LOCUS       NM_001712               3491 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens CEA cell adhesion molecule 1 (CEACAM1), transcript
            variant 1, mRNA.
ACCESSION   NM_001712
VERSION     NM_001712.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3491)
  AUTHORS   Muturi,H.T., Ghadieh,H.E., Asalla,S., Lester,S.G., Belew,G.D.,
            Zaidi,S., Abdolahipour,R., Shrestha,A.P., Portuphy,A.O.,
            Stankus,H.L., Helal,R.A., Verhulst,S., Duarte,S., Zarrinpar,A., van
            Grunsven,L.A., Friedman,S.L., Schwabe,R.F., Hinds,T.D. Jr.,
            Kumarasamy,S. and Najjar,S.M.
  TITLE     Conditional deletion of CEACAM1 in hepatic stellate cells causes
            their activation
  JOURNAL   Mol Metab 88, 102010 (2024)
   PUBMED   39168268
  REMARK    GeneRIF: Conditional deletion of CEACAM1 in hepatic stellate cells
            causes their activation.
REFERENCE   2  (bases 1 to 3491)
  AUTHORS   Zaidi,S., Asalla,S., Muturi,H.T., Russo,L., Abdolahipour,R.,
            Belew,G.D., Iglesias,M.B., Feraudo,M., Leon,L., Kuo,E., Liu,X.,
            Kumarasamy,S., Ghadieh,H.E., Gatto-Weis,C., Zarrinpar,A., Duarte,S.
            and Najjar,S.M.
  TITLE     Loss of CEACAM1 in hepatocytes causes hepatic fibrosis
  JOURNAL   Eur J Clin Invest 54 (7), e14177 (2024)
   PUBMED   38381498
  REMARK    GeneRIF: Loss of CEACAM1 in hepatocytes causes hepatic fibrosis.
REFERENCE   3  (bases 1 to 3491)
  AUTHORS   Yazdani,H.O., Geller,D.A. and Tohme,S.
  TITLE     Spliced CEACAM1: A Potential Novel Biomarker and Target for
            Ameliorating Liver Ischemia-reperfusion Injury
  JOURNAL   Transplantation 108 (3), 585-587 (2024)
   PUBMED   38385338
  REMARK    GeneRIF: Spliced CEACAM1: A Potential Novel Biomarker and Target
            for Ameliorating Liver Ischemia-reperfusion Injury.
REFERENCE   4  (bases 1 to 3491)
  AUTHORS   Gotz,L., Rueckschloss,U., Balk,G., Pfeiffer,V., Ergun,S. and
            Kleefeldt,F.
  TITLE     The role of carcinoembryonic antigen-related cell adhesion molecule
            1 in cancer
  JOURNAL   Front Immunol 14, 1295232 (2023)
   PUBMED   38077351
  REMARK    GeneRIF: The role of carcinoembryonic antigen-related cell adhesion
            molecule 1 in cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3491)
  AUTHORS   Dery,K.J., Kojima,H., Kageyama,S., Kadono,K., Hirao,H., Cheng,B.,
            Zhai,Y., Farmer,D.G., Kaldas,F.M., Yuan,X., Eltzschig,H.K. and
            Kupiec-Weglinski,J.W.
  TITLE     Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha
            enhances tolerance to hepatic ischemia in mice and humans
  JOURNAL   Sci Transl Med 15 (707), eadf2059 (2023)
   PUBMED   37531413
  REMARK    GeneRIF: Alternative splicing of CEACAM1 by hypoxia-inducible
            factor-1alpha enhances tolerance to hepatic ischemia in mice and
            humans.
REFERENCE   6  (bases 1 to 3491)
  AUTHORS   Thompson,J., Zimmermann,W., Osthus-Bugat,P., Schleussner,C.,
            Eades-Perner,A.M., Barnert,S., Von Kleist,S., Willcocks,T.,
            Craig,I., Tynan,K. et al.
  TITLE     Long-range chromosomal mapping of the carcinoembryonic antigen
            (CEA) gene family cluster
  JOURNAL   Genomics 12 (4), 761-772 (1992)
   PUBMED   1572649
REFERENCE   7  (bases 1 to 3491)
  AUTHORS   Kuroki,M., Arakawa,F., Matsuo,Y., Oikawa,S., Nakazato,H. and
            Matsuoka,Y.
  TITLE     Three novel molecular forms of biliary glycoprotein deduced from
            cDNA clones from a human leukocyte library
  JOURNAL   Biochem Biophys Res Commun 176 (2), 578-585 (1991)
   PUBMED   2025273
REFERENCE   8  (bases 1 to 3491)
  AUTHORS   Barnett,T.R., Kretschmer,A., Austen,D.A., Goebel,S.J., Hart,J.T.,
            Elting,J.J. and Kamarck,M.E.
  TITLE     Carcinoembryonic antigens: alternative splicing accounts for the
            multiple mRNAs that code for novel members of the carcinoembryonic
            antigen family
  JOURNAL   J Cell Biol 108 (2), 267-276 (1989)
   PUBMED   2537311
REFERENCE   9  (bases 1 to 3491)
  AUTHORS   Hinoda,Y., Neumaier,M., Hefta,S.A., Drzeniek,Z., Wagener,C.,
            Shively,L., Hefta,L.J., Shively,J.E. and Paxton,R.J.
  TITLE     Molecular cloning of a cDNA coding biliary glycoprotein I: primary
            structure of a glycoprotein immunologically crossreactive with
            carcinoembryonic antigen
  JOURNAL   Proc Natl Acad Sci U S A 85 (18), 6959-6963 (1988)
   PUBMED   2457922
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1989 Mar;86(5):1668]
REFERENCE   10 (bases 1 to 3491)
  AUTHORS   Svenberg,T., Hammarstrom,S. and Zeromski,J.
  TITLE     Immunofluorescence studies on the occurrence and localization of
            the CEA-related biliary glycoprotein I (BGP I) in normal human
            gastrointestinal tissues
  JOURNAL   Clin Exp Immunol 36 (3), 436-441 (1979)
   PUBMED   385181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA432598.1, X16354.1 and
            AC004785.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001712.4.
            
            Summary: This gene encodes a member of the carcinoembryonic antigen
            (CEA) gene family, which belongs to the immunoglobulin superfamily.
            Two subgroups of the CEA family, the CEA cell adhesion molecules
            and the pregnancy-specific glycoproteins, are located within a 1.2
            Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of
            the CEA cell adhesion molecule subgroup are also found in the
            cluster. The encoded protein was originally described in bile ducts
            of liver as biliary glycoprotein. Subsequently, it was found to be
            a cell-cell adhesion molecule detected on leukocytes, epithelia,
            and endothelia. The encoded protein mediates cell adhesion via
            homophilic as well as heterophilic binding to other proteins of the
            subgroup. Multiple cellular activities have been attributed to the
            encoded protein, including roles in the differentiation and
            arrangement of tissue three-dimensional structure, angiogenesis,
            apoptosis, tumor suppression, metastasis, and the modulation of
            innate and adaptive immune responses. Multiple transcript variants
            encoding different isoforms have been reported, but the full-length
            nature of all variants has not been defined. [provided by RefSeq,
            May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein (isoform 1). This
            variant has been referred to by multiple names, including
            transmembrane carcinoembryonic antigen BGPa, TM1-CEA, and
            CEACAM1-4L.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X16354.1, J03858.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000161559.11/ ENSP00000161559.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                DA432598.1         30-64
            36-1765             X16354.1           1-1730
            1766-3465           AC004785.1         13650-15349         c
            3466-3491           X16354.1           3430-3455
FEATURES             Location/Qualifiers
     source          1..3491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3491
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /note="CEA cell adhesion molecule 1"
                     /db_xref="GeneID:634"
                     /db_xref="HGNC:HGNC:1814"
                     /db_xref="MIM:109770"
     exon            1..171
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1688
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; antigen CD66; carcinoembryonic antigen related
                     cell adhesion molecule 1; CD66a antigen; carcinoembryonic
                     antigen-related cell adhesion molecule 1 (biliary
                     glycoprotein); cell adhesion molecule CEACAM1"
                     /codon_start=1
                     /product="cell adhesion molecule CEACAM1 isoform 1
                     precursor"
                     /protein_id="NP_001703.2"
                     /db_xref="CCDS:CCDS12609.1"
                     /db_xref="GeneID:634"
                     /db_xref="HGNC:HGNC:1814"
                     /db_xref="MIM:109770"
                     /translation="MGHLSAPLHRVRVPWQGLLLTASLLTFWNPPTTAQLTTESMPFN
                     VAEGKEVLLLVHNLPQQLFGYSWYKGERVDGNRQIVGYAIGTQQATPGPANSGRETIY
                     PNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDK
                     DAVAFTCEPETQDTTYLWWINNQSLPVSPRLQLSNGNRTLTLLSVTRNDTGPYECEIQ
                     NPVSANRSDPVTLNVTYGPDTPTISPSDTYYRPGANLSLSCYAASNPPAQYSWLINGT
                     FQQSTQELFIPNITVNNSGSYTCHANNSVTGCNRTTVKTIIVTELSPVVAKPQIKASK
                     TTVTGDKDSVNLTCSTNDTGISIRWFFKNQSLPSSERMKLSQGNTTLSINPVKREDAG
                     TYWCEVFNPISKNQSDPIMLNVNYNALPQENGLSPGAIAGIVIGVVALVALIAVALAC
                     FLHFGKTGRASDQRDLTEHKPSVSNHTQDHSNDPPNKMNEVTYSTLNFEAQQPTQPTS
                     ASPSLTATEIIYSEVKKQ"
     exon            172..531
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            532..810
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            811..1065
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1353
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1483
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1536
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1568
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..3491
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1673..1678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /note="hexamer: AGTAAA"
     polyA_site      1693
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /note="major polyA site"
     regulatory      3466..3471
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /note="hexamer: AATAAA"
     polyA_site      3491
                     /gene="CEACAM1"
                     /gene_synonym="BGP; BGP1; BGPI"
                     /note="major polyA site"
ORIGIN      
        1 agcacagaga gtggaaaaca gcagaggtga cagagcagcc gtgctcgaag cgttcctgga
       61 gcccaagctc tcctccacag gtgaagacag ggccagcagg agacaccatg gggcacctct
      121 cagccccact tcacagagtg cgtgtaccct ggcaggggct tctgctcaca gcctcacttc
      181 taaccttctg gaacccgccc accactgccc agctcactac tgaatccatg ccattcaatg
      241 ttgcagaggg gaaggaggtt cttctccttg tccacaatct gccccagcaa ctttttggct
      301 acagctggta caaaggggaa agagtggatg gcaaccgtca aattgtagga tatgcaatag
      361 gaactcaaca agctacccca gggcccgcaa acagcggtcg agagacaata taccccaatg
      421 catccctgct gatccagaac gtcacccaga atgacacagg attctacacc ctacaagtca
      481 taaagtcaga tcttgtgaat gaagaagcaa ctggacagtt ccatgtatac ccggagctgc
      541 ccaagccctc catctccagc aacaactcca accctgtgga ggacaaggat gctgtggcct
      601 tcacctgtga acctgagact caggacacaa cctacctgtg gtggataaac aatcagagcc
      661 tcccggtcag tcccaggctg cagctgtcca atggcaacag gaccctcact ctactcagtg
      721 tcacaaggaa tgacacagga ccctatgagt gtgaaataca gaacccagtg agtgcgaacc
      781 gcagtgaccc agtcaccttg aatgtcacct atggcccgga cacccccacc atttcccctt
      841 cagacaccta ttaccgtcca ggggcaaacc tcagcctctc ctgctatgca gcctctaacc
      901 cacctgcaca gtactcctgg cttatcaatg gaacattcca gcaaagcaca caagagctct
      961 ttatccctaa catcactgtg aataatagtg gatcctatac ctgccacgcc aataactcag
     1021 tcactggctg caacaggacc acagtcaaga cgatcatagt cactgagcta agtccagtag
     1081 tagcaaagcc ccaaatcaaa gccagcaaga ccacagtcac aggagataag gactctgtga
     1141 acctgacctg ctccacaaat gacactggaa tctccatccg ttggttcttc aaaaaccaga
     1201 gtctcccgtc ctcggagagg atgaagctgt cccagggcaa caccaccctc agcataaacc
     1261 ctgtcaagag ggaggatgct gggacgtatt ggtgtgaggt cttcaaccca atcagtaaga
     1321 accaaagcga ccccatcatg ctgaacgtaa actataatgc tctaccacaa gaaaatggcc
     1381 tctcacctgg ggccattgct ggcattgtga ttggagtagt ggccctggtt gctctgatag
     1441 cagtagccct ggcatgtttt ctgcatttcg ggaagaccgg cagggcaagc gaccagcgtg
     1501 atctcacaga gcacaaaccc tcagtctcca accacactca ggaccactcc aatgacccac
     1561 ctaacaagat gaatgaagtt acttattcta ccctgaactt tgaagcccag caacccacac
     1621 aaccaacttc agcctcccca tccctaacag ccacagaaat aatttattca gaagtaaaaa
     1681 agcagtaatg aaacctgtcc tgctcactgc agtgctgatg tatttcaagt ctctcaccct
     1741 catcactagg agattccttt cccctgtagg ggtagagggg tggggacaga aacaactttc
     1801 tcctactctt ccttcctaat aggcatctcc aggctgcctg gtcactgccc ctctctcagt
     1861 gtcaatagat gaaagtacat tgggagtctg taggaaaccc aaccttcttg tcattgaaat
     1921 ttggcaaagc tgactttggg aaagagggac cagaacttcc cctcccttcc ccttttccca
     1981 acctggactt gttttaaact tgcctgttca gagcactcat tccttcccac ccccagtcct
     2041 gtcctatcac tctaattcgg atttgccata gccttgaggt tatgtccttt tccattaagt
     2101 acatgtgcca ggaaacaaga gagagagaaa gtaaaggcag taatgccttc tcctatttct
     2161 ccaaagcctt gtgtgaactc accaaacaca agaaaatcaa atatataacc aatagtgaaa
     2221 tgccacacct ttgtccactg tcagggttgt ctacctgtag gatcagggtc taagcacctt
     2281 ggtgcttagc tagaatacca cctaatcctt ctggcaagcc tgtcttcaga gaacccacta
     2341 gaagcaacta ggaaaatcac ttgccaaaat ccaaggcaat tcctgatgga aaatgcaaaa
     2401 gcacatatat gttttaatat ctttatgggc tctgttcaag gcagtgctga gagggagggg
     2461 ttatagcttc aggagggaac cagcttctga taaacacaat ctgctaggaa cttgggaaag
     2521 gaatcagaga gctgcccttc agcgattatt taaattattg ttaaagaata cacaatttgg
     2581 ggtattggga tttttctcct tttctctgag acattccacc attttaattt ttgtaactgc
     2641 ttatttatgt gaaaagggtt atttttactt agcttagcta tgtcagccaa tccgattgcc
     2701 ttaggtgaaa gaaaccaccg aaatccctca ggtcccttgg tcaggagcct ctcaagattt
     2761 tttttgtcag aggctccaaa tagaaaataa gaaaaggttt tcttcattca tggctagagc
     2821 tagatttaac tcagtttcta ggcacctcag accaatcatc aactaccatt ctattccatg
     2881 tttgcacctg tgcattttct gtttgccccc attcactttg tcaggaaacc ttggcctctg
     2941 ctaaggtgta tttggtcctt gagaagtggg agcaccctac agggacacta tcactcatgc
     3001 tggtggcatt gtttacagct agaaagctgc actggtgcta atgccccttg gggaaatggg
     3061 gctgtgagga ggaggattat aacttaggcc tagcctcttt taacagcctc tgaaatttat
     3121 cttttcttct atggggtcta taaatgtatc ttataataaa aaggaaggac aggaggaaga
     3181 caggcaaatg tacttctcac ccagtcttct acacagatgg aatctctttg gggctaagag
     3241 aaaggtttta ttctatattg cttacctgat ctcatgttag gcctaagagg ctttctccag
     3301 gaggattagc ttggagttct ctatactcag gtacctcttt cagggttttc taaccctgac
     3361 acggactgtg catactttcc ctcatccatg ctgtgctgtg ttatttaatt tttcctggct
     3421 aagatcatgt ctgaattatg tatgaaaatt attctatgtt tttataataa aaataatata
     3481 tcagacatcg a
//
