggc aggagaagac atcatggtgt ccagcaactc
     2401 agcaaagcca ttcttaagag tcgtgaggtc cttctgaatg taaaactgga gcccaggaga
     2461 agctgtccca ggagggctgt taactcccta tagagccagg agacaggata ggggtttcta
     2521 gggtccaaca ccagcttacc ttggagtatg aatctaccca tgaaggatga gagatgtttt
     2581 gaaaaactag ccaggacaca cccacaggat cctactggct ccttagcagc tgattggtgt
     2641 tacataatta acttaattgg agatgcatta ggtcacttga atgtataagc aagcacctat
     2701 ggtaggcgct acagacattt aaatctcttg ggaattcgat gctcccatgg aatttatacc
     2761 agttatatga attgacttaa gtatcttgaa aaagaaactt tagagaaagc atcaggggtg
     2821 tgtactcagt atttcaaatc agaacacaag attggaactt ttggaaaaat gggttcaagc
     2881 tttcctatta gccatggaaa tgcaaagttt agcagaagca agcaattagg cagagaacaa
     2941 aaatgttaag catggtgttg tctatcttat tgaagtggtt ggaaatgaaa gcttttaatt
     3001 tgatagattt atcagtataa aattagggaa accacgtgtg gggaatgaat caatttagag
     3061 cttcgggaat tgtgaggtga cttttgtaac ttttgttctg tgtgtgacct gtgaaccact
     3121 aggatgtgat ctgcccttgt gggcaggtcc agcatagtta ggagttaggc tttagcataa
     3181 atttctagct gcatctgagt ctcctgggat gggtgctctt tggctggttt tggctgcgga
     3241 tggtgagatc agagcagctc ttcctgctgc tggcccctgc aatcagttgt tgggatgcca
     3301 gtgcagatca ctaagtagta agattttaat caaacacgac caggtccgaa atgcaggtca
     3361 tgagtgtgaa attctcaaat ttacataaaa agtagaagta tagacagttt aacatttggt
     3421 attaaaggag aggaaattgt agcagctttt cacgtttccc agtccccatt agagggcttg
     3481 agaccttgta cctgaacaac ccattttgca ctcagtgctt tctgatgcct taggagaatt
     3541 gttttgtttc acaaaagctg ggaaggaaga agtccattct gcagctgtta gatctgcctc
     3601 tcaggaaaaa gtactaactt gttctttttg ttcctggctt tcatcagttt gtgagatttc
     3661 tctatttttt ttaaatataa ttttatttct ttcaacaaat ataaaataaa aaacaacttt
     3721 ggaacaatga
//
