LOCUS       NM_001378964            8265 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens cell adhesion associated, oncogene regulated (CDON),
            transcript variant 3, mRNA.
ACCESSION   NM_001378964 XM_011542866
VERSION     NM_001378964.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8265)
  AUTHORS   Ahn,B.Y., Jeong,Y., Kim,S., Zhang,Y., Kim,S.W., Leem,Y.E. and
            Kang,J.S.
  TITLE     Cdon suppresses vascular smooth muscle calcification via repression
            of the Wnt/Runx2 Axis
  JOURNAL   Exp Mol Med 55 (1), 120-131 (2023)
   PUBMED   36609601
  REMARK    GeneRIF: Cdon suppresses vascular smooth muscle calcification via
            repression of the Wnt/Runx2 Axis.
REFERENCE   2  (bases 1 to 8265)
  AUTHORS   Islam,F., Htun,S., Lai,L.W., Krall,M., Poranki,M., Martin,P.M.,
            Sobreira,N., Wohler,E.S., Yu,J., Moore,A.T. and Slavotinek,A.M.
  TITLE     Exome sequencing in patients with microphthalmia, anophthalmia, and
            coloboma (MAC) from a consanguineous population
  JOURNAL   Clin Genet 98 (5), 499-506 (2020)
   PUBMED   32799327
  REMARK    GeneRIF: Exome sequencing in patients with microphthalmia,
            anophthalmia, and coloboma (MAC) from a consanguineous population.
REFERENCE   3  (bases 1 to 8265)
  AUTHORS   Reis,L.M., Basel,D., McCarrier,J., Weinberg,D.V. and Semina,E.V.
  TITLE     Compound heterozygous splicing CDON variants result in isolated
            ocular coloboma
  JOURNAL   Clin Genet 98 (5), 486-492 (2020)
   PUBMED   32729136
  REMARK    GeneRIF: Compound heterozygous splicing CDON variants result in
            isolated ocular coloboma.
REFERENCE   4  (bases 1 to 8265)
  AUTHORS   Bashamboo,A., Bignon-Topalovic,J., Rouba,H., McElreavey,K. and
            Brauner,R.
  TITLE     A Nonsense Mutation in the Hedgehog Receptor CDON Associated With
            Pituitary Stalk Interruption Syndrome
  JOURNAL   J Clin Endocrinol Metab 101 (1), 12-15 (2016)
   PUBMED   26529631
  REMARK    GeneRIF: We identified a novel heterozygous nonsense CDON mutation
            in a case of Pituitary Stalk Interruption Syndrome who presented
            with neonatal hypoglycemia and cholestasis
REFERENCE   5  (bases 1 to 8265)
  AUTHORS   Leem,Y.E., Ha,H.L., Bae,J.H., Baek,K.H. and Kang,J.S.
  TITLE     CDO, an Hh-coreceptor, mediates lung cancer cell proliferation and
            tumorigenicity through Hedgehog signaling
  JOURNAL   PLoS One 9 (11), e111701 (2014)
   PUBMED   25369201
  REMARK    GeneRIF: CDO is required for proliferation and survival of lung
            cancer cells via Hh signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8265)
  AUTHORS   Kang,J.S., Feinleib,J.L., Knox,S., Ketteringham,M.A. and
            Krauss,R.S.
  TITLE     Promyogenic members of the Ig and cadherin families associate to
            positively regulate differentiation
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 3989-3994 (2003)
   PUBMED   12634428
  REMARK    GeneRIF: CDO and BOC forms complexes with specific cadherins that
            mediate some of the promyogenic effects of cell-cell contact.
REFERENCE   7  (bases 1 to 8265)
  AUTHORS   Cole,F. and Krauss,R.S.
  TITLE     Microform holoprosencephaly in mice that lack the Ig superfamily
            member Cdon
  JOURNAL   Curr Biol 13 (5), 411-415 (2003)
   PUBMED   12620190
  REMARK    GeneRIF: Targeted inactivation of Cdon in the mouse results in mild
            holoprosencephaly, suggesting a link to signaling pathways that
            control midline development such as the Sonic hedgehog pathway.
REFERENCE   8  (bases 1 to 8265)
  AUTHORS   Kang,J.S., Mulieri,P.J., Hu,Y., Taliana,L. and Krauss,R.S.
  TITLE     BOC, an Ig superfamily member, associates with CDO to positively
            regulate myogenic differentiation
  JOURNAL   EMBO J 21 (1-2), 114-124 (2002)
   PUBMED   11782431
REFERENCE   9  (bases 1 to 8265)
  AUTHORS   Kang,J.S., Gao,M., Feinleib,J.L., Cotter,P.D., Guadagno,S.N. and
            Krauss,R.S.
  TITLE     CDO: an oncogene-, serum-, and anchorage-regulated member of the
            Ig/fibronectin type III repeat family
  JOURNAL   J Cell Biol 138 (1), 203-213 (1997)
   PUBMED   9214393
REFERENCE   10 (bases 1 to 8265)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000821.5 and AP000842.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 16, 2020 this sequence version replaced XM_011542866.3.
            
            Summary: This gene encodes a cell surface receptor that is a member
            of the immunoglobulin superfamily. The encoded protein contains
            three fibronectin type III domains and five immunoglobulin-like
            C2-type domains. This protein is a member of a cell-surface
            receptor complex that mediates cell-cell interactions between
            muscle precursor cells and positively regulates myogenesis.
            [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.2077594.1,
                                           SRR11853566.5677.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000531738.6/ ENSP00000432901.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AP000821.5         90553-90840         c
            289-425             AP000821.5         51375-51511         c
            426-698             AP000821.5         49222-49494         c
            699-845             AP000821.5         47593-47739         c
            846-989             AP000821.5         46304-46447         c
            990-1277            AP000842.6         179353-179640       c
            1278-1547           AP000842.6         177506-177775       c
            1548-1901           AP000842.6         172606-172959       c
            1902-2200           AP000842.6         168024-168322       c
            2201-2375           AP000842.6         166167-166341       c
            2376-2507           AP000842.6         163984-164115       c
            2508-2711           AP000842.6         159472-159675       c
            2712-2893           AP000842.6         157136-157317       c
            2894-2999           AP000842.6         156549-156654       c
            3000-3122           AP000842.6         151902-152024       c
            3123-3344           AP000842.6         146137-146358       c
            3345-3625           AP000842.6         143314-143594       c
            3626-3705           AP000842.6         140569-140648       c
            3706-3980           AP000842.6         123989-124263       c
            3981-8265           AP000842.6         119086-123370       c
FEATURES             Location/Qualifiers
     source          1..8265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..8265
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /note="cell adhesion associated, oncogene regulated"
                     /db_xref="GeneID:50937"
                     /db_xref="HGNC:HGNC:17104"
                     /db_xref="MIM:608707"
     exon            1..288
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            289..425
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..4144
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; surface glycoprotein, Ig superfamily member;
                     cell adhesion molecule-related/down-regulated by
                     oncogenes; Cdon homolog"
                     /codon_start=1
                     /product="cell adhesion molecule-related/down-regulated by
                     oncogenes isoform 2 precursor"
                     /protein_id="NP_001365893.1"
                     /db_xref="CCDS:CCDS8468.1"
                     /db_xref="GeneID:50937"
                     /db_xref="HGNC:HGNC:17104"
                     /db_xref="MIM:608707"
                     /translation="MHPDLGPLCTLLYVTLTILCSSVSSDLAPYFTSEPLSAVQKLGG
                     PVVLHCSAQPVTTRISWLHNGKTLDGNLEHVKIHQGTLTILSLNSSLLGYYQCLANNS
                     IGAIVSGPATVSVAVLGDFGSSTKHVITAEEKSAGFIGCRVPESNPKAEVRYKIRGKW
                     LEHSTENYLILPSGNLQILNVSLEDKGSYKCAAYNPVTHQLKVEPIGRKLLVSRPSSD
                     DVHILHPTHSQALAVLSRSPVTLECVVSGVPAPQVYWLKDGQDIAPGSNWRRLYSHLA
                     TDSVDPADSGNYSCMAGNKSGDVKYVTYMVNVLEHASISKGLQDQIVSLGATVHFTCD
                     VHGNPAPNCTWFHNAQPIHPSARHLTAGNGLKISGVTVEDVGMYQCVADNGIGFMHST
                     GRLEIENDGGFKPVIITAPVSAKVADGDFVTLSCNASGLPVPVIRWYDSHGLITSHPS
                     QVLRSKSRKSQLSRPEGLNLEPVYFVLSQAGASSLHIQAVTQEHAGKYICEAANEHGT
                     TQAEASLMVVPFETNTKAETVTLPDAAQNDDRSKRDGSETGLLSSFPVKVHPSAVESA
                     PEKNASGISVPDAPIILSPPQTHTPDTYNLVWRAGKDGGLPINAYFVKYRKLDDGVGM
                     LGSWHTVRVPGSENELHLAELEPSSLYEVLMVARSAAGEGQPAMLTFRTSKEKTASSK
                     NTQASSPPVGIPKYPVVSEAANNNFGVVLTDSSRHSGVPEAPDRPTISTASETSVYVT
                     WIPRANGGSPITAFKVEYKRMRTSNWLVAAEDIPPSKLSVEVRSLEPGSTYKFRVIAI
                     NHYGESFRSSASRPYQVVGFPNRFSSRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNN
                     TPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHMIGHLQPETSYDIKMQCFNEGGESE
                     FSNVMICETKVKRVPGASEYPVKDLSTPPNSLGSGGNVGPATSPARSSDMLYLIVGCV
                     LGVMVLILMVFIAMCLWKNRQQNTIQKYDPPGYLYQGSDMNGQMVDYTTLSGASQING
                     NVHGGFLTNGGLSSGYSHLHHKVPNAVNGIVNGSLNGGLYSGHSNSLTRTHVDFEHPH
                     HLVNGGGMYTAVPQIDPLECVNCRNCRNNNRCFTKTNSTFSSSPPPVVPVVAPYPQDG
                     LEMKPLSHVKVPVCLTSAVPDCGQLPEESVKDNVEPVPTQRTCCQDIVNDVSSDGSED
                     PAEFSRGDSCAHSETEINIVSWNALILPPVPEGCAEKTMWSPPGIPLDSPTEVLQQPR
                     ET"
     exon            426..698
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            699..845
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            846..989
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1277
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1547
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1901
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2200
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2375
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2507
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2508..2711
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2893
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            2894..2999
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3122
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3344
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3625
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3705
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3706..3980
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            3981..8265
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7611..7616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /note="hexamer: ATTAAA"
     polyA_site      7651
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /note="major polyA site"
     regulatory      8238..8243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /note="hexamer: AATAAA"
     polyA_site      8265
                     /gene="CDON"
                     /gene_synonym="CDO; CDON1; HPE11; Ihog; ORCAM"
                     /note="major polyA site"
ORIGIN      
        1 gactccgccc ctcagctccc ctcccctgag cccgggagcc cggctcgcgc ggctaggtgc
       61 gaggagaccc gggaccccac gcccgcccgc cctgcccagc gccccagccc cggcgtgcga
      121 ggcgccgctc cctcctctgc cctgcgcggt gcatggaggg gcccgttcgg atcgcagccg
      181 ccgccaccgt agccgccgcc gcgcgcgcgc ggggggatga cctgggggtg gctttccgag
      241 ccggctgcag cgcaggaggt ctggaggctt agccagcccc gcggagagtg aaccaaggac
      301 tgggttttgc tctggaagcc tgtcctgatt gcttctgtaa tctggcgcta tgcatccgga
      361 tcttggaccc ttatgtacac tgctgtatgt tactcttaca attctgtgct cttctgtgag
      421 ttcagacttg gcaccttatt ttacttctga gccgctctct gctgtccaga aacttggtgg
      481 acctgtagta ctgcattgtt ctgctcaacc tgtgaccact cgtatctcat ggctgcataa
      541 cggaaaaaca ttggatggaa acctggaaca tgttaagatt catcagggga ctctgacaat
      601 tctttctctc aactcctctc ttttgggtta ctaccagtgc cttgccaaca atagcatcgg
      661 tgccattgtg agtggccctg cgacagtatc tgtggcagtt cttggtgatt ttggttcatc
      721 cacaaagcat gttattacag cagaagaaaa aagtgctggt ttcattggct gcagggtacc
      781 ggagagtaac cccaaagctg aggtgcgcta taaaatccgg ggaaaatggc tggaacattc
      841 cacagagaat tacttaatcc ttccatcagg aaatcttcag attttgaatg tatccttaga
      901 ggacaaggga tcatacaaat gtgcagctta taatcctgtc acacatcaat taaaagttga
      961 acctattggc cgaaagctcc ttgtgagtcg tccttcttca gatgatgttc acattcttca
     1021 ccccacccat tcacaggcat tagctgttct ttctcgtagc cctgtaacct tggagtgtgt
     1081 ggtgagtggg gtcccggctc ctcaagtgta ttggctaaag gacgggcagg acattgcacc
     1141 aggaagcaac tggagaaggt tgtattctca tcttgccact gatagcgttg acccggcgga
     1201 ctccggaaac tattcctgca tggcgggaaa caagtctgga gatgtaaaat atgtgactta
     1261 catggttaat gtacttgaac atgcttccat ttctaaagga ctacaggatc agatagtgtc
     1321 tctgggtgcc acagtacact ttacctgcga cgttcatggg aacccagccc ccaactgtac
     1381 ctggtttcac aatgcacagc ctattcatcc ttctgcacga catctaactg caggaaacgg
     1441 actgaaaatc agtggggtta ctgtggaaga tgttgggatg tatcagtgtg tagcagataa
     1501 tgggattgga tttatgcact ctactggaag acttgaaatt gaaaatgacg gtggattcaa
     1561 gccagttata attacggcac cagtaagtgc aaaggttgca gacggagact ttgttactct
     1621 gtcctgcaat gccagtgggc tgccggttcc ggtcattcgt tggtatgaca gccatggatt
     1681 gataaccagc catccatctc aagtcctgag atcgaaatcc cgaaaatcac agttatcaag
     1741 acctgagggc ttgaacctgg agcctgtgta cttcgtcctg tcccaagctg gtgcaagctc
     1801 tctccatatt caggctgtga ctcaggaaca tgcggggaaa tacatctgcg aagctgcaaa
     1861 tgaacatggt accacacagg cagaagcatc tctcatggtt gttccttttg aaacaaatac
     1921 aaaagcagag acagtcacac ttcctgatgc tgctcagaat gatgacagaa gtaagagaga
     1981 tggttcagaa actgggttac tgagctcatt tccggtgaag gtccatccca gtgcagtgga
     2041 atcagcacca gagaaaaacg ccagcggcat ctctgttcct gatgccccca tcatactgag
     2101 ccccccacag acccacacac cagacacgta caacctggtg tggagggcag gcaaggatgg
     2161 tgggctgccc atcaatgctt actttgtgaa gtatcgaaag ctggatgatg gggttggcat
     2221 gctgggaagc tggcacacgg ttcgagtccc aggaagtgaa aatgagctcc atttagctga
     2281 gctggagcca tctagtcttt atgaagtctt gatggtagca agaagcgcag caggtgaagg
     2341 ccaacctgcc atgcttacct tccgaaccag caaagaaaaa acagcgtcat caaaaaacac
     2401 ccaggcatcc tctccacccg tgggcatccc taagtatccc gttgtttcag aggctgcaaa
     2461 caacaatttt ggagtggtac ttacagattc ctctaggcac agtggagttc cagaggcacc
     2521 agatcggcct accatctcca ctgcatcaga gacatcagtc tatgtcactt ggattcctcg
     2581 ggcaaacggg ggttctccaa tcactgcctt caaagtcgaa tataaacgga tgaggaccag
     2641 caattggctg gtggcagctg aagacatccc tccttccaaa ctttcagtgg aagttcgtag
     2701 tttagaacca ggttcaacat acaaatttag ggtcattgcc atcaaccatt atggtgagag
     2761 ttttcggagt tcagcatctc gtccttatca agtggttggg ttccccaatc gcttttccag
     2821 ccgtccaata actggacctc acattgcata cacagaggct gtcagcgata ctcagatcat
     2881 gctaaagtgg acgtacattc catcaagtaa caataacact cccattcaag gattttatat
     2941 ctattaccga ccaacagata gtgacaatga cagtgattac aagagggatg ttgtagaagg
     3001 ttcaaagcag tggcacatga ttggccacct gcagccagaa acctcctatg acattaaaat
     3061 gcaatgcttc aatgaaggag gagaaagtga atttagcaat gtgatgatct gcgagactaa
     3121 agtgaaacgt gttcctggag cttctgaata tcctgtcaaa gacttgagta cccctccaaa
     3181 ttctttggga agtggaggaa atgtggggcc tgcaaccagc cctgccagaa gcagtgacat
     3241 gttatatctg atcgttggct gtgtgctggg cgtcatggtc ctcattctga tggttttcat
     3301 tgcaatgtgc ctgtggaaga atcgccagca gaataccata caaaaatatg acccaccagg
     3361 atatctctac caaggatcag atatgaacgg gcagatggtg gactacacca ctctctcagg
     3421 agcaagtcag ataaatggaa atgttcacgg aggcttccta accaatggcg gtctcagcag
     3481 tggctattcc caccttcacc ataaggtccc caatgcagtc aatggaattg tgaatgggag
     3541 cctaaatgga gggctttact ccgggcacag caactctcta accaggacac acgtggattt
     3601 tgaacatcct catcatctag tgaatggtgg tggaatgtac acggccgtgc ctcagattga
     3661 ccctctggag tgtgttaact gccgaaattg tcgaaacaac aataggtgtt tcaccaaaac
     3721 caacagcact ttcagcagca gccctcctcc tgtggtccct gtggtagcac cttatcctca
     3781 ggatggtttg gaaatgaagc ccctcagtca cgtgaaggtg cctgtatgcc tgacttccgc
     3841 agtccctgat tgtggccagt tgccggagga gagcgtcaag gacaatgtgg aaccagtccc
     3901 tactcagcgt acctgctgtc aggacattgt aaatgacgtc agctctgatg gctcagaaga
     3961 tccagcagag ttcagcagag gagacagctg tgcccattca gaaacagaga tcaacattgt
     4021 aagttggaat gctcttattt tgccacctgt ccccgagggc tgtgctgaga agacaatgtg
     4081 gtctccacct ggcattcctt tagacagccc gacagaggtc cttcagcagc cccgggaaac
     4141 ctgaggacat gcaaacaacc agtcatgttc caacttcaag ccggtaactg cacacaacag
     4201 gcctgggagc gaactgtgtg aaggacctta attcaaatca gagaaaatca ttatttattt
     4261 ttttgtagta gtaatgtcat atgaatgtat cttaaaacgt gtgccctttt atattattta
     4321 tgccttaaat gttttcttcc ccattccttc ctccccctcg gtaggaaaca accttgtttt
     4381 gcatagtatt cagtcacctg gagggcagag gggtccttcc atgttttcta acagctatag
     4441 tgacagcaag agctcctcat gcaaaggatc ccatctcttg gctgcttcgg ctaggaggga
     4501 atgcaggggc ccgttgaagg ttgccaccag ctgggttttc aggtggaaaa tggtctttca
     4561 atagtgtatt ctcagacttt tttttgtttg ttttttgaga tggagtcttg ctgtcatcca
     4621 ggctggagtg caatggctcg atcttggctc actgcaacct ccgcctccca ggttcaagca
     4681 attctcccgc ctcagcctcc tgagtagctg ggactacagg cacctgccac cacgtccagc
     4741 taattgtctt gtatttttat tagagacaag gtttcaggct ggttttgaac tcctgacctc
     4801 aagtgatcca cccgcctccg cctcccaaag tgcgaggatt acaggcgtga gccaccacgt
     4861 ctggcctgta ttatcagact tcctgagaac actttgaaat caactgcagt tgtgacccat
     4921 gtttataata acagacctgg ctgacggatt ttacaagagt gccttccaca gaagtggtaa
     4981 tgtgacctgt tgactttgta tctgcacgtg ggcacgagtg atgttcagtt tgctaggcac
     5041 tagtcatagt gttatggacg tggtggagtg taaggtcttg atgaattacg gcagtatgca
     5101 gaaaaggaac caaggccaga gagacaaata atgcctcatg tcccactgct ttaaaattac
     5161 attaatttat aaaatggcca ctatgggctc tttttgactg tttctcggag taggaacaaa
     5221 ataagacatt aaatggtggc ttgaagagaa agatacacat tttcagaaga aagaaagggg
     5281 agggctgcag ggagcctgtc ttggcgggag ctctccagtc tgttggatta gcacagggac
     5341 acgcttatgg tgccatgacg ccgaaactag tcatccccca tctccagcat aggcaacggc
     5401 ctgcaggggt gagtgtcaga aaagacttac tttggaagaa aagggttttt ttttgtttgt
     5461 ttgttttttg tttttttttg tttgtttgtt ttgggttttt ttcctgaaat ttcctgatac
     5521 ctttttcaga atgtcaccct tgtaaatagg cacctaaagc caagttggtc agcagagctc
     5581 ctgaccacgg ctgcctctgc gtgacaagga catttgcagc tgcctttgga aggctcttca
     5641 cattaaaaaa caataattat gtaagtgtgt ttcatagctt gagtcaagct ttcaaggatc
     5701 actgctcctt tgtgcattgt gcatcccttt ggggaaagaa acagaaaatt attctctttc
     5761 tatagagtca agcaattcca gcagaagtga agaaatgtta gtttcccaga aatcgcagtg
     5821 gaatagaata caatactgtg ttaaccaact ttctgtataa atgcatcagt attcccttac
     5881 atatgtctat atattttata atagaactgt tagtgaaaat gtgcttgttt aagctgggtc
     5941 actatgcaag agttacttcc agtagaatgt agtgaatgta attccctagt cggatattag
     6001 ggatgctgta gacccaagtt ctacattcca gatgtccgtg cctatagtat actggattta
     6061 ttcttcatgt tgcttaaatg cagttagctc tggaggggga tagctgcatc ccttacttct
     6121 gtgactagca aaggacaaag tcccagcgca cagaatatga aaacataccc tgtgttagcc
     6181 aatcaagtta cagcaatgct gtcacaaagg gagttttaga aaactgggga gtcattgtcc
     6241 gtagacagcc attttgattt aggaaacagg tgtattagca tgagccttag gtcatgaact
     6301 gcttttaaag attgagtttg aatatgggat ctgtccacga ggaagagaaa atggctttac
     6361 ctttaggaca atctcattgt ggactgcttt atttatatta ttagtaacgc tgttttaagt
     6421 gttattcttt ttattgtatt ttatttataa aaaatgcctt tatatattga aatatataaa
     6481 tatatatata taaacacaca cacacacaca cacacacaca tatatatata tatatataat
     6541 tgcctttata tttaggcggt atgagttctc cctaagcgtg agttggctct gccctgcaca
     6601 ggcacccaaa cagtcctacc taatgtcact tcaccaggaa atgagaggac atggtacagt
     6661 gtgggagaca gcactaacac gtgctgaata actactgtgt accaggcact gtgctcggtg
     6721 cttgttactg ttaactcatt taacccccac aactcatcta caaagttggc attaaaatcc
     6781 ccaagtcact cagtgagcca tgggacctga atccgaacct agtttatctg gagccataat
     6841 ctgggctcct cccatttttc catactgctt tccaaaagca ttgtggttca ctctttggat
     6901 ggaaccagtc ccgttccgta tgctgtgatc tatccctgcc gtggaattcc tccgaggctc
     6961 caactccgca gccagagaag ctgctctctg gcctccgcgg gcagagctct gcttatgact
     7021 tcgtcttcca gaggtccaca tttctcccct tgacgccccc tgtctaccac ctccacctgg
     7081 aaatttgatc tttactgtgc tcagtgatca cgaaattggt caagcctatt catgttcctt
     7141 ctcatctaga attctgtgtg attgttttag cataaactgc cccgctccca ctgtatcatt
     7201 tcacgatctc cttttaatgt ttttctttca gttttgcact gacagtctgg tgacaggtgc
     7261 tgccagggtg caagttacat tgcaatgttc taaacctttt gaagtgttct tagcaaaagc
     7321 ctttctttct gggtgttttt gtcgaatgag tctatgaaga ctcaatgcat ccatcttggg
     7381 ctgatcatgc cacagatctc attccagcta tagtactgcc aagaagtgaa gtttatcatt
     7441 gaattttacc tgtgttgctc tcttttaaag taatgacttt gagatgcatg ctttgtatca
     7501 tattgaaaag tatgttttat tttccttaaa gttgtaatat tgtgtgtgaa actgtacata
     7561 ttttaaatga tgtagctttg gcaggtttta tttggttgat atgattttat attaaaagag
     7621 aaggctgctt tcatatagca tagcccctga aggtgggaat actccctgtt tgtacaacgc
     7681 tgcttatagt ttgtgattgg ggtgggcgaa tgtcttcctc tgaaattctt tggaaccccc
     7741 cacccctgtc ctcccctgaa actcccctgt gcacacccct ctgttctgac tgcagagatc
     7801 aaggccctga aggagcagga tcttgggcaa gtgttttagg ggacgctgag aacatacctg
     7861 accctggggg cgatgtggag gcaggcccac ctcctcgggg caactttgcg tttccttgga
     7921 gggaagggag gtgggtagga gaggagcttg ggaggatgag gaggagcggt cccgcctcac
     7981 acattgtcta tttttaccat taaccgagcg ccacatgttt atgaacttca ggatagaaat
     8041 ttagcctcct tgtgaaaacg ttttgtttta ctgccctaag aaaatacaca tctctaggct
     8101 tgtctgacca gaaagccagc aaagtctttt gcatcgggtg tggccctttt gtattttatt
     8161 tcccatattt aaataagcct tccttaaacc ctagccccag tcctgagagc tttgagggta
     8221 gccgaaaccc cttatctaat aaagtctaac tctgtgagaa ccaca
//
