LOCUS       NM_003818               9076 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens CDP-diacylglycerol synthase 2 (CDS2), mRNA.
ACCESSION   NM_003818
VERSION     NM_003818.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9076)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   2  (bases 1 to 9076)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 9076)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 9076)
  AUTHORS   Xu,Y., Mak,H.Y., Lukmantara,I., Li,Y.E., Hoehn,K.L., Huang,X.,
            Du,X. and Yang,H.
  TITLE     CDP-DAG synthase 1 and 2 regulate lipid droplet growth through
            distinct mechanisms
  JOURNAL   J Biol Chem 294 (45), 16740-16755 (2019)
   PUBMED   31548309
  REMARK    GeneRIF: CDP-DAG synthase 1 and 2 regulate lipid droplet growth
            through distinct mechanisms
REFERENCE   5  (bases 1 to 9076)
  AUTHORS   Qi,Y., Kapterian,T.S., Du,X., Ma,Q., Fei,W., Zhang,Y., Huang,X.,
            Dawes,I.W. and Yang,H.
  TITLE     CDP-diacylglycerol synthases regulate the growth of lipid droplets
            and adipocyte development
  JOURNAL   J Lipid Res 57 (5), 767-780 (2016)
   PUBMED   26946540
  REMARK    GeneRIF: CDS1 and CDS2 are important novel regulators of lipid
            storage.
REFERENCE   6  (bases 1 to 9076)
  AUTHORS   Halford,S., Inglis,S., Gwilliam,R., Spencer,P., Mohamed,M.,
            Ebenezer,N.D. and Hunt,D.M.
  TITLE     Genomic organization of human CDS2 and evaluation as a candidate
            gene for corneal hereditary endothelial dystrophy 2 on chromosome
            20p13
  JOURNAL   Exp Eye Res 75 (5), 619-623 (2002)
   PUBMED   12457874
REFERENCE   7  (bases 1 to 9076)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 9076)
  AUTHORS   Volta,M., Bulfone,A., Gattuso,C., Rossi,E., Mariani,M.,
            Consalez,G.G., Zuffardi,O., Ballabio,A., Banfi,S. and Franco,B.
  TITLE     Identification and characterization of CDS2, a mammalian homolog of
            the Drosophila CDP-diacylglycerol synthase gene
  JOURNAL   Genomics 55 (1), 68-77 (1999)
   PUBMED   9889000
REFERENCE   9  (bases 1 to 9076)
  AUTHORS   Halford,S., Dulai,K.S., Daw,S.C., Fitzgibbon,J. and Hunt,D.M.
  TITLE     Isolation and chromosomal localization of two human
            CDP-diacylglycerol synthase (CDS) genes
  JOURNAL   Genomics 54 (1), 140-144 (1998)
   PUBMED   9806839
REFERENCE   10 (bases 1 to 9076)
  AUTHORS   Lykidis,A., Jackson,P.D., Rock,C.O. and Jackowski,S.
  TITLE     The role of CDP-diacylglycerol synthetase and phosphatidylinositol
            synthase activity levels in the regulation of cellular
            phosphatidylinositol content
  JOURNAL   J Biol Chem 272 (52), 33402-33409 (1997)
   PUBMED   9407135
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK315489.1 and AL121755.23.
            
            On Nov 22, 2018 this sequence version replaced NM_003818.3.
            
            Summary: Breakdown products of phosphoinositides are ubiquitous
            second messengers that function downstream of many G
            protein-coupled receptors and tyrosine kinases regulating cell
            growth, calcium metabolism, and protein kinase C activity. This
            gene encodes an enzyme which regulates the amount of
            phosphatidylinositol available for signaling by catalyzing the
            conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme
            is an integral membrane protein localized to two subcellular
            domains, the matrix side of the inner mitochondrial membrane where
            it is thought to be involved in the synthesis of
            phosphatidylglycerol and cardiolipin and the cytoplasmic side of
            the endoplasmic reticulum where it functions in
            phosphatidylinositol biosynthesis. Two genes encoding this enzyme
            have been identified in humans, one mapping to human chromosome
            4q21 and a second to 20p13. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.40721.1,
                                           SRR1660805.211200.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000460006.6/ ENSP00000419879.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1423              AK315489.1         229-1651
            1424-9076           AL121755.23        17645-25297
FEATURES             Location/Qualifiers
     source          1..9076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p12.3"
     gene            1..9076
                     /gene="CDS2"
                     /note="CDP-diacylglycerol synthase 2"
                     /db_xref="GeneID:8760"
                     /db_xref="HGNC:HGNC:1801"
                     /db_xref="MIM:603549"
     exon            1..142
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1423
                     /gene="CDS2"
                     /EC_number="2.7.7.41"
                     /note="CDP-diglyceride synthetase 2; CDP-diglyceride
                     pyrophosphorylase 2; CDP-diglyceride diphosphorylase 2;
                     CDP-DAG synthase 2; CDP-DG synthetase 2; CTP:phosphatidate
                     cytidylyltransferase 2; CDS 2; CDP-DG synthase 2;
                     CDP-diglyceride synthase 2; CDP-diacylglycerol synthase
                     (phosphatidate cytidylyltransferase) 2"
                     /codon_start=1
                     /product="phosphatidate cytidylyltransferase 2"
                     /protein_id="NP_003809.1"
                     /db_xref="CCDS:CCDS13088.1"
                     /db_xref="GeneID:8760"
                     /db_xref="HGNC:HGNC:1801"
                     /db_xref="MIM:603549"
                     /translation="MTELRQRVAHEPVAPPEDKESESEAKVDGETASDSESRAESAPL
                     PVSADDTPEVLNRALSNLSSRWKNWWVRGILTLAMIAFFFIIIYLGPMVLMIIVMCVQ
                     IKCFHEIITIGYNVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLR
                     ILSKYHRFISFTLYLIGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLVIHNL
                     FEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFATVVFGLL
                     LSYVMSGYRCFVCPVEYNNDTNSFTVDCEPSDLFRLQEYNIPGVIQSVIGWKTVRMYP
                     FQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATF
                     VNVYIASFIRGPNPSKLIQQFLTLRPDQQLHIFNTLRSHLIDKGMLTSTTEDE"
     exon            143..279
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            280..376
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..474
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            475..614
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            615..673
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            674..756
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            757..844
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            845..913
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1066
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1186
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1290
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..9076
                     /gene="CDS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1618..1623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDS2"
                     /note="hexamer: AGTAAA"
     polyA_site      1646
                     /gene="CDS2"
                     /note="major polyA site"
     regulatory      3832..3837
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDS2"
                     /note="hexamer: AATAAA"
     polyA_site      3849
                     /gene="CDS2"
     regulatory      9055..9060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDS2"
                     /note="hexamer: AATAAA"
     polyA_site      9076
                     /gene="CDS2"
ORIGIN      
        1 gggagtccgc gcgtgcccgc gccgagctgc ctgctccggc ggcttcgctg ctagctcgcg
       61 gcgacgtcgg gccgattttc ccaggatgac agagctgagg cagagggtgg cccatgagcc
      121 ggttgcgcca cccgaggaca aggagtcaga gtcagaagca aaggtagatg gagagactgc
      181 atcggacagt gagagccggg cagaatccgc acccctgcca gtctctgcag atgatacccc
      241 ggaggtcctc aatagggccc tttccaactt gtcttcaaga tggaagaact ggtgggtgag
      301 aggcatcctg actttggcca tgattgcatt tttcttcatc atcatttacc tgggaccaat
      361 ggttttgatg ataatcgtga tgtgcgttca gattaagtgt ttccatgaga taatcactat
      421 tggctacaac gtctaccact catatgatct gccctggttc aggacgctca gctggtactt
      481 tctcctgtgt gtaaactatt tcttctatgg tgagacagtg acggattact tcttcaccct
      541 ggtccagaga gaagagcctt tgcggattct cagtaaatac caccggttca tttcctttac
      601 tctctatcta ataggattct gcatgtttgt actgagtctg gtcaagaagc attatcgact
      661 gcagttctac atgtttggct ggacccatgt gacattgctg attgttgtaa cacagtcaca
      721 tcttgttatc cacaacctat ttgaaggaat gatctggttc attgtcccca tatcttgtgt
      781 gatctgtaat gacatcatgg cctatatgtt tggctttttc tttggtcgga ccccactcat
      841 caagctgtcc ccgaagaaga cctgggaagg cttcattggg ggcttctttg ctactgtggt
      901 gtttggcctt ctgctgtcct atgtgatgtc cgggtacaga tgctttgtct gccctgtgga
      961 gtacaacaat gacaccaaca gcttcactgt ggactgtgag ccctcggacc tgtttcgcct
     1021 gcaggagtac aacattcctg gggtgatcca gtcagtcatt ggctggaaaa cggtccggat
     1081 gtaccccttc cagattcaca gcatcgctct ctccaccttt gcctcgctca ttggcccctt
     1141 tggaggattc ttcgcaagtg gattcaaacg agcctttaaa atcaaagact ttgccaatac
     1201 cattcctggc catggaggca tcatggatcg ctttgactgc cagtatctga tggccacctt
     1261 tgtcaatgta tacatcgcca gttttatcag aggccctaac ccaagcaaac tgattcagca
     1321 gttcctgact ttacggccag atcagcagct ccacatcttc aacacgctgc ggtctcatct
     1381 gatcgacaaa gggatgctga catccaccac agaggacgag taggggccac ccagggccag
     1441 gagaacagga acagaactga gcaggggcag gtctccaagg caagcccagc tggtgtgact
     1501 tagacaatga cgaggcttca actcactgtc tttttttttt ttttttggag ggtatttttt
     1561 atttgtgggt tcaaaaaatc tgtatataca gtctatgtgt ttagaatttg tgttgtaagt
     1621 aaactacagc tttgagttgg aaagaagtca cgggttgtaa aaccatttgg atttttttaa
     1681 aacaaaagta ttaataatct ggaagacagt gttgcccagg tcaggagtgt tttcttggtg
     1741 gttccagccc ccatcaattg aactgtttct gggctcagtc agacacagac attcatctgt
     1801 gtctgaccaa atcaggggac ttccccacct gtggtgggag gcacagctta gatgttttgt
     1861 acacctggtc ttttctagaa atccctgctt ggagctgcag aagggttgcc ttctgtaggt
     1921 cggaggaatg gaggcttact aaccaggtaa gccttctatg catccacacc aaaatcctgc
     1981 agaatgtaag taagctctgc tttataagat gggttcacct tcatcgcaga ctgaaagttt
     2041 cagtttttat ttttttcaga aagcacgaaa aattatttat aatagtctgg agaaaaaaca
     2101 cactgtaata tttcaagtgt atgcagtaga atgtactgta actgagccct ttcccacatg
     2161 tctaggctcc aatgtctcct gtaggtccac ctaactgtgt gttttcaggg acaatgccat
     2221 ccatgtttgt gctgtagact tgctgctgct gaatcctttc tggggacttt ctcatcgggc
     2281 agggagcaga gggcttctcg ttcatgcacc ctttgcctga acacccatgt agctgctgtg
     2341 ttgtgtatat attactctta agaggagtgt gtgtgtctgt gtttgtttta aaagtcactt
     2401 atttcttaca gtgatttcaa ttgcaccatg acttcttcac taaaaccaca aagtcctgct
     2461 taaaactatg gaaaacctaa cctgattaga gccttgacta ttttgaagat taaatgcaca
     2521 ctttttatat aatgtgacca gtttaaatgt agtttgtatt gtactggggg acctttcgtt
     2581 gttgttgttt gcttaaactg tgattttttt tcccctccct aatttcaggg gtgagattga
     2641 ctttgggaag acagattagt tctttgtcag gccaacaagt gatggagtgc gggagagaga
     2701 acttggcacc caaatatatc aaactattcc gtgccgtgga tgttttcatt gccaacgagg
     2761 gtgtaatgat ttgcttctgc accttggtct agtgctggtt tgtggtgttt ttgtttgtaa
     2821 attagcctca ctgcctccct gaaagtgcac agtcagccca ggtctctaga gtgtccagca
     2881 gaggatggag ccctcgggat gtttcagctc acacatcctt gagtgacttc ccatatgtgt
     2941 gtggggctga agcggcttct ttccgctgaa cttttatttc catttcagcc tcgtggcttc
     3001 tcttattcag gtccaaggcc ccttaaaaac aaaacatatt atcgcaaggg ctttcatttc
     3061 agtattggct gtgtcactgg caggatgcat cactctccag ggcctctttt tcggagctac
     3121 tcccaattcc actcttctgt gattctggct gagcaagttc atgccggtag aggctcatta
     3181 agtgaggtcc tgggcacccc ccaaacagga agtgttttca ggcccttaca tgcttatcct
     3241 taaggtgagt aggtatctca gcagcacacc cgaacagtaa aggtgatcaa taacgaaact
     3301 gtagttttca gattgaagaa tgaacctgga tcaccaaact agataccgaa agggctcctc
     3361 atttgtctct tttgtcccat tgtgggcata tggtgggctc cttgagagga gggagtctca
     3421 gctggggcct ggctgcagag acctgctctt gaatagggct gcctttggga tcagggagcc
     3481 gagcatactg ggcaaggctc atcatgttcc tttgtggaag tggttacttg gtgggggtgg
     3541 ggtggggaag gggggtctag gaagccgaag ctgagtgcgc actagagctg ctagcaggca
     3601 ggccagaggg tcagcttgtg ttttattttc tgatttctcc tgcatgcttt ctggagatga
     3661 ggattttttg tcaggtagct aggagagcac tgccaccttg tgtccatata gcacaatgtt
     3721 tctctttcct attcacagac aagattcaag aaaccatttt tacgtgtgta cattcaaatc
     3781 ttcatgaatg gcatcacttg ctttagaccc attttttttt tattggtcag aaataaaatg
     3841 tgactgcaac tgtgtgccct cccttgtcgt gaattccctg tttatcactt ccatgcatgg
     3901 ttttatgctt ctcatttgtt tatgtattca tgaatactgc atagtcctga ttcagagact
     3961 tttgctttgc tttccaactt gtatccctac attctcacaa cagccttctt acctcgggtg
     4021 agagtcatga gcaccttacc aggcagggag cttccccagg atagtgtggt ggagtcagga
     4081 ctcactccat cctgcacttt acccacagga cacctggagg gtcccccagc cctgcttgct
     4141 tttgtgaacg tcgtgtgagt acaccgaggt gttgcagctt tccttccctc tagctcagga
     4201 ggcctggcct gagccaggtt ggagcttaaa ttgctgttgg ctcctgcctg gtggaacaag
     4261 ggggtcatag aaaccagggc tgatgggcac cccccagccc ctgggagctc tgctcatgac
     4321 cgctcacagg gtaccgagtc tttgcctttt gtgtgtgcgc atgctgccct cttaactgct
     4381 tttagtattc agaaaggttc catttatgtt ttactcctga aagtgaaacc ctcttaggca
     4441 acttgtttca tattctgggc attttagtag ctacagtatt ttgcatttaa aatgtaatta
     4501 ctcttagtat tgtacagccc tataatgtat gagaactagt ttcacatcct ttgaaactaa
     4561 tctctttcat tggggaggat acaacttttg actttacaca ggtggacttt gaatccattt
     4621 ttatagaatt tttttccact gtaacttgac ctatattatg caagaaaatc ccaaaaatat
     4681 gttttaaggg agactacaca gaccttgtga tttggtctga gctagttgct gagttgactg
     4741 gagccttatt tgaatggatc tttgagttga gatcttcaca ctgtcagtga gcccttggct
     4801 cagcccttgt cacctgtttg tatggggacc atgtttccca aagctcaggt tcatctccac
     4861 tattgacaga gtcgggtagt gggagagtat aagtgacttg agacagagtg tccttgctca
     4921 gaaaactgtg aagcaggggt cttgttagtt acaaagccag tcctagttgc atgtccaagg
     4981 gggtagattt tcatcaccct actaaatgtg gtatgtcact gctgaagcct tttcctgttt
     5041 tagtaatatc ttaggcacta ttgtcttttg tcttccagag taacatatct gggcccacct
     5101 ttcttgcaca ctgtgattat gtgctaagaa aagggtggag ttgggaggac aatttcactt
     5161 gaacaggttt ctgttcttct gaggtcaggg tggggaggat gtccaggtga cttttatgga
     5221 cacattgcaa gacagtaagc cgcggatgga ctctcacttg tgctttggaa cactggactc
     5281 caaagagcag gtggaacaaa ctctggcctg aagatgatgg ctaatactca ggcagagccc
     5341 cgtattcttc cctgacttgg tcaaaacaaa cttccttttc ccttgatcac cctgcacgca
     5401 gctgcccagc ttccagtttt taaagagatg aacagctctc acttcctgac tcagtttctc
     5461 ttgttgggtg ggggccttgt gccacaacct gcatggggtg ctagggttta aaccaagtgg
     5521 tcacgaagga ttcttatctc agggctctgc ctggcccacc ttctcttggg cctggactct
     5581 ccttatccac atccctgcag aaggtgggcc ctattctcag aagagtcctg gctgctgttg
     5641 ccatctgaat gcgcccttcc ctttcaggtt gaccagcagt ggccttacct ggcctctcag
     5701 gtggatggag gctgttctca tctggggctg tctcttgatt aaggctgtca cctgtttgta
     5761 tagggaccat gtttcccaac gcactttgag tgcagtttag gaggtatcct ttggatgctg
     5821 aagtgttggg attttgagga catgcggatg atttatgaga atagaggggc agagtttgtg
     5881 aagtctaggg ttttttgtcc agtgggtttc aaatttgttg gctgtttaaa gaccctgtct
     5941 cctcccccac cctccccttc cttttcccat caaatgccta cctactgagg cgccttctct
     6001 ttttattctt gagccaatga gatatcagtg tgtttattaa taaggattgc aatagtatag
     6061 tgcttaatat gtgccaggca tagtgctaag ggtttacata cgttatccct tttaatccag
     6121 aaaacagcct ttgattaggt attgttgtct ccattttata gatgaggaaa ctgaggcagt
     6181 atgactgagg ccgagagcag tggttaagac agactttggg atcaaatcac cctaggtgcg
     6241 ggcaggtttc taggctgctc taagcttcta ccttgaaggc agttgggtct gataatagta
     6301 ccttcttcct ggggtggttg tgaggatata acgaggtaat gcatgtaagc atttagtacc
     6361 atgcctggca catagtaagc actcaataaa tggtagttac ttttgttgag ctcagctggt
     6421 agtttgacct ccgttggtgc aatgccagag atgggattgt cagccaccac actgccacca
     6481 ccctgcacac agtctgggtc cctccgagag aagcacgcca accttaacat cccctacagc
     6541 atcttggtgc ttcacacacc atttaggagg ccaccctaac gaggcaagag gacatggggg
     6601 tgtgcagaag ttctgttctt agtgagaatg gctggcctga gaatccagct cacctcctct
     6661 gcccacagtc tggactgctt gtgggaaggc catctcctcc tgtctggtgg tacctccact
     6721 ctgggcaggg agggcctgtc tgtgactcgc tctggacccc acttcccgct ctggccaagg
     6781 gctgtcttct gtgcacatag ctcaggagcc tgcagcagtt ccctgtatgg gtggatgtcc
     6841 tcaggggcca agaagagaag aatggggaca acagaaacct gctttgtagg ggattatgta
     6901 gactaaaagc ctagaagttc tgcccacatc cttatgacgc agccaatctg gagcttcatg
     6961 tttccttcta aaagtagtaa ccgggtagaa gtgggtgacc cattgaggac acatgatgtg
     7021 aggtatttct gccggattct aggttagcaa agactcaaat gggtgactca tgaatgaagg
     7081 gagaacaggc acaggactta atgaaaagag tttcttgaac ttagttttct gaatgggggt
     7141 ggggagttgg ggcacgtgtg tgtaagggga ggctgcctca ctttgaagga atggtgttgg
     7201 ctaacaggat ccatgaaatt cctaggtcag ttgaataata actgaactac tggtttgact
     7261 gtggattatt tcctgggtat tagtgggacc caacagcaca ttgctattaa tagtatggaa
     7321 ataatggtcc ctctgtttca ttgaattgct gaagtaatga taatgccatg aaccaggaga
     7381 agatggttgt gggggtttct aggaagcagc tgctgtgaca ggccaatccc aggcttgccc
     7441 ccgagccctc ctgtccttct gggtttgtgt ttgccttgcc tggtgcttcc tccctcattg
     7501 tgttgttgaa tagacctagg cagccttgta tccatagaaa gcctccactg ctgggccggg
     7561 gagggggttg tggtaagggc cctctggaaa tcaagcagag aatgcctttg cagtggtctc
     7621 ccgggcattg ggcagggcct agccttttgc agcccccaga ggaccttgcc tgcataaagc
     7681 actcagaagg gttagccacc tggtgatttt gtctctagtg aaactgtgtt tgccgataat
     7741 catccacata gccacctctg tcctcgcagt ttggatgcct ttttttgaca cctgcgctag
     7801 gttcttgtat gctggctttt cttaaaggaa cagcagagta gaaaagaggt tgagaatgtt
     7861 ttctagcagg cagaatgtgc atacatgttt tcatgagtgt cctttgggtg ctgtttcttt
     7921 taaatcctct gtgcacaggg ctctggcctt tagtaaactg tttttctgtc ttacgtcatg
     7981 ctgactgggt gctaggggct gattacaaag gggaagagtt gaacagacat caggggccga
     8041 tgaaaccaaa ggactaggag tcaggagaac aagtcaggga ttaggagaca gcggtttggt
     8101 ttattgttat ccagctggag gactcctagg ggcagcagca ggaggaatac cagggccacg
     8161 gaggggccag gagtctcaca gtggagggca gactctaaca gatgccagct gaacgctcgc
     8221 tggccctgga tgtcatacga gttggggacc agaaatctgg gctcagagaa cccgtccagg
     8281 gagatttgaa gccatgggtt atcttctaga gttgatactg ataatatatt ttaattttta
     8341 ttgatgttta ataccttctg aaacaggagg gtaagatcag atgggaagcc cctctgttga
     8401 aggatcttgg gaaccttggt ggtttttttt ttttttttgg tttttttttt ttgatcgagc
     8461 tgtggacatc cttcttaatt cgattctgag gatttgttta actaaaaagt tcccaaacac
     8521 agaaagggcc tccccacctg ctttggggag ctgtctgtgc tgggagtgcc aggcatccca
     8581 tgggacccat cactgccagt gtctgtgcct cccagaggtc agccgtgtct gccctggctc
     8641 tgtctcctct gtgacagggc agagcatttc tggtcagttt ctccatggtg cctcccaccc
     8701 ctttgtaaag tggatggaca tgatggaatt cagttgtctc accctgatag cctgggtgtt
     8761 gatattcact ttacccgcac tcagacacag gcgaccttga agcagttctc ggtgtgtaga
     8821 gtccacgtga cagtccccac agcctcccca gatagctgtg tgcctgtgcg ctactgctgt
     8881 gccattttcc caacttggcg tttcactaaa tgcagctgat ctctctctct gtgcactcgt
     8941 gatccatgtt gaacaataca tgtaggttct ttttccacgc aatgtaagaa catgatatac
     9001 tgtacgttgg aaagcattta ccttatttat atacctgaat gttcctacta cacaaataaa
     9061 catatattaa attcta
//
