LOCUS       NM_001291485            2376 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 7 (CEACAM7), transcript
            variant 2, mRNA.
ACCESSION   NM_001291485 XM_005278379
VERSION     NM_001291485.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Perez-Garcia,F., Jimenez-Sousa,M.A., Gomez-Sanchez,E.,
            Gonzalo-Benito,H., Fernandez-Rodriguez,A., Lorenzo-Lopez,M.,
            Heredia-Rodriguez,M., Martinez-Paz,P., Gomez-Pesquera,E., Tamayo,E.
            and Resino,S.
  TITLE     CEACAM7 polymorphisms predict genetic predisposition to mortality
            in post-surgical septic shock patients
  JOURNAL   J Microbiol Immunol Infect 55 (3), 540-544 (2022)
   PUBMED   34657826
  REMARK    GeneRIF: CEACAM7 polymorphisms predict genetic predisposition to
            mortality in post-surgical septic shock patients.
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: CEACAM7 expression is significantly upregulated in human
            masticatory mucosa during wound healing
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Bonsor,D.A., Beckett,D. and Sundberg,E.J.
  TITLE     Structure of the N-terminal dimerization domain of CEACAM7
  JOURNAL   Acta Crystallogr F Struct Biol Commun 71 (Pt 9), 1169-1175 (2015)
   PUBMED   26323304
  REMARK    GeneRIF: crystal structure of the N-terminal dimerization domain of
            CEACAM has been determined at 1.47 A resolution
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Wakabayashi-Nakao,K., Hatakeyama,K., Ohshima,K., Ken Yamaguchi,K.
            and Mochizuki,T.
  TITLE     Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4)
            is specifically expressed in medullary thyroid carcinoma cells
  JOURNAL   Biomed Res 35 (4), 237-242 (2014)
   PUBMED   25152032
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Huynh-Torlakovic,H., Bjerkan,L., Schenck,K. and Blix,I.J.
  TITLE     Distribution of carcinoembryonic antigen-related cellular adhesion
            molecules in human gingiva
  JOURNAL   Eur J Oral Sci 120 (5), 395-401 (2012)
   PUBMED   22984996
REFERENCE   6  (bases 1 to 2376)
  AUTHORS   Thompson,J., Seitz,M., Chastre,E., Ditter,M., Aldrian,C.,
            Gespach,C. and Zimmermann,W.
  TITLE     Down-regulation of carcinoembryonic antigen family member 2
            expression is an early event in colorectal tumorigenesis
  JOURNAL   Cancer Res 57 (9), 1776-1784 (1997)
   PUBMED   9135022
REFERENCE   7  (bases 1 to 2376)
  AUTHORS   Thompson,J., Zimmermann,W., Nollau,P., Neumaier,M., Weber-Arden,J.,
            Schrewe,H., Craig,I. and Willcocks,T.
  TITLE     CGM2, a member of the carcinoembryonic antigen gene family is
            down-regulated in colorectal carcinomas
  JOURNAL   J Biol Chem 269 (52), 32924-32931 (1994)
   PUBMED   7806520
REFERENCE   8  (bases 1 to 2376)
  AUTHORS   Khan,W.N., Frangsmyr,L., Teglund,S., Israelsson,A., Bremer,K. and
            Hammarstrom,S.
  TITLE     Identification of three new genes and estimation of the size of the
            carcinoembryonic antigen family
  JOURNAL   Genomics 14 (2), 384-390 (1992)
   PUBMED   1427854
REFERENCE   9  (bases 1 to 2376)
  AUTHORS   Thompson,J., Zimmermann,W., Osthus-Bugat,P., Schleussner,C.,
            Eades-Perner,A.M., Barnert,S., Von Kleist,S., Willcocks,T.,
            Craig,I., Tynan,K. et al.
  TITLE     Long-range chromosomal mapping of the carcinoembryonic antigen
            (CEA) gene family cluster
  JOURNAL   Genomics 12 (4), 761-772 (1992)
   PUBMED   1572649
REFERENCE   10 (bases 1 to 2376)
  AUTHORS   Thompson,J.A., Mauch,E.M., Chen,F.S., Hinoda,Y., Schrewe,H.,
            Berling,B., Barnert,S., von Kleist,S., Shively,J.E. and
            Zimmermann,W.
  TITLE     Analysis of the size of the carcinoembryonic antigen (CEA) gene
            family: isolation and sequencing of N-terminal domain exons
  JOURNAL   Biochem Biophys Res Commun 158 (3), 996-1004 (1989)
   PUBMED   2537643
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292213.1 and AC243960.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001291485.1.
            
            Summary: This gene encodes a cell surface glycoprotein and member
            of the carcinoembryonic antigen (CEA) family of proteins.
            Expression of this gene may be downregulated in colon and rectal
            cancer. Additionally, lower expression levels of this gene may be
            predictive of rectal cancer recurrence. This gene is present in a
            CEA family gene cluster on chromosome 19. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jul
            2015].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' UTR, compared to variant 1. Both variants 1 and 2 encode
            the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292213.1, DRR138519.332043.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401731.6/ ENSP00000385932.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1236              AK292213.1         1-1236
            1237-2376           AC243960.3         7559-8698
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2376
                     /gene="CEACAM7"
                     /gene_synonym="CGM2"
                     /note="CEA cell adhesion molecule 7"
                     /db_xref="GeneID:1087"
                     /db_xref="HGNC:HGNC:1819"
                     /db_xref="MIM:619160"
     exon            1..169
                     /gene="CEACAM7"
                     /gene_synonym="CGM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..903
                     /gene="CEACAM7"
                     /gene_synonym="CGM2"
                     /note="carcinoembryonic antigen gene family member 2;
                     carcinoembryonic antigen CGM2; carcinoembryonic antigen
                     related cell adhesion molecule 7; cell adhesion molecule
                     CEACAM7"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM7 preproprotein"
                     /protein_id="NP_001278414.1"
                     /db_xref="CCDS:CCDS12583.1"
                     /db_xref="GeneID:1087"
                     /db_xref="HGNC:HGNC:1819"
                     /db_xref="MIM:619160"
                     /translation="MGSPSACPYRVCIPWQGLLLTASLLTFWNLPNSAQTNIDVVPFN
                     VAEGKEVLLVVHNESQNLYGYNWYKGERVHANYRIIGYVKNISQENAPGPAHNGRETI
                     YPNGTLLIQNVTHNDAGIYTLHVIKENLVNEEVTRQFYVFSEPPKPSITSNNFNPVEN
                     KDIVVLTCQPETQNTTYLWWVNNQSLLVSPRLLLSTDNRTLVLLSATKNDIGPYECEI
                     QNPVGASRSDPVTLNVRYESVQASSPDLSAGTAVSIMIGVLAGMALI"
     exon            170..532
                     /gene="CEACAM7"
                     /gene_synonym="CGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            533..811
                     /gene="CEACAM7"
                     /gene_synonym="CGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            812..939
                     /gene="CEACAM7"
                     /gene_synonym="CGM2"
                     /inference="alignment:Splign:2.1.0"
     exon            940..2376
                     /gene="CEACAM7"
                     /gene_synonym="CGM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2353..2358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM7"
                     /gene_synonym="CGM2"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="CEACAM7"
                     /gene_synonym="CGM2"
                     /note="major polyA site"
ORIGIN      
        1 acagaggtag gaaggacagc agagctgaca gtcacagcag ccctgacaag agagttcctg
       61 gagcccaagc tcttctccac agaggacaag caggcagcag agaccatggg gtccccttca
      121 gcctgtccat acagagtgtg cattccctgg caggggctcc tgctcacagc ctcgctttta
      181 accttctgga acctgccaaa cagtgcccag accaatattg atgtcgtgcc gttcaatgtc
      241 gcagaaggga aggaggtcct tctagtagtc cataatgagt cccagaatct ttatggctac
      301 aactggtaca aaggggaaag ggtgcatgcc aactatcgaa ttataggata tgtaaaaaat
      361 ataagtcaag aaaatgcccc agggcccgca cacaacggtc gagagacaat ataccccaat
      421 ggaaccctgc tgatccagaa cgtcacccac aatgacgcag gaatctatac cctacacgtt
      481 ataaaagaaa atcttgtgaa tgaagaagta accagacaat tctacgtatt ctcggagcca
      541 cccaagccct ccatcaccag caacaacttc aatccggtgg agaacaaaga tattgtggtt
      601 ttaacctgtc aacctgagac tcagaacaca acctacctgt ggtgggtaaa caatcagagc
      661 ctcctggtca gtcccaggct gctgctctcc actgacaaca ggaccctcgt tctactcagc
      721 gccacaaaga atgacatagg accctatgaa tgtgaaatac agaacccagt gggtgccagc
      781 cgcagtgacc cagtcaccct gaatgtccgc tatgagtcag tacaagcaag ttcacctgac
      841 ctctcagctg ggaccgctgt cagcatcatg attggagtac tggctgggat ggctctgata
      901 tagcagcctt ggtgtagttt ctgcatttcg ggaagagtga ctggactgga ttcttctagc
      961 tccttcaatc ccattttctc ctgtggcatc actaagtata agacctgctc tcttcctgaa
     1021 gacctataag ctggaggtgg acaactcaat gtaaatttca aggaaaaacc ctcatgcctg
     1081 agatgtgggc cactcagagc taaccaaaat gttcaacacc ataactagag acactcaaat
     1141 tgccaaccag gacaagaagt tgatgacttc atgctgtgga cagtttttcc caagatgtcc
     1201 caagcctcat cgtgacgagg ctcttatccc actccatttt tccctgctca tgcctgcctc
     1261 tttaatttgg taagataatg ctgtaactag aatttcacaa tcagcgcctt gtgcaggtaa
     1321 tttgacagag tgttggatgt gtcatgtcat catgtcaaac ccaaatattt gacctaaggg
     1381 atcctttatt ctgcccagtg gctaacttta acaacatccc taatacaact gtttattcaa
     1441 atgcacggtg gtccctgtta gagttagacc tctagactca cctgttctca cgccctgttt
     1501 taatttaacc cagctatggg atgccagata acagaattgc tgcctactag ctgaacaggg
     1561 aggagtttgt gcagttgctg acacttcttg ttgcacataa ataaatacag tgggtactat
     1621 agagactcag ttgcaaaaat taacaaatat gctgcttgat taaaatgggt aggcttctca
     1681 tgtggctcat tctttaatct attctctttt atttggtttg gttcatgggg tctctgccta
     1741 tggatcatac ttcaaactct tggtgtgatc ctcctgattg tcacaatatt agttaccctg
     1801 gtgtgctgta ttctctaaaa cctttaaatg tttgcatgca gccattcgtc aaatgtcaaa
     1861 tattctctct ttggctggaa tgacaaaaac tcaaataaat gtatgattag gaggacatca
     1921 taacctatga atgatggaag tccaaaatga tggtaactga cagtagtgtt aatgccttat
     1981 gtttagtcaa actctcattt aggtgacagc ctggtgactc cagaatggag ccagtcatgc
     2041 taaatgccat atactcacac tgaaacatga ggaagcaggt agatcccaga acagacaaaa
     2101 ttttcctaaa aacatgagag tccaggctgt ctgagtcagc acagtaagaa agtcctttct
     2161 gctttaactc ttagaaaaaa gtaatatgaa gtattctgaa attaaccaat cagtttattt
     2221 aaatcaattt atttatattc ttctgttcct ggattcccat tttacaaaac ccactgttct
     2281 actgttgtat tgcccagtag gagctatcac tatattttgc agaatggaaa ctgccctgac
     2341 tcatgaatca caaataaaag ccaattgtat ctataa
//
