LOCUS       NM_002483               2594 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 6 (CEACAM6), mRNA.
ACCESSION   NM_002483
VERSION     NM_002483.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2594)
  AUTHORS   Saraji,A., Wulf,K., Stegmann-Frehse,J., Kang,D., Offermann,A.,
            Shaghoyan,G., Jonigk,D., Kuhnel,M.P., Perner,S., Kirfel,J. and
            Sailer,V.
  TITLE     CEACAM6 Promotes Lung Metastasis via Enhancing Proliferation,
            Migration and Suppressing Apoptosis of Prostate Cancer Cells
  JOURNAL   Cancer Genomics Proteomics 21 (4), 405-413 (2024)
   PUBMED   38944419
  REMARK    GeneRIF: CEACAM6 Promotes Lung Metastasis via Enhancing
            Proliferation, Migration and Suppressing Apoptosis of Prostate
            Cancer Cells.
REFERENCE   2  (bases 1 to 2594)
  AUTHORS   Michl,J., White,B., Monterisi,S., Bodmer,W.F. and Swietach,P.
  TITLE     Phenotypic screen of sixty-eight colorectal cancer cell lines
            identifies CEACAM6 and CEACAM5 as markers of acid resistance
  JOURNAL   Proc Natl Acad Sci U S A 121 (13), e2319055121 (2024)
   PUBMED   38502695
  REMARK    GeneRIF: Phenotypic screen of sixty-eight colorectal cancer cell
            lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
REFERENCE   3  (bases 1 to 2594)
  AUTHORS   Wu,G., Wang,D., Xiong,F., Wang,Q., Liu,W., Chen,J. and Chen,Y.
  TITLE     The emerging roles of CEACAM6 in human cancer (Review)
  JOURNAL   Int J Oncol 64 (3) (2024)
   PUBMED   38240103
  REMARK    GeneRIF: The emerging roles of CEACAM6 in human cancer (Review).
            Review article
REFERENCE   4  (bases 1 to 2594)
  AUTHORS   Chu,Y.D., Cheng,L.C., Lim,S.N., Lai,M.W., Yeh,C.T. and Lin,W.R.
  TITLE     Aldolase B-driven lactagenesis and CEACAM6 activation promote cell
            renewal and chemoresistance in colorectal cancer through the
            Warburg effect
  JOURNAL   Cell Death Dis 14 (10), 660 (2023)
   PUBMED   37816733
  REMARK    GeneRIF: Aldolase B-driven lactagenesis and CEACAM6 activation
            promote cell renewal and chemoresistance in colorectal cancer
            through the Warburg effect.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2594)
  AUTHORS   Jantscheff,P., Terracciano,L., Lowy,A., Glatz-Krieger,K.,
            Grunert,F., Micheel,B., Brummer,J., Laffer,U., Metzger,U.,
            Herrmann,R. and Rochlitz,C.
  TITLE     Expression of CEACAM6 in resectable colorectal cancer: a factor of
            independent prognostic significance
  JOURNAL   J Clin Oncol 21 (19), 3638-3646 (2003)
   PUBMED   14512395
  REMARK    GeneRIF: the first study to demonstrate the prognostic relevance of
            CEACAM6 overexpression in human colorectal cancer
REFERENCE   6  (bases 1 to 2594)
  AUTHORS   Oikawa,S., Inuzuka,C., Kuroki,M., Arakawa,F., Matsuoka,Y.,
            Kosaki,G. and Nakazato,H.
  TITLE     A specific heterotypic cell adhesion activity between members of
            carcinoembryonic antigen family, W272 and NCA, is mediated by
            N-domains
  JOURNAL   J Biol Chem 266 (13), 7995-8001 (1991)
   PUBMED   2022629
REFERENCE   7  (bases 1 to 2594)
  AUTHORS   Hefta,S.A., Paxton,R.J. and Shively,J.E.
  TITLE     Sequence and glycosylation site identity of two distinct glycoforms
            of nonspecific cross-reacting antigen as demonstrated by sequence
            analysis and fast atom bombardment mass spectrometry
  JOURNAL   J Biol Chem 265 (15), 8618-8626 (1990)
   PUBMED   2341397
REFERENCE   8  (bases 1 to 2594)
  AUTHORS   Hefta,L.J., Schrewe,H., Thompson,J.A., Oikawa,S., Nakazato,H. and
            Shively,J.E.
  TITLE     Expression of complementary DNA and genomic clones for
            carcinoembryonic antigen and nonspecific cross-reacting antigen in
            Chinese hamster ovary and mouse fibroblast cells and
            characterization of the membrane-expressed products
  JOURNAL   Cancer Res 50 (8), 2397-2403 (1990)
   PUBMED   2317824
REFERENCE   9  (bases 1 to 2594)
  AUTHORS   Haus,O., Noworolska,A., Laskowski,M., Kuliszkiewicz-Janus,M.,
            Kozlowska,J., Harlozinska-Szmyrka,A., Jagielski,J. and
            Kotlarek-Haus,S.
  TITLE     Prognostic significance of secondary cytogenetic changes and
            nonspecific cross-reacting antigen (NCA) in patients with
            Ph-positive chronic myeloid leukemia
  JOURNAL   Exp Mol Pathol 52 (2), 235-242 (1990)
   PUBMED   2332039
REFERENCE   10 (bases 1 to 2594)
  AUTHORS   Barnett,T., Goebel,S.J., Nothdurft,M.A. and Elting,J.J.
  TITLE     Carcinoembryonic antigen family: characterization of cDNAs coding
            for NCA and CEA and suggestion of nonrandom sequence variation in
            their conserved loop-domains
  JOURNAL   Genomics 3 (1), 59-66 (1988)
   PUBMED   3220478
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA763751.1, AK312542.1,
            BC005008.1, M18728.1 and AC243967.3.
            
            On Nov 22, 2018 this sequence version replaced NM_002483.6.
            
            Summary: This gene encodes a protein that belongs to the
            carcinoembryonic antigen (CEA) family whose members are glycosyl
            phosphatidyl inositol (GPI) anchored cell surface glycoproteins.
            Members of this family play a role in cell adhesion and are widely
            used as tumor markers in serum immunoassay determinations of
            carcinoma. This gene affects the sensitivity of tumor cells to
            adenovirus infection. The protein encoded by this gene acts as a
            receptor for adherent-invasive E. coli adhesion to the surface of
            ileal epithelial cells in patients with Crohn's disease. This gene
            is clustered with genes and pseudogenes of the cell adhesion
            molecules subgroup of the CEA family on chromosome 19. [provided by
            RefSeq, Apr 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M18728.1, M18216.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000199764.7/ ENSP00000199764.6
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-140               DA763751.1         363-502
            141-1144            AK312542.1         136-1139
            1145-2302           BC005008.1         1076-2233
            2303-2336           M18728.1           2244-2277
            2337-2591           M18728.1           2279-2533
            2592-2594           AC243967.3         139694-139696       c
FEATURES             Location/Qualifiers
     source          1..2594
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2594
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /note="CEA cell adhesion molecule 6"
                     /db_xref="GeneID:4680"
                     /db_xref="HGNC:HGNC:1818"
                     /db_xref="MIM:163980"
     exon            1..173
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1144
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /note="normal cross-reacting antigen; Cluster of
                     Differentiation 66c; carcinoembryonic antigen related cell
                     adhesion molecule 6; carcinoembryonic antigen-related cell
                     adhesion molecule 6 (non-specific cross reacting antigen);
                     cell adhesion molecule CEACAM6"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM6 preproprotein"
                     /protein_id="NP_002474.4"
                     /db_xref="CCDS:CCDS12585.1"
                     /db_xref="GeneID:4680"
                     /db_xref="HGNC:HGNC:1818"
                     /db_xref="MIM:163980"
                     /translation="MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFN
                     VAEGKEVLLLAHNLPQNRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIY
                     PNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDK
                     DAVAFTCEPEVQNTTYLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQ
                     NPASANRSDPVTLNVLYGPDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGT
                     FQQSTQELFIPNITVNNSGSYMCQAHNSATGLNRTTVTMITVSGSAPVLSAVATVGIT
                     IGVLARVALI"
     exon            174..533
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /inference="alignment:Splign:2.1.0"
     exon            534..812
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /inference="alignment:Splign:2.1.0"
     exon            813..1067
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1184
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..2594
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2566..2571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /note="hexamer: AATAAA"
     polyA_site      2594
                     /gene="CEACAM6"
                     /gene_synonym="CD66c; CEAL; NCA; NCA-50/90"
                     /note="major polyA site"
ORIGIN      
        1 acagaaggag gaaggacagc agggccaaca gtcacagcag ccctgaccag agcattcctg
       61 gagctcaagc tcctctacaa agaggtggac agagaagaca gcagagacca tgggaccccc
      121 ctcagcccct ccctgcagat tgcatgtccc ctggaaggag gtcctgctca cagcctcact
      181 tctaaccttc tggaacccac ccaccactgc caagctcact attgaatcca cgccgttcaa
      241 tgtcgcagag gggaaggagg ttcttctact cgcccacaac ctgccccaga atcgtattgg
      301 ttacagctgg tacaaaggcg aaagagtgga tggcaacagt ctaattgtag gatatgtaat
      361 aggaactcaa caagctaccc cagggcccgc atacagtggt cgagagacaa tataccccaa
      421 tgcatccctg ctgatccaga acgtcaccca gaatgacaca ggattctata ccctacaagt
      481 cataaagtca gatcttgtga atgaagaagc aaccggacag ttccatgtat acccggagct
      541 gcccaagccc tccatctcca gcaacaactc caaccccgtg gaggacaagg atgctgtggc
      601 cttcacctgt gaacctgagg ttcagaacac aacctacctg tggtgggtaa atggtcagag
      661 cctcccggtc agtcccaggc tgcagctgtc caatggcaac atgaccctca ctctactcag
      721 cgtcaaaagg aacgatgcag gatcctatga atgtgaaata cagaacccag cgagtgccaa
      781 ccgcagtgac ccagtcaccc tgaatgtcct ctatggccca gatgtcccca ccatttcccc
      841 ctcaaaggcc aattaccgtc caggggaaaa tctgaacctc tcctgccacg cagcctctaa
      901 cccacctgca cagtactctt ggtttatcaa tgggacgttc cagcaatcca cacaagagct
      961 ctttatcccc aacatcactg tgaataatag cggatcctat atgtgccaag cccataactc
     1021 agccactggc ctcaatagga ccacagtcac gatgatcaca gtctctggaa gtgctcctgt
     1081 cctctcagct gtggccaccg tcggcatcac gattggagtg ctggccaggg tggctctgat
     1141 atagcagccc tggtgtattt tcgatatttc aggaagactg gcagattgga ccagaccctg
     1201 aattcttcta gctcctccaa tcccatttta tcccatggaa ccactaaaaa caaggtctgc
     1261 tctgctcctg aagccctata tgctggagat ggacaactca atgaaaattt aaagggaaaa
     1321 ccctcaggcc tgaggtgtgt gccactcaga gacttcacct aactagagac agtcaaactg
     1381 caaaccatgg tgagaaattg acgacttcac actatggaca gcttttccca agatgtcaaa
     1441 acaagactcc tcatcatgat aaggctctta ccccctttta atttgtcctt gcttatgcct
     1501 gcctctttcg cttggcagga tgatgctgtc attagtattt cacaagaagt agcttcagag
     1561 ggtaacttaa cagagtgtca gatctatctt gtcaatccca acgttttaca taaaataaga
     1621 gatcctttag tgcacccagt gactgacatt agcagcatct ttaacacagc cgtgtgttca
     1681 aatgtacagt ggtccttttc agagttggac ttctagactc acctgttctc actccctgtt
     1741 ttaattcaac ccagccatgc aatgccaaat aatagaattg ctccctacca gctgaacagg
     1801 gaggagtctg tgcagtttct gacacttgtt gttgaacatg gctaaataca atgggtatcg
     1861 ctgagactaa gttgtagaaa ttaacaaatg tgctgcttgg ttaaaatggc tacactcatc
     1921 tgactcattc tttattctat tttagttggt ttgtatcttg cctaaggtgc gtagtccaac
     1981 tcttggtatt accctcctaa tagtcatact agtagtcata ctccctggtg tagtgtattc
     2041 tctaaaagct ttaaatgtct gcatgcagcc agccatcaaa tagtgaatgg tctctctttg
     2101 gctggaatta caaaactcag agaaatgtgt catcaggaga acatcataac ccatgaagga
     2161 taaaagcccc aaatggtggt aactgataat agcactaatg ctttaagatt tggtcacact
     2221 ctcacctagg tgagcgcatt gagccagtgg tgctaaatgc tacatactcc aactgaaatg
     2281 ttaaggaaga agatagatcc aattaaaaaa aattaaaacc aatttaaaaa aaaaaagaac
     2341 acaggagatt ccagtctact tgagttagca taatacagaa gtcccctcta ctttaacttt
     2401 tacaaaaaag taacctgaac taatctgatg ttaaccaatg tatttatttc tgtggttctg
     2461 tttccttgtt ccaatttgac aaaacccact gttcttgtat tgtattgccc agggggagct
     2521 atcactgtac ttgtagagtg gtgctgcttt aattcataaa tcacaaataa aagccaatta
     2581 gctctataac taaa
//
