LOCUS       NM_005195               1252 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens CCAAT enhancer binding protein delta (CEBPD), mRNA.
ACCESSION   NM_005195
VERSION     NM_005195.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1252)
  AUTHORS   Zhu,D., Huang,M.F., Xu,A., Gao,X., Huang,Y.W., Phan,T.T.T., Lu,L.,
            Chi,T.Y., Dai,Y., Pang,L.K., Gingold,J.A., Tu,J., Huo,Z.,
            Bazer,D.A., Shoemaker,R., Wang,J., Ambrose,C.G., Shen,J.,
            Kameoka,J., Zhao,Z., Wang,L.L., Zhang,Y., Zhao,R. and Lee,D.F.
  TITLE     Systematic transcriptome profiling of hPSC-derived osteoblasts
            unveils CORIN's mastery in governing osteogenesis through CEBPD
            modulation
  JOURNAL   J Biol Chem 300 (8), 107494 (2024)
   PUBMED   38925326
  REMARK    GeneRIF: Systematic transcriptome profiling of hPSC-derived
            osteoblasts unveils CORIN's mastery in governing osteogenesis
            through CEBPD modulation.
REFERENCE   2  (bases 1 to 1252)
  AUTHORS   Zhao,Y., Yu,Y., Li,X. and Guo,A.
  TITLE     CCAAT enhancer binding protein delta activates vesicle associated
            membrane protein 3 transcription to enhance chemoresistance and
            extracellular PD-L1 expression in triple-negative breast cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 115 (2024)
   PUBMED   38627816
  REMARK    GeneRIF: CCAAT enhancer binding protein delta activates vesicle
            associated membrane protein 3 transcription to enhance
            chemoresistance and extracellular PD-L1 expression in
            triple-negative breast cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1252)
  AUTHORS   Wang,T.Y., Weng,E.F., Hsu,Y.C., Shiu,L.P., Huang,T.W., Wu,H.C.,
            Hong,J.S. and Wang,S.M.
  TITLE     Inhibition of MMP8 effectively alleviates manic-like behavior and
            reduces neuroinflammation by modulating astrocytic CEBPD
  JOURNAL   J Neuroinflammation 21 (1), 61 (2024)
   PUBMED   38419037
  REMARK    GeneRIF: Inhibition of MMP8 effectively alleviates manic-like
            behavior and reduces neuroinflammation by modulating astrocytic
            CEBPD.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1252)
  AUTHORS   Hartl,L., Roelofs,J.J.T.H., Dijk,F., Bijlsma,M.F., Duitman,J. and
            Spek,C.A.
  TITLE     C/EBP-Family Redundancy Determines Patient Survival and Lymph Node
            Involvement in PDAC
  JOURNAL   Int J Mol Sci 24 (2), 1537 (2023)
   PUBMED   36675048
  REMARK    GeneRIF: C/EBP-Family Redundancy Determines Patient Survival and
            Lymph Node Involvement in PDAC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1252)
  AUTHORS   Hartl,L., Maarschalkerweerd,P.A.F., Butler,J.M., Manz,X.D.,
            Thijssen,V.L.J.L., Bijlsma,M.F., Duitman,J. and Spek,C.A.
  TITLE     C/EBPdelta Suppresses Motility-Associated Gene Signatures and
            Reduces PDAC Cell Migration
  JOURNAL   Cells 11 (21), 3334 (2022)
   PUBMED   36359732
  REMARK    GeneRIF: C/EBPdelta Suppresses Motility-Associated Gene Signatures
            and Reduces PDAC Cell Migration.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1252)
  AUTHORS   Nagulapalli,S., Pongubala,J.M. and Atchison,M.L.
  TITLE     Multiple proteins physically interact with PU.1. Transcriptional
            synergy with NF-IL6 beta (C/EBP delta, CRP3)
  JOURNAL   J Immunol 155 (9), 4330-4338 (1995)
   PUBMED   7594592
REFERENCE   7  (bases 1 to 1252)
  AUTHORS   Wood,S., Schertzer,M. and Yaremko,M.L.
  TITLE     Sequence identity locates CEBPD and FGFR1 to mapped human loci
            within proximal 8p
  JOURNAL   Cytogenet Cell Genet 70 (3-4), 188-191 (1995)
   PUBMED   7789168
REFERENCE   8  (bases 1 to 1252)
  AUTHORS   Kinoshita,S., Akira,S. and Kishimoto,T.
  TITLE     A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and
            transcriptionally synergizes with NF-IL6
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1473-1476 (1992)
   PUBMED   1741402
REFERENCE   9  (bases 1 to 1252)
  AUTHORS   Williams,S.C., Cantwell,C.A. and Johnson,P.F.
  TITLE     A family of C/EBP-related proteins capable of forming covalently
            linked leucine zipper dimers in vitro
  JOURNAL   Genes Dev 5 (9), 1553-1567 (1991)
   PUBMED   1884998
REFERENCE   10 (bases 1 to 1252)
  AUTHORS   Cao,Z., Umek,R.M. and McKnight,S.L.
  TITLE     Regulated expression of three C/EBP isoforms during adipose
            conversion of 3T3-L1 cells
  JOURNAL   Genes Dev 5 (9), 1538-1552 (1991)
   PUBMED   1840554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M83667.1, BC105109.1,
            BQ773696.1 and AC023991.9.
            
            On May 17, 2019 this sequence version replaced NM_005195.3.
            
            Summary: The protein encoded by this intronless gene is a bZIP
            transcription factor which can bind as a homodimer to certain DNA
            regulatory regions. It can also form heterodimers with the related
            protein CEBP-alpha. The encoded protein is important in the
            regulation of genes involved in immune and inflammatory responses,
            and may be involved in the regulation of genes associated with
            activation and/or differentiation of macrophages. The cytogenetic
            location of this locus has been reported as both 8p11 and 8q11.
            [provided by RefSeq, Sep 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: ERR279841.786.1, ERR279834.2094.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000408965.4/ ENSP00000386165.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                M83667.1           45-92
            49-884              BC105109.1         44-879
            885-1251            BQ773696.1         19-385              c
            1252-1252           AC023991.9         125195-125195       c
FEATURES             Location/Qualifiers
     source          1..1252
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.21"
     gene            1..1252
                     /gene="CEBPD"
                     /gene_synonym="C/EBP-delta; CELF; CRP3; NF-IL6-beta"
                     /note="CCAAT enhancer binding protein delta"
                     /db_xref="GeneID:1052"
                     /db_xref="HGNC:HGNC:1835"
                     /db_xref="MIM:116898"
     exon            1..1252
                     /gene="CEBPD"
                     /gene_synonym="C/EBP-delta; CELF; CRP3; NF-IL6-beta"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..854
                     /gene="CEBPD"
                     /gene_synonym="C/EBP-delta; CELF; CRP3; NF-IL6-beta"
                     /note="c/EBP delta; nuclear factor NF-IL6-beta;
                     CCAAT/enhancer binding protein (C/EBP), delta"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein delta"
                     /protein_id="NP_005186.2"
                     /db_xref="CCDS:CCDS6142.1"
                     /db_xref="GeneID:1052"
                     /db_xref="HGNC:HGNC:1835"
                     /db_xref="MIM:116898"
                     /translation="MSAALFSLDGPARGAPWPAEPAPFYEPGRAGKPGRGAEPGALGE
                     PGAAAPAMYDDESAIDFSAYIDSMAAVPTLELCHDELFADLFNSNHKAGGAGPLELLP
                     GGPARPLGPGPAAPRLLKREPDWGDGDAPGSLLPAQVAACAQTVVSLAAAGQPTPPTS
                     PEPPRSSPRQTPAPGPAREKSAGKRGPDRGSPEYRQRRERNNIAVRKSRDKAKRRNQE
                     MQQKLVELSAENEKLHQRVEQLTRDLAGLRQFFKQLPSPPFLPAAGTADCR"
     regulatory      1230..1235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEBPD"
                     /gene_synonym="C/EBP-delta; CELF; CRP3; NF-IL6-beta"
                     /note="hexamer: AATAAA"
     polyA_site      1252
                     /gene="CEBPD"
                     /gene_synonym="C/EBP-delta; CELF; CRP3; NF-IL6-beta"
                     /note="major polyA site"
ORIGIN      
        1 aggtgacagc ctcgcttgga cgcagagccc ggcccgacgc cgccatgagc gccgcgctct
       61 tcagcctgga cggcccggcg cgcggcgcgc cctggcctgc ggagcctgcg cccttctacg
      121 aaccgggccg ggcgggcaag ccgggccgcg gggccgagcc aggggcccta ggcgagccag
      181 gcgccgccgc ccccgccatg tacgacgacg agagcgccat cgacttcagc gcctacatcg
      241 actccatggc cgccgtgccc accctggagc tgtgccacga cgagctcttc gccgacctct
      301 tcaacagcaa tcacaaggcg ggcggcgcgg ggcccctgga gcttcttccc ggcggccccg
      361 cgcgcccctt gggcccgggc cctgccgctc cccgcctgct caagcgcgag cccgactggg
      421 gcgacggcga cgcgcccggc tcgctgttgc ccgcgcaggt ggccgcgtgc gcacagaccg
      481 tggtgagctt ggcggccgca gggcagccca ccccgcccac gtcgccggag ccgccgcgca
      541 gcagccccag gcagaccccc gcgcccggcc ccgcccggga gaagagcgcc ggcaagaggg
      601 gcccggaccg cggcagcccc gagtaccggc agcggcgcga gcgcaacaac atcgccgtgc
      661 gcaagagccg cgacaaggcc aagcggcgca accaggagat gcagcagaag ttggtggagc
      721 tgtcggctga gaacgagaag ctgcaccagc gcgtggagca gctcacgcgg gacctggccg
      781 gcctccggca gttcttcaag cagctgccca gcccgccctt cctgccggcc gccgggacag
      841 cagactgccg gtaacgcgcg gccggggcgg gagagactca gcaacgaccc atacctcaga
      901 cccgacggcc cggagcggag cgcgccctgc cctggcgcag ccagagccgc cgggtgcccg
      961 ctgcagtttc ttgggacata ggagcgcaaa gaagctacag cctggactta ccaccactaa
     1021 actgcgagag aagctaaacg tgtttatttt cccttaaatt atttttgtaa tggtagcttt
     1081 ttctacatct tactcctgtt gatgcagcta aggtacattt gtaaaaagaa aaaaaaccag
     1141 acttttcaga caaacccttt gtattgtaga taagaggaaa agactgagca tgctcacttt
     1201 tttatattaa tttttacagt atttgtaaga ataaagcagc atttgaaatc gc
//
