LOCUS       NM_004363               3501 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 5 (CEACAM5), transcript
            variant 1, mRNA.
ACCESSION   NM_004363
VERSION     NM_004363.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3501)
  AUTHORS   Ye,M., Lu,F., Gu,D., Xue,B., Xu,L., Hu,C., Chen,J., Yu,P.,
            Zheng,H., Gao,Y., Wang,J. and Tang,Q.
  TITLE     Hypoxia exosome derived CEACAM5 promotes tumor-associated
            macrophages M2 polarization to accelerate pancreatic neuroendocrine
            tumors metastasis via MMP9
  JOURNAL   FASEB J 38 (13), e23762 (2024)
   PUBMED   38923643
  REMARK    GeneRIF: Hypoxia exosome derived CEACAM5 promotes tumor-associated
            macrophages M2 polarization to accelerate pancreatic neuroendocrine
            tumors metastasis via MMP9.
REFERENCE   2  (bases 1 to 3501)
  AUTHORS   Michl,J., White,B., Monterisi,S., Bodmer,W.F. and Swietach,P.
  TITLE     Phenotypic screen of sixty-eight colorectal cancer cell lines
            identifies CEACAM6 and CEACAM5 as markers of acid resistance
  JOURNAL   Proc Natl Acad Sci U S A 121 (13), e2319055121 (2024)
   PUBMED   38502695
  REMARK    GeneRIF: Phenotypic screen of sixty-eight colorectal cancer cell
            lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
REFERENCE   3  (bases 1 to 3501)
  AUTHORS   Huang,S.C., Chang,S.C., Liao,T.T. and Yang,M.H.
  TITLE     Detection and clinical significance of CEACAM5 methylation in
            colorectal cancer patients
  JOURNAL   Cancer Sci 115 (1), 270-282 (2024)
   PUBMED   37942534
  REMARK    GeneRIF: Detection and clinical significance of CEACAM5 methylation
            in colorectal cancer patients.
REFERENCE   4  (bases 1 to 3501)
  AUTHORS   Sun,J., Lu,P., Guan,S. and Liu,S.
  TITLE     [Heterogeneity analysis of pancreatic cancer and identification of
            molecular subtypes of tumor cells based on CEACAM5, LGALS1 and
            CENPF gene expression]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (9), 1567-1576 (2023)
   PUBMED   37814871
  REMARK    GeneRIF: [Heterogeneity analysis of pancreatic cancer and
            identification of molecular subtypes of tumor cells based on
            CEACAM5, LGALS1 and CENPF gene expression].
REFERENCE   5  (bases 1 to 3501)
  AUTHORS   Suer,H., Erus,S., Cesur,E.E., Yavuz,O., Agcaoglu,O., Bulutay,P.,
            Onder,T.T., Tanju,S. and Dilege,S.
  TITLE     Combination of CEACAM5, EpCAM and CK19 gene expressions in
            mediastinal lymph node micrometastasis is a prognostic factor for
            non-small cell lung cancer
  JOURNAL   J Cardiothorac Surg 18 (1), 189 (2023)
   PUBMED   37312199
  REMARK    GeneRIF: Combination of CEACAM5, EpCAM and CK19 gene expressions in
            mediastinal lymph node micrometastasis is a prognostic factor for
            non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3501)
  AUTHORS   Beauchemin,N. and Arabzadeh,A.
  TITLE     Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs)
            in cancer progression and metastasis
  JOURNAL   Cancer Metastasis Rev 32 (3-4), 643-671 (2013)
   PUBMED   23903773
  REMARK    Review article
REFERENCE   7  (bases 1 to 3501)
  AUTHORS   Willcocks,T.C. and Craig,I.W.
  TITLE     Characterization of the genomic organization of human
            carcinoembryonic antigen (CEA): comparison with other family
            members and sequence analysis of 5' controlling region
  JOURNAL   Genomics 8 (3), 492-500 (1990)
   PUBMED   2286372
REFERENCE   8  (bases 1 to 3501)
  AUTHORS   Schrewe,H., Thompson,J., Bona,M., Hefta,L.J., Maruya,A.,
            Hassauer,M., Shively,J.E., von Kleist,S. and Zimmermann,W.
  TITLE     Cloning of the complete gene for carcinoembryonic antigen: analysis
            of its promoter indicates a region conveying cell type-specific
            expression
  JOURNAL   Mol Cell Biol 10 (6), 2738-2748 (1990)
   PUBMED   2342461
REFERENCE   9  (bases 1 to 3501)
  AUTHORS   Hefta,L.J., Schrewe,H., Thompson,J.A., Oikawa,S., Nakazato,H. and
            Shively,J.E.
  TITLE     Expression of complementary DNA and genomic clones for
            carcinoembryonic antigen and nonspecific cross-reacting antigen in
            Chinese hamster ovary and mouse fibroblast cells and
            characterization of the membrane-expressed products
  JOURNAL   Cancer Res 50 (8), 2397-2403 (1990)
   PUBMED   2317824
REFERENCE   10 (bases 1 to 3501)
  AUTHORS   Barnett,T. and Zimmermann,W.
  TITLE     Workshop report: proposed nomenclature for the carcinoembryonic
            antigen (CEA) gene family
  JOURNAL   Tumour Biol 11 (1-2), 59-63 (1990)
   PUBMED   2309067
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB006625.1, M15042.1 and
            AC243967.3.
            
            On Jun 2, 2019 this sequence version replaced NM_004363.5.
            
            Summary: This gene encodes a cell surface glycoprotein that
            represents the founding member of the carcinoembryonic antigen
            (CEA) family of proteins. The encoded protein is used as a clinical
            biomarker for gastrointestinal cancers and may promote tumor
            development through its role as a cell adhesion molecule.
            Additionally, the encoded protein may regulate differentiation,
            apoptosis, and cell polarity. This gene is present in a CEA family
            gene cluster on chromosome 19. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Jul 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Both variants 1 and
            2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M15042.1, DRR138512.392754.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221992.11/ ENSP00000221992.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               DB006625.1         16-132
            118-2423            M15042.1           1-2306
            2424-3501           AC243967.3         181472-182549       c
FEATURES             Location/Qualifiers
     source          1..3501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3501
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /note="CEA cell adhesion molecule 5"
                     /db_xref="GeneID:1048"
                     /db_xref="HGNC:HGNC:1817"
                     /db_xref="MIM:114890"
     exon            1..170
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..2215
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; meconium antigen 100; carcinoembryonic antigen
                     related cell adhesion molecule 5; cell adhesion molecule
                     CEACAM5"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM5 isoform 1
                     preproprotein"
                     /protein_id="NP_004354.3"
                     /db_xref="CCDS:CCDS12584.1"
                     /db_xref="GeneID:1048"
                     /db_xref="HGNC:HGNC:1817"
                     /db_xref="MIM:114890"
                     /translation="MESPSAPPHRWCIPWQRLLLTASLLTFWNPPTTAKLTIESTPFN
                     VAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIY
                     PNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPELPKPSISSNNSKPVEDK
                     DAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQ
                     NPVSARRSDSVILNVLYGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGT
                     FQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPKPFITSNNSNP
                     VEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYE
                     CGIQNELSVDHSDPVILNVLYGPDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWL
                     IDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSISSN
                     NSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDA
                     RAYVCGIQNSVSANRSDPVTLDVLYGPDTPIISPPDSSYLSGANLNLSCHSASNPSPQ
                     YSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPG
                     LSAGATVGIMIGVLVGVALI"
     exon            171..530
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     exon            531..809
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1064
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1343
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1598
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1877
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2132
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     exon            2133..2251
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..3501
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2966..2971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /note="hexamer: AATAAA"
     polyA_site      2994
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /note="major polyA site"
     regulatory      3069..3074
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
                     /note="hexamer: AATAAA"
     polyA_site      3095
                     /gene="CEACAM5"
                     /gene_synonym="CD66e; CEA"
ORIGIN      
        1 agagggagga aggacagcag accagacagt cacagcagcc ttgacaaaac gttcctggaa
       61 ctcaagctct tctccacaga ggaggacaga gcagacagca gagaccatgg agtctccctc
      121 ggcccctccc cacagatggt gcatcccctg gcagaggctc ctgctcacag cctcacttct
      181 aaccttctgg aacccgccca ccactgccaa gctcactatt gaatccacgc cgttcaatgt
      241 cgcagagggg aaggaggtgc ttctacttgt ccacaatctg ccccagcatc tttttggcta
      301 cagctggtac aaaggtgaaa gagtggatgg caaccgtcaa attataggat atgtaatagg
      361 aactcaacaa gctaccccag ggcccgcata cagtggtcga gagataatat accccaatgc
      421 atccctgctg atccagaaca tcatccagaa tgacacagga ttctacaccc tacacgtcat
      481 aaagtcagat cttgtgaatg aagaagcaac tggccagttc cgggtatacc cggagctgcc
      541 caagccctcc atctccagca acaactccaa acccgtggag gacaaggatg ctgtggcctt
      601 cacctgtgaa cctgagactc aggacgcaac ctacctgtgg tgggtaaaca atcagagcct
      661 cccggtcagt cccaggctgc agctgtccaa tggcaacagg accctcactc tattcaatgt
      721 cacaagaaat gacacagcaa gctacaaatg tgaaacccag aacccagtga gtgccaggcg
      781 cagtgattca gtcatcctga atgtcctcta tggcccggat gcccccacca tttcccctct
      841 aaacacatct tacagatcag gggaaaatct gaacctctcc tgccacgcag cctctaaccc
      901 acctgcacag tactcttggt ttgtcaatgg gactttccag caatccaccc aagagctctt
      961 tatccccaac atcactgtga ataatagtgg atcctatacg tgccaagccc ataactcaga
     1021 cactggcctc aataggacca cagtcacgac gatcacagtc tatgcagagc cacccaaacc
     1081 cttcatcacc agcaacaact ccaaccccgt ggaggatgag gatgctgtag ccttaacctg
     1141 tgaacctgag attcagaaca caacctacct gtggtgggta aataatcaga gcctcccggt
     1201 cagtcccagg ctgcagctgt ccaatgacaa caggaccctc actctactca gtgtcacaag
     1261 gaatgatgta ggaccctatg agtgtggaat ccagaacgaa ttaagtgttg accacagcga
     1321 cccagtcatc ctgaatgtcc tctatggccc agacgacccc accatttccc cctcatacac
     1381 ctattaccgt ccaggggtga acctcagcct ctcctgccat gcagcctcta acccacctgc
     1441 acagtattct tggctgattg atgggaacat ccagcaacac acacaagagc tctttatctc
     1501 caacatcact gagaagaaca gcggactcta tacctgccag gccaataact cagccagtgg
     1561 ccacagcagg actacagtca agacaatcac agtctctgcg gagctgccca agccctccat
     1621 ctccagcaac aactccaaac ccgtggagga caaggatgct gtggccttca cctgtgaacc
     1681 tgaggctcag aacacaacct acctgtggtg ggtaaatggt cagagcctcc cagtcagtcc
     1741 caggctgcag ctgtccaatg gcaacaggac cctcactcta ttcaatgtca caagaaatga
     1801 cgcaagagcc tatgtatgtg gaatccagaa ctcagtgagt gcaaaccgca gtgacccagt
     1861 caccctggat gtcctctatg ggccggacac ccccatcatt tcccccccag actcgtctta
     1921 cctttcggga gcgaacctca acctctcctg ccactcggcc tctaacccat ccccgcagta
     1981 ttcttggcgt atcaatggga taccgcagca acacacacaa gttctcttta tcgccaaaat
     2041 cacgccaaat aataacggga cctatgcctg ttttgtctct aacttggcta ctggccgcaa
     2101 taattccata gtcaagagca tcacagtctc tgcatctgga acttctcctg gtctctcagc
     2161 tggggccact gtcggcatca tgattggagt gctggttggg gttgctctga tatagcagcc
     2221 ctggtgtagt ttcttcattt caggaagact gacagttgtt ttgcttcttc cttaaagcat
     2281 ttgcaacagc tacagtctaa aattgcttct ttaccaagga tatttacaga aaagactctg
     2341 accagagatc gagaccatcc tagccaacat cgtgaaaccc catctctact aaaaatacaa
     2401 aaatgagctg ggcttggtgg cgcacacctg tagtcccagt tactcgggag gctgaggcag
     2461 gagaatcgct tgaacccggg aggtggagat tgcagtgagc ccagatcgca ccactgcact
     2521 ccagtctggc aacagagcaa gactccatct caaaaagaaa agaaaagaag actctgacct
     2581 gtactcttga atacaagttt ctgataccac tgcactgtct gagaatttcc aaaactttaa
     2641 tgaactaact gacagcttca tgaaactgtc caccaagatc aagcagagaa aataattaat
     2701 ttcatgggac taaatgaact aatgaggata atattttcat aattttttat ttgaaatttt
     2761 gctgattctt taaatgtctt gtttcccaga tttcaggaaa ctttttttct tttaagctat
     2821 ccacagctta cagcaatttg ataaaatata cttttgtgaa caaaaattga gacatttaca
     2881 ttttctccct atgtggtcgc tccagacttg ggaaactatt catgaatatt tatattgtat
     2941 ggtaatatag ttattgcaca agttcaataa aaatctgctc tttgtatgac agaatacatt
     3001 tgaaaacatt ggttatatta ccaagacttt gactagaatg tcgtatttga ggatataaac
     3061 ccataggtaa taaacccaca ggtactacaa acaaagtctg aagtcagcct tggtttggct
     3121 tcctagtgtc aattaaactt ctaaaagttt aatctgagat tccttataaa aacttccagc
     3181 aaagcaactt taaaaaagtc tgtgtgggcc gggcgcggtg gctcacgcct gtaatcccag
     3241 cactttgatc cgccgaggcg ggcggatcac gaggtcagga gatccagacc atcctggcta
     3301 acacagtgaa accccgtctc tactaaaaat acaaaaaaag ttagccgggc gtggtggtgg
     3361 gggcctgtag tcccagctac tcaggaggct gaggcaggag aacggcatga acccgggagg
     3421 cagggcttgc agtgagccaa gatcatgccg ctgcactcca gcctgggaga caaagtgaga
     3481 ctccgtcaaa aaaaaaaaaa a
//
