LOCUS       NM_001405061            1908 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens CEA cell adhesion molecule 18 (CEACAM18), mRNA.
ACCESSION   NM_001405061
VERSION     NM_001405061.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1908)
  AUTHORS   Han,Z.W., Lyv,Z.W., Cui,B., Wang,Y.Y., Cheng,J.T., Zhang,Y.,
            Cai,W.Q., Zhou,Y., Ma,Z.W., Wang,X.W., Peng,X.C., Cui,S.Z.,
            Xiang,Y., Yang,M. and Xin,H.W.
  TITLE     The old CEACAMs find their new role in tumor immunotherapy
  JOURNAL   Invest New Drugs 38 (6), 1888-1898 (2020)
   PUBMED   32488569
  REMARK    Review article
            Erratum:[Invest New Drugs. 2020 Dec;38(6):1899-1900. doi:
            10.1007/s10637-020-00967-6.. PMID: 32572666]
REFERENCE   2  (bases 1 to 1908)
  AUTHORS   Zebhauser,R., Kammerer,R., Eisenried,A., McLellan,A., Moore,T. and
            Zimmermann,W.
  TITLE     Identification of a novel group of evolutionarily conserved members
            within the rapidly diverging murine Cea family
  JOURNAL   Genomics 86 (5), 566-580 (2005)
   PUBMED   16139472
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC020914.9.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2153932, SAMN03267782
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000396477.5/ ENSP00000379738.4
            RefSeq Select criteria    :: based on manual assertion, longest
                                         protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC020914.9         46770-46925
            157-504             AC020914.9         48564-48911
            505-777             AC020914.9         49624-49896
            778-1057            AC020914.9         51248-51527
            1058-1193           AC020914.9         53218-53353
            1194-1908           AC020914.9         58818-59532
FEATURES             Location/Qualifiers
     source          1..1908
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1908
                     /gene="CEACAM18"
                     /note="CEA cell adhesion molecule 18"
                     /db_xref="GeneID:729767"
                     /db_xref="HGNC:HGNC:31949"
     exon            1..156
                     /gene="CEACAM18"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1259
                     /gene="CEACAM18"
                     /note="carcinoembryonic antigen related cell adhesion
                     molecule 18; cell adhesion molecule CEACAM18"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM18 precursor"
                     /protein_id="NP_001391990.1"
                     /db_xref="GeneID:729767"
                     /db_xref="HGNC:HGNC:31949"
                     /translation="MDLSRPRWSLWRRVFLMASLLACGICQASGQIFITQTLGIKGYR
                     TVVALDKVPEDVQEYSWYWGANDSAGNMIISHKPPSAQQPGPMYTGRERVNREGSLLI
                     RPTALNDTGNYTVRVVAGNETQRATGWLEVLELGSNLGISVNASSLVENMDSVAADCL
                     TNVTNITWYVNDVPTSSSDRMTISPDGKTLVILRVSRYDRTIQCMIESFPEIFQRSER
                     ISLTVAYGPDYVLLRSNPDDFNGIVTAEIGSQVEMECICYSFLDLKYHWIHNGSLLNF
                     SDAKMNLSSLAWEQMGRYRCTVENPVTQLIMYMDVRIQAPHEDLTCCPQRFLHLRIHG
                     DVPHHADSAGWRLHLWSPDPCSDQPLLNQDKSGSMSVHPRPEDKTRRASR"
     exon            157..504
                     /gene="CEACAM18"
                     /inference="alignment:Splign:2.1.0"
     exon            505..777
                     /gene="CEACAM18"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1057
                     /gene="CEACAM18"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1193
                     /gene="CEACAM18"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1908
                     /gene="CEACAM18"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaccggca gcctctgtgc caggagacac aggtcttgga gggagcagag gaggtggctg
       61 tgtctctgga gggacccctc ctcctggagg accccaggca gctcatggac ctttccagac
      121 ccagatggag cctgtggagg agggtcttcc tcatggccag tctgctggcc tgtgggatct
      181 gccaggcctc tggccaaatc ttcatcaccc aaaccctggg gatcaaggga tatcggactg
      241 tcgtggccct ggataaggtc cctgaggatg ttcaggaata cagctggtac tggggtgcaa
      301 acgacagcgc aggaaacatg attatcagcc acaaaccgcc cagtgcccag cagcctgggc
      361 ccatgtacac tggcagggag agagtgaaca gagaaggcag cctgttgatc aggccgactg
      421 cattaaatga cacgggaaac tacactgttc gggtggttgc aggcaatgag acccaaagag
      481 caaccggctg gctggaggtt ctagagttgg gaagcaatct gggcatctcc gtcaatgcca
      541 gctccctggt ggagaacatg gattctgtgg ctgctgactg cctcacaaat gtcaccaaca
      601 tcacgtggta tgtgaatgat gtgcctacct ctagtagtga ccggatgaca atttccccag
      661 acggcaagac cctcgtcatc ctcagggtca gccgctatga cagaacaatt cagtgcatga
      721 tagagagttt cccagagatc tttcagagaa gtgaacgcat ctctctgact gtggcctatg
      781 ggcccgacta tgtgctgctg aggagcaatc ctgatgattt caacggcatt gtgacagctg
      841 agatcggctc ccaagtggaa atggagtgta tctgctattc cttcctggat ctcaagtacc
      901 actggatcca caatggctcc ctcctgaact tctcagatgc aaagatgaac ctctcgagtc
      961 ttgcctggga gcagatgggc cgttaccgat gcactgtgga gaaccccgtg acacagctga
     1021 tcatgtacat ggacgtcagg atccaggccc cccatgagga tcttacctgt tgtccacaga
     1081 gatttctcca tctcaggatc catggtgatg ttcctcatca tgctgacagt gctgggtggc
     1141 gtttacatct gtggagtcct gatccatgct ctgatcaacc actactcaat caggacaaat
     1201 cgggctccat gagtgtccac cccagacctg aggacaagac cagaagggca agcaggtgag
     1261 gagagggtga tggagaaggg ctgggggtcc ccatagggcc agcgaggctg aaaagggtcc
     1321 agggtctctt tggagggtac tggcaagaga gggacccagc ccagtcacac ggaagcctgg
     1381 agatggaggc tccagtagga ggtctgcaga ccccacccgg gacctgaaga tgatgtcgtg
     1441 ggtagcgtgg ccattgggcg cttcatctgc caatcagagc tggtcaatgg gttgcaggtc
     1501 ggggcgggcc atgcgcaaag ctgggctcta attccaagcg cctcctccct cagctccggc
     1561 gcttccagct tctcagattt cttcacccat ggaatcaaca gcgatgctgt aaacttatgg
     1621 ccaaggggtg ccaatcagtg gttgttccac tcagtgccga atgagagaag agaccttaga
     1681 atcaggcagg gattaaattt cagtcctgcc ctgagtaccg gagcgacctg aacgcagccc
     1741 cagtgaggct ccctcacctg gatgcaccgt ggaaccatcg tcagcatgat tagcacatcc
     1801 gtcagctcaa atatttaatt tttttttttt tttggtgaca acatttaaac tcctctcttt
     1861 tagccatttt gaaatattca atacattatt ctgttatttg gaacaaca
//
