LOCUS       NM_001098506            1372 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens CEA cell adhesion molecule 21 (CEACAM21), transcript
            variant 1, mRNA.
ACCESSION   NM_001098506
VERSION     NM_001098506.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1372)
  AUTHORS   Han,Z.W., Lyv,Z.W., Cui,B., Wang,Y.Y., Cheng,J.T., Zhang,Y.,
            Cai,W.Q., Zhou,Y., Ma,Z.W., Wang,X.W., Peng,X.C., Cui,S.Z.,
            Xiang,Y., Yang,M. and Xin,H.W.
  TITLE     The old CEACAMs find their new role in tumor immunotherapy
  JOURNAL   Invest New Drugs 38 (6), 1888-1898 (2020)
   PUBMED   32488569
  REMARK    Review article
            Erratum:[Invest New Drugs. 2020 Dec;38(6):1899-1900. doi:
            10.1007/s10637-020-00967-6.. PMID: 32572666]
REFERENCE   2  (bases 1 to 1372)
  AUTHORS   Amin Al Olama,A., Kote-Jarai,Z., Schumacher,F.R., Wiklund,F.,
            Berndt,S.I., Benlloch,S., Giles,G.G., Severi,G., Neal,D.E.,
            Hamdy,F.C., Donovan,J.L., Hunter,D.J., Henderson,B.E., Thun,M.J.,
            Gaziano,M., Giovannucci,E.L., Siddiq,A., Travis,R.C., Cox,D.G.,
            Canzian,F., Riboli,E., Key,T.J., Andriole,G., Albanes,D.,
            Hayes,R.B., Schleutker,J., Auvinen,A., Tammela,T.L., Weischer,M.,
            Stanford,J.L., Ostrander,E.A., Cybulski,C., Lubinski,J.,
            Thibodeau,S.N., Schaid,D.J., Sorensen,K.D., Batra,J.,
            Clements,J.A., Chambers,S., Aitken,J., Gardiner,R.A., Maier,C.,
            Vogel,W., Dork,T., Brenner,H., Habuchi,T., Ingles,S., John,E.M.,
            Dickinson,J.L., Cannon-Albright,L., Teixeira,M.R., Kaneva,R.,
            Zhang,H.W., Lu,Y.J., Park,J.Y., Cooney,K.A., Muir,K.R.,
            Leongamornlert,D.A., Saunders,E., Tymrakiewicz,M., Mahmud,N.,
            Guy,M., Govindasami,K., O'Brien,L.T., Wilkinson,R.A., Hall,A.L.,
            Sawyer,E.J., Dadaev,T., Morrison,J., Dearnaley,D.P., Horwich,A.,
            Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N., Woodhouse,C.J.,
            Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S., Lophatonanon,A.,
            Southey,M.C., Hopper,J.L., English,D., Virtamo,J., Le Marchand,L.,
            Campa,D., Kaaks,R., Lindstrom,S., Diver,W.R., Gapstur,S.,
            Yeager,M., Cox,A., Stern,M.C., Corral,R., Aly,M., Isaacs,W.,
            Adolfsson,J., Xu,J., Zheng,S.L., Wahlfors,T., Taari,K., Kujala,P.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Frikke-Schmidt,R.,
            Bojesen,S.E., FitzGerald,L.M., Kolb,S., Kwon,E.M., Karyadi,D.M.,
            Orntoft,T.F., Borre,M., Rinckleb,A., Luedeke,M., Herkommer,K.,
            Meyer,A., Serth,J., Marthick,J.R., Patterson,B., Wokolorczyk,D.,
            Spurdle,A., Lose,F., McDonnell,S.K., Joshi,A.D., Shahabi,A.,
            Pinto,P., Santos,J., Ray,A., Sellers,T.A., Lin,H.Y.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Tsuchiya,N., Narita,S., Cao,G.W., Slavov,C., Mitev,V., Chanock,S.,
            Gronberg,H., Haiman,C.A., Kraft,P., Easton,D.F. and Eeles,R.A.
  CONSRTM   UK Genetic Prostate Cancer Study Collaborators/British Association
            of Urological Surgeons' Section of Oncology; UK ProtecT Study
            Collaborators; Australian Prostate Cancer Bioresource; PRACTICAL
            Consortium
  TITLE     A meta-analysis of genome-wide association studies to identify
            prostate cancer susceptibility loci associated with aggressive and
            non-aggressive disease
  JOURNAL   Hum Mol Genet 22 (2), 408-415 (2013)
   PUBMED   23065704
REFERENCE   3  (bases 1 to 1372)
  AUTHORS   Alkelai,A., Lupoli,S., Greenbaum,L., Kohn,Y., Kanyas-Sarner,K.,
            Ben-Asher,E., Lancet,D., Macciardi,F. and Lerer,B.
  TITLE     DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the
            Jewish population
  JOURNAL   Int J Neuropsychopharmacol 15 (4), 459-469 (2012)
   PUBMED   21682944
  REMARK    GeneRIF: This study revealed CEACAM21 as novel schizophrenia
            candidate genes in the Jewish population
            Erratum:[Int J Neuropsychopharmacol. 2012 May;15(4):541]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC243960.3, BC012001.1, BC106727.1 and AY358084.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001098506.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106727.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000401445.4/ ENSP00000385739.2
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC243960.3         105823-105835       c
            14-90               BC012001.1         1-77
            91-1091             BC106727.1         8-1008
            1092-1372           AY358084.1         1020-1300
FEATURES             Location/Qualifiers
     source          1..1372
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1372
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /note="CEA cell adhesion molecule 21"
                     /db_xref="GeneID:90273"
                     /db_xref="HGNC:HGNC:28834"
                     /db_xref="MIM:618191"
     exon            1..173
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..991
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; carcinoembryonic antigen related cell adhesion
                     molecule 21; cell adhesion molecule CEACAM21"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM21 isoform 1
                     precursor"
                     /protein_id="NP_001091976.3"
                     /db_xref="CCDS:CCDS46086.1"
                     /db_xref="GeneID:90273"
                     /db_xref="HGNC:HGNC:28834"
                     /db_xref="MIM:618191"
                     /translation="MGPPSACPHRECIPWQGLLLTASLLTFWNAPTTAWLFIASAPFE
                     VAEGENVHLSVVYLPENLYSYGWYKGKTVEPNQLIAAYVIDTHVRTPGPAYSGRETIS
                     PSGDLHFQNVTLEDTGYYNLQVTYRNSQIEQASHHLRVYESVAQPSIQASSTTVTEKG
                     SVVLTCHTNNTGTSFQWIFNNQRLQVTKRMKLSWFNHVLTIDPIRQEDAGEYQCEVSN
                     PVSSNRSDPLKLTVKSDDNTLGILIGVLVGSLLVAALVCFLLLRKTGRASDQSDFREQ
                     QPPASTPGHGPSDSSIS"
     exon            174..533
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /inference="alignment:Splign:2.1.0"
     exon            534..809
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /inference="alignment:Splign:2.1.0"
     exon            810..906
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /inference="alignment:Splign:2.1.0"
     exon            907..959
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..991
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1372
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1350..1355
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /note="hexamer: AATAAA"
     polyA_site      1372
                     /gene="CEACAM21"
                     /gene_synonym="CEACAM3; R29124_1"
                     /note="major polyA site"
ORIGIN      
        1 atagaggaag gaaggacagc agagacaaca gtcacagtaa ccctgtctag agcgttcctg
       61 gagcccaagc tcctctccac agaggaggac agagcaggca gcagagacca tggggccccc
      121 ctcagcttgt ccccacagag aatgcatccc ctggcagggg ctcttgctca cagcctcact
      181 tttaactttc tggaacgcac ccaccactgc ctggctcttt attgcatcag cgccctttga
      241 agttgctgaa ggggagaatg ttcatctctc tgtggtttat ctgcccgaga atctttacag
      301 ctatggctgg tacaaaggga aaacggtgga gcccaaccag ctaatcgcag catatgtaat
      361 agacactcac gttaggactc cagggcctgc atacagcggt cgagagacaa tatcacccag
      421 tggagatctg catttccaga acgtcaccct agaggacacg ggatactaca acctacaagt
      481 cacatacaga aattctcaga ttgaacaggc atctcaccat ctccgtgtat acgagtcagt
      541 ggctcagccc tccatccaag ccagcagcac cacagtcaca gagaagggct ccgtggtcct
      601 gacctgccac acaaataaca ctggaacctc tttccagtgg attttcaaca accagcgtct
      661 gcaggtcacg aagaggatga agctgtcctg gtttaaccat gtgctcacca tagaccccat
      721 caggcaggag gacgctgggg agtatcagtg tgaggtctcc aacccagtca gctccaacag
      781 gagcgacccc ctcaagctga ctgtaaaatc agatgacaac actctaggca tcctgatcgg
      841 ggtcctggtt gggagtcttc tggtggctgc acttgtgtgt ttcctgctcc tccgaaaaac
      901 tggcagggcc agcgatcaga gtgacttcag ggagcagcag cccccagcct ccacccccgg
      961 ccatggaccc tctgacagct ccatctccta ggaattgcta cactctgaca caaacattta
     1021 ctgctggatc gaccacaaag cagatgtggc ttcttaggtt cctctgggag ctgctcctgt
     1081 gggttgatgg agcgtccctg aagcccccag ccctggggat ggggaaggac atggagcctg
     1141 agccagagaa ccagctctga gtcctgagga gacacaggcc tggggacagg aagggatggg
     1201 ggtccctgct gaatatatag agacctcaac agactgcccc gggctctggg tgggccaagg
     1261 cgaaggcttc ccatcaccac aggaagtggg ggcttgcagg gaaagtgaat gggcctatgg
     1321 cccacccggg gtcacctgga aaggatctga ataaagggga aacttcctct ca
//
