LOCUS       NM_001039213            1696 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 16, tectorial membrane
            component (CEACAM16), mRNA.
ACCESSION   NM_001039213 XM_371177 XM_941070
VERSION     NM_001039213.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1696)
  AUTHORS   Zhang,Q., Wu,K., Zhao,C., Xie,L., Xiong,F., Lan,L. and Wang,Q.
  TITLE     [Identification of a novel mutation of CEACAM16 gene in a Chinese
            family with autosomal dominant nonsyndromic hearing loss]
  JOURNAL   Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 34 (9), 777-781
            (2020)
   PUBMED   33040498
  REMARK    GeneRIF: [Identification of a novel mutation of CEACAM16 gene in a
            Chinese family with autosomal dominant nonsyndromic hearing loss].
REFERENCE   2  (bases 1 to 1696)
  AUTHORS   Yan,L., Wang,Y., Wang,Z.Z., Rong,Y.T., Chen,L.L., Li,Q., Liu,T.,
            Chen,Y.H., Li,Y.D., Huang,Z.H. and Peng,J.
  TITLE     Cell motility and spreading promoted by CEACAM6 through cyclin
            D1/CDK4 in human pancreatic carcinoma
  JOURNAL   Oncol Rep 35 (1), 418-426 (2016)
   PUBMED   26497080
  REMARK    GeneRIF: Results confirm that CEACAM6 promoted cell proliferation
            mediated by cyclin D1/CDK4.
REFERENCE   3  (bases 1 to 1696)
  AUTHORS   Wang,H., Wang,X., He,C., Li,H., Qing,J., Grati,M., Hu,Z., Li,J.,
            Hu,Y., Xia,K., Mei,L., Wang,X., Yu,J., Chen,H., Jiang,L., Liu,Y.,
            Men,M., Zhang,H., Guan,L., Xiao,J., Zhang,J., Liu,X. and Feng,Y.
  TITLE     Exome sequencing identifies a novel CEACAM16 mutation associated
            with autosomal dominant nonsyndromic hearing loss DFNA4B in a
            Chinese family
  JOURNAL   J Hum Genet 60 (3), 119-126 (2015)
   PUBMED   25589040
  REMARK    GeneRIF: Data indicate that a heterozygous missense mutation,
            c.505G>A (p.G169R) in exon 3 of the CEACAM16 gene (carcinoembryonic
            antigen-related cell adhesion molecule 16) was identified in
            autosomal dominant nonsyndromic hearing loss family.
REFERENCE   4  (bases 1 to 1696)
  AUTHORS   Miyashita,A., Koike,A., Jun,G., Wang,L.S., Takahashi,S.,
            Matsubara,E., Kawarabayashi,T., Shoji,M., Tomita,N., Arai,H.,
            Asada,T., Harigaya,Y., Ikeda,M., Amari,M., Hanyu,H., Higuchi,S.,
            Ikeuchi,T., Nishizawa,M., Suga,M., Kawase,Y., Akatsu,H., Kosaka,K.,
            Yamamoto,T., Imagawa,M., Hamaguchi,T., Yamada,M., Morihara,T.,
            Takeda,M., Takao,T., Nakata,K., Fujisawa,Y., Sasaki,K.,
            Watanabe,K., Nakashima,K., Urakami,K., Ooya,T., Takahashi,M.,
            Yuzuriha,T., Serikawa,K., Yoshimoto,S., Nakagawa,R., Kim,J.W.,
            Ki,C.S., Won,H.H., Na,D.L., Seo,S.W., Mook-Jung,I., St
            George-Hyslop,P., Mayeux,R., Haines,J.L., Pericak-Vance,M.A.,
            Yoshida,M., Nishida,N., Tokunaga,K., Yamamoto,K., Tsuji,S.,
            Kanazawa,I., Ihara,Y., Schellenberg,G.D., Farrer,L.A. and Kuwano,R.
  CONSRTM   Alzheimer Disease Genetics Consortium
  TITLE     SORL1 is genetically associated with late-onset Alzheimer's disease
            in Japanese, Koreans and Caucasians
  JOURNAL   PLoS One 8 (4), e58618 (2013)
   PUBMED   23565137
  REMARK    Erratum:[PLoS One. 2013;8(7).
            doi:10.1371/annotation/fcb56ea7-d32a-4e45-818d-39cef330c731.
            Moriaha, Takashi [corrected to Morihara, Takashi]]
REFERENCE   5  (bases 1 to 1696)
  AUTHORS   Kammerer,R., Ruttiger,L., Riesenberg,R., Schauble,C., Krupar,R.,
            Kamp,A., Sunami,K., Eisenried,A., Hennenberg,M., Grunert,F.,
            Bress,A., Battaglia,S., Schrewe,H., Knipper,M., Schneider,M.R. and
            Zimmermann,W.
  TITLE     Loss of mammal-specific tectorial membrane component
            carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads
            to hearing impairment at low and high frequencies
  JOURNAL   J Biol Chem 287 (26), 21584-21598 (2012)
   PUBMED   22544735
  REMARK    GeneRIF: CEACAM16 can probably form higher order structures with
            other tectorial membrane proteins such as alpha-tectorin and
            beta-tectorin and influences the physical properties of the
            tectorial membrane
REFERENCE   6  (bases 1 to 1696)
  AUTHORS   Zheng,J., Miller,K.K., Yang,T., Hildebrand,M.S., Shearer,A.E.,
            DeLuca,A.P., Scheetz,T.E., Drummond,J., Scherer,S.E., Legan,P.K.,
            Goodyear,R.J., Richardson,G.P., Cheatham,M.A., Smith,R.J. and
            Dallos,P.
  TITLE     Carcinoembryonic antigen-related cell adhesion molecule 16
            interacts with alpha-tectorin and is mutated in autosomal dominant
            hearing loss (DFNA4)
  JOURNAL   Proc Natl Acad Sci U S A 108 (10), 4218-4223 (2011)
   PUBMED   21368133
  REMARK    GeneRIF: data identify CEACAM16 as an alpha-tectorin-interacting
            protein that concentrates at the point of attachment of the TM to
            the stereocilia and, when mutated, results in ADNSHL at the DFNA4
            locus
REFERENCE   7  (bases 1 to 1696)
  AUTHORS   Zebhauser,R., Kammerer,R., Eisenried,A., McLellan,A., Moore,T. and
            Zimmermann,W.
  TITLE     Identification of a novel group of evolutionarily conserved members
            within the rapidly diverging murine Cea family
  JOURNAL   Genomics 86 (5), 566-580 (2005)
   PUBMED   16139472
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC144608.1, AC243964.3 and
            BF589367.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 21, 2018 this sequence version replaced NM_001039213.3.
            
            Summary: The protein encoded by this gene is a secreted
            glycoprotein that in mouse interacts with tectorial membrane
            proteins in the inner ear. The encoded adhesion protein is found in
            cochlear outer hair cells and appears to be important for proper
            hearing over an extended frequency range. Defects in this gene
            likely are a cause of non-syndromic autosomal dominant hearing
            loss. [provided by RefSeq, May 2012].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC144608.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587331.7/ ENSP00000466561.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                BC144608.1         1-11
            12-53               AC243964.3         43097-43138         c
            54-1420             BC144608.1         54-1420
            1421-1421           AC243964.3         34165-34165         c
            1422-1613           BC144608.1         1422-1613
            1614-1692           BF589367.1         1-79                c
            1693-1696           AC243964.3         31582-31585         c
FEATURES             Location/Qualifiers
     source          1..1696
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31-q13.32"
     gene            1..1696
                     /gene="CEACAM16"
                     /gene_synonym="CEAL2; DFNA4B; DFNB113"
                     /note="CEA cell adhesion molecule 16, tectorial membrane
                     component"
                     /db_xref="GeneID:388551"
                     /db_xref="HGNC:HGNC:31948"
                     /db_xref="MIM:614591"
     exon            1..110
                     /gene="CEACAM16"
                     /gene_synonym="CEAL2; DFNA4B; DFNB113"
                     /inference="alignment:Splign:2.1.0"
     exon            111..243
                     /gene="CEACAM16"
                     /gene_synonym="CEAL2; DFNA4B; DFNB113"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1484
                     /gene="CEACAM16"
                     /gene_synonym="CEAL2; DFNA4B; DFNB113"
                     /note="carcinoembryonic antigen like-2 protein;
                     carcinoembryonic antigen related cell adhesion molecule
                     16; cell adhesion molecule CEACAM16"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM16 precursor"
                     /protein_id="NP_001034302.2"
                     /db_xref="CCDS:CCDS54278.1"
                     /db_xref="GeneID:388551"
                     /db_xref="HGNC:HGNC:31948"
                     /db_xref="MIM:614591"
                     /translation="MALTGYSWLLLSATFLNVGAEISITLEPAQPSEGDNVTLVVHGL
                     SGELLAYSWYAGPTLSVSYLVASYIVSTGDETPGPAHTGREAVRPDGSLDIQGILPRH
                     SGTYILQTFNRQLQTEVGYGHVQVHEILAQPTVLANSTALVERRDTLRLMCSSPSPTA
                     EVRWFFNGGALPVALRLGLSPDGRVLARHGIRREEAGAYQCEVWNPVSVSRSEPINLT
                     VYFGPERVAILQDSTTRTGCTIKVDFNTSLTLWCVSRSCPEPEYVWTFNGQALKNGQD
                     HLNISSMTAAQEGTYTCIAKNTKTLLSGSASVVVKLSAAAVATMIVPVPTKPTEGQDV
                     TLTVQGYPKDLLVYAWYRGPASEPNRLLSQLPSGTWIAGPAHTGREVGFPNCSLLVQK
                     LNLTDTGRYTLKTVTVQGKTETLEVELQVAPLG"
     exon            244..588
                     /gene="CEACAM16"
                     /gene_synonym="CEAL2; DFNA4B; DFNB113"
                     /inference="alignment:Splign:2.1.0"
     exon            589..867
                     /gene="CEACAM16"
                     /gene_synonym="CEAL2; DFNA4B; DFNB113"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1146
                     /gene="CEACAM16"
                     /gene_synonym="CEAL2; DFNA4B; DFNB113"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..1473
                     /gene="CEACAM16"
                     /gene_synonym="CEAL2; DFNA4B; DFNB113"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1696
                     /gene="CEACAM16"
                     /gene_synonym="CEAL2; DFNA4B; DFNB113"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcatcctc agcgcctaga acagcacctg gcaaacaata ggtgctcatt cagtatttgt
       61 ccaataagtg aatgagtgat ttactgagca tttactctgc gccagtcgtg gtcctgcggc
      121 agacggagcc gagccccaac caggaaggga gtccgagcac tgggacttca acgccaccat
      181 ctccaagact cggtttgggg tgaaagatgg cgctgactgg gtacagctgg ctgctcctca
      241 gtgccacatt cctgaatgtg ggggccgaga tctctatcac cctggagcct gcccagccga
      301 gcgaagggga caacgtcacg ctggtcgtcc atgggctttc gggggaactg ctcgcctaca
      361 gctggtatgc ggggcccaca ctcagcgtgt catacctggt ggccagctac atcgtgagca
      421 caggcgatga gactcctggc ccggcccaca cggggcggga ggctgtgcgc cccgatggca
      481 gcctggacat ccagggcatc ctgccccggc actcaggcac ctacatcctg cagaccttca
      541 acaggcagtt gcagaccgag gtgggctacg gacacgtgca ggtccatgag atcctggccc
      601 agcccacagt cttggccaac agcacagcgc tggtggaacg tcgagacacc ctgcgcctta
      661 tgtgcagcag ccccagcccc accgccgagg tccgctggtt cttcaacggt ggggccctgc
      721 ccgtcgctct ccgcctgggc ctgtcccctg acggccgggt gctggccagg catggcatcc
      781 gccgggagga ggccggcgcc tatcagtgtg aggtgtggaa cccggtcagt gtcagccgca
      841 gcgagcccat caacctgacc gtgtactttg gcccagagcg tgtggccatc ctccaggatt
      901 ccaccacccg cacaggctgc accatcaaag ttgacttcaa cacgtccctc accctgtggt
      961 gcgtgtccag gtcctgccca gagcccgagt atgtgtggac cttcaacggg caggccctaa
     1021 agaacggcca agaccacctc aacatcagca gcatgacagc cgcccaggag gggacgtaca
     1081 catgtattgc gaagaacacc aagaccctgc tatctggatc tgcctcagtc gtggtcaagc
     1141 tctctgctgc agcagttgcc acgatgatcg tgcccgtgcc caccaagcca acggagggcc
     1201 aggacgtaac actgaccgtg cagggctacc ccaaggacct gctggtctac gcctggtacc
     1261 gcgggcctgc ctccgagccc aaccggctgc tcagccagct gccgtcagga acctggattg
     1321 caggccccgc gcacacaggc cgggaggtgg gcttccccaa ctgctcgctg ttggtgcaga
     1381 agctgaacct cacagacact ggccgctaca cactcaagac tgtcacagtg cagggcaaga
     1441 ctgagacact ggaagtggag ctgcaggtgg cccccctggg gtaacagcgt gaccctggag
     1501 acgtccagag agaagagctc ttcgcaccat cctctggtcc tcgccctctg agtgggaacc
     1561 actcccccac agcgaggatg ccaggctgtg gtcctgctgt tctcctgcct ccaccctaga
     1621 gctagagcca cagggcccca ctccctcgct gagctgttgg ggagccaccg aggccataaa
     1681 cgtcctggtt aatgca
//
