LOCUS       NM_078626                995 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens cyclin dependent kinase inhibitor 2C (CDKN2C),
            transcript variant 2, mRNA.
ACCESSION   NM_078626
VERSION     NM_078626.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 995)
  AUTHORS   Chen,H., Su,Y., Yang,L., Xi,L., Li,X., Lan,B., Liu,M. and Xuan,C.
  TITLE     CBX8 promotes lung adenocarcinoma growth and metastasis through
            transcriptional repression of CDKN2C and SCEL
  JOURNAL   J Cell Physiol 238 (11), 2710-2723 (2023)
   PUBMED   37733753
  REMARK    GeneRIF: CBX8 promotes lung adenocarcinoma growth and metastasis
            through transcriptional repression of CDKN2C and SCEL.
REFERENCE   2  (bases 1 to 995)
  AUTHORS   Bai,F., Liu,X., Zhang,X., Mao,Z., Wen,H., Ma,J. and Pei,X.H.
  TITLE     p18INK4C and BRCA1 inhibit follicular cell proliferation and
            dedifferentiation in thyroid cancer
  JOURNAL   Cell Cycle 22 (13), 1637-1653 (2023)
   PUBMED   37345432
  REMARK    GeneRIF: p18INK4C and BRCA1 inhibit follicular cell proliferation
            and dedifferentiation in thyroid cancer.
REFERENCE   3  (bases 1 to 995)
  AUTHORS   Zhu,Q., Zhu,Z., Renaud,S.J., Hu,L. and Guo,Y.
  TITLE     The Oncogenic Role of Cyclin-Dependent Kinase Inhibitor 2C in
            Lower-Grade Glioma
  JOURNAL   J Mol Neurosci 73 (6), 327-344 (2023)
   PUBMED   37223854
  REMARK    GeneRIF: The Oncogenic Role of Cyclin-Dependent Kinase Inhibitor 2C
            in Lower-Grade Glioma.
REFERENCE   4  (bases 1 to 995)
  AUTHORS   Mazarico-Altisent,I., Capel,I., Baena,N., Bella-Cueto,M.R.,
            Barcons,S., Guirao,X., Albert,L., Cano,A., Pareja,R., Caixas,A. and
            Rigla,M.
  TITLE     Novel germline variants of CDKN1B and CDKN2C identified during
            screening for familial primary hyperparathyroidism
  JOURNAL   J Endocrinol Invest 46 (4), 829-840 (2023)
   PUBMED   36334246
  REMARK    GeneRIF: Novel germline variants of CDKN1B and CDKN2C identified
            during screening for familial primary hyperparathyroidism.
REFERENCE   5  (bases 1 to 995)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 995)
  AUTHORS   Ragione,F.D., Russo,G.L., Oliva,A., Mercurio,C., Mastropietro,S.,
            Pietra,V.D. and Zappia,V.
  TITLE     Biochemical characterization of p16INK4- and p18-containing
            complexes in human cell lines
  JOURNAL   J Biol Chem 271 (27), 15942-15949 (1996)
   PUBMED   8663131
REFERENCE   7  (bases 1 to 995)
  AUTHORS   Simos,G., Maison,C. and Georgatos,S.D.
  TITLE     Characterization of p18, a component of the lamin B receptor
            complex and a new integral membrane protein of the avian
            erythrocyte nuclear envelope
  JOURNAL   J Biol Chem 271 (21), 12617-12625 (1996)
   PUBMED   8647873
REFERENCE   8  (bases 1 to 995)
  AUTHORS   Guan,K.L., Jenkins,C.W., Li,Y., Nichols,M.A., Wu,X., O'Keefe,C.L.,
            Matera,A.G. and Xiong,Y.
  TITLE     Growth suppression by p18, a p16INK4/MTS1- and
            p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb
            function
  JOURNAL   Genes Dev 8 (24), 2939-2952 (1994)
   PUBMED   8001816
REFERENCE   9  (bases 1 to 995)
  AUTHORS   Serrano,M., Hannon,G.J. and Beach,D.
  TITLE     A new regulatory motif in cell-cycle control causing specific
            inhibition of cyclin D/CDK4
  JOURNAL   Nature 366 (6456), 704-707 (1993)
   PUBMED   8259215
REFERENCE   10 (bases 1 to 995)
  AUTHORS   Ghosh,P.K., Anderson,J., Cohen,N., Takeshita,K., Atweh,G.F. and
            Lebowitz,P.
  TITLE     Expression of the leukemia-associated gene, p18, in normal and
            malignant tissues; inactivation of expression in a patient with
            cleaved B cell lymphoma/leukemia
  JOURNAL   Oncogene 8 (10), 2869-2872 (1993)
   PUBMED   8397372
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BE831176.1, U17074.1 and
            BE783451.1.
            
            On Nov 23, 2018 this sequence version replaced NM_078626.2.
            
            Summary: The protein encoded by this gene is a member of the INK4
            family of cyclin-dependent kinase inhibitors. This protein has been
            shown to interact with CDK4 or CDK6, and prevent the activation of
            the CDK kinases, thus function as a cell growth regulator that
            controls cell cycle G1 progression. Ectopic expression of this gene
            was shown to suppress the growth of human cells in a manner that
            appears to correlate with the presence of a wild-type RB1 function.
            Studies in the knockout mice suggested the roles of this gene in
            regulating spermatogenesis, as well as in suppressing
            tumorigenesis. Two alternatively spliced transcript variants of
            this gene, which encode an identical protein, have been reported.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) contains a different 5' UTR
            region, and encodes an identical protein, when compared to variant
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.178934.1,
                                           SRR5189658.127989.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371761.4/ ENSP00000360826.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                BE831176.1         304-334
            32-631              U17074.1           1-600
            632-995             BE783451.1         56-419
FEATURES             Location/Qualifiers
     source          1..995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..995
                     /gene="CDKN2C"
                     /gene_synonym="INK4C; p18; p18-INK4C"
                     /note="cyclin dependent kinase inhibitor 2C"
                     /db_xref="GeneID:1031"
                     /db_xref="HGNC:HGNC:1789"
                     /db_xref="MIM:603369"
     exon            1..253
                     /gene="CDKN2C"
                     /gene_synonym="INK4C; p18; p18-INK4C"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..631
                     /gene="CDKN2C"
                     /gene_synonym="INK4C; p18; p18-INK4C"
                     /note="cyclin-dependent kinase 6 inhibitor p18; CDK6
                     inhibitor p18; cyclin-dependent inhibitor; p18-INK6;
                     cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4 inhibitor C"
                     /protein_id="NP_523240.1"
                     /db_xref="CCDS:CCDS555.1"
                     /db_xref="GeneID:1031"
                     /db_xref="HGNC:HGNC:1789"
                     /db_xref="MIM:603369"
                     /translation="MAEPWGNELASAAARGDLEQLTSLLQNNVNVNAQNGFGRTALQV
                     MKLGNPEIARRLLLRGANPDLKDRTGFAVIHDAARAGFLDTLQTLLEFQADVNIEDNE
                     GNLPLHLAAKEGHLRVVEFLVKHTASNVGHRNHKGDTACDLARLYGRNEVVSLMQANG
                     AGGATNLQ"
     exon            254..995
                     /gene="CDKN2C"
                     /gene_synonym="INK4C; p18; p18-INK4C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      973..978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDKN2C"
                     /gene_synonym="INK4C; p18; p18-INK4C"
                     /note="hexamer: ATTAAA"
     polyA_site      995
                     /gene="CDKN2C"
                     /gene_synonym="INK4C; p18; p18-INK4C"
                     /note="major polyA site"
ORIGIN      
        1 agattaacca tcccagtcct tctgtcagtc tccgatgcca tcatgcagcc tggttaggag
       61 caaaggaaag gggaaaaaga aaaacgacta attcatcttt tcctgatcgt caggacccta
      121 aagaatggcc gagccttggg ggaacgagtt ggcgtccgca gctgccaggg gggacctaga
      181 gcaacttact agtttgttgc aaaataatgt aaacgtcaat gcacaaaatg gatttggaag
      241 gactgcgctg caggttatga aacttggaaa tcccgagatt gccaggagac tgctacttag
      301 aggtgctaat cccgatttga aagaccgaac tggtttcgct gtcattcatg atgcggccag
      361 agcaggtttc ctggacactt tacagacttt gctggagttt caagctgatg ttaacatcga
      421 ggataatgaa gggaacctgc ccttgcactt ggctgccaaa gaaggccacc tccgggtggt
      481 ggagttcctg gtgaagcaca cggccagcaa tgtggggcat cggaaccata agggggacac
      541 cgcctgtgat ttggccaggc tctatgggag gaatgaggtt gttagcctga tgcaggcaaa
      601 cggggctggg ggagccacaa atcttcaata aacgtgggga gggctccccc acgttgcctc
      661 tactttatca attaactgag tagctctcct gacttttaat gtcatttgtt aaaatacagt
      721 tctgtcatat gttaagcagc taaattttct gaaactgcat aagtgaaaat cttacaacag
      781 gcttatgaat atatttaagc aacatctttt taacctgcaa aatctgttct aacatgtaat
      841 tgcagataac tttgactttc ttctgaatat tttatctttc cttggctttt cccttgcttc
      901 cccttttgcc aatctcaaca cccaagttga agactttgtt tttaaaatgg tttgtcctga
      961 tgcttttgtc taattaaaac actttcaaaa cagga
//
