LOCUS       NM_001252296            4044 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens CCAAT enhancer binding protein gamma (CEBPG),
            transcript variant 2, mRNA.
ACCESSION   NM_001252296
VERSION     NM_001252296.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4044)
  AUTHORS   Hartl,L., Roelofs,J.J.T.H., Dijk,F., Bijlsma,M.F., Duitman,J. and
            Spek,C.A.
  TITLE     C/EBP-Family Redundancy Determines Patient Survival and Lymph Node
            Involvement in PDAC
  JOURNAL   Int J Mol Sci 24 (2), 1537 (2023)
   PUBMED   36675048
  REMARK    GeneRIF: C/EBP-Family Redundancy Determines Patient Survival and
            Lymph Node Involvement in PDAC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4044)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4044)
  AUTHORS   Poh,J., Ponsford,A.H., Boyd,J., Woodsmith,J., Stelzl,U., Wanker,E.,
            Harper,N., MacEwan,D. and Sanderson,C.M.
  TITLE     A functionally defined high-density NRF2 interactome reveals new
            conditional regulators of ARE transactivation
  JOURNAL   Redox Biol 37, 101686 (2020)
   PUBMED   32911434
REFERENCE   4  (bases 1 to 4044)
  AUTHORS   Yan,C., Zhang,L., Yang,L., Zhang,Q. and Wang,X.
  TITLE     C/EBPgamma is a critical negative regulator of LPS-/IgG immune
            complex-induced acute lung injury through the downregulation of
            C/EBPbeta-/C/EBPdelta-dependent C/EBP transcription activation
  JOURNAL   FASEB J 34 (10), 13696-13710 (2020)
   PUBMED   32786052
  REMARK    GeneRIF: C/EBPgamma is a critical negative regulator of LPS-/IgG
            immune complex-induced acute lung injury through the downregulation
            of C/EBPbeta-/C/EBPdelta-dependent C/EBP transcription activation.
REFERENCE   5  (bases 1 to 4044)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 4044)
  AUTHORS   Cooper,C., Henderson,A., Artandi,S., Avitahl,N. and Calame,K.
  TITLE     Ig/EBP (C/EBP gamma) is a transdominant negative inhibitor of C/EBP
            family transcriptional activators
  JOURNAL   Nucleic Acids Res 23 (21), 4371-4377 (1995)
   PUBMED   7501458
REFERENCE   7  (bases 1 to 4044)
  AUTHORS   Thomassin,H., Hamel,D., Bernier,D., Guertin,M. and Belanger,L.
  TITLE     Molecular cloning of two C/EBP-related proteins that bind to the
            promoter and the enhancer of the alpha 1-fetoprotein gene. Further
            analysis of C/EBP beta and C/EBP gamma
  JOURNAL   Nucleic Acids Res 20 (12), 3091-3098 (1992)
   PUBMED   1377818
REFERENCE   8  (bases 1 to 4044)
  AUTHORS   Nishizawa,M. and Nagata,S.
  TITLE     cDNA clones encoding leucine-zipper proteins which interact with
            G-CSF gene promoter element 1-binding protein
  JOURNAL   FEBS Lett 299 (1), 36-38 (1992)
   PUBMED   1371974
REFERENCE   9  (bases 1 to 4044)
  AUTHORS   Williams,S.C., Cantwell,C.A. and Johnson,P.F.
  TITLE     A family of C/EBP-related proteins capable of forming covalently
            linked leucine zipper dimers in vitro
  JOURNAL   Genes Dev 5 (9), 1553-1567 (1991)
   PUBMED   1884998
REFERENCE   10 (bases 1 to 4044)
  AUTHORS   Nishizawa,M., Wakabayashi-Ito,N. and Nagata,S.
  TITLE     Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP,
            a nuclear protein which binds to granulocyte colony-stimulating
            factor promoter element 1
  JOURNAL   FEBS Lett 282 (1), 95-97 (1991)
   PUBMED   1709121
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008744.6, CN353219.1 and
            BC013128.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001252296.1.
            
            Summary: The C/EBP family of transcription factors regulates viral
            and cellular CCAAT/enhancer element-mediated transcription. C/EBP
            proteins contain the bZIP region, which is characterized by two
            motifs in the C-terminal half of the protein: a basic region
            involved in DNA binding and a leucine zipper motif involved in
            dimerization. The C/EBP family consist of several related proteins,
            C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form
            homodimers and that form heterodimers with each other.
            CCAAT/enhancer binding protein gamma may cooperate with Fos to bind
            PRE-I enhancer elements. Two transcript variants encoding the same
            protein have been found for this gene. [provided by RefSeq, Nov
            2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.866038.1,
                                           SRR14038193.489158.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-411               AC008744.6         71120-71530
            412-890             CN353219.1         213-691
            891-2861            BC013128.1         535-2505
            2862-2862           AC008744.6         78511-78511
            2863-4044           BC013128.1         2507-3688
FEATURES             Location/Qualifiers
     source          1..4044
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..4044
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="CCAAT enhancer binding protein gamma"
                     /db_xref="GeneID:1054"
                     /db_xref="HGNC:HGNC:1837"
                     /db_xref="MIM:138972"
     exon            1..501
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..4044
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             598..1050
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="CCAAT/enhancer binding protein (C/EBP), gamma;
                     c/EBP gamma"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein gamma"
                     /protein_id="NP_001239225.1"
                     /db_xref="CCDS:CCDS12432.1"
                     /db_xref="GeneID:1054"
                     /db_xref="HGNC:HGNC:1837"
                     /db_xref="MIM:138972"
                     /translation="MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGK
                     AVAPSKQSKKSSPMDRNSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENE
                     RLEAKIKLLTKELSVLKDLFLEHAHNLADNVQSISTENTTADGDNAGQ"
     regulatory      1331..1336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="hexamer: AATAAA"
     polyA_site      1350
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="major polyA site"
     regulatory      4019..4024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="hexamer: AATAAA"
     polyA_site      4044
                     /gene="CEBPG"
                     /gene_synonym="GPE1BP; IG/EBP-1"
                     /note="major polyA site"
ORIGIN      
        1 attcctggcc gcggcccagc gctgcggcgc cgcccgtcga cccccgcgct gcccggggcg
       61 cccctcgcgg cgggccggga gcgcgcgaac ggccggggaa tgccccctgc ggagcccggc
      121 cccctctcgg tgaaacgggc gctgtgaccc gccaggctcg cattggcccc tggggatgaa
      181 gggtgttccc agaatagcag aaggtggacc gagtcgagct ttagaatcct gatcttctag
      241 aagggctcag cttgcggtga tcgaaaatct gttcagaagt tcaaagactg atcaataaaa
      301 tagggaaagc aactggtttt taaatgcatg actttgcaga gataatattt tgcttctttg
      361 tggagctgtt ggaatgtcct gcactttact gttgaacgta gtttagaaga acacgcaaca
      421 cctacgggtc gaatagagaa gaaatgaagc acttcgcagg catagttgga gggagcggag
      481 cagggccgac agccagcgga ggtacatgtg aagatttttt ggcagcttag cgtggaaacc
      541 attgatcacc ctgctctcat ttctacctgt tctgtgttgg caagggagag tgcccaaatg
      601 agcaagatat cgcagcaaaa cagcactcca ggggtgaacg gaattagtgt tatccatacc
      661 caggcacatg ccagcggctt acagcaggtt cctcagctgg tgcctgctgg ccctggggga
      721 ggaggcaaag ctgtggctcc cagcaagcag agcaaaaaga gttcgcccat ggatcgaaac
      781 agtgacgagt atcggcaacg ccgagagagg aacaacatgg ctgtgaaaaa gagccggttg
      841 aaaagcaagc agaaagcaca agacacactg cagagagtca atcagctcaa agaagagaat
      901 gaacggttgg aagcaaaaat caaattgctg accaaggaat taagtgtact caaagatttg
      961 tttcttgagc atgcacacaa ccttgcagac aacgtacagt ccattagcac tgaaaatacg
     1021 acagcagatg gcgacaatgc aggacagtag acctcaccct ttccagactt tagagcttgt
     1081 ggcttgaatg ttaaaggtgt gaccaccgac accactcatg tcaatggctg aaagttgtcc
     1141 atttccatga ctcaaagacc cattggaggc tattttctgg gatcagcact gaagagttga
     1201 ttagctaaaa atgttagcct tgtaattcga atatctggtt ttaaatgata gaggtttttg
     1261 tgggaatcaa aatcccccaa atgttaaggt atatggtaaa aaaagaaata tctgggatcc
     1321 cgatgttctt aataaatcct gacttcccaa gaaatgcttc ttttttaagt tgacaaaagg
     1381 aatggggaac tggcaggccg cgcagaaggt tcttggtttt aatggatagg ctgaattgga
     1441 ttaagaaaag ttgaatgcca cctatggtaa tctatttgtg attttcttct aaattatgta
     1501 ttataaattc gtagagctat agaaagcaat gagtgtgtaa tttggagtga ttttatatat
     1561 ggcataaact ttgttttaac ataattagta ctgttttccc ccaaaagtac aagtttttga
     1621 gtagcaatgt caggttaagt aaagaaactt catcacatct tataggtagt gtgtggccaa
     1681 ttgacttaaa aaatacaaat aacatttagg aagcaaatag attaaacaca aaaataaaac
     1741 taaagcatag gaattatgtt tttgagatac ctttgggctt agattggcat tgttttattc
     1801 taaaaaccca actcagtggt gtagagaaac ttgtgtacca aaattttagt ttctgcagat
     1861 gctagtgttt ttttggatac aattttgaca accaagttag taaacaaaat atcttaacag
     1921 tttgatgaca caagctactg atgagggttt ggaatattaa ttcagaaggt agtttctctt
     1981 gtgttcaaaa tagctgccat ggggctgtta cttttaaagt caaaattttc ttctgaaggc
     2041 tcattttggt atttgatctt aaccaagtga ttattagaga aatgtatcaa ctccatgcca
     2101 tctcccaaaa taattgtcta agaaaacttg aaagtgtaag gttttaacct ttaatttatt
     2161 tctcttaaat acatcttttg atattgttgt tgtgacattt ctttttctgg ttagtgggct
     2221 ttccagactt tgtaccactg cttctgttta ttcatttata tgcttttgtg tcccataaat
     2281 tatttcagaa aatgctgata aaactcagga tattgacatt tttgttgaga ctaaaaaatg
     2341 gcagtcgcta aagtagggac tctagagtct ggcttacgtc agtgttggta gtttagattg
     2401 tctttgtcaa cgttttttct tctctctttt gctttctttt ctttctcttt ttttcttagc
     2461 acagttctag ctcaaatttg tgtatttttt gtgtgcctgg gctggagatg agagactgag
     2521 tcataactga tttaaaagtt tgtgttatca ggtatcttat ttgaacatgg tcatttttgg
     2581 ccacattgct gtttcatact aggacttggg atgatgtagc cagaataaaa ctcaagttgc
     2641 accctccggt tggtggaaga ttgctgaccg tgccgtttct gggcaggaga agacatcatg
     2701 gtgtccagca actcagcaaa gccattctta agagtcgtga ggtccttctg aatgtaaaac
     2761 tggagcccag gagaagctgt cccaggaggg ctgttaactc cctatagagc caggagacag
     2821 gataggggtt tctagggtcc aacaccagct taccttggag tatgaatcta cccatgaagg
     2881 atgagagatg ttttgaaaaa ctagccagga cacacccaca ggatcctact ggctccttag
     2941 cagctgattg gtgttacata attaacttaa ttggagatgc attaggtcac ttgaatgtat
     3001 aagcaagcac ctatggtagg cgctacagac atttaaatct cttgggaatt cgatgctccc
     3061 atggaattta taccagttat atgaattgac ttaagtatct tgaaaaagaa actttagaga
     3121 aagcatcagg ggtgtgtact cagtatttca aatcagaaca caagattgga acttttggaa
     3181 aaatgggttc aagctttcct attagccatg gaaatgcaaa gtttagcaga agcaagcaat
     3241 taggcagaga acaaaaatgt taagcatggt gttgtctatc ttattgaagt ggttggaaat
     3301 gaaagctttt aatttgatag atttatcagt ataaaattag ggaaaccacg tgtggggaat
     3361 gaatcaattt agagcttcgg gaattgtgag gtgacttttg taacttttgt tctgtgtgtg
     3421 acctgtgaac cactaggatg tgatctgccc ttgtgggcag gtccagcata gttaggagtt
     3481 aggctttagc ataaatttct agctgcatct gagtctcctg ggatgggtgc tctttggctg
     3541 gttttggctg cggatggtga gatcagagca gctcttcctg ctgctggccc ctgcaatcag
     3601 ttgttgggat gccagtgcag atcactaagt agtaagattt taatcaaaca cgaccaggtc
     3661 cgaaatgcag gtcatgagtg tgaaattctc aaatttacat aaaaagtaga agtatagaca
     3721 gtttaacatt tggtattaaa ggagaggaaa ttgtagcagc ttttcacgtt tcccagtccc
     3781 cattagaggg cttgagacct tgtacctgaa caacccattt tgcactcagt gctttctgat
     3841 gccttaggag aattgttttg tttcacaaaa gctgggaagg aagaagtcca ttctgcagct
     3901 gttagatctg cctctcagga aaaagtacta acttgttctt tttgttcctg gctttcatca
     3961 gtttgtgaga tttctctatt ttttttaaat ataattttat ttctttcaac aaatataaaa
     4021 taaaaaacaa ctttggaaca atga
//
