LOCUS       NM_001817               1161 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 4 (CEACAM4), transcript
            variant 1, mRNA.
ACCESSION   NM_001817
VERSION     NM_001817.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1161)
  AUTHORS   Delgado Tascon,J., Adrian,J., Kopp,K., Scholz,P., Tschan,M.P.,
            Kuespert,K. and Hauck,C.R.
  TITLE     The granulocyte orphan receptor CEACAM4 is able to trigger
            phagocytosis of bacteria
  JOURNAL   J Leukoc Biol 97 (3), 521-531 (2015)
   PUBMED   25567962
  REMARK    GeneRIF: CEACAM4 has phagocytic function.
REFERENCE   2  (bases 1 to 1161)
  AUTHORS   Wakabayashi-Nakao,K., Hatakeyama,K., Ohshima,K., Ken Yamaguchi,K.
            and Mochizuki,T.
  TITLE     Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4)
            is specifically expressed in medullary thyroid carcinoma cells
  JOURNAL   Biomed Res 35 (4), 237-242 (2014)
   PUBMED   25152032
  REMARK    GeneRIF: CEACAM4 is expressed in tumor-derived cell lines, and this
            expression is specific to an medullary thyroid carcinoma derived
            cell line.
REFERENCE   3  (bases 1 to 1161)
  AUTHORS   Kuroki,M., Arakawa,F., Matsuo,Y., Oikawa,S., Misumi,Y., Nakazato,H.
            and Matsuoka,Y.
  TITLE     Molecular cloning of nonspecific cross-reacting antigens in human
            granulocytes
  JOURNAL   J Biol Chem 266 (18), 11810-11817 (1991)
   PUBMED   2050678
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX644579.1, BX644557.1, D90276.1, BF819374.1, AC243960.3 and
            AC005955.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001817.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90276.1, DRR138517.127304.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221954.7/ ENSP00000221954.2
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               BX644579.1         3-181
            180-195             BX644557.1         181-196
            196-460             BX644579.1         198-462
            461-778             D90276.1           447-764
            779-888             BF819374.1         352-461
            889-889             AC243960.3         62714-62714
            890-891             BF819374.1         463-464
            892-1161            AC005955.1         29157-29426         c
FEATURES             Location/Qualifiers
     source          1..1161
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1161
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /note="CEA cell adhesion molecule 4"
                     /db_xref="GeneID:1089"
                     /db_xref="HGNC:HGNC:1816"
                     /db_xref="MIM:619159"
     exon            1..175
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..846
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; carcinoembryonic antigen gene family member 7;
                     nonspecific cross-reacting antigen W236; carcinoembryonic
                     antigen related cell adhesion molecule 4; Nonspecific
                     cross-reacting antigen (NCA); carcinoembryonic antigen
                     CGM7; non-specific cross-reacting antigen W236;
                     carcinoembryonic antigen-related cell adhesion molecule
                     4-sv1; carcinoembryonic antigen-related cell adhesion
                     molecule 4-sv2; cell adhesion molecule CEACAM4"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM4 isoform 1
                     precursor"
                     /protein_id="NP_001808.2"
                     /db_xref="CCDS:CCDS33033.1"
                     /db_xref="GeneID:1089"
                     /db_xref="HGNC:HGNC:1816"
                     /db_xref="MIM:619159"
                     /translation="MGPPSAAPRGGHRPWQGLLITASLLTFWHPPTTVQFTIEALPSS
                     AAEGKDVLLLACNISETIQAYYWHKGKTAEGSPLIAGYITDIQANIPGAAYSGRETVY
                     PNGSLLFQNITLEDAGSYTLRTINASYDSDQATGQLHVHQNNVPGLPVGAVAGIVTGV
                     LVGVALVAALVCFLLLSRTGRASIQRDLREQPPPASTPGHGPSHRSTFSAPLPSPRTA
                     TPIYEELLYSDANIYCQIDHKADVVS"
     exon            176..535
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /inference="alignment:Splign:2.1.0"
     exon            536..653
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /inference="alignment:Splign:2.1.0"
     exon            654..706
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /inference="alignment:Splign:2.1.0"
     exon            707..738
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /inference="alignment:Splign:2.1.0"
     exon            739..780
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1161
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1139..1144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /note="hexamer: AATAAA"
     polyA_site      1161
                     /gene="CEACAM4"
                     /gene_synonym="CGM7; CGM7_HUMAN; NCA"
                     /note="major polyA site"
ORIGIN      
        1 acagaaggag gaaggtcagc agccccgaca gccgacagtc acagcagctc tgacaagagc
       61 gttcctggag cccagctcct ctccacagag gacaagcagg cagcagagac catgggcccc
      121 ccctcagccg ctccccgtgg agggcacagg ccctggcagg ggctcctgat cacagcctca
      181 cttttaacct tctggcaccc gcccaccact gtccagttca ctattgaagc cctgccgtcc
      241 agtgctgcag agggaaagga tgttcttcta ctggcctgca atatttcaga aactattcaa
      301 gcctattatt ggcacaaggg gaaaacggca gaagggagcc ctctcattgc tggttatata
      361 acagacattc aagcaaatat cccaggggcc gcatacagtg gtcgagagac agtatacccc
      421 aatggatccc tgctgttcca aaacatcacc ctggaggacg caggatccta caccctacga
      481 accataaatg ccagttacga ctctgaccaa gcaactggcc agctccacgt acaccaaaac
      541 aacgtcccag gccttcctgt gggggccgtc gctggcatcg tgactggggt cctggttggg
      601 gtggctctgg tggccgccct ggtgtgtttt ctgcttctct ccaggactgg aagggccagc
      661 atccagcgtg acctcaggga gcagccgccc ccagcctcca cccctggcca tggtccctct
      721 cacagatcca ccttctcggc ccctctaccc agccccagaa cagccactcc catctatgag
      781 gaattgctat actctgatgc aaacatttac tgccagatcg accacaaagc agatgtggtc
      841 tcttaggttc ctctgggagc tgctcttgtg ggttgatgga gcgtccccga agctcccagc
      901 cctggggacg gggaaggaca tggagcctga gccagagaac cagctctgag tcctgaggag
      961 acacaggcct ggggacaggg agggatggga gtccctgctg aatatctgga gaccctgaca
     1021 ggttgccctg ggctctgggt gggccgggac aaaggcctct catcaccaca ggaagcgggg
     1081 gcttgcaagg aaagtgaatg ggcctgtggc ccacccgggg tcaccaggaa aggatctgaa
     1141 taaagaggac ccttcctctc a
//
