LOCUS       NM_001003894            2227 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens chromodomain Y-linked 1B (CDY1B), transcript variant
            1, mRNA.
ACCESSION   NM_001003894
VERSION     NM_001003894.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2227)
  AUTHORS   Ghorbel,M., Baklouti-Gargouri,S., Keskes,R., Chakroun,N.,
            Sellami,A., Fakhfakh,F. and Ammar-Keskes,L.
  TITLE     gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male
            infertility in Tunisian population
  JOURNAL   Gene 592 (1), 29-35 (2016)
   PUBMED   27457284
  REMARK    GeneRIF: study reported a new type of AZFc deletion
            (gr/gr-DAZ2-DAZ4-CDY1b) and hypothesis that this new deletion is
            the result of 2 successive events favored by the unstable structure
            of AZFc region; also demonstrated that this deletion constitutes a
            relative high-risk factor for male infertility in Tunisian
            population
REFERENCE   2  (bases 1 to 2227)
  AUTHORS   Fischle,W., Franz,H., Jacobs,S.A., Allis,C.D. and Khorasanizadeh,S.
  TITLE     Specificity of the chromodomain Y chromosome family of
            chromodomains for lysine-methylated ARK(S/T) motifs
  JOURNAL   J Biol Chem 283 (28), 19626-19635 (2008)
   PUBMED   18450745
REFERENCE   3  (bases 1 to 2227)
  AUTHORS   Kleiman,S.E., Yogev,L., Hauser,R., Botchan,A., Bar-Shira Maymon,B.,
            Schreiber,L., Paz,G. and Yavetz,H.
  TITLE     Members of the CDY family have different expression patterns: CDY1
            transcripts have the best correlation with complete spermatogenesis
  JOURNAL   Hum Genet 113 (6), 486-492 (2003)
   PUBMED   14569460
  REMARK    Erratum:[Hum Genet. 2004 Feb;114(3):322]
REFERENCE   4  (bases 1 to 2227)
  AUTHORS   Dorus,S., Gilbert,S.L., Forster,M.L., Barndt,R.J. and Lahn,B.T.
  TITLE     The CDY-related gene family: coordinated evolution in copy number,
            expression profile and protein sequence
  JOURNAL   Hum Mol Genet 12 (14), 1643-1650 (2003)
   PUBMED   12837688
REFERENCE   5  (bases 1 to 2227)
  AUTHORS   Skaletsky,H., Kuroda-Kawaguchi,T., Minx,P.J., Cordum,H.S.,
            Hillier,L., Brown,L.G., Repping,S., Pyntikova,T., Ali,J., Bieri,T.,
            Chinwalla,A., Delehaunty,A., Delehaunty,K., Du,H., Fewell,G.,
            Fulton,L., Fulton,R., Graves,T., Hou,S.F., Latrielle,P.,
            Leonard,S., Mardis,E., Maupin,R., McPherson,J., Miner,T., Nash,W.,
            Nguyen,C., Ozersky,P., Pepin,K., Rock,S., Rohlfing,T., Scott,K.,
            Schultz,B., Strong,C., Tin-Wollam,A., Yang,S.P., Waterston,R.H.,
            Wilson,R.K., Rozen,S. and Page,D.C.
  TITLE     The male-specific region of the human Y chromosome is a mosaic of
            discrete sequence classes
  JOURNAL   Nature 423 (6942), 825-837 (2003)
   PUBMED   12815422
REFERENCE   6  (bases 1 to 2227)
  AUTHORS   Saut,N., Terriou,P., Navarro,A., Levy,N. and Mitchell,M.J.
  TITLE     The human Y chromosome genes BPY2, CDY1 and DAZ are not essential
            for sustained fertility
  JOURNAL   Mol Hum Reprod 6 (9), 789-793 (2000)
   PUBMED   10956550
REFERENCE   7  (bases 1 to 2227)
  AUTHORS   Jones,D.O., Cowell,I.G. and Singh,P.B.
  TITLE     Mammalian chromodomain proteins: their role in genome organisation
            and expression
  JOURNAL   Bioessays 22 (2), 124-137 (2000)
   PUBMED   10655032
  REMARK    Review article
REFERENCE   8  (bases 1 to 2227)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Retroposition of autosomal mRNA yielded testis-specific gene family
            on human Y chromosome
  JOURNAL   Nat Genet 21 (4), 429-433 (1999)
   PUBMED   10192397
  REMARK    Erratum:[Nat Genet 1999 Jun;22(2):209]
REFERENCE   9  (bases 1 to 2227)
  AUTHORS   Yen,P.H.
  TITLE     A long-range restriction map of deletion interval 6 of the human Y
            chromosome: a region frequently deleted in azoospermic males
  JOURNAL   Genomics 54 (1), 5-12 (1998)
   PUBMED   9806824
REFERENCE   10 (bases 1 to 2227)
  AUTHORS   Lahn,B.T. and Page,D.C.
  TITLE     Functional coherence of the human Y chromosome
  JOURNAL   Science 278 (5338), 675-680 (1997)
   PUBMED   9381176
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068601.8.
            
            On Aug 13, 2020 this sequence version replaced NM_001003894.1.
            
            Summary: This gene encodes a protein containing a chromodomain and
            a histone acetyltransferase catalytic domain. Chromodomain proteins
            are components of heterochromatin-like complexes and can act as
            gene repressors. This protein is localized to the nucleus of late
            spermatids where histone hyperacetylation takes place. Histone
            hyperacetylation is thought to facilitate the transition in which
            protamines replace histones as the major DNA-packaging protein. The
            human chromosome Y has two identical copies of this gene within a
            palindromic region; this record represents the more centromeric
            copy. Chromosome Y also contains a pair of closely related genes in
            another more telomeric palindrome as well as several related
            pseudogenes. Two protein isoforms are encoded by transcript
            variants of this gene. Additional transcript variants have been
            described, but their full-length nature has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1), also called the major
            transcript, is unspliced. It encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC033041.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382407.1/ ENSP00000371844.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AC068601.8         64716-64720         c
            6-2227              AC068601.8         62494-64715         c
FEATURES             Location/Qualifiers
     source          1..2227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="Y"
                     /map="Yq11.23"
     gene            1..2227
                     /gene="CDY1B"
                     /gene_synonym="CDY"
                     /note="chromodomain Y-linked 1B"
                     /db_xref="GeneID:253175"
                     /db_xref="HGNC:HGNC:23920"
     exon            1..2227
                     /gene="CDY1B"
                     /gene_synonym="CDY"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..1954
                     /gene="CDY1B"
                     /gene_synonym="CDY"
                     /EC_number="2.3.1.48"
                     /note="isoform a is encoded by transcript variant 1;
                     chromodomain protein, Y chromosome, 1, centromeric;
                     testis-specific chromodomain protein on Y, centromeric;
                     testis-specific chromodomain protein Y 1; chromodomain
                     protein, Y-linked, 1B"
                     /codon_start=1
                     /product="testis-specific chromodomain protein Y 1 isoform
                     a"
                     /protein_id="NP_001003894.1"
                     /db_xref="CCDS:CCDS35487.1"
                     /db_xref="GeneID:253175"
                     /db_xref="HGNC:HGNC:23920"
                     /translation="MASQEFEVEAIVDKRQDKNGNTQYLVRWKGYDKQDDTWEPEQHL
                     MNCEKCVHDFNRRQTEKQKKLTWTTTSRIFSNNARRRTSRSTKANYSKNSPKTPVTDK
                     HHRSKNRKLFAASKNVRRKAASILSDTKNMEIINSTIETLAPDSPFDHKTVSGFQKLE
                     KLDPIAADQQDTVVFKVTEGKLLRDPLSRPGAEQTGIQNKTQIHPLMSQMSGSVTASM
                     ATGSATRKGIVVLIDPLAANGTTDMHTSVPRVKGGQRNITDDSRDQPFIKKMHFTIRL
                     TESASTYRDIVVKKEDGFTQIVLSTRSTEKNALNTEVIKEIVNALNSAAADDSKLVLF
                     SAAGSVFCCGLDFGYFVKHLRNNRNTASLEMVDTIKNFVNTFIQFKKPIVVSVNGPAI
                     GLGASILPLCDLVWANEKAWFQTPYTTFGQSPDGCSSITFPKMMGKASANEMLIAGRK
                     LTAREACAKGLVSQVFLTGTFTQEVMIQIKELASYNPIVLEECKALVRCNIKLELEQA
                     NERECEVLRKIWSSAQGIESMLKYVENKIDEF"
ORIGIN      
        1 agagtaacag gcaggaagaa agctttctgt actacaccag agggttgggg ctgtggattt
       61 agctactctc acctgaggct actgagcaag ttgtcatgca ccatgagaca aagcccaagc
      121 tgtcccacca ggcagtaagt atggagaggt tcaggcacat ggcatagctg ctatttcgca
      181 caattttcac tacaccagtg gtgacaaaat agaagaggtt catccataca cagaacctgg
      241 tgaagagctg gaggcagaaa gaagtgtcta tgtggagacg caactgaaac aaaggtggca
      301 cagcaactgt tccaatcccg tgtctttcct catggcttcc caggagtttg aggttgaagc
      361 tattgttgac aaaagacagg ataaaaatgg gaatacacag tatttggttc ggtggaaagg
      421 ttatgacaaa caggatgaca cttgggaacc agagcagcac ctcatgaact gtgaaaaatg
      481 tgtacatgat tttaatagac gacagactga aaaacagaaa aaactgacat ggactacaac
      541 cagtagaatt ttttcaaaca atgccagaag aagaacttcc agatctacaa aagcaaacta
      601 ttctaagaac tctcctaaaa cgccagtgac tgataaacac cacaggtcca aaaaccgcaa
      661 gttatttgct gccagcaaga acgttaggag aaaggcagct tcaattctct ccgacacaaa
      721 gaatatggag ataataaatt caactattga gacccttgca cctgacagcc cctttgacca
      781 caaaactgtg agtggctttc agaaacttga gaaactggac cctattgcag cagatcagca
      841 ggacacggtg gtcttcaagg tgacagaagg gaaactcctc cgggaccctt tgtcacgtcc
      901 tggtgcagaa cagactggaa tacagaacaa gactcagata cacccactaa tgtcgcagat
      961 gtctggctca gttactgctt ctatggccac aggttcagct acccgaaagg gtatagtggt
     1021 attaatagac ccattagcag ccaatgggac aacagacatg catacctcag ttccaagagt
     1081 gaaaggtggg caaagaaata ttactgatga cagcagagac cagcctttta tcaagaagat
     1141 gcacttcacc ataaggctaa cagaaagtgc cagcacatac agagacattg tagtgaagaa
     1201 agaggatgga ttcacccaga tagtgctatc aactagatcg acagaaaaaa atgcactgaa
     1261 tacagaagta attaaagaaa tagttaatgc tctgaatagc gctgctgcag atgacagcaa
     1321 gctcgtgctg ttcagtgcag ctggaagtgt cttttgctgc ggtcttgatt ttgggtactt
     1381 tgtgaagcac ttaaggaata acagaaacac agcaagcctt gaaatggtgg acaccatcaa
     1441 gaactttgtg aatactttta ttcaatttaa aaagcctatt gttgtatcag tcaatggccc
     1501 tgcgattgga ctaggtgcat ccatcctgcc tctttgtgat ctcgtgtggg ctaatgaaaa
     1561 ggcttggttc caaacccctt atacgacctt tggacagagt ccagatggct gttcttctat
     1621 tacattcccc aaaatgatgg gtaaagcatc tgccaatgaa atgttaattg ctgggcgaaa
     1681 gctgacagca agggaggcat gcgccaaagg cctggtctct caggtatttt tgactggaac
     1741 tttcacccaa gaggttatga ttcaaattaa ggagcttgcc tcatacaatc caattgtact
     1801 ggaagaatgt aaggccctcg ttcgctgtaa tattaagttg gagttggaac aggccaatga
     1861 gagagagtgt gaggtgctga ggaagatctg gagctcagcc caagggatag aatccatgtt
     1921 aaagtatgtt gaaaataaaa ttgatgagtt ttaattgtca gtctgtctgc tcaggacaca
     1981 agaactaagg ggcaacaaat gcatcatgag ttgcaagatg ccctaatcca tcttcatagc
     2041 ccaaaacaat ttcacccata gctaaggctt ggaaacagaa ctggaaatgt ccaagctatg
     2101 tatttaaatt atcacatcat ttttaagcac tgtagcttta caaggagtaa caaaacagcc
     2161 tctttgccca aatgtgatta ttttatgcac acctaagccc aaatataaaa acagactctt
     2221 cttgcaa
//
