LOCUS       NM_001102597            1959 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 20 (CEACAM20), transcript
            variant 5L, mRNA.
ACCESSION   NM_001102597
VERSION     NM_001102597.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Daniwijaya,E.W., Murata,Y., Kotani,T., Kitamura,Y.,
            Mantilidewi,K.I., Kusakari,S., Ohnishi,H., Okazawa,H. and
            Matozaki,T.
  TITLE     Tyrosine Phosphorylation of Carcinoembryonic Antigen-related Cell
            Adhesion Molecule 20 and Its Functional Role
  JOURNAL   Kobe J Med Sci 59 (5), E172-E183 (2013)
   PUBMED   28659570
  REMARK    GeneRIF: tyrosine phosphorylation of CEACAM20 likely promotes
            phagocytic activity
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Zhang,H., Eisenried,A., Zimmermann,W. and Shively,J.E.
  TITLE     Role of CEACAM1 and CEACAM20 in an in vitro model of prostate
            morphogenesis
  JOURNAL   PLoS One 8 (1), e53359 (2013)
   PUBMED   23358633
  REMARK    GeneRIF: conclude that CEACAM20 and CEACAM1 not only mark the
            lumina of adult prostate tissue but also play a critical role in
            the vitro generation of prostate organoids
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Zebhauser,R., Kammerer,R., Eisenried,A., McLellan,A., Moore,T. and
            Zimmermann,W.
  TITLE     Identification of a novel group of evolutionarily conserved members
            within the rapidly diverging murine Cea family
  JOURNAL   Genomics 86 (5), 566-580 (2005)
   PUBMED   16139472
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC245748.2, EU008600.1 and AY358129.1.
            
            On May 17, 2019 this sequence version replaced NM_001102597.2.
            
            Transcript Variant: This variant (5L) represents the longest
            transcript and encodes the longest isoform (5L).
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU008600.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000614924.5/ ENSP00000481937.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC245748.2         199744-199893       c
            151-213             EU008600.1         1-63
            214-1496            AY358129.1         327-1609
            1497-1959           EU008600.1         1347-1809
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..1959
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /note="CEA cell adhesion molecule 20"
                     /db_xref="GeneID:125931"
                     /db_xref="HGNC:HGNC:24879"
     exon            1..218
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1957
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /note="isoform 5L precursor is encoded by transcript
                     variant 5L; GPAD9366; carcinoembryonic antigen related
                     cell adhesion molecule 20; cell adhesion molecule
                     CEACAM20"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM20 isoform 5L
                     precursor"
                     /protein_id="NP_001096067.2"
                     /db_xref="CCDS:CCDS74393.1"
                     /db_xref="GeneID:125931"
                     /db_xref="HGNC:HGNC:24879"
                     /translation="MGPADSWGHHWMGILLSASLCTVWSPPAAAQLTLNANPLDATQS
                     EDVVLPVFGTPRTPQIHGRSRELAKPSIAVSPGTAIEQKDMVTFYCTTKDVNITIHWV
                     SNNLSIVFHERMQLSKDGKILTILIVQREDSGTYQCEARDALLSQRSDPIFLDVKYGP
                     DPVEIKLESGVASGEVVEVMEGSSMTFLAETKSHPPCAYTWFLLDSILSHTTRTFTIH
                     AVSREHEGLYRCLVSNSATHLSSLGTLKVRVLETLTMPQVVPSSLNLVENARSVDLTC
                     QTVNQSVNVQWFLSGQPLLPSEHLQLSADNRTLIIHGLQRNDTGPYACEVWNWGSRAR
                     SEPLELTINYGPDQVHITRESASEMISTIEAELNSSLTLQCWAESKPGAEYRWTLEHS
                     TGEHLGEQLIIRALTWEHDGIYNCTASNSLTGLARSTSVLVKVVGPQSSSLSSGAIAG
                     IVIGILAVIAVASELGYFLCIRNARRPSRKTTEDPSHETSQPIPKEEHPTEPSSESLS
                     PEYRNISQLQGRIRVELMQPPDLPEETYETKLPSASRRGNSFSPWKPPPKPLMPPLRL
                     VSTVPKNMESIYEELVNPEPNTYIQINPSV"
     exon            219..362
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            363..638
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            639..917
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1196
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1475
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1593
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1679
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1741
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1777
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1903
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..1959
                     /gene="CEACAM20"
                     /gene_synonym="UNQ9366"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgtcctg ggagctgcag ttactgcagt gtgtgtgtga gtttgtagca gggtgggaga
       61 ggagagaagg gaggtggagg ggctgcacct ggagtgagga ctgtatctgt gtgtgcaagc
      121 cggggcgaca gacggcctgg cacactgaag tcaggtgccg ggacccatgg ggcctgctga
      181 ctcatgggga caccactgga tgggaatcct gctttcagcc tcgctttgta ccgtatggag
      241 tcctccagct gcagcccagc tcaccctcaa tgccaaccca cttgatgcca cccaaagtga
      301 ggatgttgtt ctgcctgtgt ttgggacccc caggacaccc cagattcatg gcagatccag
      361 agagctggcc aaaccctcca ttgcagtcag cccaggcact gccatagagc agaaggacat
      421 ggtgaccttc tactgcacca ctaaggacgt caacattacc atccactggg tttccaacaa
      481 cctctccatt gtgttccatg agcgcatgca gctgtccaag gatggcaaga tcctcaccat
      541 tctcattgtc cagcgggagg actcagggac ttaccaatgt gaagctcgag atgcccttct
      601 gagccagagg agcgacccca tcttcctgga tgtgaagtat ggtcctgatc ctgttgaaat
      661 caaattggag tctggtgttg ccagtgggga ggtggttgag gtgatggagg gctccagcat
      721 gaccttctta gcggaaacaa agtctcaccc accctgtgcc tatacttggt ttctccttga
      781 ctccattctg tctcacacca cgagaacatt caccatccat gctgtgtcca gagaacatga
      841 gggcctgtac aggtgcttgg tgtccaacag tgccacccac ctgtccagcc tgggtactct
      901 gaaggtccga gtacttgaaa cactgaccat gcctcaagtc gtgccttcaa gcctgaacct
      961 tgtggagaat gctaggtctg tggacctgac ctgccaaacc gtcaatcaga gtgtgaatgt
     1021 ccagtggttc ctaagtggcc agcccctcct gcccagtgag cacctgcagc tgtcagctga
     1081 caacaggacc ctaatcatcc atggcctcca gcggaatgac accgggccct atgcctgtga
     1141 ggtctggaac tggggcagcc gggcccggag tgagcccctt gagctgacca tcaactatgg
     1201 tcctgaccaa gtgcacatca ccagggagtc ggcatctgag atgatcagca ccatagaggc
     1261 agagctcaac tccagcctga ccctgcagtg ttgggccgag tccaagccag gtgctgagta
     1321 tcgctggact cttgaacact ccaccgggga gcacctgggt gagcagctga ttatcagggc
     1381 tctgacctgg gaacacgacg ggatctacaa ctgcacagcc tccaactctc tcactggcct
     1441 ggcccgctcc acttcagtcc tggtcaaggt ggtaggtccc cagtcctcct ccctgtcctc
     1501 aggggccatc gctggtattg tcatcgggat cctggctgtc attgctgtgg cctcagaact
     1561 gggctatttt ctctgcatca gaaatgccag acggccctca aggaaaacaa cagaggaccc
     1621 cagtcatgag acctcacaac ccatcccgaa ggaggagcac cccacagagc ccagttccga
     1681 aagcctgagt cctgagtatc gcaatatatc ccagcttcag ggacggatca gagtcgaact
     1741 gatgcaacca ccagaccttc cagaggagac ctatgagacg aagctgcctt cagcaagccg
     1801 tagaggcaat tctttcagcc cctggaagcc accacccaaa cctctgatgc ccccactcag
     1861 attggtctcc actgtgccaa aaaacatgga gtcaatctat gaggagcttg tgaatccaga
     1921 gcccaacact tacatccaaa tcaacccctc cgtctaatg
//
