LOCUS       NM_004936               3853 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens cyclin dependent kinase inhibitor 2B (CDKN2B),
            transcript variant 1, mRNA.
ACCESSION   NM_004936
VERSION     NM_004936.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3853)
  AUTHORS   Ranade,M., Epari,S., Shetty,O., Dhanavade,S., Chavan,S., Sahay,A.,
            Sahu,A., Shetty,P., Moiyadi,A., Singh,V., Dasgupta,A.,
            Chatterjee,A., Kannan,S. and Gupta,T.
  TITLE     CDKN2A/B deletion in IDH-mutant astrocytomas: An evaluation by
            Fluorescence in-situ hybridization
  JOURNAL   J Neurooncol 167 (1), 189-198 (2024)
   PUBMED   38265748
  REMARK    GeneRIF: CDKN2A/B deletion in IDH-mutant astrocytomas: An
            evaluation by Fluorescence in-situ hybridization.
            Erratum:[J Neurooncol. 2024 Mar;167(1):199. doi:
            10.1007/s11060-024-04597-3.. PMID: 38358407]
REFERENCE   2  (bases 1 to 3853)
  AUTHORS   Takata,K., Miyata-Takata,T. and Sato,Y.
  TITLE     Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular
            lymphoma is related to duodenal reactive lymphoid hyperplasia
  JOURNAL   J Clin Exp Hematop 64 (2), 129-137 (2024)
   PUBMED   38925973
  REMARK    GeneRIF: Frequent CDKN2B/P15 and DAPK1 methylation in duodenal
            follicular lymphoma is related to duodenal reactive lymphoid
            hyperplasia.
REFERENCE   3  (bases 1 to 3853)
  AUTHORS   Beihaghi,M., Sahebi,R., Beihaghi,M.R., Nessiani,R.K., Yarasmi,M.R.,
            Gholamalizadeh,S., Shahabnavaie,F. and Shojaei,M.
  TITLE     Evaluation of rs10811661 polymorphism in CDKN2A / B in colon and
            gastric cancer
  JOURNAL   BMC Cancer 23 (1), 985 (2023)
   PUBMED   37845622
  REMARK    GeneRIF: Evaluation of rs10811661 polymorphism in CDKN2A / B in
            colon and gastric cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3853)
  AUTHORS   Ruan,Y., Xie,L. and Zou,A.
  TITLE     Association of CDKN2A/B mutations, PD-1, and PD-L1 with the risk of
            acute lymphoblastic leukemia in children
  JOURNAL   J Cancer Res Clin Oncol 149 (12), 10841-10850 (2023)
   PUBMED   37314514
  REMARK    GeneRIF: Association of CDKN2A/B mutations, PD-1, and PD-L1 with
            the risk of acute lymphoblastic leukemia in children.
REFERENCE   5  (bases 1 to 3853)
  AUTHORS   Mokhtari,M., Gholipour,M., Eslami,S., Abak,A., Hussen,B.M.,
            Rakhshan,A. and Ghafouri-Fard,S.
  TITLE     Expression analysis of cytoskeleton regulator RNA and Cyclin
            Dependent Kinase Inhibitor 2B genes in breast cancer
  JOURNAL   Hum Antibodies 31 (3), 51-57 (2023)
   PUBMED   37482988
  REMARK    GeneRIF: Expression analysis of cytoskeleton regulator RNA and
            Cyclin Dependent Kinase Inhibitor 2B genes in breast cancer.
REFERENCE   6  (bases 1 to 3853)
  AUTHORS   Hall,M., Bates,S. and Peters,G.
  TITLE     Evidence for different modes of action of cyclin-dependent kinase
            inhibitors: p15 and p16 bind to kinases, p21 and p27 bind to
            cyclins
  JOURNAL   Oncogene 11 (8), 1581-1588 (1995)
   PUBMED   7478582
REFERENCE   7  (bases 1 to 3853)
  AUTHORS   Stone,S., Dayananth,P., Jiang,P., Weaver-Feldhaus,J.M.,
            Tavtigian,S.V., Cannon-Albright,L. and Kamb,A.
  TITLE     Genomic structure, expression and mutational analysis of the P15
            (MTS2) gene
  JOURNAL   Oncogene 11 (5), 987-991 (1995)
   PUBMED   7675459
REFERENCE   8  (bases 1 to 3853)
  AUTHORS   Okamoto,A., Hussain,S.P., Hagiwara,K., Spillare,E.A., Rusin,M.R.,
            Demetrick,D.J., Serrano,M., Hannon,G.J., Shiseki,M., Zariwala,M. et
            al.
  TITLE     Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes
            in primary and metastatic lung cancer
  JOURNAL   Cancer Res 55 (7), 1448-1451 (1995)
   PUBMED   7882351
REFERENCE   9  (bases 1 to 3853)
  AUTHORS   Guan,K.L., Jenkins,C.W., Li,Y., Nichols,M.A., Wu,X., O'Keefe,C.L.,
            Matera,A.G. and Xiong,Y.
  TITLE     Growth suppression by p18, a p16INK4/MTS1- and
            p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb
            function
  JOURNAL   Genes Dev 8 (24), 2939-2952 (1994)
   PUBMED   8001816
REFERENCE   10 (bases 1 to 3853)
  AUTHORS   Jen,J., Harper,J.W., Bigner,S.H., Bigner,D.D., Papadopoulos,N.,
            Markowitz,S., Willson,J.K., Kinzler,K.W. and Vogelstein,B.
  TITLE     Deletion of p16 and p15 genes in brain tumors
  JOURNAL   Cancer Res 54 (24), 6353-6358 (1994)
   PUBMED   7987828
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI560960.1, BC014469.1,
            BC018984.2 and AF488731.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004936.3.
            
            Summary: This gene lies adjacent to the tumor suppressor gene
            CDKN2A in a region that is frequently mutated and deleted in a wide
            variety of tumors. This gene encodes a cyclin-dependent kinase
            inhibitor, which forms a complex with CDK4 or CDK6, and prevents
            the activation of the CDK kinases, thus the encoded protein
            functions as a cell growth regulator that controls cell cycle G1
            progression. The expression of this gene was found to be
            dramatically induced by TGF beta, which suggested its role in the
            TGF beta induced growth inhibition. Two alternatively spliced
            transcript variants of this gene, which encode distinct proteins,
            have been reported. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA583791.1, SRR1660809.249517.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000276925.7/ ENSP00000276925.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BI560960.1         62-85
            25-1613             BC014469.1         1-1589
            1614-2382           BC014469.1         1592-2360
            2383-2426           BC018984.2         1285-1328
            2427-3853           AF488731.1         1-1427
FEATURES             Location/Qualifiers
     source          1..3853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..3853
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
                     /note="cyclin dependent kinase inhibitor 2B"
                     /db_xref="GeneID:1030"
                     /db_xref="HGNC:HGNC:1788"
                     /db_xref="MIM:600431"
     exon            1..508
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
                     /inference="alignment:Splign:2.1.0"
     CDS             353..769
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multiple tumor suppressor 2; p14_CDK inhibitor; p14_INK4B;
                     p15_INK4B; CDK4B inhibitor; p15 CDK inhibitor;
                     cyclin-dependent kinases 4 and 6 binding protein; CDK
                     inhibitory protein; cyclin-dependent kinase 4 inhibitor B;
                     cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4);
                     MTS-2; p14-INK4b; p15-INK4b"
                     /codon_start=1
                     /product="cyclin-dependent kinase 4 inhibitor B isoform 1"
                     /protein_id="NP_004927.2"
                     /db_xref="CCDS:CCDS6512.1"
                     /db_xref="GeneID:1030"
                     /db_xref="HGNC:HGNC:1788"
                     /db_xref="MIM:600431"
                     /translation="MREENKGMPSGGGSDEGLASAAARGLVEKVRQLLEAGADPNGVN
                     RFGRRAIQVMMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRA
                     GARLDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD"
     exon            509..3853
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2168..2173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
                     /note="hexamer: AATAAA"
     polyA_site      2197
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
                     /note="major polyA site"
     regulatory      2358..2363
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
                     /note="hexamer: ATTAAA"
     polyA_site      2382
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
     regulatory      3830..3835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
                     /note="hexamer: AATAAA"
     polyA_site      3853
                     /gene="CDKN2B"
                     /gene_synonym="CDK4I; INK4B; MTS2; P15; p15INK4b; TP15"
                     /note="major polyA site"
ORIGIN      
        1 actctgccag agcgaggcgg ggcagtgagg actccgcgac gcgtccgcac cctgcggcca
       61 gagcggcttt gagctcggct gcgtccgcgc taggcgcttt ttcccagaag caatccaggc
      121 gcgcccgctg gttcttgagc gccaggaaaa gcccggagct aacgaccggc cgctcggcca
      181 ctgcacgggg ccccaagccg cagaaggacg acgggagggt aatgaagctg agcccaggtc
      241 tcctaggaag gagagagtgc gccggagcag cgtgggaaag aagggaagag tgtcgttaag
      301 tttacggcca acggtggatt atccgggccg ctgcgcgtct gggggctgcg gaatgcgcga
      361 ggagaacaag ggcatgccca gtgggggcgg cagcgatgag ggtctggcca gcgccgcggc
      421 gcggggacta gtggagaagg tgcgacagct cctggaagcc ggcgcggatc ccaacggagt
      481 caaccgtttc gggaggcgcg cgatccaggt catgatgatg ggcagcgccc gcgtggcgga
      541 gctgctgctg ctccacggcg cggagcccaa ctgcgcagac cctgccactc tcacccgacc
      601 ggtgcatgat gctgcccggg agggcttcct ggacacgctg gtggtgctgc accgggccgg
      661 ggcgcggctg gacgtgcgcg atgcctgggg tcgtctgccc gtggacttgg ccgaggagcg
      721 gggccaccgc gacgttgcag ggtacctgcg cacagccacg ggggactgac gccaggttcc
      781 ccagccgccc acaacgactt tattttctta cccaatttcc cacccccacc cacctaattc
      841 gatgaaggct gccaacgggg agcggcggaa agcctgtaag cctgcaagcc tgtctgagac
      901 tcacaggaag gaggagccga ccgggaataa ccttccatac atttttttct ttgtcttatc
      961 tggccctcga cactcaccat gaagcgaaac acagagaagc ggatttccag ggatatttag
     1021 gagtgtgtga cattccaggg gtcgtttgct tttcagggtt ttctgaggga aagtgcatat
     1081 gaaatccttg actggacctg gtggctacga atcttccgat ggatgaatct cccactccag
     1141 cgctgagtgg gagaaggcag tgattagcac ttgggtgacg gcagtcgatg cgttcactcc
     1201 aatgtctgct gaggagttat ggtgaaccca caacttaggc cctagcggca gaaaggaaaa
     1261 cctgaagact gaggacaaag tggaggaggg ccgaggtggg cttcagtaag tccccggcgg
     1321 cgctttagtt tgagcgcatg gcaagtcaca tgcgtaaacg acactctctg gaagccctgg
     1381 agaccctcgc ccaactccac cagatagcag aggggtaaga gaggatgtgc aagcgacgac
     1441 agatgctaaa atccctggat cacgacgctg cagagcacct ttgcacagga tgctggcctt
     1501 tgctcttact acactgagga gagattcccg cgggttccgc aggcagacta cacaggatga
     1561 ggtggtggag tggagtgaga gcaattgtaa cggttaactg taacgttttc tttcacacac
     1621 acacacacac acacacacac acatgctagg atgcggaaat ccccttatga cttgctactt
     1681 tttgattttg tgatattttg tactttttag ttgttcagca actgtcttat ttaatgggga
     1741 gattttaagt aacataacta gtggctctca gttaaaatgt gaggaagaac tacagctctt
     1801 aaatgtagca atggcactgt tgcaaactca gtgcaaacgc ctagattgct ttcttcttaa
     1861 cctatttatt tctttgttaa atttttctga ttgtttcctt tatagagtgt ctcagggtgc
     1921 agaggtcaga ctaagaaata ttccaaatgt cttttagaag atagatgcac ttatgcagta
     1981 aattatcttg ggatagttcc caaaagattg ctgaaaaagt agattgagta taaaaacttg
     2041 aaaatatatg atggctcgtg ggatgtccta ctatcactga acaaactaaa ggtgcactgc
     2101 tttgggattt aatttccagg gttgcttgat cattatatca ttggaacaac tgatacttca
     2161 ctactttaat aaagaattaa cagagattga actccaagag gtgggtaatt tggtttaaaa
     2221 atacatgttc atgggtttac cactaactcc tgagaaatgt taaaggttca caggggttcc
     2281 cttctctcaa tgtttgtaat aattgctcat aagcaatacc agcaattcat aaaaactgct
     2341 tacttatgcc atagaaaatt aaacacaaag tgtatacatg tattatgctt ctaaatgctc
     2401 attctaccag atacacattt aaaagagaaa aaaggaacag aaacaagtca tttgagagtg
     2461 gagacttata agaaggagta catttgagtt gaatacacaa atctttactt ctctaccaat
     2521 tcctattccc aaaatgaaca tattactggg gaaagttagt tgagaatcag agcatatgtt
     2581 attggggaaa ggatatgttt attgacacat aatctgtacc aggtatgcat taaaatatat
     2641 ttgttaattt aatatttaaa cctgagagat aggtattgtt tcccagatga ggacaatgag
     2701 gcaaagaaat atcaagtaac ttgccaaagg ttacaagata ttcattccat ggatgcacaa
     2761 agaagtgcat ctagttccac agctgattat ggttgtcttg cttttcttcc cattgcacca
     2821 gcttgtcctc caaaatcatg aatgatacac atgaagataa ctttttttaa aaaaaagcag
     2881 aaatacacaa tgatctccct tgtaagctcc taaggtggct tttctttctc taacttctag
     2941 taaatataaa cggtttgttt gaaaactatt ttaaaatgtc aacaatatgg agaataaccc
     3001 cccccaacac acctataaaa acccaaattt ttggaacaaa gataatggaa cctccatttt
     3061 caaactgaag cacagggaca gaaaatatat ttctagttat cacttaagca ctcaatcatt
     3121 agaggctaca agaataatat ttttaaagtt acagtatttt acaattatta gaaaacattc
     3181 tatataaaag aagtcagttg atactttaaa atctcccatt tggtttataa aatcccttaa
     3241 tttgacctct atatcttaaa ttccaagatg tttaaatttg ctagttgcat tatactgggt
     3301 catgaaaaat tatcccttga aatagatatg aaacatgtta cttcatttct ggtttaaata
     3361 acttgtggaa tctttcctaa tgacaacctg atattaaggg aaactaaaga aaatgttatt
     3421 gtggatccca cagtactata ttacactgtt ttttttgttt gttttgttag ttttttttat
     3481 ttaaagcaaa cctcaaacat tattgggtat caattaccac ctggttgtat tgaaatagta
     3541 acttatcaat gccatgtaaa aattaattcc attttcgaag ccacctggca gacaggttta
     3601 gctgtttcat cagcagccta atatatactg ttaaatttgt taaggatttc actttgaagg
     3661 atacatgcaa aacatatagt tactattttc atgagtcctg cttctagctc cattgtggaa
     3721 tacagaaaat taaatatacc tgttaagttc gtatctaaac ctaagacatt accaaggttt
     3781 gtacaaattc tactacctga catttattcc aagaagatct ggaaagttaa ataaatttat
     3841 aaatttaata aca
//
