LOCUS       NM_001802               2704 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cerebellar degeneration related protein 2 (CDR2),
            mRNA.
ACCESSION   NM_001802 XM_071866
VERSION     NM_001802.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2704)
  AUTHORS   Erikstad,K.I., Herdlevaer,I., Peter,E., Haugen,M., Totland,C. and
            Vedeler,C.
  TITLE     A cerebellar degeneration-related protein 2-like cell-based assay
            for anti-Yo detection in patients with paraneoplastic cerebellar
            degeneration
  JOURNAL   Eur J Neurol 30 (6), 1727-1733 (2023)
   PUBMED   36912432
  REMARK    GeneRIF: A cerebellar degeneration-related protein 2-like
            cell-based assay for anti-Yo detection in patients with
            paraneoplastic cerebellar degeneration.
REFERENCE   2  (bases 1 to 2704)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2704)
  AUTHORS   Mo,J.S. and Chae,S.C.
  TITLE     MicroRNA 452 regulates ASB8, NOL8, and CDR2 expression in
            colorectal cancer cells
  JOURNAL   Genes Genomics 43 (1), 33-41 (2021)
   PUBMED   33398662
  REMARK    GeneRIF: MicroRNA 452 regulates ASB8, NOL8, and CDR2 expression in
            colorectal cancer cells.
REFERENCE   4  (bases 1 to 2704)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2704)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2704)
  AUTHORS   Fletcher,C.F., Okano,H.J., Gilbert,D.J., Yang,Y., Yang,C.,
            Copeland,N.G., Jenkins,N.A. and Darnell,R.B.
  TITLE     Mouse chromosomal locations of nine genes encoding homologs of
            human paraneoplastic neurologic disorder antigens
  JOURNAL   Genomics 45 (2), 313-319 (1997)
   PUBMED   9344654
REFERENCE   7  (bases 1 to 2704)
  AUTHORS   Gress,T., Baldini,A., Rocchi,M., Furneaux,H., Posner,J.B. and
            Siniscalco,M.
  TITLE     In situ mapping of the gene coding for a leucine zipper DNA binding
            protein (CDR62) to 16p12-16p13.1
  JOURNAL   Genomics 13 (4), 1340-1342 (1992)
   PUBMED   1505970
REFERENCE   8  (bases 1 to 2704)
  AUTHORS   Sakai,K., Mitchell,D.J., Tsukamoto,T. and Steinman,L.
  TITLE     Isolation of a complementary DNA clone encoding an autoantigen
            recognized by an anti-neuronal cell antibody from a patient with
            paraneoplastic cerebellar degeneration
  JOURNAL   Ann Neurol 30 (5), 738 (1991)
   PUBMED   1763903
  REMARK    Correction to:[Ann Neurol. 1990 Nov;28(5):692-8. doi:
            10.1002/ana.410280515.. PMID: 2260856]
REFERENCE   9  (bases 1 to 2704)
  AUTHORS   Fathallah-Shaykh,H., Wolf,S., Wong,E., Posner,J.B. and
            Furneaux,H.M.
  TITLE     Cloning of a leucine-zipper protein recognized by the sera of
            patients with antibody-associated paraneoplastic cerebellar
            degeneration
  JOURNAL   Proc Natl Acad Sci U S A 88 (8), 3451-3454 (1991)
   PUBMED   2014264
REFERENCE   10 (bases 1 to 2704)
  AUTHORS   Sakai,K., Mitchell,D.J., Tsukamoto,T. and Steinman,L.
  TITLE     Isolation of a complementary DNA clone encoding an autoantigen
            recognized by an anti-neuronal cell antibody from a patient with
            paraneoplastic cerebellar degeneration
  JOURNAL   Ann Neurol 28 (5), 692-698 (1990)
   PUBMED   2260856
  REMARK    Erratum:[Ann Neurol. 1991 Nov;30(5):738. doi:
            10.1002/ana.410300523.. PMID: 1763903]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092338.4, CB990819.1, BG386156.1, BG750955.1, BC017503.1,
            M63256.1 and BM714067.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001802.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017503.1, SRR1163658.234190.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268383.7/ ENSP00000268383.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC092338.4         91835-91836         c
            3-10                CB990819.1         28-35
            11-19               BG386156.1         1-9
            20-20               BG750955.1         1-1
            21-1869             BC017503.1         1-1849
            1870-2110           M63256.1           1722-1962
            2111-2129           M63256.1           1965-1983
            2130-2251           M63256.1           1987-2108
            2252-2655           BC017503.1         2234-2637
            2656-2704           BM714067.1         513-561
FEATURES             Location/Qualifiers
     source          1..2704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..2704
                     /gene="CDR2"
                     /gene_synonym="CDR62; Yo"
                     /note="cerebellar degeneration related protein 2"
                     /db_xref="GeneID:1039"
                     /db_xref="HGNC:HGNC:1799"
                     /db_xref="MIM:117340"
     exon            1..389
                     /gene="CDR2"
                     /gene_synonym="CDR62; Yo"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1675
                     /gene="CDR2"
                     /gene_synonym="CDR62; Yo"
                     /note="Yo paraneoplastic antigen; major Yo paraneoplastic
                     antigen; paraneoplastic cerebellar degeneration-associated
                     antigen; cerebellar degeneration-related protein 2, 62kDa"
                     /codon_start=1
                     /product="cerebellar degeneration-related protein 2"
                     /protein_id="NP_001793.1"
                     /db_xref="CCDS:CCDS32404.1"
                     /db_xref="GeneID:1039"
                     /db_xref="HGNC:HGNC:1799"
                     /db_xref="MIM:117340"
                     /translation="MLAENLVEEFEMKEDEPWYDHQDLQQDLQLAAELGKTLLDRNTE
                     LEDSVQQMYTTNQEQLQEIEYLTKQVELLRQMNEQHAKVYEQLDVTARELEETNQKLV
                     ADSKASQQKILSLTETIECLQTNIDHLQSQVEELKSSGQGRRSPGKCDQEKPAPSFAC
                     LKELYDLRQHFVYDHVFAEKITSLQGQPSPDEEENEHLKKTVTMLQAQLSLERQKRVT
                     MEEEYGLVLKENSELEQQLGATGAYRARALELEAEVAEMRQMLQSEHPFVNGVEKLVP
                     DSLYVPFKEPSQSLLEEMFLTVPESHRKPLKRSSSETILSSLAGSDIVKGHEETCIRR
                     AKAVKQRGISLLHEVDTQYSALKVKYEELLKKCQEEQDSLSHKAVQTSRAAAKDLTGV
                     NAQSEPVASGWELASVNPEPVSSPTTPPEYKALFKEIFSCIKKTKQEIDEQRTKYRSL
                     SSHS"
     exon            390..502
                     /gene="CDR2"
                     /gene_synonym="CDR62; Yo"
                     /inference="alignment:Splign:2.1.0"
     exon            503..651
                     /gene="CDR2"
                     /gene_synonym="CDR62; Yo"
                     /inference="alignment:Splign:2.1.0"
     exon            652..816
                     /gene="CDR2"
                     /gene_synonym="CDR62; Yo"
                     /inference="alignment:Splign:2.1.0"
     exon            817..2704
                     /gene="CDR2"
                     /gene_synonym="CDR62; Yo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2681..2686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDR2"
                     /gene_synonym="CDR62; Yo"
                     /note="hexamer: AATAAA"
     polyA_site      2704
                     /gene="CDR2"
                     /gene_synonym="CDR62; Yo"
                     /note="major polyA site"
ORIGIN      
        1 ctgccaaagt gccacgttgg gcccggcggc ggcgtgaaga ctggcggctg cgtgagactc
       61 cggctccagg cgttcgcacc gtaatgcccg gccgttgggg ccgtcggtag gcgcgaggcg
      121 agtcgaggca gccggccggt cggcggccgc cggcgggaac ggggctgagg cggcgcagcg
      181 gagtctgggc ggcggcgcgt cccgcccgag ggcggctctg gctgagggcg gaggggccgg
      241 ggaagagccc ggggcagcgg ctgaggcggg acggcggcgg gggccgctgc ccctagaaga
      301 cccagccgag atgctggcgg aaaacctggt agaggagttt gagatgaagg aggacgagcc
      361 gtggtacgac caccaggacc tccagcaaga tcttcaactt gctgctgagc ttgggaagac
      421 attactggat cggaacacag agttggagga ctctgttcag cagatgtata caaccaatca
      481 ggagcagtta caggaaattg agtatctgac gaagcaagtg gaacttctac ggcagatgaa
      541 cgaacaacat gcaaaggttt atgaacaatt agacgtcaca gcaagggaac tggaagaaac
      601 aaatcaaaag ctagttgctg acagcaaggc ctcacagcaa aagattctga gcctgactga
      661 aacgattgaa tgcctgcaaa ccaacattga tcacctccag agccaagtgg aggagctgaa
      721 gtcatctggc caagggagaa ggagcccggg aaagtgtgac caggagaaac cggcacccag
      781 ctttgcatgt ctgaaggagc tgtatgacct ccgccaacac ttcgtgtatg atcatgtgtt
      841 cgctgagaag atcacttcct tgcaaggtca gccaagccct gatgaagagg aaaatgagca
      901 cttgaaaaaa acagtgacaa tgttgcaggc ccagctgagc ctggagcggc agaagcgggt
      961 gactatggag gaggaatatg ggctcgtgtt aaaggagaac agtgaactgg agcagcagct
     1021 gggggccaca ggtgcctacc gagcacgggc gctggaacta gaggccgagg tggcagagat
     1081 gcgacagatg ttgcagtcag agcatccatt tgtgaatgga gttgagaagc tggtgccaga
     1141 ctctctgtat gttcctttca aagagcccag ccagagcctg ctggaagaga tgttcctgac
     1201 tgtgccggaa tcacatagaa agcctctcaa gcgcagcagc agtgagacga tcctcagcag
     1261 cttggcaggg agtgacatcg tgaagggcca cgaggagacc tgcatcagga gggccaaggc
     1321 tgtgaaacag aggggcatct cccttctgca cgaagtggac acgcagtaca gcgccctgaa
     1381 ggtgaagtat gaagagttgc tgaagaagtg ccaagaggaa caggactccc tgtcacacaa
     1441 ggctgtgcag acctccaggg ctgcagccaa ggacctgact ggagtgaacg cccagtctga
     1501 gcctgttgcc agcggctggg aactggcctc tgtcaaccca gagcccgtga gttcccctac
     1561 aacacctcca gaatacaaag cgttgtttaa ggagatcttt agttgcatca agaaaactaa
     1621 gcaggaaata gatgaacaga gaacaaaata ccgatcactc tcctctcatt cttaattgaa
     1681 cctctagctc tactactaat ttgcctattg cctatcgcct ctctctccca ttcagacaag
     1741 tgtttgtaga ctctgaagcc taatgttact catgacgttt gcctcattgc tttgcttatt
     1801 tagcaaatgc atacaacgag gaaaggaggt ggctagtggt atcagttctc tgatccactt
     1861 ccatttaagc tccccaggaa atcccatgac aaactggcct ctggctggcg cgctgattag
     1921 acttcagttc ctgaaaagga ccagtggagg gaagagctat acttctggag aagtaggcct
     1981 ggagttacta cagtatgggg gaaaagggtc gagttagaac aaagctaagg caattcctat
     2041 tgcttccttg cgcaacttct caaaacgatg aaagtcagaa ggctgtcaaa ctcaaatatc
     2101 tttgcaaaca gtttgaatac tgtgaattca ttacgaagaa tgttcgagag aaagcagggg
     2161 tctaatccaa aagaaatgtc attaaccaat actccaagtc cttgagtttt gttatatctg
     2221 aactagttga actgtgactg acaggtaatc ctaatatatc caaatccaac tgaataccaa
     2281 attgagatgg caaatttttg tttgatataa gttagcttgt tagcatatgc cctagagggc
     2341 ctccatccct gtattctaat gtttttactc aaagctctag cctttaggat aggtgaatat
     2401 gtaaatcttt tatcactttc tcaaattcaa actaaagggg aaagatcaaa ccccttccct
     2461 tcctacctgt tttctgagct ggctgacttg ccagccacaa gctgctcttg cagagttctt
     2521 accattcctg taaatgtttt gacttgttgc agaaattcct atctacttta ttaagcagta
     2581 ttgatctgac tgtggaaaca tcctctcact tgcattcttt taacttaaaa ctatttaaga
     2641 actgatgttc cgattattgt atatattttt ctaaaaacca aataaagcta cctatgaaaa
     2701 tgaa
//
