LOCUS       NM_005192                841 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin dependent kinase inhibitor 3 (CDKN3),
            transcript variant 1, mRNA.
ACCESSION   NM_005192
VERSION     NM_005192.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 841)
  AUTHORS   Qin,H., Wang,Q., Xu,J., Zeng,H., Liu,J., Yu,F. and Yang,J.
  TITLE     Integrative analysis of anoikis-related genes prognostic signature
            with immunotherapy and identification of CDKN3 as a key oncogene in
            lung adenocarcinoma
  JOURNAL   Int Immunopharmacol 143 (Pt 1), 113282 (2024)
   PUBMED   39383787
  REMARK    GeneRIF: Integrative analysis of anoikis-related genes prognostic
            signature with immunotherapy and identification of CDKN3 as a key
            oncogene in lung adenocarcinoma.
            Erratum:[Int Immunopharmacol. 2024 Dec 25;143(Pt 3):113584. doi:
            10.1016/j.intimp.2024.113584.. PMID: 39580329]
REFERENCE   2  (bases 1 to 841)
  AUTHORS   Zhang,J., Zhang,Y. and Zhang,J.
  TITLE     N6-Methyladenosine modified circ-NAB1 modulates cell cycle and
            epithelial-mesenchymal transition via CDKN3 in endometrial cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (5), 161-169 (2024)
   PUBMED   38814199
  REMARK    GeneRIF: N6-Methyladenosine modified circ-NAB1 modulates cell cycle
            and epithelial-mesenchymal transition via CDKN3 in endometrial
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 841)
  AUTHORS   Chen,Y., Li,D., Sha,K., Zhang,X. and Liu,T.
  TITLE     Human pan-cancer analysis of the predictive biomarker for the CDKN3
  JOURNAL   Eur J Med Res 29 (1), 272 (2024)
   PUBMED   38720365
  REMARK    GeneRIF: Human pan-cancer analysis of the predictive biomarker for
            the CDKN3.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 841)
  AUTHORS   Al Sharie,A.H., Abu Zahra,A.M., El-Elimat,T., Darweesh,R.F.,
            Al-Khaldi,A.K., Abu Mousa,B.M., Amer,M.S.B., Al Zu'bi,Y.O.,
            Al-Kammash,K., Abu Lil,A., Al Malkawi,A.A., Alazzeh,Z. and
            Alali,F.Q.
  TITLE     Cyclin dependent kinase inhibitor 3 (CDKN3) upregulation is
            associated with unfavorable prognosis in clear cell renal cell
            carcinoma and shapes tumor immune microenvironment: A
            bioinformatics analysis
  JOURNAL   Medicine (Baltimore) 102 (36), e35004 (2023)
   PUBMED   37682177
  REMARK    GeneRIF: Cyclin dependent kinase inhibitor 3 (CDKN3) upregulation
            is associated with unfavorable prognosis in clear cell renal cell
            carcinoma and shapes tumor immune microenvironment: A
            bioinformatics analysis.
REFERENCE   5  (bases 1 to 841)
  AUTHORS   Zhu,S. and Fang,Z.
  TITLE     MicroRNA-127-3p Inhibits Cardiomyocyte Inflammation and Apoptosis
            after Acute Myocardial Infarction via Targeting CDKN3
  JOURNAL   Int Heart J 64 (6), 1133-1139 (2023)
   PUBMED   38030294
  REMARK    GeneRIF: MicroRNA-127-3p Inhibits Cardiomyocyte Inflammation and
            Apoptosis after Acute Myocardial Infarction via Targeting CDKN3.
REFERENCE   6  (bases 1 to 841)
  AUTHORS   Poon,R.Y. and Hunter,T.
  TITLE     Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent
            kinase-interacting phosphatase KAP in the absence of cyclin
  JOURNAL   Science 270 (5233), 90-93 (1995)
   PUBMED   7569954
REFERENCE   7  (bases 1 to 841)
  AUTHORS   Demetrick,D.J., Matsumoto,S., Hannon,G.J., Okamoto,K., Xiong,Y.,
            Zhang,H. and Beach,D.H.
  TITLE     Chromosomal mapping of the genes for the human cell cycle proteins
            cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)
  JOURNAL   Cytogenet Cell Genet 69 (3-4), 190-192 (1995)
   PUBMED   7698009
REFERENCE   8  (bases 1 to 841)
  AUTHORS   Hannon,G.J., Casso,D. and Beach,D.
  TITLE     KAP: a dual specificity phosphatase that interacts with
            cyclin-dependent kinases
  JOURNAL   Proc Natl Acad Sci U S A 91 (5), 1731-1735 (1994)
   PUBMED   8127873
REFERENCE   9  (bases 1 to 841)
  AUTHORS   Harper,J.W., Adami,G.R., Wei,N., Keyomarsi,K. and Elledge,S.J.
  TITLE     The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1
            cyclin-dependent kinases
  JOURNAL   Cell 75 (4), 805-816 (1993)
   PUBMED   8242751
REFERENCE   10 (bases 1 to 841)
  AUTHORS   Gyuris,J., Golemis,E., Chertkov,H. and Brent,R.
  TITLE     Cdi1, a human G1 and S phase protein phosphatase that associates
            with Cdk2
  JOURNAL   Cell 75 (4), 791-803 (1993)
   PUBMED   8242750
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK098653.1 and BC064965.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005192.3.
            
            Summary: The protein encoded by this gene belongs to the dual
            specificity protein phosphatase family. It was identified as a
            cyclin-dependent kinase inhibitor, and has been shown to interact
            with, and dephosphorylate CDK2 kinase, thus prevent the activation
            of CDK2 kinase. This gene was reported to be deleted, mutated, or
            overexpressed in several kinds of cancers. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Aug 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.434556.1,
                                           SRR1163655.602463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335183.11/ ENSP00000335357.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-837               AK098653.1         53-889
            838-841             BC064965.1         730-733
FEATURES             Location/Qualifiers
     source          1..841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.2"
     gene            1..841
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /note="cyclin dependent kinase inhibitor 3"
                     /db_xref="GeneID:1033"
                     /db_xref="HGNC:HGNC:1791"
                     /db_xref="MIM:123832"
     exon            1..71
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..701
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /EC_number="3.1.3.16"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cyclin-dependent kinase interactor 1; cyclin-dependent
                     kinase interacting protein 2; CDK2-associated dual
                     specificity phosphatase; cyclin-dependent kinase
                     inhibitor; kinase-associated phosphatase; Cdk-associated
                     protein phosphatase"
                     /codon_start=1
                     /product="cyclin-dependent kinase inhibitor 3 isoform 1"
                     /protein_id="NP_005183.2"
                     /db_xref="CCDS:CCDS9716.1"
                     /db_xref="GeneID:1033"
                     /db_xref="HGNC:HGNC:1791"
                     /db_xref="MIM:123832"
                     /translation="MKPPSSIQTSEFDSSDEEPIEDEQTPIHISWLSLSRVNCSQFLG
                     LCALPGCKFKDVRRNVQKDTEELKSCGIQDIFVFCTRGELSKYRVPNLLDLYQQCGII
                     THHHPIADGGTPDIASCCEIMEELTTCLKNYRKTLIHCYGGLGRSCLVAACLLLYLSD
                     TISPEQAIDSLRDLRGSGAIQTIKQYNYLHEFRDKLAAHLSSRDSQSRSVSR"
     exon            72..154
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            155..210
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            211..255
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            256..478
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..510
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            511..614
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..841
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      841
                     /gene="CDKN3"
                     /gene_synonym="CDI1; CIP2; KAP; KAP1"
                     /note="major polyA site"
ORIGIN      
        1 accggtgagt cgccggcgct gcagagggag gcggcactgg tctcgacgtg gggcggccag
       61 cgatgaagcc gcccagttca atacaaacaa gtgagtttga ctcatcagat gaagagccta
      121 ttgaagatga acagactcca attcatatat catggctatc tttgtcacga gtgaattgtt
      181 ctcagtttct cggtttatgt gctcttccag gttgtaaatt taaagatgtt agaagaaatg
      241 tccaaaaaga tacagaagaa ctaaagagct gtggtataca agacatattt gttttctgca
      301 ccagagggga actgtcaaaa tatagagtcc caaaccttct ggatctctac cagcaatgtg
      361 gaattatcac ccatcatcat ccaatcgcag atggagggac tcctgacata gccagctgct
      421 gtgaaataat ggaagagctt acaacctgcc ttaaaaatta ccgaaaaacc ttaatacact
      481 gctatggagg acttgggaga tcttgtcttg tagctgcttg tctcctacta tacctgtctg
      541 acacaatatc accagagcaa gccatagaca gcctgcgaga cctaagagga tccggggcaa
      601 tacagaccat caagcaatac aattatcttc atgagtttcg ggacaaatta gctgcacatc
      661 tatcatcaag agattcacaa tcaagatctg tatcaagata aaggaattca aatagcatat
      721 atatgaccat gtctgaaatg tcagttctct agcataattt gtattgaaat gaaaccacca
      781 gtgttatcaa cttgaatgta aatgtacatg tgcagatatt cctaaagttt tattgacaaa
      841 a
//
