LOCUS       NM_001816               2297 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 8 (CEACAM8), mRNA.
ACCESSION   NM_001816
VERSION     NM_001816.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Kovaleva,O.V., Podlesnaya,P.A., Mochalnikova,V.V., Kushlinskii,N.E.
            and Gratchev,A.N.
  TITLE     Clinical Significance of CD66b Expression in Non-Small Cell Lung
            Cancer
  JOURNAL   Bull Exp Biol Med 174 (6), 779-783 (2023)
   PUBMED   37162631
  REMARK    GeneRIF: Clinical Significance of CD66b Expression in Non-Small
            Cell Lung Cancer.
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Horzum,U., Yoyen-Ermis,D., Taskiran,E.Z., Yilmaz,K.B.,
            Hamaloglu,E., Karakoc,D. and Esendagli,G.
  TITLE     CD66b+ monocytes represent a proinflammatory myeloid subpopulation
            in cancer
  JOURNAL   Cancer Immunol Immunother 70 (1), 75-87 (2021)
   PUBMED   32632664
  REMARK    GeneRIF: CD66b(+) monocytes represent a proinflammatory myeloid
            subpopulation in cancer.
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Iwabuchi,E., Miki,Y., Onodera,Y., Shibahara,Y., Takagi,K.,
            Suzuki,T., Ishida,T. and Sasano,H.
  TITLE     Co-expression of carcinoembryonic antigen-related cell adhesion
            molecule 6 and 8 inhibits proliferation and invasiveness of breast
            carcinoma cells
  JOURNAL   Clin Exp Metastasis 36 (5), 423-432 (2019)
   PUBMED   31222613
  REMARK    GeneRIF: High CEACAM8 expression is associated with metastases in
            breast carcinoma.
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   Yamada,Y., Nakagawa,T., Sugihara,T., Horiuchi,T., Yoshizaki,U.,
            Fujimura,T., Fukuhara,H., Urano,T., Takayama,K., Inoue,S., Kume,H.
            and Homma,Y.
  TITLE     Prognostic value of CD66b positive tumor-infiltrating neutrophils
            in testicular germ cell tumor
  JOURNAL   BMC Cancer 16 (1), 898 (2016)
   PUBMED   27863478
  REMARK    GeneRIF: Increased CD66b positive tumor-infiltrating neutrophils
            (CD66b + TINs) was significantly associated with presence of
            metastasis, S stage, and nonseminomatous germ cell tumor diagnosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Skov,V., Burton,M., Thomassen,M., Stauffer Larsen,T., Riley,C.H.,
            Brinch Madelung,A., Kjaer,L., Bondo,H., Stamp,I., Ehinger,M.,
            Dahl-Sorensen,R., Brochmann,N., Nielsen,K., Thiele,J., Jensen,M.K.,
            Weis Bjerrum,O., Kruse,T.A. and Hasselbalch,H.C.
  TITLE     A 7-Gene Signature Depicts the Biochemical Profile of Early
            Prefibrotic Myelofibrosis
  JOURNAL   PLoS One 11 (8), e0161570 (2016)
   PUBMED   27579896
  REMARK    GeneRIF: a 7-gene signature was identified which correctly
            predicted the primary prefibrotic myelofibrosis group with a
            sensitivity of 100% and a specificity of 89%. The 7 genes included
            MPO, CEACAM8, CRISP3, MS4A3, CEACAM6, HEMGN, and MMP8
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Yamanaka,T., Kuroki,M., Kinugasa,T., Matsuo,Y. and Matsuoka,Y.
  TITLE     Preparation and characterization of two human carcinoembryonic
            antigen family proteins of neutrophils, CD66b and c, in silkworm
            larvae
  JOURNAL   Protein Expr Purif 7 (4), 438-446 (1996)
   PUBMED   8776764
REFERENCE   7  (bases 1 to 2297)
  AUTHORS   Khan,W.N., Frangsmyr,L., Teglund,S., Israelsson,A., Bremer,K. and
            Hammarstrom,S.
  TITLE     Identification of three new genes and estimation of the size of the
            carcinoembryonic antigen family
  JOURNAL   Genomics 14 (2), 384-390 (1992)
   PUBMED   1427854
REFERENCE   8  (bases 1 to 2297)
  AUTHORS   Oikawa,S., Inuzuka,C., Kuroki,M., Arakawa,F., Matsuoka,Y.,
            Kosaki,G. and Nakazato,H.
  TITLE     A specific heterotypic cell adhesion activity between members of
            carcinoembryonic antigen family, W272 and NCA, is mediated by
            N-domains
  JOURNAL   J Biol Chem 266 (13), 7995-8001 (1991)
   PUBMED   2022629
REFERENCE   9  (bases 1 to 2297)
  AUTHORS   Berling,B., Kolbinger,F., Grunert,F., Thompson,J.A., Brombacher,F.,
            Buchegger,F., von Kleist,S. and Zimmermann,W.
  TITLE     Cloning of a carcinoembryonic antigen gene family member expressed
            in leukocytes of chronic myeloid leukemia patients and bone marrow
  JOURNAL   Cancer Res 50 (20), 6534-6539 (1990)
   PUBMED   2208113
REFERENCE   10 (bases 1 to 2297)
  AUTHORS   Arakawa,F., Kuroki,M., Misumi,Y., Oikawa,S., Nakazato,H. and
            Matsuoka,Y.
  TITLE     Characterization of a cDNA clone encoding a new species of the
            nonspecific cross-reacting antigen (NCA), a member of the CEA gene
            family
  JOURNAL   Biochem Biophys Res Commun 166 (3), 1063-1071 (1990)
   PUBMED   2306228
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA464901.1, BC026263.1 and AK297012.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001816.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026263.1, D90064.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154529 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244336.10/ ENSP00000244336.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               DA464901.1         7-566
            561-1456            BC026263.1         535-1430
            1457-1986           AK297012.1         1152-1681
            1987-2297           BC026263.1         1957-2267
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2297
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /note="CEA cell adhesion molecule 8"
                     /db_xref="GeneID:1088"
                     /db_xref="HGNC:HGNC:1820"
                     /db_xref="MIM:615747"
     exon            1..160
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1146
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /note="carcinoembryonic antigen gene family member 6; CD67
                     antigen; carcinoembryonic antigen related cell adhesion
                     molecule 8; carcinoembryonic antigen CGM6; non-specific
                     cross-reacting antigen NCA-95; cell adhesion molecule
                     CEACAM8"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM8 precursor"
                     /protein_id="NP_001807.2"
                     /db_xref="CCDS:CCDS12610.1"
                     /db_xref="GeneID:1088"
                     /db_xref="HGNC:HGNC:1820"
                     /db_xref="MIM:615747"
                     /translation="MGPISAPSCRWRIPWQGLLLTASLFTFWNPPTTAQLTIEAVPSN
                     AAEGKEVLLLVHNLPQDPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIY
                     PNASLLMRNVTRNDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDK
                     DAVAFTCEPETQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQ
                     NPASANFSDPVTLNVLYGPDAPTISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGT
                     FQQYTQKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSDALVQGSSPGLSARA
                     TVSIMIGVLARVALI"
     exon            161..520
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /inference="alignment:Splign:2.1.0"
     exon            521..799
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /inference="alignment:Splign:2.1.0"
     exon            800..1054
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1186
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..2297
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2270..2275
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /note="hexamer: AATAAA"
     polyA_site      2297
                     /gene="CEACAM8"
                     /gene_synonym="CD66b; CD67; CGM6; NCA-95"
                     /note="major polyA site"
ORIGIN      
        1 aaaggaggaa ggacagcaca gctgacagcc gtgctcagaa agtttctgga tcccaggctc
       61 atctccacag aggagaacac gcaggcagca gagaccatgg ggcccatctc agccccttcc
      121 tgcagatggc gcatcccctg gcaggggctc ctgctcacag cctcactttt caccttctgg
      181 aacccgccca ccactgctca gctcactatt gaagctgtgc catccaatgc tgcagagggg
      241 aaggaggttc ttctacttgt ccacaatctg ccccaggacc ctcgtggcta caactggtac
      301 aaaggggaaa cagtggatgc caaccgtcga attataggat atgtaatatc aaatcaacag
      361 attaccccag ggcctgcata cagcaatcga gagacaatat accccaatgc atccctgctg
      421 atgcggaacg tcaccagaaa tgacacagga tcctacaccc tacaagtcat aaagctaaat
      481 cttatgagtg aagaagtaac tggccagttc agcgtacatc cggagactcc caagccctcc
      541 atctccagca acaactccaa ccccgtggag gacaaggatg ctgtggcctt cacctgtgaa
      601 cctgagactc agaacacaac ctacctgtgg tgggtaaatg gtcagagtct cccggtcagt
      661 cccaggctgc agctgtccaa tggcaacagg accctcactc tactcagtgt cacaaggaat
      721 gacgtaggac cctatgaatg tgaaatacag aacccagcga gtgcaaactt cagtgaccca
      781 gtcaccctga atgtcctcta tggcccagat gcccccacca tttccccttc agacacctat
      841 taccatgcag gggtaaatct caacctctcc tgccatgcgg cctctaatcc accctcacag
      901 tattcttggt ctgtcaatgg cacattccag caatacacac aaaagctctt tatccccaac
      961 atcactacaa agaacagcgg atcctatgcc tgccacacca ctaactcagc cactggccgc
     1021 aacaggacca cagtcaggat gatcacagtc tctgatgctt tagtacaagg aagttctcct
     1081 ggcctctcag ctagagccac tgtcagcatc atgattggag tactggccag ggtggctctg
     1141 atatagtagc tctggtgtag tttctgcatt tcaagaagac tggcagacag ttgtttttat
     1201 tcttcctcaa agcatttgca atcagctacc attcaaaatt gcttcttctt caagatttat
     1261 ggaaaatact ctgacgagta ctcttgaaca caagttcctg ataactttaa gatcacgcca
     1321 ctggactgtc tatgaacttg caaacaggct gatacctttg tgaagttgcc caccaaaaca
     1381 cagaaggaaa aaaacatgaa tttcattgaa ctaaataata atgaggataa tgtttttaag
     1441 attttttttt tttttttttt gagatggaat ctcgctctgt cgcccaggct ggagtgcagt
     1501 ggcacgatct caactcactg caagctccgc ctcctgggtt cacaccattc tcctgcctca
     1561 gcctcctgag tagctgggac tacaggcgcc tgccacaacg cccggctaat tttttgtatt
     1621 tttagtagag acggggtttc actgtggtct caatctcctg acttcatggt ccgcctgcct
     1681 cagcctccca aagttctggg attacaggtg tgagccaccg cgcccagccc gtttttaaga
     1741 ttttttattt gaaaaattgc caattcttta agtgttttct ttttcagatt tatgaatttc
     1801 tttatctttt aagctatcta taccttactg caatttggta aagcagactt ttgtgaacaa
     1861 aaattataac atttactttt gctccctacc tgactgccac agaactgggc aactattcat
     1921 gagtattcat atgtttatgg taattcagtt atttgcacaa gttcagtgag aatctgctgt
     1981 ctttataatg ggatatagtt taaaacattg gttatattac caaggctttg attgggatgt
     2041 tatatttgag aaaatacaga gaatgataga ttaacggagt gtctaatcta tcgtgtcaac
     2101 cccaaatttt tacgtatgag atcctttagt ccacccaatg gctgacagta acagcatctt
     2161 taacacaact ctttgttcaa atgtactatg gtctctttta gagtcagact cctagactca
     2221 cttgttctca ctgtctgttt taatttaacc caggcatgca atgctagata ataaaattgc
     2281 tccctattgg ctgatca
//
