LOCUS       NM_001800               1425 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens cyclin dependent kinase inhibitor 2D (CDKN2D),
            transcript variant 1, mRNA.
ACCESSION   NM_001800
VERSION     NM_001800.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1425)
  AUTHORS   Duparc,H., Muller,D., Gilles,L., Chedeville,A.L., El Khoury,M.,
            Guignard,R., Debili,N., Wittner,M., Kauskot,A., Pasquier,F.,
            Antony-Debre,I., Marty,C., Vainchenker,W., Plo,I. and Raslova,H.
  TITLE     Deregulation of the p19/CDK4/CDK6 axis in Jak2V617F megakaryocytes
            accelerates the development of myelofibrosis
  JOURNAL   Leukemia 38 (4), 898-902 (2024)
   PUBMED   38378843
  REMARK    GeneRIF: Deregulation of the p19/CDK4/CDK6 axis in Jak2[V617F]
            megakaryocytes accelerates the development of myelofibrosis.
REFERENCE   2  (bases 1 to 1425)
  AUTHORS   Lucci,V., De Marino,E., Tagliaferri,D., Amente,S., Pollice,A.,
            Calabro,V., Vivo,M., Falco,G. and Angrisano,T.
  TITLE     Identification of Cdk8 and Cdkn2d as New Prame-Target Genes in
            2C-like Embryonic Stem Cells
  JOURNAL   Genes (Basel) 13 (10), 1745 (2022)
   PUBMED   36292630
  REMARK    GeneRIF: Identification of <i>Cdk8</i> and <i>Cdkn2d</i> as New
            Prame-Target Genes in 2C-like Embryonic Stem Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1425)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1425)
  AUTHORS   Kuang,Y., Han,X., Cao,P., Xiong,D., Peng,Y., Liu,Z., Xu,Z.,
            Liang,L., Roy,M., Liu,J., Nie,L. and Zhang,J.
  TITLE     p19INK4d inhibits proliferation and enhances imatinib efficacy
            through BCR-ABL signaling pathway in chronic myeloid leukemia
  JOURNAL   Blood Cells Mol Dis 85, 102477 (2020)
   PUBMED   32711219
  REMARK    GeneRIF: p19(INK4d) inhibits proliferation and enhances imatinib
            efficacy through BCR-ABL signaling pathway in chronic myeloid
            leukemia.
REFERENCE   5  (bases 1 to 1425)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   6  (bases 1 to 1425)
  AUTHORS   Schwaller,J., Pabst,T., Koeffler,H.P., Niklaus,G., Loetscher,P.,
            Fey,M.F. and Tobler,A.
  TITLE     Expression and regulation of G1 cell-cycle inhibitors (p16INK4A,
            p15INK4B, p18INK4C, p19INK4D) in human acute myeloid leukemia and
            normal myeloid cells
  JOURNAL   Leukemia 11 (1), 54-63 (1997)
   PUBMED   9001419
REFERENCE   7  (bases 1 to 1425)
  AUTHORS   Guan,K.L., Jenkins,C.W., Li,Y., O'Keefe,C.L., Noh,S., Wu,X.,
            Zariwala,M., Matera,A.G. and Xiong,Y.
  TITLE     Isolation and characterization of p19INK4d, a p16-related inhibitor
            specific to CDK6 and CDK4
  JOURNAL   Mol Biol Cell 7 (1), 57-70 (1996)
   PUBMED   8741839
REFERENCE   8  (bases 1 to 1425)
  AUTHORS   Okuda,T., Hirai,H., Valentine,V.A., Shurtleff,S.A., Kidd,V.J.,
            Lahti,J.M., Sherr,C.J. and Downing,J.R.
  TITLE     Molecular cloning, expression pattern, and chromosomal localization
            of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases
  JOURNAL   Genomics 29 (3), 623-630 (1995)
   PUBMED   8575754
REFERENCE   9  (bases 1 to 1425)
  AUTHORS   Chan,F.K., Zhang,J., Cheng,L., Shapiro,D.N. and Winoto,A.
  TITLE     Identification of human and mouse p19, a novel CDK4 and CDK6
            inhibitor with homology to p16ink4
  JOURNAL   Mol Cell Biol 15 (5), 2682-2688 (1995)
   PUBMED   7739548
REFERENCE   10 (bases 1 to 1425)
  AUTHORS   Hirai,H., Roussel,M.F., Kato,J.Y., Ashmun,R.A. and Sherr,C.J.
  TITLE     Novel INK4 proteins, p19 and p18, are specific inhibitors of the
            cyclin D-dependent kinases CDK4 and CDK6
  JOURNAL   Mol Cell Biol 15 (5), 2672-2681 (1995)
   PUBMED   7739547
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011475.6.
            
            On May 17, 2019 this sequence version replaced NM_001800.3.
            
            Summary: The protein encoded by this gene is a member of the INK4
            family of cyclin-dependent kinase inhibitors. This protein has been
            shown to form a stable complex with CDK4 or CDK6, and prevent the
            activation of the CDK kinases, thus function as a cell growth
            regulator that controls cell cycle G1 progression. The abundance of
            the transcript of this gene was found to oscillate in a cell-cycle
            dependent manner with the lowest expression at mid G1 and a maximal
            expression during S phase. The negative regulation of the cell
            cycle involved in this protein was shown to participate in
            repressing neuronal proliferation, as well as spermatogenesis. Two
            alternatively spliced variants of this gene, which encode an
            identical protein, have been reported. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) contains a different 5' UTR
            region, and encodes an identical protein, as compared to variant 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138524.474597.1,
                                           DRR138517.885339.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393599.3/ ENSP00000377224.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               AC011475.6         158947-159413
            468-1425            AC011475.6         160509-161466
FEATURES             Location/Qualifiers
     source          1..1425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1425
                     /gene="CDKN2D"
                     /gene_synonym="INK4D; p19; p19-INK4D"
                     /note="cyclin dependent kinase inhibitor 2D"
                     /db_xref="GeneID:1032"
                     /db_xref="HGNC:HGNC:1790"
                     /db_xref="MIM:600927"
     exon            1..467
                     /gene="CDKN2D"
                     /gene_synonym="INK4D; p19; p19-INK4D"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..827
                     /gene="CDKN2D"
                     /gene_synonym="INK4D; p19; p19-INK4D"
                     /note="CDK inhibitor p19INK4d; cyclin-dependent kinase 4
                     inhibitor D p19; inhibitor of cyclin-dependent kinase 4d;
                     cell cycle inhibitor, Nur77 associating protein;
                     cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4 inhibitor D"
                     /protein_id="NP_001791.1"
                     /db_xref="CCDS:CCDS12244.1"
                     /db_xref="GeneID:1032"
                     /db_xref="HGNC:HGNC:1790"
                     /db_xref="MIM:600927"
                     /translation="MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKT
                     ALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLVEHGADVNV
                     PDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDILQG
                     HMVAPL"
     exon            468..1425
                     /gene="CDKN2D"
                     /gene_synonym="INK4D; p19; p19-INK4D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDKN2D"
                     /gene_synonym="INK4D; p19; p19-INK4D"
                     /note="hexamer: ATTAAA"
     polyA_site      1425
                     /gene="CDKN2D"
                     /gene_synonym="INK4D; p19; p19-INK4D"
                     /note="major polyA site"
ORIGIN      
        1 agagcagacc ccgcccggcg aggaggaggg agggtgagtt agggggagac ccggccccca
       61 aggggcgggc gccgggcagg gccccgcggg cggccgaggg ttgggcccgg ctcccagccc
      121 ctcgccgtcc tccggctgac agggggagga gcccgccggg agggccgggg tctcgggctg
      181 gggagccggg acgggagagc agcgcagccg ggtgcaccgc ggccgcgccc cgggagggct
      241 gttcgggcca gcgcccgccg gctgctccgc gctgacagcg ccgggctggg gcggggcggg
      301 gggctttgca ggccgccagt gtcgacatgc tgctggagga ggttcgcgcc ggcgaccggc
      361 tgagtggggc ggcggcccgg ggcgacgtgc aggaggtgcg ccgccttctg caccgggagc
      421 tggtgcatcc cgacgccctc aaccgcttcg gcaagacggc gctgcaggtc atgatgtttg
      481 gcagcaccgc catcgccctg gagctgctga agcaaggtgc cagccccaat gtccaggaca
      541 cctccggtac cagtccagtc catgacgcag cccgcactgg attcctggac accctgaagg
      601 tcctagtgga gcacggggct gatgtcaacg tgcctgatgg caccggggca cttccaatcc
      661 atctggcagt tcaagagggt cacactgctg tggtcagctt tctggcagct gaatctgatc
      721 tccatcgcag ggacgccagg ggtctcacac ccttggagct ggcactgcag agaggggctc
      781 aggacctcgt ggacatcctg cagggccaca tggtggcccc gctgtgatct ggggtcaccc
      841 tctccagcaa gagaaccccg tggggttatg tatcagaaga gaggggaaga aacactttct
      901 cttcttgttt ctcctgccca ctgctgcagt aggggaggag cacagtttgt ggcttatagg
      961 tgttggtttt gggggtgtga gtgtttgggg gacgtttctc atttgttttt ctcactcctt
     1021 ttggtgtgtt ggacagagaa gggctcctgc aggccacagc cacctaaacg gttcagtttc
     1081 ttctgcgcct caggctgctg gggcctcaga cgagacccaa gggcagagca tttaagagtg
     1141 aagtcatgac ctccagggag cctagaagct ggtggccttg gccggctgtg ctcagagacc
     1201 tgaagtgtgc acgttgcttc aggcatgggg ggtgggggga gcgtcccaaa tcaataagaa
     1261 ggtagaatga gttatgagtt attcatattc tgttggaagc ttgttttcca gtctcttgta
     1321 cagcgtttta aaagaaatgg attctattta ttatgcttta ttggaaaaaa tgttgtaata
     1381 atttaatgtt tttacccatt aaattaagac ttgtgcatga tcaca
//
