LOCUS       NM_001801               1565 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens cysteine dioxygenase type 1 (CDO1), transcript variant
            2, mRNA.
ACCESSION   NM_001801
VERSION     NM_001801.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1565)
  AUTHORS   Wang,R., Yu,X., Ye,H., Ao,M., Xi,M. and Hou,M.
  TITLE     LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial cancer by
            promoting DNMT1-mediated CDO1 promoter hypermethylation
  JOURNAL   J Biol Chem 300 (9), 107680 (2024)
   PUBMED   39159808
  REMARK    GeneRIF: LncRNA FAM83H-AS1 inhibits ferroptosis of endometrial
            cancer by promoting DNMT1-mediated CDO1 promoter hypermethylation.
REFERENCE   2  (bases 1 to 1565)
  AUTHORS   Liu,Q. and Shen,W.Q.
  TITLE     [Molecular mechanism of CDO1 regulating common metabolic diseases]
  JOURNAL   Sheng Li Xue Bao 76 (4), 576-586 (2024)
   PUBMED   39192790
  REMARK    GeneRIF: [Molecular mechanism of CDO1 regulating common metabolic
            diseases].
            Review article
REFERENCE   3  (bases 1 to 1565)
  AUTHORS   Zhang,J., Yimamu,M., Cheng,Z., Ji,J., Wu,L., Feng,J., Xu,X., Wu,J.
            and Guo,C.
  TITLE     TRIM47-CDO1 axis dictates hepatocellular carcinoma progression by
            modulating ferroptotic cell death through the ubiquitin-proteasome
            system
  JOURNAL   Free Radic Biol Med 219, 31-48 (2024)
   PUBMED   38614226
  REMARK    GeneRIF: TRIM47-CDO1 axis dictates hepatocellular carcinoma
            progression by modulating ferroptotic cell death through the
            ubiquitin-proteasome system.
REFERENCE   4  (bases 1 to 1565)
  AUTHORS   Yan,X., Qi,Y., Yao,X., Zhou,N., Ye,X. and Chen,X.
  TITLE     DNMT3L inhibits hepatocellular carcinoma progression through DNA
            methylation of CDO1: insights from big data to basic research
  JOURNAL   J Transl Med 22 (1), 128 (2024)
   PUBMED   38308276
  REMARK    GeneRIF: DNMT3L inhibits hepatocellular carcinoma progression
            through DNA methylation of CDO1: insights from big data to basic
            research.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1565)
  AUTHORS   Yang,J., Sun,L., Liu,X.Y., Huang,C., Peng,J., Zeng,X., Zheng,H.,
            Cen,W., Xu,Y.X., Zhu,W., Wu,X.Y., Ling,D., Zhang,L.L., Wei,M.,
            Liu,Y., Wang,D., Wang,F.H., Li,Y.H., Li,Q. and Du,Z.
  TITLE     Targeted demethylation of the CDO1 promoter based on CRISPR system
            inhibits the malignant potential of breast cancer cells
  JOURNAL   Clin Transl Med 13 (9), e1423 (2023)
   PUBMED   37740473
  REMARK    GeneRIF: Targeted demethylation of the CDO1 promoter based on
            CRISPR system inhibits the malignant potential of breast cancer
            cells.
REFERENCE   6  (bases 1 to 1565)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   7  (bases 1 to 1565)
  AUTHORS   Qusti,S., Parsons,R.B., Abouglila,K.D., Waring,R.H., Williams,A.C.
            and Ramsden,D.B.
  TITLE     Development of an in vitro model for cysteine dioxygenase
            expression in the brain
  JOURNAL   Cell Biol Toxicol 16 (4), 243-255 (2000)
   PUBMED   11101006
REFERENCE   8  (bases 1 to 1565)
  AUTHORS   Ramsden,D.B., Kapadi,A., Fitch,N.J., Farmer,M.J., Bennett,P. and
            Williams,A.C.
  TITLE     Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5'
            flanking region and intron-exon structure of the gene
  JOURNAL   Mol Pathol 50 (5), 269-271 (1997)
   PUBMED   9497919
REFERENCE   9  (bases 1 to 1565)
  AUTHORS   Jeremiah,S., McCann,K.P., Williams,A.C., Ramsden,D.B., Pilz,A.J.,
            Fox,M.F. and Povey,S.
  TITLE     Chromosomal localisation of genes coding for human and mouse liver
            cytosolic cysteine dioxygenase
  JOURNAL   Ann Hum Genet 60 (1), 29-33 (1996)
   PUBMED   8835096
REFERENCE   10 (bases 1 to 1565)
  AUTHORS   McCann,K.P., Akbari,M.T., Williams,A.C. and Ramsden,D.B.
  TITLE     Human cysteine dioxygenase type I: primary structure derived from
            base sequencing of cDNA
  JOURNAL   Biochim Biophys Acta 1209 (1), 107-110 (1994)
   PUBMED   7524679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026449.6, AK130357.1 and BC024241.2.
            
            On Nov 23, 2018 this sequence version replaced NM_001801.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.703766.1,
                                           SRR5189664.105002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146, SAMEA2467147
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250535.5/ ENSP00000250535.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC026449.6         39819-39822         c
            5-1563              AK130357.1         16-1574
            1564-1565           BC024241.2         1563-1564
FEATURES             Location/Qualifiers
     source          1..1565
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q22.3"
     gene            1..1565
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /note="cysteine dioxygenase type 1"
                     /db_xref="GeneID:1036"
                     /db_xref="HGNC:HGNC:1795"
                     /db_xref="MIM:603943"
     exon            1..432
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..865
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /EC_number="1.13.11.20"
                     /note="isoform 2 is encoded by transcript variant 2;
                     cysteine dioxygenase, type I"
                     /codon_start=1
                     /product="cysteine dioxygenase type 1 isoform 2"
                     /protein_id="NP_001792.2"
                     /db_xref="CCDS:CCDS4121.1"
                     /db_xref="GeneID:1036"
                     /db_xref="HGNC:HGNC:1795"
                     /db_xref="MIM:603943"
                     /translation="MEQTEVLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDP
                     TEWAMYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNL
                     KETLFAWPDKKSNEMVKKSERVLRENQCAYINDSIGLHRVENISHTEPAVSLHLYSPP
                     FDTCHAFDQRTGHKNKVTMTFHSKFGIRTPNATSGSLENN"
     exon            433..510
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /inference="alignment:Splign:2.1.0"
     exon            511..665
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /inference="alignment:Splign:2.1.0"
     exon            666..835
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1565
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1544..1549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /note="hexamer: AATAAA"
     polyA_site      1565
                     /gene="CDO1"
                     /gene_synonym="CDO-I"
                     /note="major polyA site"
ORIGIN      
        1 acagatctga acctgatttg tgtgtgcacc gcgtctccag cgatcccgga tccactgcgc
       61 tgccaggggc ctgggggtgg gtctcttgct gtctctgcga cgacatcctt acgtttcggc
      121 actctaatgc tgggtttgtg cgtgtgtgtc tgcttagcgg tctagcgggc tgttaggctc
      181 cctcgccccc agctccttgg ctcgctcagc tcctccaccg cagcccagca gtgagacgcg
      241 cgcgcagcca gctccccacg agatggaaca gaccgaagtg ctgaagccac ggaccctggc
      301 tgatctgatc cgcatcctgc accagctctt tgccggcgat gaggtcaatg tagaggaggt
      361 gcaggccatc atggaagcct acgagagcga ccccaccgag tgggcaatgt acgccaagtt
      421 cgaccagtac aggtataccc gaaatcttgt ggatcaagga aatggaaaat ttaatctgat
      481 gattctctgt tggggtgaag gacatggcag cagtattcat gatcatacca actcccactg
      541 ctttctgaag atgctacagg gaaatctaaa ggagacatta tttgcctggc ctgacaaaaa
      601 atccaatgag atggtcaaga agtctgaaag agtcttgagg gaaaaccagt gtgcctacat
      661 caatgattcc attggcttac atcgagtaga gaacatcagc catacggaac ctgctgtgag
      721 ccttcacttg tacagtccac cttttgatac atgccatgcc tttgatcaaa gaacaggaca
      781 taaaaacaaa gtcacaatga cattccatag taaatttgga atcagaactc caaatgcaac
      841 ttcgggctcg ctggagaaca actaaggggc accaaaccct ctgaggtttt actttaaggt
      901 tcgctgtatg tttgccttgg acaaaaaggc tacctaccac gtgctatcca gtaatatact
      961 taaataagcc aatacttaga tctactgtaa ggcagatgct aattataagg cattaagtaa
     1021 gcaaatagtg ccctcagcta ctgcagaaga aaagtcccac tgaggaaaag aaagtcttgt
     1081 gatttttaaa ggcaagtttt caagtgctct catagttcta tcctctaatt ccattaaatc
     1141 catactagga gcgtcagtga gggttttcat agcttttgga aatactttgg tctctgaact
     1201 gtaattagca agaagtaaaa acagaaacgt caaacgtcaa atgtttgctt tgttacctgg
     1261 aggactaaat gtagatgtct ttagtatact ttgtatgttc ttaatattgg aagataattt
     1321 tgtgaatctg tagattttat tttttcagtc ttaccttaca aatttctttt ctatgaataa
     1381 tagaggaact tacggcactc tgccatttgt taatgaaagg aagtgcagag gatttagaaa
     1441 agtacatgat ccccagacca caacaaacca aaacataaac tcatgtctgt gtcccatggt
     1501 catagtcaaa gattttgtac tgctaaaatt accaaataat ttaaataaag tggatttgaa
     1561 cacaa
//
