LOCUS       NM_001029954            1390 bp    mRNA    linear   PRI 19-AUG-2024
DEFINITION  Homo sapiens cerebral dopamine neurotrophic factor (CDNF), mRNA.
ACCESSION   NM_001029954 XM_497214
VERSION     NM_001029954.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1390)
  AUTHORS   Nam,J., Richie,C.T., Harvey,B.K. and Voutilainen,M.H.
  TITLE     Delivery of CDNF by AAV-mediated gene transfer protects dopamine
            neurons and regulates ER stress and inflammation in an acute MPTP
            mouse model of Parkinson's disease
  JOURNAL   Sci Rep 14 (1), 16487 (2024)
   PUBMED   39019902
  REMARK    GeneRIF: Delivery of CDNF by AAV-mediated gene transfer protects
            dopamine neurons and regulates ER stress and inflammation in an
            acute MPTP mouse model of Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1390)
  AUTHORS   Konovalova,J., Gerasymchuk,D., Arroyo,S.N., Kluske,S.,
            Mastroianni,F., Pereyra,A.V. and Domanskyi,A.
  TITLE     Human-Specific Regulation of Neurotrophic Factors MANF and CDNF by
            microRNAs
  JOURNAL   Int J Mol Sci 22 (18), 9691 (2021)
   PUBMED   34575854
  REMARK    GeneRIF: Human-Specific Regulation of Neurotrophic Factors MANF and
            CDNF by microRNAs.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1390)
  AUTHORS   Albert,K., Raymundo,D.P., Panhelainen,A., Eesmaa,A., Shvachiy,L.,
            Araujo,G.R., Chmielarz,P., Yan,X., Singh,A., Cordeiro,Y.,
            Palhano,F.L., Foguel,D., Luk,K.C., Domanskyi,A., Voutilainen,M.H.,
            Huttunen,H.J., Outeiro,T.F., Saarma,M., Almeida,M.S. and
            Airavaara,M.
  TITLE     Cerebral dopamine neurotrophic factor reduces alpha-synuclein
            aggregation and propagation and alleviates behavioral alterations
            in vivo
  JOURNAL   Mol Ther 29 (9), 2821-2840 (2021)
   PUBMED   33940158
  REMARK    GeneRIF: Cerebral dopamine neurotrophic factor reduces
            alpha-synuclein aggregation and propagation and alleviates
            behavioral alterations in vivo.
REFERENCE   4  (bases 1 to 1390)
  AUTHORS   Eremin,D.V., Ilchibaeva,T.V. and Tsybko,A.S.
  TITLE     Cerebral Dopamine Neurotrophic Factor (CDNF): Structure, Functions,
            and Therapeutic Potential
  JOURNAL   Biochemistry (Mosc) 86 (7), 852-866 (2021)
   PUBMED   34284712
  REMARK    GeneRIF: Cerebral Dopamine Neurotrophic Factor (CDNF): Structure,
            Functions, and Therapeutic Potential.
            Review article
REFERENCE   5  (bases 1 to 1390)
  AUTHORS   Jaumotte,J.D., Saarma,M. and Zigmond,M.J.
  TITLE     Protection of dopamine neurons by CDNF and neurturin variant N4
            against MPP+ in dissociated cultures from rat mesencephalon
  JOURNAL   PLoS One 16 (2), e0245663 (2021)
   PUBMED   33534843
  REMARK    GeneRIF: Protection of dopamine neurons by CDNF and neurturin
            variant N4 against MPP+ in dissociated cultures from rat
            mesencephalon.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1390)
  AUTHORS   Choi,J.M., Hong,J.H., Chae,M.J., Ngyuen,P.H., Kang,H.S., Ma,H.I.
            and Kim,Y.J.
  TITLE     Analysis of mutations and the association between polymorphisms in
            the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson
            disease
  JOURNAL   Neurosci Lett 493 (3), 97-101 (2011)
   PUBMED   21320571
  REMARK    GeneRIF: Although no CDNF mutations are found in early-onset
            Parkinson's disease patient samples, a trend towards increased risk
            for Parkinson's in carriers of the C allele of rs7094179 single
            nucleotide polymorphism (SNP) is found.
REFERENCE   7  (bases 1 to 1390)
  AUTHORS   Lohoff,F.W., Bloch,P.J., Ferraro,T.N., Berrettini,W.H.,
            Pettinati,H.M., Dackis,C.A., O'Brien,C.P., Kampman,K.M. and
            Oslin,D.W.
  TITLE     Association analysis between polymorphisms in the conserved
            dopamine neurotrophic factor (CDNF) gene and cocaine dependence
  JOURNAL   Neurosci Lett 453 (3), 199-203 (2009)
   PUBMED   19429035
  REMARK    GeneRIF: Study suggests that there is no association between
            variants in the CDNF gene and cocaine dependence.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 1390)
  AUTHORS   Parkash,V., Lindholm,P., Peranen,J., Kalkkinen,N., Oksanen,E.,
            Saarma,M., Leppanen,V.M. and Goldman,A.
  TITLE     The structure of the conserved neurotrophic factors MANF and CDNF
            explains why they are bifunctional
  JOURNAL   Protein Eng Des Sel 22 (4), 233-241 (2009)
   PUBMED   19258449
  REMARK    GeneRIF: structures of MANF and CDNF were solved; structure
            explains why MANF and CDNF are bifunctional; neurotrophic activity
            may reside in the N-terminal domain and ER stress response in the
            C-terminal domain
REFERENCE   9  (bases 1 to 1390)
  AUTHORS   Lindholm,P., Voutilainen,M.H., Lauren,J., Peranen,J.,
            Leppanen,V.M., Andressoo,J.O., Lindahl,M., Janhunen,S.,
            Kalkkinen,N., Timmusk,T., Tuominen,R.K. and Saarma,M.
  TITLE     Novel neurotrophic factor CDNF protects and rescues midbrain
            dopamine neurons in vivo
  JOURNAL   Nature 448 (7149), 73-77 (2007)
   PUBMED   17611540
  REMARK    GeneRIF: expressed in several tissues; might be beneficial for the
            treatment of Parkinson's disease
REFERENCE   10 (bases 1 to 1390)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069544.9, AV657190.1, CN311321.1, BG213461.1, BQ025443.1 and
            AK131035.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001029954.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DC391788.1, SRR1660803.244857.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467146 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000465530.2/ ENSP00000419395.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC069544.9         151223-151275       c
            54-77               AV657190.1         97-120
            78-584              CN311321.1         1-507
            585-883             BG213461.1         112-410
            884-1232            BQ025443.1         163-511             c
            1233-1383           AK131035.1         438-588
            1384-1390           AC069544.9         132483-132489       c
FEATURES             Location/Qualifiers
     source          1..1390
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..1390
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /note="cerebral dopamine neurotrophic factor"
                     /db_xref="GeneID:441549"
                     /db_xref="HGNC:HGNC:24913"
                     /db_xref="MIM:611233"
     exon            1..206
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..655
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /note="conserved dopamine neurotrophic factor;
                     arginine-rich, mutated in early stage tumors-like 1;
                     ARMET-like protein 1"
                     /codon_start=1
                     /product="cerebral dopamine neurotrophic factor precursor"
                     /protein_id="NP_001025125.2"
                     /db_xref="CCDS:CCDS31148.1"
                     /db_xref="GeneID:441549"
                     /db_xref="HGNC:HGNC:24913"
                     /db_xref="MIM:611233"
                     /translation="MWCASPVAVVAFCAGLLVSHPVLTQGQEAGGRPGADCEVCKEFL
                     NRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRP
                     MSVHMPAMKICEKLKKLDSQICELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRA
                     CAEKTDYVNLIQELAPKYAATHPKTEL"
     exon            207..334
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            335..476
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /inference="alignment:Splign:2.1.0"
     exon            477..1390
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1074..1079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /note="hexamer: AATACA"
     polyA_site      1104
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /note="major polyA site"
     regulatory      1348..1353
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /note="hexamer: ATTAAA"
     regulatory      1358..1363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /note="hexamer: ATTAAA"
     polyA_site      1367
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
                     /note="major polyA site"
     polyA_site      1390
                     /gene="CDNF"
                     /gene_synonym="ARMETL1"
ORIGIN      
        1 ctttccaacc tcgaattctg ctcagctcgc tttggcagct tggtgggcgg tgggcgcggg
       61 tggcggaggc gattgaagct gctggcccag catgtggtgc gcgagcccag ttgctgtggt
      121 ggccttttgc gccgggcttt tggtctctca cccggtgctg acgcagggcc aggaggccgg
      181 ggggcggcca ggggccgact gtgaagtatg taaagaattc ttgaaccgat tctacaagtc
      241 actgatagac agaggagtta acttttcgct ggacactata gagaaagaat tgatcagttt
      301 ttgcttggac accaaaggaa aagaaaaccg cctgtgctat tatctaggag ccacaaaaga
      361 cgcagccaca aagatcctaa gtgaagtcac tcgcccaatg agtgtgcata tgcctgcaat
      421 gaagatttgt gagaagctga agaagttgga tagccagatc tgtgagctga aatatgaaaa
      481 aacactggac ttggcatcag ttgacctgcg gaagatgaga gtggcagagc tgaagcagat
      541 cctgcatagc tggggggagg agtgcagggc ctgtgcagaa aaaactgact atgtgaatct
      601 cattcaagag ctggccccca agtatgcagc gacacacccc aaaacagagc tctgatctcc
      661 aatgccagca catttgtgac ttgtaattag agagaaaagt gactctctag gatatggaca
      721 tgttgattaa ggataactgg gaatgcatca tatttggtct catgcttttt gtgttggtat
      781 tattcctcag aattttgtta cgtgggttta tgagtgaaac taatactact gataacttac
      841 atttgcagtg taccaaaagc taaaagttcc tttctcataa gtttcttgga atgactatgc
      901 cagttttcat tgcctgtctc ctaaaagtga cctactgaca aattgatgga gtaaattgat
      961 tccaagaaag aagaaggcat tcagagactc ctctctggat gcaattttaa aatatattgg
     1021 actaaaacaa aagacacaac agtcagctta tctaatgcac aacttcaatc ccaaatacag
     1081 aatcaaaagt ttttttcaag tgaattttct gttttcactc tatattgtag ctctctttgg
     1141 tatcagaaat ggtcaggcag gagtactcgt ttttcccatt ggaagaaaac ccacttaaac
     1201 ctacttaaag aaaatagaga gatcaagaaa ccgtataagt atagccaatg tttggcaatt
     1261 atatcaacat ttacattgtt aattgaacca agctcaaggt ctttttcatt ccttacagtc
     1321 acatatcaga caagtttttg atggaagatt aaagcatatt aaaaacactc ataggcaact
     1381 tggaacttta
//
