LOCUS       NM_001001722            1961 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens chromodomain Y-linked 2B (CDY2B), mRNA.
ACCESSION   NM_001001722 XM_016548
VERSION     NM_001001722.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1961)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   2  (bases 1 to 1961)
  AUTHORS   Lahn,B.T., Tang,Z.L., Zhou,J., Barndt,R.J., Parvinen,M., Allis,C.D.
            and Page,D.C.
  TITLE     Previously uncharacterized histone acetyltransferases implicated in
            mammalian spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 99 (13), 8707-8712 (2002)
   PUBMED   12072557
REFERENCE   3  (bases 1 to 1961)
  AUTHORS   Rottger,S., Yen,P.H. and Schempp,W.
  TITLE     A fiber-FISH contig spanning the non-recombining region of the
            human Y chromosome
  JOURNAL   Chromosome Res 10 (8), 621-635 (2002)
   PUBMED   12575791
REFERENCE   4  (bases 1 to 1961)
  AUTHORS   Wimmer,R., Kuhl,H., Rottger,S. and Schempp,W.
  TITLE     Comparative mapping of CDY and DAZ in higher primates
  JOURNAL   Cytogenet Genome Res 96 (1-4), 287-289 (2002)
   PUBMED   12438810
REFERENCE   5  (bases 1 to 1961)
  AUTHORS   Jones,D.O., Cowell,I.G. and Singh,P.B.
  TITLE     Mammalian chromodomain proteins: their role in genome organisation
            and expression
  JOURNAL   Bioessays 22 (2), 124-137 (2000)
   PUBMED   10655032
  REMARK    Review article
REFERENCE   6  (bases 1 to 1961)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Retroposition of autosomal mRNA yielded testis-specific gene family
            on human Y chromosome
  JOURNAL   Nat Genet 21 (4), 429-433 (1999)
   PUBMED   10192397
  REMARK    Erratum:[Nat Genet 1999 Jun;22(2):209]
REFERENCE   7  (bases 1 to 1961)
  AUTHORS   Yen,P.H.
  TITLE     A long-range restriction map of deletion interval 6 of the human Y
            chromosome: a region frequently deleted in azoospermic males
  JOURNAL   Genomics 54 (1), 5-12 (1998)
   PUBMED   9806824
REFERENCE   8  (bases 1 to 1961)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009976.4 and BC069087.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001001722.1.
            
            Summary: This intronless gene encodes a protein containing a
            chromodomain and a histone acetyltransferase catalytic domain.
            Chromodomain proteins are components of heterochromatin-like
            complexes and can act as gene repressors. This protein is localized
            to the nucleus of late spermatids where histone hyperacetylation
            takes place. Histone hyperacetylation is thought to facilitate the
            transition in which protamines replace histones as the major
            DNA-packaging protein. Two nearly identical copies of this gene are
            found in a palindromic region on chromosome Y; this record
            represents the centromeric copy. Chromosome Y also contains a pair
            of closely related genes in another more telomeric palindrome as
            well as several related pseudogenes. [provided by RefSeq, Jul
            2008].
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC069087.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382867.4/ ENSP00000372319.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC009976.4         27275-27275         c
            2-1961              BC069087.1         1-1960
FEATURES             Location/Qualifiers
     source          1..1961
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.222"
     gene            1..1961
                     /gene="CDY2B"
                     /gene_synonym="CDY"
                     /note="chromodomain Y-linked 2B"
                     /db_xref="GeneID:203611"
                     /db_xref="HGNC:HGNC:23921"
     exon            1..1961
                     /gene="CDY2B"
                     /gene_synonym="CDY"
                     /inference="alignment:Splign:2.1.0"
     CDS             329..1954
                     /gene="CDY2B"
                     /gene_synonym="CDY"
                     /EC_number="2.3.1.48"
                     /note="chromodomain protein, Y chromosome, 2 related;
                     testis-specific chromodomain protein Y protein 2 related;
                     Y chromosome chromodomain protein 2B; chromodomain
                     protein, Y-linked, 2B"
                     /codon_start=1
                     /product="testis-specific chromodomain protein Y 2"
                     /protein_id="NP_001001722.1"
                     /db_xref="CCDS:CCDS35473.1"
                     /db_xref="GeneID:203611"
                     /db_xref="HGNC:HGNC:23921"
                     /translation="MASQEFEVEAIVDKRQDKNGNTQYLVRWKGYDKQDDTWEPEQHL
                     MNCEKCVHDFNRRQTEKQKKLTWTTTSRIFSNNARRRTSRSTKANYSKNSPKTPVTDK
                     HHRSKNCKLFAASKNVRRKAASTLSDTKNMEIINSTIETLAPDSPFDHKKTVSGFQKL
                     EKLDPIAADQQDTVVFKVTEGKLLRDPLSHPGAEQTGIQNKTQMHPLMSQMSGSVTAS
                     MATGSATRKGIVVLIDPLAANGTTDMHTSVPRVKGGQRNITDDSRGQPFIKKMHFTIR
                     LTESAITYRDIVVKKEDGFTQIVLSTRSTEKNALNTEVIKEMVNALNSAAADDSKLVL
                     FSAAGSVFCCGLDFGYFVRHLRNDRNTASLEMVDTIKNFVNTFIQFKKPIVVSVNGPA
                     IGLGASILPLCDLVWANEKAWFQTPYTTFGQSPDGCSSITFPKMMGKASANEMLIAGR
                     KLTAREACAKGLVSQVFLTGTFTQEVMIQIKELASYNAIVLEECKALVRCNIKLELEQ
                     ANERECEVLRKIWSSAQGIESMLKYVENKIDEF"
ORIGIN      
        1 gtaacaggca ggaagaaagc tttctgtact acaccagagg gttggggctg tggatttagc
       61 tactctcacc tgaggctact gagcaagctg tcatgcacca cgagacaaag cccaagctgt
      121 cccaccaggc agtaagtgtg gagaggttca ggcacatggc atagctgcta tttcgcacaa
      181 ttttcactac accagtggtg accaaataga agaggttcat ccatacacag aacctggtga
      241 agagctggag gcagaaagaa gtgtctatgt ggagacgcaa ctgaaacaaa ggtggcacag
      301 caactgttcc aatcccgtgt ctttcctcat ggcttcccag gagtttgagg ttgaagctat
      361 tgttgacaaa agacaggata aaaatgggaa tacacagtat ttggttcggt ggaaaggtta
      421 tgacaaacag gatgacactt gggaaccaga gcagcacctc atgaactgtg aaaaatgtgt
      481 acatgatttt aatagacgac agactgaaaa acagaaaaaa ctgacatgga ctacaaccag
      541 tagaattttt tcaaacaatg ccagaagaag aacttccaga tctacaaaag caaactattc
      601 taagaactct cctaaaactc cagtgactga taaacaccac aggtccaaaa actgcaagtt
      661 atttgctgcc agcaagaacg ttaggagaaa ggcagcttca actctctccg acacaaagaa
      721 tatggagata ataaattcaa ctattgagac ccttgcacct gacagcccct ttgaccacaa
      781 gaaaactgtg agtggctttc agaaacttga gaaactggac cctattgcag cagatcagca
      841 ggacacggtg gtcttcaagg tgacagaagg gaaactcctc cgggaccctt tgtcacatcc
      901 tggtgcagaa cagactggaa tacagaacaa gactcagatg cacccactaa tgtcgcagat
      961 gtctggctca gttactgctt ctatggccac aggttcagct acccgaaagg gtatagtggt
     1021 attaatagac ccattagcag ccaatgggac aacagacatg catacctcag ttccaagagt
     1081 gaaaggtggg caaagaaata ttactgatga cagcagaggc cagcctttta tcaagaagat
     1141 gcacttcacc ataaggctaa cagaaagtgc catcacatac agagacattg tagtgaagaa
     1201 agaggatgga ttcacccaga tagtgctatc aactagatcg acagaaaaaa atgcactgaa
     1261 tacagaagta attaaagaaa tggttaatgc tctgaatagc gctgctgcag atgacagcaa
     1321 gctcgtgctg ttcagtgcag ctggaagtgt cttttgctgc ggtcttgatt ttgggtactt
     1381 tgtgaggcac ttaaggaatg acagaaacac agcaagcctt gaaatggtgg acaccatcaa
     1441 gaactttgtg aatactttta ttcaatttaa aaagcctatt gttgtatcag tcaatggccc
     1501 tgccattgga ctaggtgcat ccatcctgcc tctttgtgat ctcgtgtggg ctaatgaaaa
     1561 ggcttggttc caaacccctt atacgacctt tggacagagt ccagatggct gttcttctat
     1621 tacattcccc aaaatgatgg gtaaagcatc tgccaatgaa atgttaattg ctgggcgaaa
     1681 gctgacagca cgggaggcat gcgccaaagg cctggtctct caggtatttt tgactggaac
     1741 tttcacccaa gaggttatga ttcaaattaa ggagcttgcc tcatacaatg caattgtact
     1801 ggaagaatgt aaggccctcg ttcgctgtaa tattaagttg gagttggaac aggccaatga
     1861 gagagagtgt gaggtgctga ggaagatctg gagctcagcc caagggatag aatccatgtt
     1921 aaagtatgtt gaaaataaaa ttgatgagtt ttaattgtca g
//
