LOCUS       NM_001815               1167 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 3 (CEACAM3), transcript
            variant 1, mRNA.
ACCESSION   NM_001815
VERSION     NM_001815.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1167)
  AUTHORS   Chen,X., Chen,C., Huang,L. and Wu,P.
  TITLE     Pretreatment controlling nutritional status (CONUT) score and
            carcinoembryonic antigen level provide tumor progression and
            prognostic information in gastric cancer: A retrospective study
  JOURNAL   Medicine (Baltimore) 102 (49), e36535 (2023)
   PUBMED   38065858
  REMARK    GeneRIF: Pretreatment controlling nutritional status (CONUT) score
            and carcinoembryonic antigen level provide tumor progression and
            prognostic information in gastric cancer: A retrospective study.
REFERENCE   2  (bases 1 to 1167)
  AUTHORS   Nunes Pereira,P., Francoise Derchain,S., Yoshida,A., Hoelz de
            Oliveira Barros,R., Menezes Jales,R. and Sarian,L.O.
  TITLE     Diffusion-weighted magnetic resonance sequence and CA125/CEA ratio
            can be used as add-on tools to ultrasound for the differentiation
            of ovarian from non-ovarian pelvic masses
  JOURNAL   PLoS One 18 (3), e0283212 (2023)
   PUBMED   36928256
  REMARK    GeneRIF: Diffusion-weighted magnetic resonance sequence and
            CA125/CEA ratio can be used as add-on tools to ultrasound for the
            differentiation of ovarian from non-ovarian pelvic masses.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1167)
  AUTHORS   Goob,G., Adrian,J., Cossu,C. and Hauck,C.R.
  TITLE     Phagocytosis mediated by the human granulocyte receptor CEACAM3 is
            limited by the receptor-type protein tyrosine phosphatase PTPRJ
  JOURNAL   J Biol Chem 298 (9), 102269 (2022)
   PUBMED   35850306
  REMARK    GeneRIF: Phagocytosis mediated by the human granulocyte receptor
            CEACAM3 is limited by the receptor-type protein tyrosine
            phosphatase PTPRJ.
REFERENCE   4  (bases 1 to 1167)
  AUTHORS   Klaile,E., Prada Salcedo,J.P., Klassert,T.E., Besemer,M.,
            Bothe,A.K., Durotin,A., Muller,M.M., Schmitt,V., Luther,C.H.,
            Dittrich,M., Singer,B.B., Dandekar,T. and Slevogt,H.
  TITLE     Antibody ligation of CEACAM1, CEACAM3, and CEACAM6, differentially
            enhance the cytokine release of human neutrophils in responses to
            Candida albicans
  JOURNAL   Cell Immunol 371, 104459 (2022)
   PUBMED   34847408
  REMARK    GeneRIF: Antibody ligation of CEACAM1, CEACAM3, and CEACAM6,
            differentially enhance the cytokine release of human neutrophils in
            responses to Candida albicans.
REFERENCE   5  (bases 1 to 1167)
  AUTHORS   Tsai,C.H., Wu,A.C., Chiang,B.L., Yang,Y.H., Hung,S.P., Su,M.W.,
            Chang,Y.J. and Lee,Y.L.
  TITLE     CEACAM3 decreases asthma exacerbations and modulates respiratory
            syncytial virus latent infection in children
  JOURNAL   Thorax 75 (9), 725-734 (2020)
   PUBMED   32606071
  REMARK    GeneRIF: CEACAM3 decreases asthma exacerbations and modulates
            respiratory syncytial virus latent infection in children.
REFERENCE   6  (bases 1 to 1167)
  AUTHORS   Skubitz,K.M., Campbell,K.D. and Skubitz,A.P.
  TITLE     CD66a, CD66b, CD66c, and CD66d each independently stimulate
            neutrophils
  JOURNAL   J Leukoc Biol 60 (1), 106-117 (1996)
   PUBMED   8699114
REFERENCE   7  (bases 1 to 1167)
  AUTHORS   Nagel,G., Grunert,F., Kuijpers,T.W., Watt,S.M., Thompson,J. and
            Zimmermann,W.
  TITLE     Genomic organization, splice variants and expression of CGM1, a
            CD66-related member of the carcinoembryonic antigen gene family
  JOURNAL   Eur J Biochem 214 (1), 27-35 (1993)
   PUBMED   8508798
REFERENCE   8  (bases 1 to 1167)
  AUTHORS   Khan,W.N., Frangsmyr,L., Teglund,S., Israelsson,A., Bremer,K. and
            Hammarstrom,S.
  TITLE     Identification of three new genes and estimation of the size of the
            carcinoembryonic antigen family
  JOURNAL   Genomics 14 (2), 384-390 (1992)
   PUBMED   1427854
REFERENCE   9  (bases 1 to 1167)
  AUTHORS   Kuroki,M., Arakawa,F., Matsuo,Y., Oikawa,S., Misumi,Y., Nakazato,H.
            and Matsuoka,Y.
  TITLE     Molecular cloning of nonspecific cross-reacting antigens in human
            granulocytes
  JOURNAL   J Biol Chem 266 (18), 11810-11817 (1991)
   PUBMED   2050678
REFERENCE   10 (bases 1 to 1167)
  AUTHORS   Thompson,J.A., Mauch,E.M., Chen,F.S., Hinoda,Y., Schrewe,H.,
            Berling,B., Barnert,S., von Kleist,S., Shively,J.E. and
            Zimmermann,W.
  TITLE     Analysis of the size of the carcinoembryonic antigen (CEA) gene
            family: isolation and sequencing of N-terminal domain exons
  JOURNAL   Biochem Biophys Res Commun 158 (3), 996-1004 (1989)
   PUBMED   2537643
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243967.3, DC428993.1,
            BC106728.1, D90277.1 and D90278.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001815.4.
            
            Summary: This gene encodes a member of the family of
            carcinoembryonic antigen-related cell adhesion molecules (CEACAMs),
            which are used by several bacterial pathogens to bind and invade
            host cells. The encoded transmembrane protein directs phagocytosis
            of several bacterial species that is dependent on the small GTPase
            Rac. It is thought to serve an important role in controlling
            human-specific pathogens by the innate immune system. Alternatively
            spliced transcript variants have been described. [provided by
            RefSeq, Mar 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D90277.1, L00692.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357396.8/ ENSP00000349971.3
            RefSeq Select criteria :: based on longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC243967.3         115316-115318       c
            4-65                DC428993.1         1-62
            66-855              BC106728.1         1-790
            856-856             AC243967.3         100662-100662       c
            857-874             BC106728.1         792-809
            875-875             AC243967.3         100643-100643       c
            876-884             BC106728.1         811-819
            885-980             D90277.1           868-963
            981-981             AC243967.3         100537-100537       c
            982-1011            D90277.1           965-994
            1012-1166           D90278.1           1486-1640
            1167-1167           AC243967.3         100351-100351       c
FEATURES             Location/Qualifiers
     source          1..1167
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1167
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /note="CEA cell adhesion molecule 3"
                     /db_xref="GeneID:1084"
                     /db_xref="HGNC:HGNC:1815"
                     /db_xref="MIM:609142"
     exon            1..155
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..850
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; carcinoembryonic antigen gene family member 1;
                     cell adhesion molecule CEACAM3; carcinoembryonic antigen
                     CGM1; carcinoembryonic antigen related cell adhesion
                     molecule 3; CD66d antigen; nonspecific cross-reacting
                     antigen"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM3 isoform 1
                     precursor"
                     /protein_id="NP_001806.2"
                     /db_xref="CCDS:CCDS12586.2"
                     /db_xref="GeneID:1084"
                     /db_xref="HGNC:HGNC:1815"
                     /db_xref="MIM:609142"
                     /translation="MGPPSASPHRECIPWQGLLLTASLLNFWNPPTTAKLTIESMPLS
                     VAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNSLIVGYVIGTQQATPGAAYSGRETIY
                     TNASLLIQNVTQNDIGFYTLQVIKSDLVNEEATGQFHVYQENAPGLPVGAVAGIVTGV
                     LVGVALVAALVCFLLLAKTGRTSIQRDLKEQQPQALAPGRGPSHSSAFSMSPLSTAQA
                     PLPNPRTAASIYEELLKHDTNIYCRMDHKAEVAS"
     exon            156..515
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /inference="alignment:Splign:2.1.0"
     exon            516..633
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /inference="alignment:Splign:2.1.0"
     exon            634..686
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /inference="alignment:Splign:2.1.0"
     exon            687..718
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /inference="alignment:Splign:2.1.0"
     exon            719..784
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /inference="alignment:Splign:2.1.0"
     exon            785..1167
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /note="hexamer: AATAAA"
     polyA_site      1167
                     /gene="CEACAM3"
                     /gene_synonym="CD66D; CEA; CGM1; CGM1a; W264; W282"
                     /note="major polyA site"
ORIGIN      
        1 agcagagcct aagtcacagt agccctgact acagcattcc tggagcccag gctcttttcc
       61 acagaggagg aaagagcagg cagcagagac catggggccc ccctcagcct ctccccacag
      121 agaatgcatc ccctggcagg ggcttctgct cacagcctca cttctaaact tctggaaccc
      181 gcccaccact gccaagctca ctattgaatc catgccgctc agtgtcgcag aggggaagga
      241 ggtgcttcta cttgtccaca atctgcccca gcatcttttt ggctacagct ggtacaaagg
      301 ggaaagagtg gatggcaaca gtctaattgt aggatatgta ataggaactc aacaagctac
      361 cccaggggcc gcatacagcg gtcgagagac aatatacacc aatgcatccc tgctgatcca
      421 gaatgtcacc cagaatgaca taggattcta caccctacaa gtcataaagt cagatcttgt
      481 gaatgaagaa gcaactggac agttccatgt ataccaagaa aatgccccag gccttcctgt
      541 gggggccgtc gccggcatcg tgaccggggt cctggtcgga gtggcgctgg tggccgcgct
      601 ggtgtgtttc ctgctccttg ccaaaactgg aagaaccagc atccagcgtg acctcaagga
      661 gcagcagccc caagcccttg cccctggccg tggtccctcc cacagctctg ccttctcgat
      721 gtcccctctc tccactgccc aggcccccct acccaacccc aggacagcag cttccatcta
      781 tgaggaattg ctaaaacatg acacaaacat ttactgccgg atggaccaca aagcagaagt
      841 ggcttcttag cttcctccag gagctgctcc tgtgtgttga tggagagtcc ccaaggcccc
      901 cagccctggg gatggggaag gacatgaagc ctgagccaga gaaccagcta taagtcctga
      961 gaagacactg gtgtctgggg gcagggaggg atgggggtcc ctgatgaata tctggagacc
     1021 tcgacagcct gccctaggcc ctgggtgggt caggacaaag gcctctcatc accgcagaaa
     1081 gcgggggctt gcagggaaag tgaatgggcc tgtggcccac ctggggtcac ttggaaagga
     1141 tctgaataaa ggggaccctt cctctca
//
