LOCUS       NM_005194               1839 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens CCAAT enhancer binding protein beta (CEBPB),
            transcript variant 2, mRNA.
ACCESSION   NM_005194
VERSION     NM_005194.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1839)
  AUTHORS   Choi,J.H., Jeong,J., Kim,J., You,E., Keum,S., Song,S., Hwang,Y.E.,
            Ji,M., Park,K.S. and Rhee,S.
  TITLE     Genetic disruption of ATAT1 causes RhoA downregulation through
            abnormal truncation of C/EBPbeta
  JOURNAL   BMB Rep 57 (6), 293-298 (2024)
   PUBMED   38835115
  REMARK    GeneRIF: Genetic disruption of ATAT1 causes RhoA downregulation
            through abnormal truncation of C/EBPbeta.
REFERENCE   2  (bases 1 to 1839)
  AUTHORS   Huber,R., Pietsch,D., Panterodt,T. and Brand,K.
  TITLE     Regulation of C/EBPbeta and resulting functions in cells of the
            monocytic lineage
  JOURNAL   Cell Signal 24 (6), 1287-1296 (2012)
   PUBMED   22374303
  REMARK    GeneRIF: C/EBP-beta target genes in monocytic cells are summarized
            and resulting functions are described, including regulation of
            proliferation and differentiation as well as orchestration of
            processes of mainly the innate immune response. [review]
            Review article
REFERENCE   3  (bases 1 to 1839)
  AUTHORS   Miglino,N., Roth,M., Lardinois,D., Sadowski,C., Tamm,M. and
            Borger,P.
  TITLE     Cigarette smoke inhibits lung fibroblast proliferation by
            translational mechanisms
  JOURNAL   Eur Respir J 39 (3), 705-711 (2012)
   PUBMED   21852335
REFERENCE   4  (bases 1 to 1839)
  AUTHORS   Wethmar,K., Smink,J.J. and Leutz,A.
  TITLE     Upstream open reading frames: molecular switches in
            (patho)physiology
  JOURNAL   Bioessays 32 (10), 885-893 (2010)
   PUBMED   20726009
  REMARK    Review article
REFERENCE   5  (bases 1 to 1839)
  AUTHORS   Xiong,W., Hsieh,C.C., Kurtz,A.J., Rabek,J.P. and
            Papaconstantinou,J.
  TITLE     Regulation of CCAAT/enhancer-binding protein-beta isoform synthesis
            by alternative translational initiation at multiple AUG start sites
  JOURNAL   Nucleic Acids Res 29 (14), 3087-3098 (2001)
   PUBMED   11452034
  REMARK    GeneRIF: mutational studies of mouse ortholog demonstrating
            alternative translational initiation
REFERENCE   6  (bases 1 to 1839)
  AUTHORS   Calkhoven,C.F., Muller,C. and Leutz,A.
  TITLE     Translational control of C/EBPalpha and C/EBPbeta isoform
            expression
  JOURNAL   Genes Dev 14 (15), 1920-1932 (2000)
   PUBMED   10921906
  REMARK    GeneRIF: mutational studies of the rat and chick orthologs
            demonstrating alternative translational initiation
REFERENCE   7  (bases 1 to 1839)
  AUTHORS   Lincoln,A.J., Monczak,Y., Williams,S.C. and Johnson,P.F.
  TITLE     Inhibition of CCAAT/enhancer-binding protein alpha and beta
            translation by upstream open reading frames
  JOURNAL   J Biol Chem 273 (16), 9552-9560 (1998)
   PUBMED   9545285
REFERENCE   8  (bases 1 to 1839)
  AUTHORS   Wegner,M., Cao,Z. and Rosenfeld,M.G.
  TITLE     Calcium-regulated phosphorylation within the leucine zipper of
            C/EBP beta
  JOURNAL   Science 256 (5055), 370-373 (1992)
   PUBMED   1314426
REFERENCE   9  (bases 1 to 1839)
  AUTHORS   Descombes,P. and Schibler,U.
  TITLE     A liver-enriched transcriptional activator protein, LAP, and a
            transcriptional inhibitory protein, LIP, are translated from the
            same mRNA
  JOURNAL   Cell 67 (3), 569-579 (1991)
   PUBMED   1934061
  REMARK    GeneRIF: Demonstration of alternative translation initiation in
            mouse
REFERENCE   10 (bases 1 to 1839)
  AUTHORS   Akira,S., Isshiki,H., Sugita,T., Tanabe,O., Kinoshita,S.,
            Nishio,Y., Nakajima,T., Hirano,T. and Kishimoto,T.
  TITLE     A nuclear factor for IL-6 expression (NF-IL6) is a member of a
            C/EBP family
  JOURNAL   EMBO J 9 (6), 1897-1906 (1990)
   PUBMED   2112087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB457615.1 and BC007538.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_005194.3.
            
            Summary: This intronless gene encodes a transcription factor that
            contains a basic leucine zipper (bZIP) domain. The encoded protein
            functions as a homodimer but can also form heterodimers with
            CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity
            of this protein is important in the regulation of genes involved in
            immune and inflammatory responses, among other processes. The use
            of alternative in-frame AUG start codons results in multiple
            protein isoforms, each with distinct biological functions.
            [provided by RefSeq, Oct 2013].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC007538.1, AK291536.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303004.5/ ENSP00000305422.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB457615.1         250-273
            25-1839             BC007538.1         1-1815
FEATURES             Location/Qualifiers
     source          1..1839
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.13"
     gene            1..1839
                     /gene="CEBPB"
                     /gene_synonym="C/EBP-beta; IL6DBP; NF-IL6; TCF5"
                     /note="CCAAT enhancer binding protein beta"
                     /db_xref="GeneID:1051"
                     /db_xref="HGNC:HGNC:1834"
                     /db_xref="MIM:189965"
     exon            1..1839
                     /gene="CEBPB"
                     /gene_synonym="C/EBP-beta; IL6DBP; NF-IL6; TCF5"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1242
                     /gene="CEBPB"
                     /gene_synonym="C/EBP-beta; IL6DBP; NF-IL6; TCF5"
                     /note="isoform a is encoded by transcript variant 2;
                     nuclear factor of interleukin 6; transcription factor 5;
                     transcription factor C/EBP beta; CCAAT/enhancer binding
                     protein (C/EBP), beta; interleukin 6-dependent DNA-binding
                     protein; nuclear factor NF-IL6"
                     /codon_start=1
                     /product="CCAAT/enhancer-binding protein beta isoform a"
                     /protein_id="NP_005185.2"
                     /db_xref="CCDS:CCDS13429.1"
                     /db_xref="GeneID:1051"
                     /db_xref="HGNC:HGNC:1834"
                     /db_xref="MIM:189965"
                     /translation="MQRLVAWDPACLPLPPPPPAFKSMEVANFYYEADCLAAAYGGKA
                     APAAPPAARPGPRPPAGELGSIGDHERAIDFSPYLEPLGAPQAPAPATATDTFEAAPP
                     APAPAPASSGQHHDFLSDLFSDDYGGKNCKKPAEYGYVSLGRLGAAKGALHPGCFAPL
                     HPPPPPPPPPAELKAEPGFEPADCKRKEEAGAPGGGAGMAAGFPYALRAYLGYQAVPS
                     GSSGSLSTSSSSSPPGTPSPADAKAPPTACYAGAAPAPSQVKSKAKKTVDKHSDEYKI
                     RRERNNIAVRKSRDKAKMRNLETQHKVLELTAENERLQKKVEQLSRELSTLRNLFKQL
                     PEPLLASSGHC"
     regulatory      1814..1819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEBPB"
                     /gene_synonym="C/EBP-beta; IL6DBP; NF-IL6; TCF5"
                     /note="hexamer: AATAAA"
     polyA_site      1839
                     /gene="CEBPB"
                     /gene_synonym="C/EBP-beta; IL6DBP; NF-IL6; TCF5"
                     /note="major polyA site"
ORIGIN      
        1 agcgagtcag agccgcgcac gggactggga aggggaccca cccgagggtc cagccaccag
       61 ccccctcact aatagcggcc accccggcag cggcggcagc agcagcagcg acgcagcggc
      121 gacagctcag agcagggagg ccgcgccacc tgcgggccgg ccggagcggg cagccccagg
      181 ccccctcccc gggcacccgc gttcatgcaa cgcctggtgg cctgggaccc agcatgtctc
      241 cccctgccgc cgccgccgcc tgcctttaaa tccatggaag tggccaactt ctactacgag
      301 gcggactgct tggctgctgc gtacggcggc aaggcggccc ccgcggcgcc ccccgcggcc
      361 agacccgggc cgcgcccccc cgccggcgag ctgggcagca tcggcgacca cgagcgcgcc
      421 atcgacttca gcccgtacct ggagccgctg ggcgcgccgc aggccccggc gcccgccacg
      481 gccacggaca ccttcgaggc ggctccgccc gcgcccgccc ccgcgcccgc ctcctccggg
      541 cagcaccacg acttcctctc cgacctcttc tccgacgact acgggggcaa gaactgcaag
      601 aagccggccg agtacggcta cgtgagcctg gggcgcctgg gggccgccaa gggcgcgctg
      661 caccccggct gcttcgcgcc cctgcaccca ccgcccccgc cgccgccgcc gcccgccgag
      721 ctcaaggcgg agccgggctt cgagcccgcg gactgcaagc ggaaggagga ggccggggcg
      781 ccgggcggcg gcgcaggcat ggcggcgggc ttcccgtacg cgctgcgcgc ttacctcggc
      841 taccaggcgg tgccgagcgg cagcagcggg agcctctcca cgtcctcctc gtccagcccg
      901 cccggcacgc cgagccccgc tgacgccaag gcgcccccga ccgcctgcta cgcgggggcc
      961 gcgccggcgc cctcgcaggt caagagcaag gccaagaaga ccgtggacaa gcacagcgac
     1021 gagtacaaga tccggcgcga gcgcaacaac atcgccgtgc gcaagagccg cgacaaggcc
     1081 aagatgcgca acctggagac gcagcacaag gtcctggagc tcacggccga gaacgagcgg
     1141 ctgcagaaga aggtggagca gctgtcgcgc gagctcagca ccctgcggaa cttgttcaag
     1201 cagctgcccg agcccctgct cgcctcctcc ggccactgct agcgcggccc ccgcgcgcgt
     1261 ccccctgccg gccggggctg agactccggg gagcgcccgc gcccgcgccc tcgcccccgc
     1321 ccccggcggc gccggcaaaa ctttggcact ggggcacttg gcagcgcggg gagcccgtcg
     1381 gtaattttaa tattttatta tatatatata tctatatttt tgtccaaacc aaccgcacat
     1441 gcagatgggg ctcccgcccg tggtgttatt taaagaagaa acgtctatgt gtacagatga
     1501 atgataaact ctctgcttct ccctctgccc ctctccaggc gccggcgggc gggccggttt
     1561 cgaagttgat gcaatcggtt taaacatggc tgaacgcgtg tgtacacggg actgacgcaa
     1621 cccacgtgta actgtcagcc gggccctgag taatcgctta aagatgttcc tacgggcttg
     1681 ttgctgttga tgttttgttt tgttttgttt tttggtcttt ttttgtatta taaaaaataa
     1741 tctatttcta tgagaaaaga ggcgtctgta tattttggga atcttttccg tttcaagcat
     1801 taagaacact tttaataaac ttttttttga gaatggtta
//
