LOCUS       NM_152342               8427 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens chromodomain Y like 2 (CDYL2), mRNA.
ACCESSION   NM_152342
VERSION     NM_152342.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8427)
  AUTHORS   Siouda,M., Dujardin,A.D., Dekeyzer,B., Schaeffer,L. and Mulligan,P.
  TITLE     Chromodomain on Y-like 2 (CDYL2) implicated in mitosis and genome
            stability regulation via interaction with CHAMP1 and POGZ
  JOURNAL   Cell Mol Life Sci 80 (2), 47 (2023)
   PUBMED   36658409
  REMARK    GeneRIF: Chromodomain on Y-like 2 (CDYL2) implicated in mitosis and
            genome stability regulation via interaction with CHAMP1 and POGZ.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8427)
  AUTHORS   Chen,X., Wang,Z., Zhao,X., Zhang,L., Zhou,L., Li,X., Ge,C.,
            Zhao,F., Chen,T., Xie,H., Cui,Y., Tian,H., Li,H., Yao,M. and Li,J.
  TITLE     STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation
            and invasion of hepatocellular carcinoma by targeting to mTORC1
  JOURNAL   Oncogene 41 (17), 2492-2504 (2022)
   PUBMED   35314791
  REMARK    GeneRIF: STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the
            proliferation and invasion of hepatocellular carcinoma by targeting
            to mTORC1.
REFERENCE   3  (bases 1 to 8427)
  AUTHORS   Ling,Y., Liang,G., Lin,Q., Fang,X., Luo,Q., Cen,Y., Mehrpour,M.,
            Hamai,A., Liu,Z., Shi,Y., Li,J., Lin,W., Jia,S., Yang,W., Liu,Q.,
            Song,E., Li,J. and Gong,C.
  TITLE     circCDYL2 promotes trastuzumab resistance via sustaining HER2
            downstream signaling in breast cancer
  JOURNAL   Mol Cancer 21 (1), 8 (2022)
   PUBMED   34980129
  REMARK    GeneRIF: circCDYL2 promotes trastuzumab resistance via sustaining
            HER2 downstream signaling in breast cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8427)
  AUTHORS   Yang,L.F., Yang,F., Zhang,F.L., Xie,Y.F., Hu,Z.X., Huang,S.L.,
            Shao,Z.M. and Li,D.Q.
  TITLE     Discrete functional and mechanistic roles of chromodomain Y-like 2
            (CDYL2) transcript variants in breast cancer growth and metastasis
  JOURNAL   Theranostics 10 (12), 5242-5258 (2020)
   PUBMED   32373210
  REMARK    GeneRIF: Discrete functional and mechanistic roles of chromodomain
            Y-like 2 (CDYL2) transcript variants in breast cancer growth and
            metastasis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8427)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 8427)
  AUTHORS   Dastani,Z., Pajukanta,P., Marcil,M., Rudzicz,N., Ruel,I.,
            Bailey,S.D., Lee,J.C., Lemire,M., Faith,J., Platko,J., Rioux,J.,
            Hudson,T.J., Gaudet,D., Engert,J.C. and Genest,J.
  TITLE     Fine mapping and association studies of a high-density lipoprotein
            cholesterol linkage region on chromosome 16 in French-Canadian
            subjects
  JOURNAL   Eur J Hum Genet 18 (3), 342-347 (2010)
   PUBMED   19844255
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 8427)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 8427)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of gene polymorphisms with chronic kidney disease in
            Japanese individuals
  JOURNAL   Int J Mol Med 24 (4), 539-547 (2009)
   PUBMED   19724895
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 8427)
  AUTHORS   Miele,A., Medina,R., van Wijnen,A.J., Stein,G.S. and Stein,J.L.
  TITLE     The interactome of the histone gene regulatory factor HiNF-P
            suggests novel cell cycle related roles in transcriptional control
            and RNA processing
  JOURNAL   J Cell Biochem 102 (1), 136-148 (2007)
   PUBMED   17577209
REFERENCE   10 (bases 1 to 8427)
  AUTHORS   Dorus,S., Gilbert,S.L., Forster,M.L., Barndt,R.J. and Lahn,B.T.
  TITLE     The CDY-related gene family: coordinated evolution in copy number,
            expression profile and protein sequence
  JOURNAL   Hum Mol Genet 12 (14), 1643-1650 (2003)
   PUBMED   12837688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009070.12, AK096185.1, BC100803.1, BX390259.2, AC092332.4 and
            AW297969.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152342.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.132965.1,
                                           SRR1660807.253557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000570137.7/ ENSP00000476295.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AC009070.12        55649-55968         c
            321-1010            AK096185.1         1-690
            1011-2093           BC100803.1         610-1692
            2094-2553           AK096185.1         1774-2233
            2554-2556           BX390259.2         757-759
            2557-7982           AC092332.4         31485-36910         c
            7983-8427           AW297969.1         25-469              c
FEATURES             Location/Qualifiers
     source          1..8427
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.2"
     gene            1..8427
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /note="chromodomain Y like 2"
                     /db_xref="GeneID:124359"
                     /db_xref="HGNC:HGNC:23030"
                     /db_xref="MIM:618816"
     exon            1..449
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..1946
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /note="prostate cancer candidate protein 1, PCCP1;
                     CDY-like 2; chromodomain protein, Y-like 2"
                     /codon_start=1
                     /product="chromodomain Y-like protein 2"
                     /protein_id="NP_689555.2"
                     /db_xref="CCDS:CCDS32493.1"
                     /db_xref="GeneID:124359"
                     /db_xref="HGNC:HGNC:23030"
                     /db_xref="MIM:618816"
                     /translation="MASGDLYEVERIVDKRKNKKGKWEYLIRWKGYGSTEDTWEPEHH
                     LLHCEEFIDEFNGLHMSKDKRIKSGKQSSTSKLLRDSRGPSVEKLSHRPSDPGKSKGT
                     SHKRKRINPPLAKPKKGYSGKPSSGGDRATKTVSYRTTPSGLQIMPLKKSQNGMENGD
                     AGSEKDERHFGNGSHQPGLDLNDHVGEQDMGECDVNHATLAENGLGSALTNGGLNLHS
                     PVKRKLEAEKDYVFDKRLRYSVRQNESNCRFRDIVVRKEEGFTHILLSSQTSDNNALT
                     PEIMKEVRRALCNAATDDSKLLLLSAVGSVFCSGLDYSYLIGRLSSDRRKESTRIAEA
                     IRDFVKAFIQFKKPIVVAINGPALGLGASILPLCDIVWASEKAWFQTPYATIRLTPAG
                     CSSYTFPQILGVALANEMLFCGRKLTAQEACSRGLVSQVFWPTTFSQEVMLRVKEMAS
                     CSAVVLEESKCLVRSFLKSVLEDVNEKECLMLKQLWSSSKGLDSLFSYLQDKIYEV"
     exon            450..1041
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1259
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1432
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1643
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1787
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1788..8427
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8409..8414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /note="hexamer: AATAAA"
     polyA_site      8427
                     /gene="CDYL2"
                     /gene_synonym="PCCP1"
                     /note="major polyA site"
ORIGIN      
        1 agtggcagca gcgtccgggc cggcggcggg cgccgggcgg cttcctgcag gcggcgccgg
       61 ggcgagccgt tgccggctgc agccaccgcc gccgggtcgc cgggtcgcgg gggccgcggc
      121 gctcgggccg cgtccgtgcc tcccgggcgc gctgcgcggc cgtcgctgct gcccgcgctc
      181 gtgccgccgc cgccgccgcc gccgctgctg ccggttacgc cagccccgcc gccgcccgct
      241 ctgattctgc gcataggcag cccccaagcc tgtcattctg caaaaacaca gtttactcaa
      301 cacaccacac acactcgcac acacacgcgc gcacacacac gcgcacaccg gaccccgcgc
      361 gcacacgcac ggagggcgcg agcgagcaga cgcgcacacc ggcgagccaa gttccgcagc
      421 ctggcatggc ttctggggac ctttacgagg ttgaaaggat tgtagacaag aggaagaaca
      481 agaaaggaaa atgggagtat cttatccgat ggaaaggcta cgggagcacc gaggacacgt
      541 gggagccgga gcaccacctc ttgcactgtg aggagtttat tgatgaattc aatgggttgc
      601 acatgtccaa ggacaagagg atcaagtcag ggaagcagtc cagtacctcc aagctgctgc
      661 gtgacagtcg aggcccgtcg gttgagaaac tgtcccacag accttcagat cctggaaaga
      721 gcaaggggac ctcccataaa cggaagcgaa ttaaccctcc cctggccaag ccaaaaaaag
      781 ggtattcagg caagccctct tcaggaggtg acagggccac caagacggtg tcttacagga
      841 ctacccccag tggtttgcaa ataatgcccc tgaaaaagtc tcagaacggg atggaaaatg
      901 gggacgccgg ctctgagaag gatgagaggc actttggaaa tgggtcccat cagcctggct
      961 tggatttgaa tgatcatgtt ggagagcaag atatgggtga atgtgacgtg aatcacgcta
     1021 cactggcgga gaacgggctc ggctctgctc tgaccaacgg gggattgaac ctgcacagtc
     1081 cagtgaagag gaagctggaa gcggagaagg actacgtctt tgacaaaagg ctcagataca
     1141 gtgtccgcca gaatgaaagc aactgtcggt ttcgagacat cgttgtgcgg aaggaagaag
     1201 ggttcacgca catcctgctg tccagtcaga cctcggataa caatgccctg acacctgaga
     1261 tcatgaaaga agtccggcga gcgctctgca acgcagccac agacgacagc aaactgctgc
     1321 tcctcagcgc agtggggagc gtgttctgca gcggcctgga ttattcctac ctaattggcc
     1381 ggttgtccag cgaccggcga aaggagagca ctcggattgc agaagccatc agggactttg
     1441 tgaaggcctt tatccagttt aagaagccta tcgtggtggc catcaatggg ccggccctgg
     1501 gcctgggtgc ctccatcctg cccctctgtg acatcgtgtg ggccagtgag aaggcctggt
     1561 tccagacgcc ctacgccacc atccgcctca cgcctgctgg ctgctcctcc tacaccttcc
     1621 cccagatcct gggcgtcgcg ctggccaatg agatgctgtt ctgtgggcgg aagctcaccg
     1681 cccaggaggc ctgcagcagg gggctggtgt cgcaggtctt ctggcccacc acgttcagcc
     1741 aggaggtcat gctgcgggtc aaggagatgg catcctgcag tgccgtggtg ttagaggagt
     1801 ccaaatgcct cgtgcggagc ttcctgaaat cagtgctgga agacgtgaac gagaaggaat
     1861 gcctcatgct caagcagctc tggagctcct ccaaaggcct tgactccctt ttcagctacc
     1921 tgcaggacaa aatttatgaa gtctgagggg ccccagctca cgggccccca acttccagct
     1981 ctgccctgtg tttcggaaac cagagcacag tgtctgcccc ggccaaggag tttgtcaagg
     2041 tgtctcttta tacgtagggt tgtgtccatt tcctcgtgtc ctttggttgc tcctccttgg
     2101 tttgattttg tgtaatggat ggaaaacgca gcatacttgg cctcccccac ctccctgccc
     2161 ttcctggcca gagagctgtc caaggctgta tcttcccagg gctccgccaa gcaccgctgt
     2221 cctttcccca cttgctgaaa tgcaccatga cggtccagga aggggaagac cactttcaca
     2281 ttcttctgac tcaggctgtg tctacacagt gcctctgact tggagacttg gccatcatgg
     2341 ctctctctgg ttgtatttag atcgggtgtc agaggacgac caatcttagg gaatttccag
     2401 accaatgagc aaaatgattg tgcacacctg gcctcagtct cctttccgac gcaaatctgt
     2461 gtgactatta gggcttggtc ttaaaaccca attgagtgat ttgcaaaccc agatattgta
     2521 catttagaaa tgttttgtta aatatatatt tttaaaacaa tgtaagtgga aattctgata
     2581 atttatgtgt attatatgta aagctagttt tgcaaaaaca aactactagg gaaatgtttt
     2641 ttctttcctt ggacttgttt tatttattta tttttgttta tatattgtga tgtctgttgt
     2701 tcacacagat actattttca tactaccctg gaccaaatcc cacacaaggt tcatgccgtt
     2761 tggtgcattc tagcaatgaa ccatgtagaa ataaagttta gagagatgaa aacagaagga
     2821 tttctgtgga caaaaggaat agcgctgcac ctctgtgtaa aacggttctc agctgtaata
     2881 atagaatact agttccttag gtttgtcctt aggagacatc ttgggagagt tttttcttcc
     2941 ctctgctgtc tttaaggagt taaagggccc tcttagcctg aatgatcctg aaacagaccc
     3001 agtcccaaat tgcgtgatgt tgggcaggag tggggatagg ccctacctga gaatagcata
     3061 ctgtctagaa taagacttct ttctttgggg caaatgactg aacttggatc ctgcagtctg
     3121 ttgcttccat gtgatcagtg atttctggta ttggccaggg ggatggggaa gagttcccac
     3181 tctgctgagc tgtctggagg tctgaatctt ttccctccag aagctgaaat gactcatctg
     3241 ttttctagtt tttttatgta catagggagc aatgaccagg aatgagatct ccttgcccct
     3301 gtgcccctgg gctgcaaggg gactccagca gctgtgttag accatcagat tcaagtccct
     3361 ggattaacta cagagaagga gggattgggg gttgtggttt tgagtggtga ggagaaagtt
     3421 caggaaaacc tgaagttgag agcagacaaa tggaagggat gtgttctgcg tgaggtttaa
     3481 accatgggtc aagcacccag aaaaagctag attctcagat tctcaggatg gagggatttt
     3541 tttccgtttc tatcacagcc cctgcgtatt cctggaggcc cttggccctc cccttcttcc
     3601 cctttcctgt tgggcaccag cctttcttgg cccttctttg aagagagtgg aataaggcag
     3661 caagaagtgg gcacagctta tggaggtgag gcaggcttag aagagagagt tctggtgaca
     3721 gttctctaac tctctgtggt cctttatctt ttcctggcaa tcaggtgcac tgggcagggc
     3781 aggtggaatg tattcgtggc cctgagcttt gagtttcaaa gaacacgttg atagtctaca
     3841 ccagatctag agacatggtc ctttaagcag tgaccctcaa gttaatctgg actgctggtc
     3901 cttctgatga ccttggttcc ctccctggaa agcgtgtctc ctttaagagt tcatgagggt
     3961 caggaaggag gggaaacctc tccttcagcc agaggaggat ggaattaaag tcctgtgcac
     4021 cctccccttt gtccatgtag gatcctgtaa ggacttcgga cctgtcctac agggagttac
     4081 tatagggaga cacctgcttt tgcccaaatg cctgttgtca cagctctatc tggatcttat
     4141 ctcctccttt gagaaagcaa atgtgagctt tccaaaaccc ttagatgacc ctggttctta
     4201 catattgtgg cagacagtgt cttcactact gctaaatttt cattagaaag agccccctct
     4261 tttctgttga acttctgatt gggcgcagtt atattcagca tcggttgaag tggggtcagg
     4321 attctccttg gacatggaag gggatgttta gaaattcctt tagatcagtg tccaccttca
     4381 ttccctgctt gaaagaacta gaaatgcttc agctttggat gtactatcaa atccaaactt
     4441 ctaaacattt caaggatctc tgaagattaa ggtaggaatg tgaaaccatt tctaaggtgg
     4501 aaatcttgct gttaagtcac aggtcctggg tgtaacgggg gtggtgaaag tctgtatttt
     4561 ggttgtttcc atacagtcag ttccaccaat tgggtgaaag caggtgaaat ctttttgctg
     4621 cagggtggac tgaatttttc actttctggg tagttgtttt gatcatgtgt aggcgaattc
     4681 caggtaactt acagcaaata gatttgggat ggaaaatacc agacctctgg ttgtgtcagg
     4741 gtttatccta atagctttcc tgagacagag ctcagacttt catttttgat cttccacccc
     4801 agggccccct ctctgtctat gggatccttt ctcccctctc tctaccattt tcccgtacct
     4861 tcccccataa gtcactccca agagcctggg caggtctttg aggaattgcg gctcattttg
     4921 gcagccccgt cctgcaatta cctttgggtt tgaaagaata gctgtgggtg ggcaattgag
     4981 gacacctctt tagtcaggga cctttctagc aatccactcc ctcccatcct gttagccatg
     5041 cagtggaact ctccttccct ctctgcccca accccggtga tggctcactc tcagcatctt
     5101 atgggaccat ctgagttaac aaccctgttc caagaagact ttgtgcagaa cttttgttag
     5161 ggtggtcata ccttctcacc accatttgga agacacagcc taatgctgat gtacttaatg
     5221 tgccccttcc ggcatagaaa taatgtctgg gtaacagcca tcaaaatcac taagaatgac
     5281 attggatagc tatgagaaag tagtagagaa ttgatttaaa atatcattct tgtttggtat
     5341 agattaaact aggaaatgtt ctctctgaag catgaaaatg tttttcccat gtgaagttta
     5401 gtacaaggat ggaaaaataa taatcacagt agactttgaa caatgcaact gtatctctga
     5461 atatccacat ttaaaaatag ccttcactga atgctgaatt gcatttccca ttaatttttg
     5521 gttttaaaaa ttttgtaaac ttttttttta tttggaattt agtcacatcc attaaatttt
     5581 ccaatctagt ttctgtggaa attttttaac agagagaaac aaatagaaac atcttcaaat
     5641 cttcctaagt gaatatttaa aatgcagaat tgcttatctt ctgtttttct gtattcagac
     5701 acttatatct gttgtatata ttagtttaga cactctcact aatatacaca gtatttaaga
     5761 ctctaaatga gatttcttaa gtattttatt ttattctctg taaatggttt tgtataatct
     5821 ttaaacatct acactttgcc tttgtagata tttaagggaa accatttggg gttgtcttgc
     5881 atgtatattt ttgttgtaga taagtgttgc ttagttattt ctgcaaattt tggttgaaat
     5941 gcttacagac tttaatacag tatatatttt caaaatataa acttttatat ttctgtgata
     6001 agttaggata tgcgttttag gcaatatttt tcattaatat cacttgttct tttgaaaaat
     6061 agcatactgg tttggtgcca attttttcat tagaatataa tgctcttata ttgttggaga
     6121 gcaggttaat cttttttcga agtaattgcg tttgaagtat aatttcaaaa tgtattgaat
     6181 ttgtgaataa gccttaccat taggatcagt aaatttttca actttgcaac tacataagta
     6241 gtttaagatc tccccgtaaa ttctcactgt gtggcagttg atggagtttg tgaacagagc
     6301 cttaagcttg ttgcaaaaaa atttaaaaag ggtaatacgg gttgtttcct ccatgcaacg
     6361 taagccatgc tgatggactg aatgcagtct gtaattcatg gctaatccga agagtttgat
     6421 tgagttgatg gcggcaggga ccagatagac accttggtga ttgtctttgg ccataagaat
     6481 agaccaagga taggttttcc agagacacct tcatactgta aacatggttt agacacggtc
     6541 atagggaagg ctgctggtcc atcatttgtt ctgaacaaat ggcatttcct gctcctgacc
     6601 ctggcagttg gccccagatt ccttgtcgat gacttggaaa cgtccattct gggtaaggtc
     6661 agcactccct gagagatgtt aacaaagttt acctatgagt cttactgtgt agacaatctg
     6721 aagtcaattt tagttacaca atcagcattc ccatgtgtcc tcagtgtctt atcaatgaac
     6781 tatgtgtatc aagccatact aaactggagt ttagcaggac aaaggcaaac taaatgtaga
     6841 acataacata tcagctgaat atgtctatcc aggactgttt ttctagaaca taaatcatgg
     6901 agctccttga cagtgtatcc actgtttttg gggtttaata aaaccaacta gaatttagac
     6961 ttaaaaagaa attattattc cttttggttg tccacataaa gtagtccagg gctatcatat
     7021 ggctaaaatc aagttatttg gttcatctct ggtatgtatt tataaagtca acttatcagc
     7081 cattaagatg gagatttgct ttaaattttt gcagtgtgtg tggcagtcag aaaaacccat
     7141 atctagtttt caacttcacc tctggtgttt ttatggctta accttatatc attgatccaa
     7201 catctagcct gatgctggag ctcttatttc tagcctgatg ctggagctct tatatctagc
     7261 ctgatgctgg agctcttgaa gctgactctt ggaagtttgg agggtgtaga gtttcccatc
     7321 tagtatttaa tttgtccctg tgccattagt cccagcttga agtcatttgc cagtgtcgat
     7381 gttgacagga ttgtgacaat attgcctttc ataaaaccga gaaccaaaga attccattat
     7441 tctaacaaag cctgagtttc atagattgtg ggcacatcta gacagatatg tgcatgcttg
     7501 atggtgcaga gaaactgctg acttccacca acctcatgct ccccctggct ggccatacag
     7561 agggattcgt tgtcatattg aaaaggctct gaaagatgag tttctaattg aagctcacta
     7621 tctcaggttg gtgtttctac tgtgtagtcc caagcctgta tccatatcat aaaagtggag
     7681 gcctggtact cctccaggtt atctggccag tgtagactcc tccatctgaa tatgaacctc
     7741 cagggtaaga atttttcaga catgtctata ctgaacagta ggatcctgca ctttccaaat
     7801 gtctgcctcc ttttgttctt cattgaccca ttctaattcc tgttaggtgt gagaagaatt
     7861 gtcttcagtt ctctctccat tctcattcat gatggaatca ttgatccatt gaccagttga
     7921 gaaatgattg atgctgaaga agtggtattc tattggtaag gcttattacc aaacttccga
     7981 taatgaagca ggctaccaaa aacttatcca gcccacccta ggagtgtttg gatttgatca
     8041 tggatgtagc atacaccaaa atccaccgag acctttgcaa aattaggcta cttgttttat
     8101 tttgccagat tatcatggga gagtctttaa ctagttctga atatttgtaa gtctgagtac
     8161 ttcatagaat tataaagaag gtacagctga ccccttctca ccatgttgta aatatttact
     8221 gagactgggt gcagtactga gggataataa tcttctgatt tatcaaatcc tgactgtcta
     8281 gagcaaattg tacactctct ttgtgaatgg tcctgtaacg tgtatgaaca catttctggg
     8341 tgccttagaa gttgtatttt tcatgtgtgc taatatgcag tatttataca ttgtgagaag
     8401 ctgctttgaa taaaaaggtt gaaactt
//
