LOCUS       NM_001263               4309 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens CDP-diacylglycerol synthase 1 (CDS1), mRNA.
ACCESSION   NM_001263
VERSION     NM_001263.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4309)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4309)
  AUTHORS   Xu,Y., Mak,H.Y., Lukmantara,I., Li,Y.E., Hoehn,K.L., Huang,X.,
            Du,X. and Yang,H.
  TITLE     CDP-DAG synthase 1 and 2 regulate lipid droplet growth through
            distinct mechanisms
  JOURNAL   J Biol Chem 294 (45), 16740-16755 (2019)
   PUBMED   31548309
  REMARK    GeneRIF: CDP-DAG synthase 1 and 2 regulate lipid droplet growth
            through distinct mechanisms
REFERENCE   3  (bases 1 to 4309)
  AUTHORS   Qi,Y., Kapterian,T.S., Du,X., Ma,Q., Fei,W., Zhang,Y., Huang,X.,
            Dawes,I.W. and Yang,H.
  TITLE     CDP-diacylglycerol synthases regulate the growth of lipid droplets
            and adipocyte development
  JOURNAL   J Lipid Res 57 (5), 767-780 (2016)
   PUBMED   26946540
  REMARK    GeneRIF: CDS1 and CDS2 are important novel regulators of lipid
            storage.
REFERENCE   4  (bases 1 to 4309)
  AUTHORS   D'Souza,K., Kim,Y.J., Balla,T. and Epand,R.M.
  TITLE     Distinct properties of the two isoforms of CDP-diacylglycerol
            synthase
  JOURNAL   Biochemistry 53 (47), 7358-7367 (2014)
   PUBMED   25375833
  REMARK    GeneRIF: distinct properties of the two isoforms of
            CDP-diacylglycerol synthase
REFERENCE   5  (bases 1 to 4309)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 4309)
  AUTHORS   Volta,M., Bulfone,A., Gattuso,C., Rossi,E., Mariani,M.,
            Consalez,G.G., Zuffardi,O., Ballabio,A., Banfi,S. and Franco,B.
  TITLE     Identification and characterization of CDS2, a mammalian homolog of
            the Drosophila CDP-diacylglycerol synthase gene
  JOURNAL   Genomics 55 (1), 68-77 (1999)
   PUBMED   9889000
REFERENCE   7  (bases 1 to 4309)
  AUTHORS   Halford,S., Dulai,K.S., Daw,S.C., Fitzgibbon,J. and Hunt,D.M.
  TITLE     Isolation and chromosomal localization of two human
            CDP-diacylglycerol synthase (CDS) genes
  JOURNAL   Genomics 54 (1), 140-144 (1998)
   PUBMED   9806839
REFERENCE   8  (bases 1 to 4309)
  AUTHORS   Lykidis,A., Jackson,P.D., Rock,C.O. and Jackowski,S.
  TITLE     The role of CDP-diacylglycerol synthetase and phosphatidylinositol
            synthase activity levels in the regulation of cellular
            phosphatidylinositol content
  JOURNAL   J Biol Chem 272 (52), 33402-33409 (1997)
   PUBMED   9407135
REFERENCE   9  (bases 1 to 4309)
  AUTHORS   Weeks,R., Dowhan,W., Shen,H., Balantac,N., Meengs,B., Nudelman,E.
            and Leung,D.W.
  TITLE     Isolation and expression of an isoform of human CDP-diacylglycerol
            synthase cDNA
  JOURNAL   DNA Cell Biol 16 (3), 281-289 (1997)
   PUBMED   9115637
REFERENCE   10 (bases 1 to 4309)
  AUTHORS   Heacock,A.M., Uhler,M.D. and Agranoff,B.W.
  TITLE     Cloning of CDP-diacylglycerol synthase from a human neuronal cell
            line
  JOURNAL   J Neurochem 67 (5), 2200-2203 (1996)
   PUBMED   8863531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U65887.1, U60808.1, CA313675.1,
            AK026697.1, DN915398.1 and BE504303.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001263.3.
            
            Summary: Breakdown products of phosphoinositides are ubiquitous
            second messengers that function downstream of many G
            protein-coupled receptors and tyrosine kinases regulating cell
            growth, calcium metabolism, and protein kinase C activity. This
            gene encodes an enzyme which regulates the amount of
            phosphatidylinositol available for signaling by catalyzing the
            conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme
            is an integral membrane protein localized to two subcellular
            domains, the matrix side of the inner mitochondrial membrane where
            it is thought to be involved in the synthesis of
            phosphatidylglycerol and cardiolipin and the cytoplasmic side of
            the endoplasmic reticulum where it functions in
            phosphatidylinositol biosynthesis. Two genes encoding this enzyme
            have been identified in humans, one mapping to human chromosome
            4q21 and a second to 20p13. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.73344.1,
                                           SRR1803614.72310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295887.6/ ENSP00000295887.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1528              U65887.1           162-1689
            1529-2177           U60808.1           1403-2051
            2178-2254           CA313675.1         124-200
            2255-3160           AK026697.1         1-906
            3161-3161           DN915398.1         142-142
            3162-4046           AK026697.1         908-1792
            4047-4309           BE504303.1         15-277              c
FEATURES             Location/Qualifiers
     source          1..4309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.23"
     gene            1..4309
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /note="CDP-diacylglycerol synthase 1"
                     /db_xref="GeneID:1040"
                     /db_xref="HGNC:HGNC:1800"
                     /db_xref="MIM:603548"
     exon            1..392
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             276..1661
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /EC_number="2.7.7.41"
                     /note="CDP-diglyceride synthetase 1; CDP-diglyceride
                     pyrophosphorylase 1; CDP-DAG synthase 1; CDP-DG synthetase
                     1; CTP:phosphatidate cytidylyltransferase 1; CDP-DG
                     synthase 1; CDP-diglyceride synthase 1; CDP-diacylglycerol
                     synthase (phosphatidate cytidylyltransferase) 1"
                     /codon_start=1
                     /product="phosphatidate cytidylyltransferase 1"
                     /protein_id="NP_001254.2"
                     /db_xref="CCDS:CCDS3608.1"
                     /db_xref="GeneID:1040"
                     /db_xref="HGNC:HGNC:1800"
                     /db_xref="MIM:603548"
                     /translation="MLELRHRGSCPGPREAVSPPHREGEAAGGDHETESTSDKETDID
                     DRYGDLDSRTDSDIPEIPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFL
                     IIYMGSFMLMLLVLGIQVKCFHEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGE
                     TVADYFATFVQREEQLQFLIRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTH
                     VTLLITVTQSHLVIQNLFEGMIWFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKT
                     WEGFIGGFFSTVVFGFIAAYVLSKYQYFVCPVEYRSDVNSFVTECEPSELFQLQTYSL
                     PPFLKAVLRQERVSLYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPG
                     HGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYKTLKTHLI
                     EKGILQPTLKV"
     exon            393..520
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..617
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            618..715
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..855
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..914
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..997
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1085
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1154
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1307
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1427
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1531
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..4309
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3064..3069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /note="hexamer: AGTAAA"
     polyA_site      3093
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
     regulatory      4288..4293
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /note="hexamer: AATAAA"
     polyA_site      4309
                     /gene="CDS1"
                     /gene_synonym="CDS 1"
                     /note="major polyA site"
ORIGIN      
        1 gccttctctg ctcgcgcctg gcgcccggag cctgcccggg acctccgccg gagccgcgct
       61 cgctgcaggc ggcctcgagc gctctctcgt tgatgccgtt ttggaggtga ccggcgcggc
      121 ggccgctcta tggtggggcc gcgttagtgg ctgcggctcc gcgggactcc agggcgcggc
      181 tgcgaggtgg cggggcgccc cgcctgcaga accctgcttg cagctcaggt ttcggggtgc
      241 ttgaggaggc cgccacggca gcgcgggagc ggaagatgtt ggagctgagg caccggggaa
      301 gctgccccgg ccccagggaa gcggtgtcgc cgccacaccg cgagggagag gcggccggcg
      361 gcgaccacga aaccgagagc accagcgaca aagaaacaga tattgatgac agatatggag
      421 atttggattc cagaacagat tctgatattc cggaaattcc accatcctca gatagaaccc
      481 ctgagattct caaaaaagct ctatctggtt tatcttcaag gtggaaaaac tggtggatac
      541 gtggaattct cactctaact atgatctcgt tgtttttcct gatcatctat atgggatcct
      601 tcatgctgat gcttcttgtt ctgggcatcc aagtgaaatg cttccatgaa attatcacta
      661 taggttatag agtctatcat tcttatgatc taccatggtt tagaacacta agttggtact
      721 ttctattgtg tgtaaactac tttttctatg gagagactgt agctgattat tttgctacat
      781 ttgttcaaag agaagaacaa cttcagttcc tcattcgcta ccatagattt atatcatttg
      841 ccctctatct ggcaggtttc tgcatgtttg tactgagttt ggtgaagaaa cattatcgtc
      901 tgcagtttta tatgttcgca tggactcatg tcactttact gataactgtc actcagtcac
      961 accttgtcat ccaaaatctg tttgaaggca tgatatggtt ccttgttcca atatcaagtg
     1021 ttatctgcaa tgacataact gcttaccttt ttggattttt ttttgggaga actccattaa
     1081 ttaagttgtc tcctaaaaag acttgggaag gattcattgg tggtttcttt tccacagttg
     1141 tgtttggatt cattgctgcc tatgtgttat ccaaatacca gtactttgtc tgcccagtgg
     1201 aataccgaag tgatgtaaac tccttcgtga cagaatgtga gccctcagaa cttttccagc
     1261 ttcagactta ctcacttcca ccctttctaa aggcagtctt gagacaggaa agagtgagct
     1321 tgtacccttt ccagatccac agcattgcac tgtcaacctt tgcatcttta attggcccat
     1381 ttggaggctt ctttgctagt ggattcaaaa gagccttcaa aatcaaggat tttgcaaata
     1441 ccattcctgg acatggtggg ataatggaca gatttgattg tcagtatttg atggcaactt
     1501 ttgtacatgt gtacatcaca agttttataa ggggcccaaa tcccagcaaa gtgctacagc
     1561 agttgttggt gcttcaacct gaacagcagt taaatatata taaaaccctg aagactcatc
     1621 tcattgagaa aggaatccta caacccacct tgaaggtata actggatcca gagagggaag
     1681 gactgacaag aaggaattat tcagaaaaac actgacagat gttttataaa ttgtacagaa
     1741 aaatagttaa aaatgcaata ggttgaagtt ttggagatat gtttctctct gaaattactg
     1801 tgaatattta acaaacactt acttgatcta tgttatgaaa taagtagcaa attgccagca
     1861 aaatgtcttg taccttttct aaagtgtatt ttctgatgtg aacttccttc cccttacttg
     1921 ctaggtttca taatttaaaa gactggtatt taaaagagtc aaacactata aaatgagtaa
     1981 gttgacgatg ttttaagatt gcacctggca gtgtgccttt ttgcacaaat atttactttt
     2041 gcacttggag ctgcttttaa ttttagcaaa atgttttatg caaggcacaa taggaagtca
     2101 gttctcctgc acttcctcct catgtagtct ggagtacttt ctaaagggct tagttggatt
     2161 taaaaaaaaa aaaaaaagat tgtctacttt tcaaagaagt aaccatttgc caggggaaaa
     2221 cattctgctt ttaggtagtt tcaaaattca ggggagggag cctgaaattt ttgccatgat
     2281 tggtttgtta gaaagagcag gcatcagact acttctgata aaattgtttg gaaggtcacg
     2341 acctcgcaaa aacttttcaa gagcaacaag gaagaattct gctgtgaaga acacagtgta
     2401 cggatcctcc gcatattatc tcaacagagg acagtagctc aggaggcagc ttcaaacggt
     2461 gacctgtggc ctgggccatc tcttcgtcat gtgcttcact tttccctgtt tccctgtgaa
     2521 ctggcttcca tggttctgta gggtagtgag tcggggttgt ggctgcagca gagcaggaga
     2581 tgcttgcccg agtgggagca acccaccccc gtgtccccaa tgcctcactc ctggcttcta
     2641 gtgcagccct ttgtagactc acctcgcaag aaggaagatc tgcctggaga cctgatccca
     2701 gtccagcttt ttgaccatag gtcatctttg tccccttgct cctttgcatc atgtcataaa
     2761 atttgaggat atcagctgat tattttttct tccaagaatg aaaatcaagc agaattgatt
     2821 cctacacgaa aaaaaagcac acgaatgcca aacctttcct ttggtggact ggacactaac
     2881 cagatgagag taaatttctt atccgtggac gtatgtaagc tactgctgct gtgtgctctc
     2941 cacagccata tttattgtat taaacaatca gcactaaacc ttcaaaaatt gcccagtgtt
     3001 cctagttaaa tgttcagagg ggagaaatag atatatttta aataatgttt tgctaatgaa
     3061 aagagtaaat atttttgttt aaatcagcaa aaactttcca ttattttata tttccgtcta
     3121 ctatacctaa aacaaaagat tgccgttata cctgggttcc actgatgcag tcagccagca
     3181 cctcctcaca tgcacacatg attagacata ggtgcactcg gtaccaagag tccattttat
     3241 ggtccagcat atactccatt gattcatcat cactgcatgt gttcagccag tgtatctcac
     3301 actatccata caaatctaaa attgatactg gaaatgttat tataggaggc agtgatcgca
     3361 tttaaaatca ggccacctac aagtttaatt ttcaacatct catgttttta tttgtcccat
     3421 tacagcctca aatgttggtc ataaaaaaaa tttaggctac caaagtttaa agaataaaat
     3481 gaaaatttta taagaactta cattaaaaac tcagtagttt gcatgagtaa gaactccttg
     3541 agatacacag atccccccac atttgtattt aaaataattg gtgaggcatt gaaatccaga
     3601 attataagaa agcattactg aatatgtgtg ttataaaatc aatattatta taaacaaaat
     3661 aggaagctag aaatatttgg gatcacagta atagcttttc tcaaatatac ttttagaatt
     3721 gaatgtacat tatcctatat gtaaaaaagc aaattattaa ttttaatgga gctctcgatt
     3781 gaccttttta gcatactttt atagcatgta tattaaaata gaatatattt tagcaaaaga
     3841 ttgccataaa accctgactt ggctcatttt gatatttgca ctgtgaagag ggcttaaatt
     3901 ccaatgtagc aatgtggtgg cagacaaatg aaaaactagg aagttctttc acagtaatgc
     3961 ctagttgttc caaatttgct atatttggag gtgctctact ggtacttcct gcttgactct
     4021 ctgacctgtg ggatgcacat tcttcctcag cgctttttcc ttgttgtggt gacgtacatt
     4081 cactatctga gagtgaaaga ccacacacac ccctcttttt aaaattattg tatctcttcc
     4141 ttttcacttt ggtttgaaca aagatagtgt caccttgttc cgtgaaaaag aaaaagcata
     4201 aacagtgtat atttagggta tatgggtgat agcttatgat gtgtgtcaat cagttctctg
     4261 aatcttttac tgaaactgag acaggaaaat aaaactgaaa caaatcata
//
