LOCUS       NM_001127893            2215 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 19 (CEACAM19), transcript
            variant 1, mRNA.
ACCESSION   NM_001127893
VERSION     NM_001127893.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   Zisi,Z., Adamopoulos,P.G., Kontos,C.K. and Scorilas,A.
  TITLE     Identification and expression analysis of novel splice variants of
            the human carcinoembryonic antigen-related cell adhesion molecule
            19 (CEACAM19) gene using a high-throughput sequencing approach
  JOURNAL   Genomics 112 (6), 4268-4276 (2020)
   PUBMED   32659328
  REMARK    GeneRIF: Identification and expression analysis of novel splice
            variants of the human carcinoembryonic antigen-related cell
            adhesion molecule 19 (CEACAM19) gene using a high-throughput
            sequencing approach.
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Zhao,H., Xu,J., Wang,Y., Jiang,R., Li,X., Zhang,L. and Che,Y.
  TITLE     Knockdown of CEACAM19 suppresses human gastric cancer through
            inhibition of PI3K/Akt and NF-kappaB
  JOURNAL   Surg Oncol 27 (3), 495-502 (2018)
   PUBMED   30217308
  REMARK    GeneRIF: High CEACAM19 expression is associated with gastric
            cancer.
REFERENCE   3  (bases 1 to 2215)
  AUTHORS   Estiar,M.A., Esmaeili,R., Zare,A.A., Farahmand,L., Fazilaty,H.,
            Zekri,A., Jafarbeik-Iravani,N. and Majidzadeh-A,K.
  TITLE     High expression of CEACAM19, a new member of carcinoembryonic
            antigen gene family, in patients with breast cancer
  JOURNAL   Clin Exp Med 17 (4), 547-553 (2017)
   PUBMED   27909883
  REMARK    GeneRIF: In conclusion, CEACAM19 showed high expression in tumor
            samples compared to normal mammary tissue.
REFERENCE   4  (bases 1 to 2215)
  AUTHORS   Michaelidou,K., Tzovaras,A., Missitzis,I., Ardavanis,A. and
            Scorilas,A.
  TITLE     The expression of the CEACAM19 gene, a novel member of the CEA
            family, is associated with breast cancer progression
  JOURNAL   Int J Oncol 42 (5), 1770-1777 (2013)
   PUBMED   23525470
  REMARK    GeneRIF: Our results suggest that CEACAM19 mRNA expression
            represents a promising, novel and clinically useful tissue
            biomarker for breast cancer management.
REFERENCE   5  (bases 1 to 2215)
  AUTHORS   Shames,S.R., Deng,W., Guttman,J.A., de Hoog,C.L., Li,Y.,
            Hardwidge,P.R., Sham,H.P., Vallance,B.A., Foster,L.J. and
            Finlay,B.B.
  TITLE     The pathogenic E. coli type III effector EspZ interacts with host
            CD98 and facilitates host cell prosurvival signalling
  JOURNAL   Cell Microbiol 12 (9), 1322-1339 (2010)
   PUBMED   20374249
REFERENCE   6  (bases 1 to 2215)
  AUTHORS   Jugessur,A., Shi,M., Gjessing,H.K., Lie,R.T., Wilcox,A.J.,
            Weinberg,C.R., Christensen,K., Boyles,A.L., Daack-Hirsch,S.,
            Nguyen,T.T., Christiansen,L., Lidral,A.C. and Murray,J.C.
  TITLE     Maternal genes and facial clefts in offspring: a comprehensive
            search for genetic associations in two population-based cleft
            studies from Scandinavia
  JOURNAL   PLoS One 5 (7), e11493 (2010)
   PUBMED   20634891
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2215)
  AUTHORS   Zebhauser,R., Kammerer,R., Eisenried,A., McLellan,A., Moore,T. and
            Zimmermann,W.
  TITLE     Identification of a novel group of evolutionarily conserved members
            within the rapidly diverging murine Cea family
  JOURNAL   Genomics 86 (5), 566-580 (2005)
   PUBMED   16139472
REFERENCE   8  (bases 1 to 2215)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 2215)
  AUTHORS   Scorilas,A., Chiang,P.M., Katsaros,D., Yousef,G.M. and
            Diamandis,E.P.
  TITLE     Molecular characterization of a new gene, CEAL1, encoding for a
            carcinoembryonic antigen-like protein with a highly conserved
            domain of eukaryotic translation initiation factors
  JOURNAL   Gene 310, 79-89 (2003)
   PUBMED   12801635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC243964.3.
            
            On Jan 12, 2021 this sequence version replaced NM_001127893.2.
            
            Transcript Variant: This variant (1) encodes the shorter protein
            (isoform 1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083499.1, SRR14038192.1333706.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358777.10/ ENSP00000351627.4
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               AC243964.3         70314-70818         c
            506-874             AC243964.3         69336-69704         c
            875-1025            AC243964.3         65879-66029         c
            1026-1109           AC243964.3         63364-63447         c
            1110-1156           AC243964.3         61966-62012         c
            1157-1242           AC243964.3         60988-61073         c
            1243-1296           AC243964.3         59680-59733         c
            1297-2215           AC243964.3         57945-58863         c
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..2215
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /note="CEA cell adhesion molecule 19"
                     /db_xref="GeneID:56971"
                     /db_xref="HGNC:HGNC:31951"
                     /db_xref="MIM:606691"
     exon            1..505
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             451..1350
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; carcinoembryonic antigen-like 1;
                     carcinoembryonic antigen related cell adhesion molecule
                     19; cell adhesion molecule CEACAM19"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM19 isoform 1
                     precursor"
                     /protein_id="NP_001121365.1"
                     /db_xref="CCDS:CCDS46108.1"
                     /db_xref="GeneID:56971"
                     /db_xref="HGNC:HGNC:31951"
                     /db_xref="MIM:606691"
                     /translation="MEIPMGTQGCFSKSLLLSASILVLWMLQGSQAALYIQKIPEQPQ
                     KNQDLLLSVQGVPDTFQDFNWYLGEETYGGTRLFTYIPGIQRPQRDGSAMGQRDIVGF
                     PNGSMLLRRAQPTDSGTYQVAITINSEWTMKAKTEVQVAEKNKELPSTHLPTNAGILA
                     ATIIGSLAAGALLISCIAYLLVTRNWRGQSHRLPAPRGQGSLSILCSAVSPVPSVTPS
                     TWMATTEKPELGPAHDAGDNNIYEVMPSPVLLVSPISDTRSINPARPLPTPPHLQAEP
                     ENHQYQDLLNPDPAPYCQLVPTS"
     exon            506..874
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1025
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1109
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1156
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1242
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1296
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..2215
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2198..2203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /note="hexamer: AATAAA"
     polyA_site      2215
                     /gene="CEACAM19"
                     /gene_synonym="CEACM19; CEAL1"
                     /note="major polyA site"
ORIGIN      
        1 ttgcctcttt tcctgggcct ctgtttccac atctgtgcaa tgggaacagt tatttatggt
       61 ggctgctgaa tgaggcagtg tgtgtttgaa caaacccagg ggaattgttc aaacagaggc
      121 tgttatgact attgctacag tgactgctgt tgtagtcacg ctgagtgaga aaaagaggtt
      181 gaagagggtc aggggaggag tcctgggaag ttccccagtc accctgaaaa actggttcaa
      241 cctctgtctg tgctcccatc ccagggagta taggtggagc ctccagagcc catggacagg
      301 gcatgctggg gctgggccag ccccagcggt gtctctaagg cacccctggg atccccactg
      361 agctggccta cttcagacag ccagggccca cccctctggc ccccttagtg tccagctcgt
      421 ggccccttgg catttccaca agacgccaag atggagattc ccatggggac ccagggctgc
      481 ttctcaaaga gcctcctgct ctcagcctca atcctggtcc tctggatgct ccaaggctcc
      541 caggcagctc tctacatcca gaagattcca gagcagcctc aaaagaacca ggaccttctc
      601 ctgtcagtcc agggtgtccc agacaccttc caggacttca actggtacct gggggaggag
      661 acgtacggag gcacgaggct atttacctac atccctggga tacaacggcc tcagagggat
      721 ggcagtgcca tgggacagcg agacatcgtg ggcttcccca atggttccat gctgctgcgc
      781 cgcgcccagc ctacagacag tggcacctac caagtagcca ttaccatcaa ctctgaatgg
      841 actatgaagg ccaagactga ggtccaggta gctgaaaaga ataaggagct gcccagtaca
      901 cacctgccca ccaacgctgg gatcctggcg gccaccatca ttggatctct tgctgccggg
      961 gcccttctca tcagctgcat tgcctatctc ctggtgacaa ggaactggag gggccagagc
     1021 cacagactgc ctgctccgag gggccaggga tctctgtcca tcttgtgctc ggctgtatcc
     1081 ccagtgcctt cagtgacgcc cagcacatgg atggcgacca cagagaagcc agaattgggc
     1141 cctgctcatg atgctggtga caacaacatc tatgaagtga tgccctctcc agtcctcctg
     1201 gtgtccccca tcagtgacac aaggtccata aacccagccc ggcccctgcc cacaccccca
     1261 cacctgcagg cggagccaga gaaccaccag taccaggacc tgctaaaccc cgaccctgcc
     1321 ccctactgcc agctggtgcc aacttcctga tgggtcctgg gccaggccag ccagggagaa
     1381 gacaaggccc cagccctcct ctgggagcct cacacctgag accagcagga caaggccatt
     1441 gggggctgtg gggccgatga ggtggactca gccaaagact cagcagcaca tggggcaggt
     1501 gtcctggcag ggggacagga gactgtaaca ggcccaggtc cttgtgcagc ccgtgaatgc
     1561 acgcccgcct tcggtctgtt ccttcaagca agctggcctg ggccatgtgc ctgtgaaagg
     1621 caggctctgg cccctttcca tgccaaagtc ccccaagatc tggatatctg gggacaagat
     1681 ggtggcctca ggcctgcctc ccaggcagtt ggctgggctc ccaactgtct gtcctcaatg
     1741 ccctacccca actccactag tgaccctcag agtcttctcc ccttaggaca aggcagacac
     1801 cccaccatgc gggcctcagg tggcagagag gcccagcctc acaggcctgt ggccccacac
     1861 accagtccca gcaaggtgac cacggctgct ggaccccttc cctgttcagg caggcccagc
     1921 ccctctcaga acctgctgcc agctgctggt cttggccccc accctgaatc ttactgagtc
     1981 cctctgggca gcagctccct tctccacccc accccagcac ccgtcccaaa tgtggcctca
     2041 gcttgtcctc cccttcccca aactatgcat tcattcagca ataaatgagc ctttgctgta
     2101 tgccagaccc agttctaggc tcttgcagcc ctggtagaaa gcaaaacaaa aactcccgct
     2161 ttcccagagg gtcacttggc aggggaaaga atcaggaaat aaaataaata atgaa
//
