LOCUS       NM_030928               2664 bp    mRNA    linear   PRI 06-DEC-2024
DEFINITION  Homo sapiens chromatin licensing and DNA replication factor 1
            (CDT1), mRNA.
ACCESSION   NM_030928
VERSION     NM_030928.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2664)
  AUTHORS   Mi,Y., Li,X., Wang,C., Lin,C., Zhao,Z., Yan,X., Shi,P. and Wang,L.
  TITLE     [miR-2110 Affects the Biological Behaviors of Lung Adenocarcinoma
            by Regulating CDT1]
  JOURNAL   Sichuan Da Xue Xue Bao Yi Xue Ban 55 (5), 1202-1209 (2024)
   PUBMED   39507968
  REMARK    GeneRIF: [miR-2110 Affects the Biological Behaviors of Lung
            Adenocarcinoma by Regulating CDT1].
REFERENCE   2  (bases 1 to 2664)
  AUTHORS   Moriyama,M., Kanda,T., Midorikawa,Y., Matsumura,H., Masuzaki,R.,
            Nakamura,H., Ogawa,M., Matsuoka,S., Shibata,T., Yamazaki,M.,
            Kuroda,K., Nakayama,H., Higaki,T., Kanemaru,K., Miki,T.,
            Sugitani,M. and Takayama,T.
  TITLE     The proliferation of atypical hepatocytes and CDT1 expression in
            noncancerous tissue are associated with the postoperative
            recurrence of hepatocellular carcinoma
  JOURNAL   Sci Rep 12 (1), 20508 (2022)
   PUBMED   36443564
  REMARK    GeneRIF: The proliferation of atypical hepatocytes and CDT1
            expression in noncancerous tissue are associated with the
            postoperative recurrence of hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2664)
  AUTHORS   Fu,Q., Wang,F., Yang,J., Sun,W., Hu,Z., Xu,L., Chu,H., Wang,X. and
            Zhang,W.
  TITLE     Long non-coding RNA-PCGEM1 contributes to prostate cancer
            progression by sponging microRNA miR-129-5p to enhance chromatin
            licensing and DNA replication factor 1 expression
  JOURNAL   Bioengineered 13 (4), 9411-9424 (2022)
   PUBMED   35412947
  REMARK    GeneRIF: Long non-coding RNA-PCGEM1 contributes to prostate cancer
            progression by sponging microRNA miR-129-5p to enhance chromatin
            licensing and DNA replication factor 1 expression.
REFERENCE   4  (bases 1 to 2664)
  AUTHORS   Shi,H.X., Huang,S.W., Luo,W.J., Pan,F., Jin,H.J. and Wei,W.
  TITLE     Elevated expression of CDT1 in childhood acute lymphoblastic
            leukemia promotes cell proliferation, invasion and migration
            through activation of EMT
  JOURNAL   J Biol Regul Homeost Agents 35 (Special Issue on Internal Medicine
            n.1) (2021)
   PUBMED   34348833
  REMARK    GeneRIF: Elevated expression of CDT1 in childhood acute
            lymphoblastic leukemia promotes cell proliferation, invasion and
            migration through activation of EMT.
REFERENCE   5  (bases 1 to 2664)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2664)
  AUTHORS   Wohlschlegel,J.A., Dwyer,B.T., Dhar,S.K., Cvetic,C., Walter,J.C.
            and Dutta,A.
  TITLE     Inhibition of eukaryotic DNA replication by geminin binding to Cdt1
  JOURNAL   Science 290 (5500), 2309-2312 (2000)
   PUBMED   11125146
REFERENCE   7  (bases 1 to 2664)
  AUTHORS   Izumi,M., Yanagi,K., Mizuno,T., Yokoi,M., Kawasaki,Y., Moon,K.Y.,
            Hurwitz,J., Yatagai,F. and Hanaoka,F.
  TITLE     The human homolog of Saccharomyces cerevisiae Mcm10 interacts with
            replication factors and dissociates from nuclease-resistant nuclear
            structures in G(2) phase
  JOURNAL   Nucleic Acids Res 28 (23), 4769-4777 (2000)
   PUBMED   11095689
REFERENCE   8  (bases 1 to 2664)
  AUTHORS   Whittaker,A.J., Royzman,I. and Orr-Weaver,T.L.
  TITLE     Drosophila double parked: a conserved, essential replication
            protein that colocalizes with the origin recognition complex and
            links DNA replication with mitosis and the down-regulation of S
            phase transcripts
  JOURNAL   Genes Dev 14 (14), 1765-1776 (2000)
   PUBMED   10898791
REFERENCE   9  (bases 1 to 2664)
  AUTHORS   Nishitani,H., Lygerou,Z., Nishimoto,T. and Nurse,P.
  TITLE     The Cdt1 protein is required to license DNA for replication in
            fission yeast
  JOURNAL   Nature 404 (6778), 625-628 (2000)
   PUBMED   10766248
REFERENCE   10 (bases 1 to 2664)
  AUTHORS   Herbig,U., Marlar,C.A. and Fanning,E.
  TITLE     The Cdc6 nucleotide-binding site regulates its activity in DNA
            replication in human cells
  JOURNAL   Mol Biol Cell 10 (8), 2631-2645 (1999)
   PUBMED   10436018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB053172.1, AC092384.5 and
            BC000137.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_030928.3.
            
            Summary: The protein encoded by this gene is involved in the
            formation of the pre-replication complex that is necessary for DNA
            replication. The encoded protein can bind geminin, which prevents
            replication and may function to prevent this protein from
            initiating replication at inappropriate origins. Phosphorylation of
            this protein by cyclin A-dependent kinases results in degradation
            of the protein. [provided by RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB053172.1, SRR1163655.442740.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301019.9/ ENSP00000301019.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-742               AB053172.1         12-753
            743-875             AC092384.5         38497-38629
            876-976             AC092384.5         38781-38881
            977-1165            AC092384.5         39246-39434
            1166-1318           AC092384.5         39811-39963
            1319-1520           AC092384.5         40041-40242
            1521-1902           AC092384.5         40875-41256
            1903-1919           AB053172.1         1914-1930
            1920-2604           BC000137.2         1893-2577
            2605-2664           AB053172.1         2616-2675
FEATURES             Location/Qualifiers
     source          1..2664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.3"
     gene            1..2664
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /note="chromatin licensing and DNA replication factor 1"
                     /db_xref="GeneID:81620"
                     /db_xref="HGNC:HGNC:24576"
                     /db_xref="MIM:605525"
     exon            1..271
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1684
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /note="Double parked, Drosophila, homolog of"
                     /codon_start=1
                     /product="DNA replication factor Cdt1"
                     /protein_id="NP_112190.2"
                     /db_xref="CCDS:CCDS32510.1"
                     /db_xref="GeneID:81620"
                     /db_xref="HGNC:HGNC:24576"
                     /db_xref="MIM:605525"
                     /translation="MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASAT
                     SGSRKRARPPAAPGRDQARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKST
                     PAAGQPPHLTSAQDQDTISELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPE
                     EPCGEKAPAYQRFHALAQPGLPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAK
                     VQRGVQDMMRRRFEECNVGQIKTVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLE
                     QEADGAAPQLTASRLLQRRQIFSQKLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPR
                     FNVDEVPDIEPAALPQPPATEKLTTAQEVLARARNLISPRMEKALSQLALRSAAPSSP
                     GSPRPALPATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQR
                     LERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEMEKHLLLLSELLPD
                     WLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL"
     exon            272..394
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..531
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     exon            532..729
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     exon            730..875
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..976
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1165
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1318
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1520
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..2664
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1895..1900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /note="hexamer: ATTAAA"
     polyA_site      1916
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /note="major polyA site"
     regulatory      2640..2645
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
                     /note="hexamer: AATAAA"
     polyA_site      2664
                     /gene="CDT1"
                     /gene_synonym="DUP; RIS2"
ORIGIN      
        1 ctcccttcct tctttccttg ctttcgccgc gcactccgcc gccatggagc agcgccgcgt
       61 caccgacttc ttcgcgcgcc gccgccccgg gcccccccgc atcgcgccgc ccaagctggc
      121 ctgccgcacc cccagccccg ccaggcccgc actccgcgcc ccggcctccg ctaccagtgg
      181 cagccgcaag cgcgcccgcc cgcccgccgc ccccggacgc gaccaggcca ggccaccggc
      241 ccgcaggaga ctgcggctgt cggtggacga ggtttccagc cccagtaccc ccgaggcccc
      301 agacatccca gcctgccctt ctccgggcca gaagataaag aaatccaccc cggcagcagg
      361 tcagccgccc cacctgacat ccgcgcagga ccaggacacc atctctgagc ttgcgtcatg
      421 cctgcaacgg gcccgggagc tgggggcaag agtccgggcg ctgaaggcca gtgcccagga
      481 tgctggggag tcctgcaccc cagaggccga gggccgccct gaggagccat gtggcgagaa
      541 ggcgcccgcc taccagcgct tccatgccct ggcccagccc ggcctgccgg gactcgtgct
      601 gccctacaag taccaggtgc tggcggagat gttccgcagc atggacacca tcgtgggcat
      661 gctccacaac cgctccgaga cgcccacctt tgccaaggtc cagcggggcg tccaggacat
      721 gatgcgtagg cgttttgagg agtgcaatgt tggccagatc aaaaccgtgt acccggcctc
      781 ctaccgcttc cgccaggagc gcagtgtccc caccttcaag gatggcacca ggaggtcaga
      841 ttaccagctc accatcgagc cactgctgga gcaggaggct gacggagcag ccccccagct
      901 cacggcctcg cgcctcctgc agcgacggca gatcttcagc cagaagctgg tggagcatgt
      961 caaggagcac cacaaggcct tcctggcctc cctgagcccc gccatggtgg tgccggagga
     1021 ccagctgacc cgctggcacc cgcgcttcaa cgtggatgaa gtacccgaca tcgagccggc
     1081 cgcgctgccc cagccacccg ccacggagaa gctcaccact gctcaggagg tgctggcccg
     1141 ggcccgcaac ctgatttcac ccaggatgga gaaggccttg agtcaattgg ccctgcgctc
     1201 tgctgcgccc agcagccccg ggtctcccag gccagcactg ccggctaccc caccagccac
     1261 cccgcctgca gcctctccca gtgctctgaa gggggtgtcc caggatctgc tggagcggat
     1321 ccgagccaag gaggcacaga agcagctggc acagatgacg cggtgcccgg agcaggagca
     1381 gcggctgcag cgcttagaac ggctgcctga gctggcccgc gtgctgcgga gcgtctttgt
     1441 gtccgaacgc aagcctgcgc tcagcatgga ggtggcctgt gccaggatgg tgggcagctg
     1501 ttgtactatc atgagccctg gggaaatgga gaagcacctg ctgctcctct ccgagctgct
     1561 gccggactgg ctcagcctcc accgcatccg caccgacacc tacgtcaagc tggacaaggc
     1621 cgcggacctc gcccacatca ctgcacgcct ggcccaccag acacgtgctg aggaggggct
     1681 gtgagcctgg gggccactgt ggacagacgt gggcttcaga agctcgctgg cctgggccca
     1741 ccagcatttt cttttatgaa catgatacac tttggccttc ctttccccag cgcccctgag
     1801 ggccagaggc agatgtgggc tgcaggctgc acagcccgag ggtctctggc tgcgggcggt
     1861 gggccccttc atggggctca cctggtggat tcacattaaa ccggtttctg tgggcacctc
     1921 tgtccttgct gctggtgggg aagggaagcc agatccagca ccccctgggg ggccatcggg
     1981 agtgtggctg ggggtgaagg gggctctgtg gcaatatggg gttgggtagt gtgggtggca
     2041 ggccatcccc tctaatcttg gaacctctga atatgggacc tcccacagca aagggtgact
     2101 tttgtcatta agaaagactg gggtgggtgt ggtggctcac gcctgtaacc ccagcacttt
     2161 gggaggccaa ggtgggcaga tcacgaggtc aagagatcga gaccatcctg gcgaacatgg
     2221 tgaaacccca tctctactaa aaatacaaaa aattagccgg gtgtggtggt gggcacctgt
     2281 cgtcccagct actagggagg ctgaggcagg agaatggtgt gaacccagga ggcacagctt
     2341 gcagtgagcg aagatcgcac cactgcacgc actccagcct gggtgacaga gcgagactcc
     2401 gtctcaaaaa aaaaaatttc aagactggag aggtgatcct gaattgtcca gctacgcccc
     2461 atgtcatcac agggccttca tgacagggcc agagccagcc agctttgaag acgcggccct
     2521 gccccgacac aggcagcctg gagaagctgg gcaggacaag taggacatcc ctggagcctc
     2581 cagaagggac tggcctctgc ccacaccttg acttcagtat ttctgacctc ctaaactcta
     2641 ataaagtcat gcttacagcc acta
//
